메뉴 건너뛰기




Volumn 89, Issue 4, 2011, Pages 513-523

Immunoconjugates against solid tumors: Mind the gap

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBONATE DEHYDRATASE IX; CETUXIMAB; DOCETAXEL; DOXORUBICIN; GEMTUZUMAB OZOGAMICIN; IBRITUMOMAB TIUXETAN; IMGN 242; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOTOXIN; INTERFERON; INTERLEUKIN 2; LABETUZUMAB; LORVOTUZUMAB MERTANSINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY BR 96; NEURADIAB; OFATUMUMAB; PANITUMUMAB; PEMTUMOMAB; PROSTATE SPECIFIC MEMBRANE ANTIGEN; RITUXIMAB; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TAXANE DERIVATIVE; TOSITUMOMAB; TOSITUMOMAB I 131; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 79952992903     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.8     Document Type: Article
Times cited : (22)

References (50)
  • 1
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Köhler, G. & Milstein, C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-497 (1975).
    • (1975) Nature , vol.256 , pp. 495-497
    • Köhler, G.1    Milstein, C.2
  • 2
    • 3042844293 scopus 로고    scopus 로고
    • Cancer immunotherapy: A treatment for the masses
    • DOI 10.1126/science.1100369
    • Blattman, J.N. & Greenberg, P.D. Cancer immunotherapy: a treatment for the masses. Science 305, 200-205 (2004). (Pubitemid 38886725)
    • (2004) Science , vol.305 , Issue.5681 , pp. 200-205
    • Blattman, J.N.1    Greenberg, P.D.2
  • 3
    • 11344291754 scopus 로고    scopus 로고
    • The evolution of antibodies into versatile tumor-targeting agents
    • Lin, M.Z., Teitell, M.A. & Schiller, G.J. The evolution of antibodies into versatile tumor-targeting agents. Clin. Cancer Res. 11, 129-138 (2005). (Pubitemid 40075787)
    • (2005) Clinical Cancer Research , vol.11 , Issue.1 , pp. 129-138
    • Lin, M.Z.1    Teitell, M.A.2    Schiller, G.J.3
  • 4
    • 0034716486 scopus 로고    scopus 로고
    • Therapeutic monoclonal antibodies
    • Breedveld, F.C. Therapeutic monoclonal antibodies. Lancet 355, 735-740 (2000). (Pubitemid 30107636)
    • (2000) Lancet , vol.355 , Issue.9205 , pp. 735-740
    • Breedveld, F.C.1
  • 5
    • 0037264969 scopus 로고    scopus 로고
    • Therapeutic antibodies for human diseases at the dawn of the twenty-first century
    • DOI 10.1038/nrd984
    • Brekke, O.H. & Sandlie, I. Therapeutic antibodies for human diseases at the dawn of the twenty-first century. Nat. Rev. Drug Discov. 2, 52-62 (2003). (Pubitemid 37361624)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.1 , pp. 52-62
    • Brekke, O.H.1    Sandlie, I.2
  • 6
    • 0021991229 scopus 로고
    • Pilot trial of murine monoclonal antibodies in patients with advanced melanoma
    • Goodman, G.E., Beaumier, P., Hellström, I., Fernyhough, B. & Hellström, K.E. Pilot trial of murine monoclonal antibodies in patients with advanced melanoma. J. Clin. Oncol. 3, 340-352 (1985). (Pubitemid 15132002)
    • (1985) Journal of Clinical Oncology , vol.3 , Issue.3 , pp. 340-352
    • Goodman, G.E.1    Beaumier, P.2    Hellstrom, I.3
  • 7
    • 0023922661 scopus 로고
    • Escherichia coli secretion of an active chimeric antibody fragment
    • Better, M., Chang, C.P., Robinson, R.R. & Horwitz, A.H. Escherichia coli secretion of an active chimeric antibody fragment. Science 240, 1041-1043 (1988).
    • (1988) Science , vol.240 , pp. 1041-1043
    • Better, M.1    Chang, C.P.2    Robinson, R.R.3    Horwitz, A.H.4
  • 8
    • 0025226085 scopus 로고
    • Phage antibodies: Filamentous phage displaying antibody variable domains
    • McCafferty, J., Griffiths, A.D., Winter, G. & Chiswell, D.J. Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552-554 (1990). (Pubitemid 120015109)
    • (1990) Nature , vol.348 , Issue.6301 , pp. 552-554
    • McCafferty, J.1    Griffiths, A.D.2    Winter, G.3    Chiswell, D.J.4
  • 9
    • 0024292736 scopus 로고
    • Assembly of a functional immunoglobulin Fv fragment in Escherichia coli
    • Skerra, A. & Plückthun, A. Assembly of a functional immunoglobulin Fv fragment in Escherichia coli. Science 240, 1038-1041 (1988).
    • (1988) Science , vol.240 , pp. 1038-1041
    • Skerra, A.1    Plückthun, A.2
  • 10
    • 0036898144 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of genetically engineered antibodies
    • DOI 10.1016/S0958-1669(02)00352-X
    • Batra, S.K., Jain, M., Wittel, U.A., Chauhan, S.C. & Colcher, D. Pharmacokinetics and biodistribution of genetically engineered antibodies. Curr. Opin. Biotechnol. 13, 603-608 (2002). (Pubitemid 35448063)
    • (2002) Current Opinion in Biotechnology , vol.13 , Issue.6 , pp. 603-608
    • Batra, S.K.1    Jain, M.2    Wittel, U.A.3    Chauhan, S.C.4    Colcher, D.5
  • 11
    • 0028470454 scopus 로고
    • Barriers to drug delivery in solid tumors
    • Jain, R.K. Barriers to drug delivery in solid tumors. Sci. Am. 271, 58-65 (1994).
    • (1994) Sci. Am. , vol.271 , pp. 58-65
    • Jain, R.K.1
  • 12
    • 0025014962 scopus 로고
    • Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors
    • Jain, R.K. Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. Cancer Res. 50, 814s-819s (1990).
    • (1990) Cancer Res. , vol.50
    • Jain, R.K.1
  • 13
    • 0026684815 scopus 로고
    • Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms
    • Yokota, T., Milenic, D.E., Whitlow, M. & Schlom, J. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res. 52, 3402-3408 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 3402-3408
    • Yokota, T.1    Milenic, D.E.2    Whitlow, M.3    Schlom, J.4
  • 14
    • 70350234894 scopus 로고    scopus 로고
    • A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
    • Schmidt, M.M. & Wittrup, K.D. A modeling analysis of the effects of molecular size and binding affinity on tumor targeting. Mol. Cancer Ther. 8, 2861-2871 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2861-2871
    • Schmidt, M.M.1    Wittrup, K.D.2
  • 15
    • 53349175018 scopus 로고    scopus 로고
    • Anti-CD30 diabody-drug conjugates with potent antitumor activity
    • Kim, K.M. et al. Anti-CD30 diabody-drug conjugates with potent antitumor activity. Mol. Cancer Ther. 7, 2486-2497 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2486-2497
    • Kim, K.M.1
  • 16
    • 58149331196 scopus 로고    scopus 로고
    • High shed antigen levels within tumors: An additional barrier to immunoconjugate therapy
    • Zhang, Y. & Pastan, I. High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy. Clin. Cancer Res. 14, 7981-7986 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7981-7986
    • Zhang, Y.1    Pastan, I.2
  • 17
    • 34047112335 scopus 로고    scopus 로고
    • Technology Insight: Cytotoxic drug immunoconjugates for cancer therapy
    • DOI 10.1038/ncponc0774, PII NCPONC0774
    • Ricart, A.D. & Tolcher, A.W. Technology insight: cytotoxic drug immunoconjugates for cancer therapy. Nat. Clin. Pract. Oncol. 4, 245-255 (2007). (Pubitemid 46510534)
    • (2007) Nature Clinical Practice Oncology , vol.4 , Issue.4 , pp. 245-255
    • Ricart, A.D.1    Tolcher, A.W.2
  • 19
    • 77954031486 scopus 로고    scopus 로고
    • Phase i study of trastuzumab-DM1, An HER2 antibody-drug conjugate, Given every 3 weeks to patients with HER2-positive metastatic breast cancer
    • Krop, I.E. et al. Phase i study of trastuzumab-DM1, An HER2 antibody-drug conjugate, Given every 3 weeks to patients with HER2-positive metastatic breast cancer. J. Clin. Oncol. 28, 2698-2704 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2698-2704
    • Krop, I.E.1
  • 20
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab - Mechanism of action and use in clinical practice
    • DOI 10.1056/NEJMra043186
    • Hudis, C.A. Trastuzumab-mechanism of action and use in clinical practice. N. Engl. J. Med. 357, 39-51 (2007). (Pubitemid 47026733)
    • (2007) New England Journal of Medicine , vol.357 , Issue.1 , pp. 39-51
    • Hudis, C.A.1
  • 22
    • 12944276968 scopus 로고    scopus 로고
    • Radioimmunotherapy-hot new treatment for lymphoma
    • Connors, J.M. Radioimmunotherapy-hot new treatment for lymphoma. N. Engl. J. Med. 352, 496-498 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 496-498
    • Connors, J.M.1
  • 23
    • 23044469097 scopus 로고    scopus 로고
    • Radioimmunotherapy of prostate cancer: Does tumor size matter?
    • DOI 10.1200/JCO.2005.01.903
    • Scott, A.M. Radioimmunotherapy of prostate cancer: does tumor size matter? J. Clin. Oncol. 23, 4567-4569 (2005). (Pubitemid 46224054)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.21 , pp. 4567-4569
    • Scott, A.M.1
  • 25
    • 22044451179 scopus 로고    scopus 로고
    • 177Lutetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer
    • DOI 10.1200/JCO.2005.05.160
    • Bander, N.H., Milowsky, M.I., Nanus, D.M., Kostakoglu, L., Vallabhajosula, S. & Goldsmith, S.J. Phase i trial of 177lutetium-labeled J591, A monoclonal antibody to prostate-specific membrane antigen, In patients with androgenindependent prostate cancer. J. Clin. Oncol. 23, 4591-4601 (2005). (Pubitemid 46224061)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.21 , pp. 4591-4601
    • Bander, N.H.1    Milowsky, M.I.2    Nanus, D.M.3    Kostakoglu, L.4    Vallabhajosula, S.5    Goldsmith, S.J.6
  • 26
    • 4344618391 scopus 로고    scopus 로고
    • Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer
    • DOI 10.1200/JCO.2004.09.154
    • Milowsky, M.I., Nanus, D.M., Kostakoglu, L., Vallabhajosula, S., Goldsmith, S.J. & Bander, N.H. Phase i trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer. J. Clin. Oncol. 22, 2522-2531 (2004). (Pubitemid 41103739)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.13 , pp. 2522-2531
    • Milowsky, M.I.1    Nanus, D.M.2    Kostakoglu, L.3    Vallabhajosula, S.4    Goldsmith, S.J.5    Bander, N.H.6
  • 29
    • 27144550160 scopus 로고    scopus 로고
    • Arming antibodies: Prospects and challenges for immunoconjugates
    • DOI 10.1038/nbt1141, PII N1141
    • Wu, A.M. & Senter, P.D. Arming antibodies: prospects and challenges for immunoconjugates. Nat. Biotechnol. 23, 1137-1146 (2005). (Pubitemid 41486395)
    • (2005) Nature Biotechnology , vol.23 , Issue.9 , pp. 1137-1146
    • Wu, A.M.1    Senter, P.D.2
  • 30
    • 79952986634 scopus 로고    scopus 로고
    • A phase i study of huC242-DM4 to assess the safety and pharmacokinetics of huC242-DM4 administered as a single intravenous infusion once every three weeks to subjects with solid tumors
    • Abstr 212
    • Tolcher, A.W. et al. A phase i study of huC242-DM4 to assess the safety and pharmacokinetics of huC242-DM4 administered as a single intravenous infusion once every three weeks to subjects with solid tumors. Eur. J. Cancer (suppl. 4) (2006) Abstr 212.
    • (2006) Eur. J. Cancer , Issue.SUPPL. 4
    • Tolcher, A.W.1
  • 31
    • 77953376431 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of iMGN242 (huC242-DM4) in patients with Canag-expressing solid tumors
    • Abstr 3066
    • Qin, A. et al. The pharmacokinetics and pharmacodynamics of iMGN242 (huC242-DM4) in patients with Canag-expressing solid tumors. J. Clin. Oncol. 26 (2008) Abstr 3066.
    • (2008) J. Clin. Oncol. , vol.26
    • Qin, A.1
  • 32
    • 56449129810 scopus 로고    scopus 로고
    • Targeting HER2-positive breast cancer with trastuzumab-DM1, An antibody-cytotoxic drug conjugate
    • Lewis Phillips, G.D. et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, An antibody-cytotoxic drug conjugate. Cancer Res. 68, 9280-9290 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 9280-9290
    • Lewis Phillips, G.D.1
  • 33
    • 70350623516 scopus 로고    scopus 로고
    • A phase ii study of trastuzumab-DM1 (T-DM1), A HER2 antibody-drug conjugate (aDC), in patients (pts) with HER2+ metastatic breast cancer (MBC): Final results
    • Abstr 1017
    • Vogel, C.L. et al. A phase ii study of trastuzumab-DM1 (T-DM1), A HER2 antibody-drug conjugate (aDC), In patients (pts) with HER2+ metastatic breast cancer (MBC): final results. J. Clin. Oncol. 27 (2009) Abstr 1017.
    • (2009) J. Clin. Oncol. , vol.27
    • Vogel, C.L.1
  • 34
    • 78651447411 scopus 로고    scopus 로고
    • A phase 2 study of trastuzumab-DM1 (T-DM1), A novel HER2 antibody-drug conjugate, in HER2+ metastatic breast cancer (MBC) patients previously treated with conventional chemotherapy, Lapatinib and trastuzumab
    • Abstr 710
    • Krop, I. et al. A phase 2 study of trastuzumab-DM1 (T-DM1), A novel HER2 antibody-drug conjugate, In HER2+ metastatic breast cancer (MBC) patients previously treated with conventional chemotherapy, Lapatinib and trastuzumab. 32nd annual San antonio Breast Cancer Symposium (2009) Abstr 710.
    • (2009) 32nd Annual San Antonio Breast Cancer Symposium
    • Krop, I.1
  • 35
    • 79551609265 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab-DM1 versus trastuzumab plus docetaxel in HER2-positive metastatic breast cáncer patients with no prior chemotherapy for metastatic disease: Preliminary results of a randomized, Multicenter, Open-label phase 2 study (TDM4450G)
    • Abstr LBa3
    • Perez, E.A. et al. Efficacy and safety of trastuzumab-DM1 versus trastuzumab plus docetaxel in HER2-positive metastatic breast cáncer patients with no prior chemotherapy for metastatic disease: preliminary results of a randomized, Multicenter, Open-label phase 2 study (TDM4450G). Ann. Oncol. 21, Vii2 (2010) Abstr LBa3.
    • (2010) Ann. Oncol. , vol.21 , Issue.2
    • Perez, E.A.1
  • 37
    • 43749092340 scopus 로고    scopus 로고
    • Phase i trial of the prostate-specific membrane antigendirected immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer
    • Galsky, M.D. et al. Phase i trial of the prostate-specific membrane antigendirected immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer. J. Clin. Oncol. 26, 2147-2154 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2147-2154
    • Galsky, M.D.1
  • 38
    • 77952239035 scopus 로고    scopus 로고
    • A phase i/ii study of CR011-vcMMaE, An antibody-drug conjugate (aDC) targeting glycoprotein NMB (GpNMB) in patients (pts) with advanced melanoma
    • Abstr 9032
    • Hwu, P. et al. A phase i/ii study of CR011-vcMMaE, An antibody-drug conjugate (aDC) targeting glycoprotein NMB (GpNMB) in patients (pts) with advanced melanoma. J. Clin. Oncol. 27, (2009) Abstr 9032.
    • (2009) J. Clin. Oncol. , vol.27
    • Hwu, P.1
  • 39
    • 56449085913 scopus 로고    scopus 로고
    • A human antibody-drug conjugate targeting Epha2 inhibits tumor growth in vivo
    • Jackson, D. et al. A human antibody-drug conjugate targeting Epha2 inhibits tumor growth in vivo. Cancer Res. 68, 9367-9374 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 9367-9374
    • Jackson, D.1
  • 40
    • 58149161759 scopus 로고    scopus 로고
    • Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker
    • Oflazoglu, E. et al. Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker. Clin. Cancer Res. 14, 6171-6180 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6171-6180
    • Oflazoglu, E.1
  • 42
    • 67649933809 scopus 로고    scopus 로고
    • Phase ii trial of recombinant immunotoxin RFB4(dsFv)-pE38 (BL22) in patients with hairy cell leukemia
    • Kreitman, R.J. et al. Phase ii trial of recombinant immunotoxin RFB4(dsFv)-pE38 (BL22) in patients with hairy cell leukemia. J. Clin. Oncol. 27, 2983-2990 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2983-2990
    • Kreitman, R.J.1
  • 44
    • 34548858453 scopus 로고    scopus 로고
    • Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers
    • DOI 10.1158/1078-0432.CCR-07-0869
    • Hassan, R. et al. Phase i study of SS1p, A recombinant anti-mesothelin immunotoxin given as a bolus i.V. Infusion to patients with mesothelinexpressing mesothelioma, Ovarian, And pancreatic cancers. Clin. Cancer Res. 13, 5144-5149 (2007). (Pubitemid 47502082)
    • (2007) Clinical Cancer Research , vol.13 , Issue.17 , pp. 5144-5149
    • Hassan, R.1    Bullock, S.2    Premkumar, A.3    Kreitman, R.J.4    Kindler, H.5    Willingham, M.C.6    Pastan, I.7
  • 45
    • 0036749889 scopus 로고    scopus 로고
    • Altering pharmacokinetics of radiolabeled antibodies by the interposition of metabolizable linkages: Metabolizable linkers and pharmacokinetics of monoclonal antibodies
    • Akizawa, H. & Arano, Y. Altering pharmacokinetics of radiolabeled antibodies by the interposition of metabolizable linkages. Metabolizable linkers and pharmacokinetics of monoclonal antibodies. Q. J. Nucl. Med. 46, 206-223 (2002). (Pubitemid 35203314)
    • (2002) Quarterly Journal of Nuclear Medicine , vol.46 , Issue.3 , pp. 206-223
    • Akizawa, H.1    Arano, Y.2
  • 46
    • 0141679544 scopus 로고    scopus 로고
    • Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates
    • DeNardo, G.L. et al. Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates. Clin. Cancer Res. 9, 3865S-3872S (2003).
    • (2003) Clin. Cancer Res. , vol.9
    • Denardo, G.L.1
  • 47
    • 0035661063 scopus 로고    scopus 로고
    • Cleavable linkers to enhance selectivity of antibody-targeted therapy of cancer
    • Kukis, D.L., Novak-Hofer, I. & DeNardo, S.J. Cleavable linkers to enhance selectivity of antibody-targeted therapy of cancer. Cancer Biother. Radiopharm. 16, 457-467 (2001). (Pubitemid 34024434)
    • (2001) Cancer Biotherapy and Radiopharmaceuticals , vol.16 , Issue.6 , pp. 457-467
    • Kukis, D.L.1    Novak-Hofer, I.2    DeNardo, S.J.3
  • 48
    • 64349107630 scopus 로고    scopus 로고
    • Development trends for therapeutic antibody fragments
    • Nelson, A.L. & Reichert, J.M. Development trends for therapeutic antibody fragments. Nat. Biotechnol. 27, 331-337 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , pp. 331-337
    • Nelson, A.L.1    Reichert, J.M.2
  • 49
    • 23244455101 scopus 로고    scopus 로고
    • Population pharmacokinetics of trastuzumab in patients with HER2+ metastatic breast cancer
    • DOI 10.1007/s00280-005-1026-z
    • Bruno, R., Washington, C.B., Lu, J.F., Lieberman, G., Banken, L. & Klein, P. Population pharmacokinetics of trastuzumab in patients with HER2+ metastatic breast cancer. Cancer Chemother. Pharmacol. 56, 361-369 (2005). (Pubitemid 41095399)
    • (2005) Cancer Chemotherapy and Pharmacology , vol.56 , Issue.4 , pp. 361-369
    • Bruno, R.1    Washington, C.B.2    Lu, J.-F.3    Lieberman, G.4    Banken, L.5    Klein, P.6
  • 50
    • 3042572930 scopus 로고    scopus 로고
    • Curtailing the high rate of late-stage attrition of investigational therapeutics against unprecedented targets in patients with lung and other malignancies
    • DOI 10.1158/1078-0432.CCR-040013
    • Rowinsky, E.K. Curtailing the high rate of late-stage attrition of investigational therapeutics against unprecedented targets in patients with lung and other malignancies. Clin. Cancer Res. 10, 4220s-4226s (2004). (Pubitemid 38812450)
    • (2004) Clinical Cancer Research , vol.10 , Issue.12
    • Rowinsky, E.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.