DNA-based authentication of TCM-plants: Current progress and future perspectives

Evidence and Rational Based Research on Chinese Drugs

Volumn , Issue , 2013, Pages 27-85

  Heubl, G ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84900449784     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-7091-0442-2_2     Document Type: Chapter

References (433)

1. Agarwal M (2008) Advances in molecular marker techniques and their applications in plant sciences. Plant Cell Rep 27:617-631
2. Akkaya MS, Shoemaker RC, Specht JE, Bhagwat AA, Cregan PB (1995) Integration of simple sequence repeat and markers into a soybean linkage map. Crop Sci 35:1439-1445
3. Albach DC, Li HQ, Zhao N, Jensen SR (2007) Molecular systematics and phytochemistry of Rehmannia (Scrophulariaceae). Biochem Syst Ecol 35:293-300
4. Albani MC, Battey NH, Wilkinson MJ (2004) The development of ISSR derived SCAR markers around the seasonal flowering locus (SFL) in Fragaria vesca. Theor Appl Genet 109:571-579
5. Alvarez I, Wendel JF (2003) Ribosomal ITS sequences and plant phylogenetic inference. Mol Phylogenet Evol 29:417-434
6. Arya M, Shergill IS, Williamson M, Gommersall L, Arya N, Patel HR (2005) Basic principles of real-time quantitative PCR. Expert Rev Mol Diagn 5(2):209-219
7. Asahina H, Shinozaki J, Masuda K et al (2010) Identification of medicinal Dendrobium species by phylogenetic analyses using matK and rbcL sequences. J Nat Med 64(2):133-138
8. Bailey CD, Carr TG, Harris SA, Hughes CE (2003) Characterization of angiosperm nrDNA polymorphism, paralogy, and pseudogenes. Mol Phylogenet Evol 29:435-455
9. Baldwin BG, Sanderson MJ, Porter JM, Wojciechowski MF, Campbell CS, Donoghue MJ (1995) The ITS region of nuclear ribosomal DNA: a valuable source of evidence on angiosperm phylogeny. Ann Missouri Bot Gard 82:247-277
10. Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants [J]. Life Sci 78(5):431-441
11. Barthelson RA (2009) Protocols for in vitro cultures and secondary metabolite analysis of aromatic and medicinal plants. Identification of medicinal plants and plant sequences: multiplexed MLPA assay. Methods Mol Biol 547(3):277-288
12. Bauer T, Weller P, Hammes WP, Hertel C (2003) The effect of processing parameters on DNA degradation in food. Eur Food Res Technol 217:338-343
13. Bhattacharya E, Dandin SB et al (2005) Single primer amplification reaction methods reveal exotic and indigenous mulberry varieties are similarly diverse. J Biosci 30:669-677
14. Blears M, De Grandis S, Lee H, Trevors J (1998) Amplified fragment length polymorphism (AFLP): a review of the procedure and its applications. J Ind Microbiol Biotechnol 21:99-114
15. Boqian Y, Jing W, Guopei C, Ting W (2009) Isolation and characterization of polymorphic microsatellite loci in a traditional Chinese medicinal plant, Schisandra sphenanthera. Cons Genetics 10:615-617
16. Borne B, Goraguer F, Joly G, Branchard M (2002) Genetic diversity in European and Argentinian cultivated potatoes (Solanum tuberosum subsp. tuberosum) detected by inter-simple sequence repeats (ISSRS). Genome 45:481-484
17. Bornet B, Branchard M (2004) Use of ISSR fingerprints to detect microsatellites and genetic diversity in several related Brassica taxa and Arabidopsis thaliana. Hereditas 140:245-248
18. Buckler ES, Ipplito SA, Holtsford TP (1997) The evolution of ribosomal DNA: divergent paralogues and phylogenetic implications. Genetics 145:111-125
19. But PPH (1994) Herbal poisoning caused by adulterants or erroneous substitutes. J Trop Med Hyg 97:371-374
20. But PP, Tomlinson B, Cheung KO, Yong SP, Szeto ML, Lee CK (1996) Adulterants of herbal products can cause poisoning. Br Med J 313:117
21. Caetano-Anollés G, Gresshoff PM (1996) Generation of sequence signatures from DNA amplification fingerprints with mini-hairpin and microsatellite primers. Biotechniques 20:1044-1056
22. Caetano-Anollés G, Bassam BJ, Gresshoff PM (1991a) DNA amplification fingerprinting: a strategy for genome analysis. Plant Mol Biol Rep 9:294-307
23. Caetano-Anollés G, Bassam BJ, Gresshoff PM (1991b) DNA amplification using very short arbitrary oligonucleotide primers. Biotechnology 9:553-557
24. Cai ZH, Li P, Dong TT, Tsim KW (1999) Molecular diversity of 5S-rRNA spacer domain in Fritillaria species revealed by PCR analysis. Planta Med 65:360-364
25. Cai H, White PS, Torney D et al (2000) Flow cytometry-based minisequencing: a new platform for high-throughput single-nucleotide polymorphism scoring. Genomics 66:135-143
26. Cao H, But PPH, Shaw PC (1996a) Authentication of the Chinese drug "ku-di-dan" (herba elephantopi) and its substitutes using random-primed polymerase chain reaction (PCR). Acta Pharm Sin 31:543-553
27. Cao H, But PPH, Shaw PC (1996b) Identification of herba taraxaci and its adulterants in Hong Kong market by DNA fingerprinting with random primed PCR. China J Chin Mater Med 22:197-200
28. Carles M, Cheung MK, Moganti S, Dong TT, Tsim KW, Ip NY et al (2005) A DNA microarray for the authentication of toxic traditional Chinese medicinal plants. Planta Med 71:580-584
29. CBOL Plant Working Group (2009) A DNA barcode for land plants. Proc Natl Acad Sci 106(31):12794-12797
30. Chakrabarty D, Yu KW, Paek KY (2003) Detection of DNA methylation changes during somatic embryogenesis of Siberian ginseng (Eleuterococcus senticosus). Plant Sci 165:61-68
31. Chan TYK (1997) Monitoring the safety of herbal medicine. Drug Saf 17:209-215
32. Chan K (2003) Some aspects of toxic contaminants in herbal medicines. Chemosphere 52:1361-1371
33. Chan TY, Critchley JA (1996) Usage and adverse effects of Chinese herbal medicines. Hum Exp Toxicol 15:5-12
34. Chan TYK, Chan JCN, Tomlinson B, Critchley JA (1993) Chinese herbal medicines revisited: a Hong Kong perspective. Lancet 342:18-25
35. Chase MW, Salamin N, Wilkinson M, Dunwell JM, Kesanakurthi RO et al (2005) Land plants and DNA barcodes: short-term and long-term goals. Philos Trans R Soc Lond B 360:1889-1895
36. Chase MW, Cowan RS, Hollingsworth PM, Van Den Berg C, Madrinan S et al (2007) A proposal for a standardised protocol to barcode all land plants. Taxon 56:295-299
37. Chatti K, Saddoud O, Salhi Hannachi A, Mars M, Marrakchi M, Trifi M (2007) Analysis of genetic diversity and relationships in a Tunisian Fig (Ficus carica) germplasm collection by random amplified microsatellite polymorphisms. J Integr Plant Biol 49:386-391
38. Chawla HS (2002) Introduction to plant biotechnology, 2nd rev. edn. Science Publishers
39. Enfield, NH Chen KT, Su YC, Lin JG, Hsin LH, Su YP, Su CH, Li SY, Cheng JH, Mao SJ (2001) Identification of Atractylodes plants in Chinese herbs and formulations by random amplified polymorphic DNA. Acta Pharm Sin 22:493-497
40. Chen J, Chen L, An Z, Shi S, Zhan Y (2002) Non-technical causes of fakes existing in Chinese medicinal material markets. Zhongyaocai 25:516-519
41. Chen F, Chan HYE et al (2008) Authentication of Saussurea lappa and endangered medicinal material, by ITS DNA and 5S rRNA sequencing. Planta Med 74:889-892
42. Chen S, Yao H, Han J, Liu C, Song J, Shi L, Zhu Y, Ma X, Gao T, Pang X, Luo K, Li Y, Li X, Jia X, Lin Y, Leon C (2010) Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species. PLOS ONE 5(1):e86137
43. Cheng KT, Chang HC, Su CH, Hsu FL (1997) Identification of dried rhizomes of Coptis species using random amplified polymorphic DNA. Bot Bull Acad Sin 38:241-244
44. Chen JH, Zhou Y, Yang YP (2011) Isolation and characterization of 20 new microsatellite loci in Coriaria nepalensis (Coriariaceae). Am J Bot 98(6):e141-e143
45. Cheng KT, Fu LC et al (1998) Identification of Anoectochilus formosanus and Anoectochilus koshunensis species with RAPD markers. Planta Med 64:46-49
46. Cheng KT, Su B, Chen CT, Lin CC (2000) RAPD analysis of Astragalus medicines marketed in Taiwan. Am J Chin Med 28:273-278
47. Cheng JL, Huang LQ, Shao AJ, Lin SF (2002) RAPD analysis on different varieties of Rehmannia glutinosa. Zhongguo Zhongyao Zazhi 27:505-508
48. Cheung KS, Kwan HS, But PPH, Shaw PC (1994) Pharmacognostical identification of American and Oriental ginseng roots by genomic fingerprinting using arbitrarily primed polymerase chain reaction (AC-PCR). J Ethnopharmacol 42:67-69
49. Cheung TP, Xue C, Leung K et al (2006) Aristolochic acids detected in some raw Chinese medicinal herbs and manufactured herbal products - a consequence of inappropriate nomenclature and imprecise labelling? Clin Toxicol 44:371
50. Chiou SJ, Yen JH et al (2007) Authentication of medicinal herbs using PCR-Amplified ITS2 with specific primers. Planta Med 73:1421-1426
51. Choi YE, Ahn CH, Kim BB, Yoon ES (2008) Development of species specific AFLP-derived SCAR marker for authentication of Panax japonicus C. A. MEYER. Biol Pharm Bull 31:135-138
52. Chun S, Jian-He W, Shi-Lin C, Huai-Qiong C, Cheng-Min Y (2009) Development of genomic SSR and potential EST-SSR markers in Bupleurum chinense DC. Afr J Biotechnol 8:6233-6240
53. Chung SM, Staub JE (2003) The development and evaluation of consensus chloroplast primer pairs that possess highly variable sequence regions in a diverse array of plant taxa. Theor Appl Genet 107:757-776
54. Clark CM, Wentworth TM, Malley DMO (2000) Genetic discontinuity revealed by chloroplast microsatellites in eastern North American Abies (Pinaceae). Am J Bot 87:774-778
55. Cole CT, Kuchenreuther MA (2001) Molecular markers reveal little genetic differentiation among Aconitum noveboracense and A. columbianum (Ranunculaceae) populations. Am J Bot 88:337-347
56. Cole IB, Saxena PK, Murch SJ (2007) Medicinal biotechnology in the genus Scutellaria. In Vitro Cell Dev Biol Plant 43(4):318-327
57. Cowan RS, Chase MW, Kress WJ, Savolainen V (2006) 300, 000 species to identify: problems, progress, and prospects in DNA barcoding of land plants. Taxon 55:611-616
58. Cui XM, Lo CK, Yip KL, Dong TT, Tsim KW (2003) Authentication of Panax notoginseng by 5S-rRNA spacer domain and random amplified polymorphic DNA (RAPD) analysis. Planta Med 69:584-586
59. Dasmahapatra KK, Mallet J (2006) DNA barcodes: recent successes and future prospects. Heredity 97:254-255
60. Datwyler SL, Weiblen GD (2006) Genetic variation in hemp and marijuana (Cannabis sativa L.) according to amplified fragment length polymorphisms. J Forensic Sci 51:371-375
61. De Groot GA, During HJ, Maas JW, Schneider H, Vogel JC et al (2011) Use of rbcL and trnL-F as a two-locus DNA barcode for identification of NW European ferns: an ecological perspective. PLoS One 6(1):e16371
62. Debelle FD, Vanherweghem JL, Nortier JL (2008) Aristolochic acid nephropathy: a worldwide problem. Kidney Int 74:158-169
63. Debouck C, Goodfellow PN (1999) DNA microarrays in drug discovery and development. Nat Genet 21:48-50
64. Desmarais E, Lanneluc I, Lagnel J (1998) Direct amplification of length polymorphisms (DALP), or how to get and characterize new genetic markers in many species. Nucleic Acids Res 26:1458-1465
65. Devaiah KM, Venkatasubramanian P (2008a) Development of SCAR marker for authentication of Pueraria tuberosa (Roxb. ex. Willd.) DC. Curr Sci 94:1306-1308
66. Devaiah KM, Venkatasubramanian P (2008b) Genetic characterization and authentication of Embelia ribes using RAPD-PCR and SCAR marker. Planta Med 74:194-196
67. Diao Y, Lin XM et al (2009) Authentication of Panax ginseng from its adulterants by PCR-RFLP and ARMS. Planta Med 75:557-560
68. Dictionary of Chinese Materia Medica (2006), 2nd edn. Shanghai Scientific & Technical, Shanghai
69. Ding T (2002) The botany database: seed plants of China (SPCH), and its applications. Geoscience and Remote Sensing Symposium, 2002. IGARSS'02. 2002 I. E. International
70. Ding X, Xu L, Wang Z, Zhou K, Xu H, Wang Y (2002) Authentication of stems of Dendrobium officinale by rDNA ITS region sequences. Planta Med 68:191-192
71. Ding G, Zhang DZ et al (2008) SNP, ARMS and SSH authentication of medicinal Dendrobium officinale Kimura et Migo and application for identification of Fengdou drugs. Biol Pharm Bull 31:553-557
72. Dnyaneshwar W, Preeti C, Kalpana J, Bhushan P (2006) Development and application of RAPD-SCAR marker for identification of Phyllanthus emblica L. Biol Pharm Bull 29:2313-2316
73. Do KR, Hwang WJ, Lyu YS, An NH, Kim HM (2001) Molecular authentication of Panax ginseng species by RAPD analysis and PCR-RFLP. Biol Pharm Bull 24:872-875
74. Dong CH, Yao YJ (2010) On the reliability of fungal materials used in studies on Ophiocordyceps sinensis. J Ind Microbiol Biotechnol. doi:10.1007
75. Dong TT, Ma XQ, Clarke C, Song ZH, Ji ZN, Lo CK et al (2003) Phylogeny of Astragalus in China: molecular evidence from the DNA sequences of 5S rRNA spacer, ITS, and 18S rRNA. J Agric Food Chem 51:6709-6714
76. Drouin G, Daoud H, Xia J (2008) Relative rates of synonymous substitutions in the mitochondrial, chloroplast and nuclear genomes of seed plants. Mol Phylogenet Evol 49(3):827-831
77. Ernst E (2004) Risks of herbal medicinal products. Pharmacoepidem. Drug Saf. 13(11):767-71
78. Eisenmann SW, Struwe L, Tucker AO (2012) Voucher specimens are essential for documenting source material used in medicinal plant investigations. J Med Active Plants 1(1):30-43
79. Erickson DL, Spouge J, Resch A, Weigt LA, Kress WJ (2008) DNA barcoding in land plants: developing standards to quantify and maximize success. Taxon 57:1304-1316
80. Fan XX, Shen L, Zhang X, Chen XY, Fu CX (2004) Assessing genetic diversity of Ginkgo biloba L. (Ginkgoaceae) populations from China by RAPD markers. Biochem Genet 42:269-278
81. Fan WJ, Luo YM et al (2009) Development of microsatellite markers in Dendrobium fimbriatum Hook, an endangered Chinese endemic herb. Mol Ecol Res 9:373-375
82. Farnsworth NR, Soejarto DD (1991) Global importance of medicinal plants. In: Akerele O, Heywood V, Synge H (eds) The conservation of medicinal plants. Cambridge University Press, Cambridge, pp 25-51
83. Fazekas AJ et al (2008) Multiple multilocus DNA barcodes from the plastid genome discriminate plant species equally well. PLoS One 3(7):e2802
84. Feliner GN, Rosselló JA (2007) Better the devil you know? Guidelines for insightful utilization of nrDNA ITS in species level evolutionary studies in plants. Mol Phylogenet Evol 44:911-919
85. Ferri G, Alù M, Corradini B, Licata M, Beduschi G (2009) Species identification through DNA "barcodes". Genet Test Mol Biomarkers 13:421-426
86. Fodor SP, Read JL, Pirrung MC, Stryer L, Lu AT, Solas D (1991) Light-directed, spatially addressable parallel chemical synthesis. Science 251:767-773
87. Fleischmann A, Heubl G (2009) Overcoming DNA extraction problems from carnivorous plants. Anal Jardín Bot Madrid 66(2):209-215
88. Fodor SP, Rava RP, Huang XC, Pease AC, Holmes CP, Adams CL (1993) Multiplexed biochemical assays with biological chips. Nature 364:555-556
89. Ford C, Ayres KL, Toomey N, Haider N et al (2009) Selection of candidate coding DNA barcoding regions for use on land plants. Bot J Linn Soc 159(1):1-11
90. Fortina P, Kricka LJ, Surrey S, Grodzinski P (2005) Nanobiotechnology: the promise and reality of new approaches to molecular recognition. Trends Biotechnol 23:168-173
91. Friar EA (2005) Isolation of DNA from plants with large amounts of secondary metabolites. Methods Enzymol 395:3-14
92. Fu RZ, Wang J, Zhang YB, Wang ZT, But PP, Li N, Shaw PC (1999) Differentiation of medicinal Codonopsis species from adulterants by polymerase chain reaction-restriction fragment length polymorphism. Planta Med 65:648-650
93. Fugh-Berman A (2000) Herb-drug interactions. Lancet 355:134-138
94. Gao WY, Jia W, Duan HQ, Huang L, Xiao X, Xiao P, Paek KY (2002) Good agriculture practice (GAP) and sustainable resource utilization of Chinese materia medica. Plant Biotechnol 4(3):103-107
95. Gao T, Yao H, Song JY, Liu C, Zhu YJ, Ma XY, Pang XH, Xu HX, Chen SL (2010a) Identification of medicinal plants in the family Fabaceae using a potential DNA barcode ITS2. J Ethnopharmacol 130:116-121
96. Gao T, Yao H, Song J, Zhu Y, Liu C, Chen S (2010b) Evaluating the feasibility of using candidate DNA barcodes in discriminating species of the large Asteraceae family. BMC Evol Biol 10:324
97. Gawel NJ, Jarret RL, Whittemore AP (1992) Restriction fragment length polymorphism (RFLP) - based phylogenetic analysis of Musa. Theor Appl Genet 84:286-290
98. Ge XJ, Yu Y, Yuan YM, Huang HW, Cheng YAN (2005) Genetic diversity and geographic differentiation in endangered Ammopiptanthus (Leguminosae) populations in desert regions of Northwest China as revealed by ISSR analysis. Ann Bot 95:843-851
99. Gebauer M (2004) Microarray applications: emerging technologies and perspectives. Drug Discov Today 9:915-917
100. Gershon D (2002) Microarray technology: an array of opportunities. Nature 416:885-891
101. Gertner E, Marshall PS, Filandrinos D, Potek AS, Smith TM (1995) Complications resulting from the use of Chinese herbal medications containing undeclared prescription drugs. Arthritis Rheum 38:614-617
102. Goldstein DB, Schlötterer C (1999) Microsatellites: evolution and applications. Oxford University Press, Oxford, UK
103. Gong W, Fu CX, Luo YP, Qiu YX (2006) Molecular identification of Sinopodophyllum hexandrum and Dysosma species using cpDNA sequences and PCR-RFLP markers. Planta Med 72:650-652
104. Govaerts R (2001) How many species of seed plants are there? Taxon 50:1085-1090
105. Graham-Brown R (1992) Toxicity of Chinese herbal remedies. Lancet 340:673-674
106. Grossmann PD, Bloch W, Brinson E et al (1994) High-density multiplex detection of nucleic acid sequences: oligonucleotide ligation assay and sequence-coded separation. Nucleic Acids Res 22:4527-4534
107. Guo BL, Wu M, Si JP, Li JS, Xiao PG (2001) Research on DNA molecular marker of Magnolia officinalis Rehd. et Wils. RAPD study on certified species. Yao Xue Xue Bao 36:386-389
108. Guo Y, Tsuruga A, Yamaguchi S, Oba K, Iwai K, Sekita S et al (2006) Sequence analysis of chloroplast chlB gene of medicinal Ephedra species and its application to authentication of Ephedra herb. Biol Pharm Bull 29:1207-1211
109. Guo HY, Wang WW, Yang N et al (2010) DNA barcoding provides distinction between Radix Astragali and its adulterants. Sci China Life Sci 53(8):992-999
110. Gupta PK, Balyan HS, Sharma PC, Ramesh B (1996) Microsatellites in plants: a new class of molecular markers. Curr Sci 70:45-54
111. Gupta AR, Patra RC, Das DK, Gupta PK, Swarup D, Saini M (2001a) Sequence characterization and polymerase chain reaction-restriction fragment length polymorphism of the mitochondrial DNA 12S rRNA gene provides a method for species identification of Indian deer. Mitochondrial DNA 19:394-400
112. Gupta PK, Roy JK, Prasad M (2001b) Single nucleotide polymorphisms: a new paradigm for molecular marker technology and DNA polymorphism detection with emphasis on their use in plants. Curr Sci 80(4):524-535
113. Ha WY, Yau FC, But PP, Wang J, Shaw PC (2001) Direct amplification of length polymorphism analysis differentiates Panax ginseng from P. quinquefolius. Planta Med 67:587-589
114. Ha WY, Shaw PC, Liu J, Yau FC, Wang J (2002) Authentication of Panax ginseng and Panax quinquefolius using amplified fragment length polymorphism (AFLP) and directed amplification of minisatellite region DNA (DAMD). J Agric Food Chem 50:1871-1875
115. Hajibabaei M, De Waard JR, Ivanova NV, Ratnasingham S, Dooh RT, Kirk SL, Mackie PM, Hebert PDN (2005) Critical factors for assembling a high volume of DNA barcodes. Philos Trans R Soc B 360(1462):1959-1967
116. Hajibabaei M, Singer GA, Hebert PDN, Hickey DA (2007) DNA barcoding: how it complements taxonomy, molecular phylogenetics and population genetics. Trends Genet 23(4):167-172
117. Hamilton AC (2003) Medicinal plants and conservation: issues and approaches. Paper presented to International Plants Conservation Unit World Wildlife Foundation, UK
118. Hamilton AC (2004) Medicinal plants, conservation and livelihoods. Biodivers Conserv 13:1477-1517
119. Han J, Shi L, Song J et al (2009) Testing potential DNA barcoding regions in the Labiatae medicinal plants. Planta Med 75:407
120. Hao DC, Chen SL, Xia PG, Peng Y (2010) Authentication of medicinal plants by DNA-based markers and genomics. Chin Herb Med 2(4):250-261
121. Hayashi K (1992) PCR-SSCP-rapid and easy detection of DNA sequence changes. Hum Cell 5:180-184
122. Hayden MJ, Nguyen TM, Waterman A, Chalmers KJ (2008) Multiplex-ready PCR: a new method for multiplexed SSR and SNP genotyping. BMC Genomics 9:80
123. He J, Wong KL, Shaw PC, Wang H, Li DZ (2010) Identification of the medicinal plants in Aconitum L. by DNA barcoding technique. Plant Med 76:1622-1628
124. Heath DD, Iwama GK, Devlin RH (1993) PCR primed with VNTR core sequences yields species specific patterns and hypervariable probes. Nucleic Acids Res 21:5782-5785
125. Hebert PDN, Cywinska A, Ball SL, De Waard JR (2003a) Biological identification through DNA barcodes. Proc R Soc Lond B 270:313-321
126. Hebert PDN, Ratnasingham S, De Waard JR (2003b) Barcoding animal life: cytochrome c oxidase subunit 1 divergences among closely related species. Proc R Soc Lond B 270(suppl):96-99
127. Hebert PDN, Stoeckle MY, Zemlak TS, Francis CM (2004) Identification of birds through DNA barcodes. PLoS Biol 2(10):e312
128. Heubl G (2010) New aspects of DNA-based authentication of Chinese medicinal plants by molecular biological techniques. Planta Med 76(17):1963-1975
129. Hildreth J, Hrabeta-Robinson E, Applequist W, Betz J, Miller J (2007) Standard operating procedure for the collection and preparation of voucher plant specimens for use in the nutraceutical industry. Anal Bioanal Chem 389:13-17
130. Hollingsworth ML, Clark A, Forrest LL, Richardson JE, Pennington RT, Long D, Cowan R, Chase MW, Gaudeul M, Hollingsworth PM (2009) Selecting barcoding loci for plants: evaluation of seven candidate loci with species level sampling in three divergent groups of land plants. Mol Ecol Resour 9:439-457
131. Hollingsworth PM, Graham SW, Little DP (2011) Choosing and using a plant DNA barcode. PLoS One 6(5):e19254
132. Hosokawa K, Minami M, Kawahara K, Nakamura I, Shibata T (2000) Discrimination among three species of medicinal Scutellaria plants using RAPD markers. Planta Med 66:270-272
133. Hosokawa K, Minami M, Nakamura I, Hishida A, Shibata T (2005) The sequences of the plastid gene rpl16 and the rpl16-rpl14 spacer region allow discrimination among six species of Scutellaria. J Ethnopharmacol 99:105-108
134. Hosokawa K, Hishida A, Nakamura I, Shibata T (2006) The sequences of the spacer region between the atpF and atpA genes in the plastid genome allows discrimination among three varieties of medicinal Angelica. Planta Med 72:570-571
135. Hsiao JIH (2007) Patent protection for Chinese herbal medicine product invention in Taiwan. J World Intell Prop 10(1):1-21
136. Hu Y, Zhang Q, Xin H, Qin LP, Lu BR, Rahman K et al (2007) Association between chemical and genetic variation of Vitex rotundifolia populations from different locations in China: its implication for quality control of medicinal plants. Biomed Chromatogr 21:967-975
137. Huang L, Wang M, Zhou C, Li N, He X, Yang B (1998) Problems and solutions in the use of RAPD to the identification of the Chinese drugs "xi-xin" (Herba asari) and its substitutes. Yao Xue Xue Bao 33:778-784
138. Huang LQ, Cui GH, Chen ML, Feng CQ, Yang B, Wang YY, Dai RW (2002a) Study on complex system of Chinese material medica GAP fulfilling-the situation, problems, and of Chinese material medica germplasm. China J Chin Mater Med 27:481-483
139. Huang LQ, Cui GH, Dai RW (2002b) Study on complex system of Chinese Material Medica GAP fulfilling. China J Chin Mater Med 27:1-3
140. ICBN, International Code of Botanical Nomenclature (2006) 2006 Electronic version of the original English text. Prepared and edited by McNeill J, Barrie FR, Burdet HM, Demoulin V, Hawksworth DL, Marhold K, Nicolson DH, Prado J, Silva PC, Skog JE, Wiersema JH, and Turland NJ. Adopted by the Seventeenth International Botanical Congress, Vienna, Austria, July 2005. Last updated 09.03.2007
141. Ince AG, Karaca AGM et al (2009) Development and utilization of diagnostic DAMD-PCR markers for Capsicum accessions. Genet Res Crop Evol 56:211-221
142. Jayasinghe R, Kong S, Coram TE, Kaganovitch J, Xue CC, Li CG, Pang EC (2007) Construction and validation of a prototype microarray for efficient and high-throughput genotyping of angiosperms. Plant Biotechnol J 5(2):282-289
143. Jo BH, Suh DS et al (2009) Characterization of polymorphic microsatellite loci in cultivated and wild Panax ginseng. Genes Genomics 31:119-127
144. Jones CJ, Edwards KJ, Castaglione S, Winfield MO, Sala F, et al (1993) Theor Appl Genet 85:985-993
145. Joshi P, Dhawan V (2007) Assessment of genetic fidelity of micropropagated Swertia chirayita plantlets by ISSR marker assay. Biol Plantarum 51(1):22-26
146. Joshi K, Chavan OP, Warude D (2004) Molecular markers in herbal drug technology. Curr Sci 87(2):159-165
147. Kaplan J, Chavan P, Warude D, Patwardhan B (2004) Molecular markers in herbal drug technology. Curr Sci 87:159-165
148. Karaca M, Ince AG et al (2008) PCR-RFLP and DAMD-PCR genotyping for Salvia species. J Sci Food Agric 88:2508-2516
149. Karp A, Edwards KJ (1997) DNA markers, a global overview. In: Caetano-Anollés G, Gresshoff PM (eds) DNA markers, protocols, applications, and overviews. Wiley-Liss, New York
150. Kelly LM (1998) Phylogenetic relationships in Asarum (Aristolochiaceae) based on morphology and ITS sequences. Am J Bot 85:1454-1467
151. Kersten T, Daniel C, König GM, Knöß W (2007) The potential of PCR-related methods to identify medicinal plants in herbal medicinal products. Planta Med 73:256
152. Kim J, Chung KW (2007) Isolation of new microsatellite-containing sequences in Acanthopanax senticosus. J Plant Biol 50:557-561
153. Kim J, Jo BH, Lee KL, Yoon ES, Ryu GH, Chung KW (2007a) Identification of new microsatellite markers in Panax ginseng. Mol Cells 24:60-68
154. Kim OT, Bang K, Dong S, Lee JW, Kim YC, Shin YS, Hyun DY, Lee SS, Cha SW, Seong NS (2007b) Molecular authentication of ginseng cultivars by comparison of internal transcribed spacer and 5.8S rDNA sequences. Plant Biotechnol Rep 1:163-167
155. Kircher M, Kelsko J (2010) High-throughput DNA sequencing-concepts and limitations. Bioessays 32(6):524-536
156. Klein D (2002) Quantification using real-time PCR technology: applications and limitations. Trends Mol Med 8(6):257-260
157. Kohjyouma M, Nakajima S, Namera A, Shimizu R, Mizukami H, Kohda H (1997) Random amplified polymorphic DNA analysis and variation of essential oil components of Atractylodes plants. Biol Pharm Bull 20:502-506
158. Kojoma M, Lida O, Makino Y, Sekita S, Satake M (2002) DNA fingerprinting of Cannabis sativa using inter-simple sequence repeat (ISSR) amplification. Planta Med 68:60-63
159. Komatsu KS, Zhu S et al (2001) Phylogenetic analysis based on 18S rRNA gene and matK gene sequences of Panax vietnamensis and five related species. Planta Med 67:461-465
160. Kondo K, Terabayashi S et al (1996) Phylogenetic relationship of medicinally important Cnidium officinale and Japanese Apiaceae based on rbcL sequences. J Plant Res 109:21-27
161. Korea Herbal Pharmacopoeia (2002) Ministry of Health Family Welfare of South Korea, Seoul, Korea
162. Kress WJ, Erickson DL (2007) A two-locus global DNA barcode for land plants: the coding rbcL gene complements the non-coding trnH-psbA spacer region. PLoS One 2(6):e508
163. Kress WJ, Wurdack KJ, Zimmer EA, Weigt LA, Janzen DH (2005) Use of DNA barcodes to identify flowering plants. Proc Natl Acad Sci USA 102:8369-8374
164. Kumar J, Verma V et al (2007) Development of simple sequence repeat markers in Cymbopogon species. Planta Med 73:262-266
165. Kumar P, Gupta VK, Misra AKL, Modi DR, Pandey BK (2009) Potential of molecular markers in plant biotechnology. Plant Omics J 2(4):141-162
166. Kurane J, Shinde V, Harsulkar A (2009) Application of ISSR marker in pharmacognosy: current update. Phcog Rev 3(6):216-228
167. Kurg A, Tõnisson N, Georgiou I, Shumaker J, Tollett J, Metspalu A (2000) Arrayed primer extension: solid-phase four-color DNA resequencing and mutation detection technology. Genet Test 4:1-7
168. Kwok PY (2001) Methods for genotyping single nucleotide polymorphisms. Annu Rev Genom Human Genet 2:235-258
169. Lahaye R, Van Der Bank M, Bogarin D, Warner J, Pupulin F, Gigot G, Maurin O, Duthoit S, Barraclough TG, Savolainen V (2008a) DNA barcoding the floras of biodiversity hotspots. Proc Natl Acad Sci USA 105:2923-2928
170. Lahaye R, Savolainen V, Duthoit S, Maurin O, Van Der Bank M (2008) A test of psbK-psbI and atpF-atpH as potential plant DNA barcodes using the flora of the Kruger National Park as a model system (South Africa). Nature Proc hdl:10101/npre.1896.1
171. Lane CE, Lindstrom SC, Saunders GW (2007) A molecular assessment of Northeast Pacific Alaria species (Laminariales, Phaeophyceae) with reference to the utility of DNA barcoding. Mol Phylogenet Evol 44(2):634-648
172. Lau DT, Shaw PC, Wang J, But PP (2001) Authentication of medicinal Dendrobium species by the internal transcribed spacer of ribosomal DNA. Planta Med 67:456-460
173. Lee C, Wen J (2004) Phylogeny of Panax using chloroplast trnC-trnD intergenic region and the utility of trnC-trnD in interspecific studies of plants. Mol Phylogenet Evol 31:894-903
174. Lee HH, Itokawa H, Kozuka M (2005) Asian herbal products: the basis for development of highquality dietary supplements and new medicines. In: Shi J, Ho CT, Shahidi F (eds) Asian functional foods. CRC, Taylor & Francis Group, Boca Raton, pp 21-72
175. Lee MY, Doh EJ, Park CH, Kim YH, Kim ES, Ko BS et al (2006a) Development of SCAR marker for discrimination of Artemisia princeps and A. argyi from other Artemisia herbs. Biol Pharm Bull 29:629-633
176. Lee SK, Li PT, Lau DT, Yung PP, Kong RY, Fong WF (2006b) Phylogeny of medicinal Phyllanthus species in China based on nuclear ITS and chloroplast atpB-rbcL sequences and multiplex PCR detection assay analysis. Planta Med 72:721-726
177. Lee HL, Yi DK, Kim JS, Kim KJ (2007) Development of plant DNA barcoding markers from the variable noncoding regions of chloroplast genome. Abstract presented at the second international barcode of life conference. Academia Sinica, Taipei, Taiwan. 18-20 September 2007
178. Lee JH, Lee JW, Sung JS, Bang KH, Moon SG (2009) Molecular authentication of 21 Korean Artemisia species (Compositae) by polymerase chain reaction-restriction fragment length polymorphism based on trnL-F region of chloroplast DNA. Biol Pharm Bull 32(11):1912-1916
179. Lerner HRL, Fleischer RC (2010) Prospects for the use of next-generation sequencing methods in ornithology. BioOne 27(1):4-15
180. Levinson G, Gutman GA (1987) Slipped-strand mispairing: a major mechanism for DNA sequence evolution. Mol Biol Evol 4:203-221
181. Li DP (2001) Progress on mechanism of KLT injection antitumous effect. Traditi Chin Drug Res Clin Pharmacol 2:122-124
182. Li ZY (2003) Advances in plant resource conservation in China: sustainable development of plant resources in China. Acta Bot Sin 45:124-130
183. Li Y, Ding WL (2010) Genetic diversity assessment of Trollius accessions in China by RAPD markers. Biochem Genet 48:34-43
184. Li MF, Xu GJ, Xu LS, Jin RL (1986) Survey and identification of commercial example of Shihu (Dendrobium) (I). Chin Trad Herbal Drugs 17:33-37
185. Li MF, Xu GJ, Xu LS, Jin RL (1991) Survey and identification of commercial example of Shihu (Dendrobium) (II). Chin Trad Herbal Drugs 22:173-178
186. Li YC, Korol AB, Fahima T, Beiles A, Nevo E (2002) Microsatellites: genomic distribution, putative functions and mutational mechanisms: a review. Mol Ecol 11(12):2453-2465
187. Li T, Wang J, Lu Z (2005) Accurate identification of closely related Dendrobium species with multiple species-specific gDNA probes. J Biochem Biophys Methods 62:111-123
188. Li SP, Yang FQ, Tsim WK (2006) Quality control of Cordyceps sinensis, a valued traditional Chinese medicine. J Pharm Biomed Anal 41:1571-1584
189. Li X, Ding X, Chu B, Ding G, Gu S, Qian L et al (2007) Molecular authentication of Alisma orientale by PCR-RFLP and ARMS. Planta Med 73:67-70
190. Li K, Wu W, Zheng Y, Dai Y, Xiang L, Liao K (2009a) Genetic diversity of Fritillaria from Sichuan province based on ISSR. Zhongguo Zhongyao Zazhi 34:2149-2154
191. Li YH, Ruan JL, Chen SL, Lu D, Zhu KX, Zhao MH, Pei HH (2009b) Study on medicinal plants of Loranthaceae resources in China. World Sci Technol Mod Tradit Chin Med 5:665-669
192. Li CI, Chiou SJ, Tong TS, Lee CY, Lee LT, Cheng CM (2010a) Development and validation of molecular markers for characterization of Boehmeria nivea var. nivea and Boehmeria nivea var. tenacissima. Chin Med 5:40
193. Li YH, Ruan JL, Chen SL et al (2010b) Authentication of Taxillus chinensis using DNA barcoding technique. J Med Plant Res 4(24):2706-2709
194. Li CI, Shu-Jiau Chiou SJ, Tong TS, Lee CY, Lee LT, Cheng CM (2010c) Development and validation of molecular markers for characterization of Boehmeria nivea var. nivea and Boehmeria nivea var. tenacissima. Chin Med 5:40
195. Li DZ, Liu JQ, Chen ZD, Wang H, Ge XJ, Zhou SL, Gao LM, Fu CX, Chen SL (2011a) Plant DNA barcoding in China. J Systemat Evol 49(3):165-168
196. Li DZ, Gao LM, Li HT, Wang H, Liu JQ, Chen ZD, Zhou SL, Chen SL, Yang YB, Fu CX, Zeng CX, Yan HF, Zhu YJ, Sun YS, Chen SY, Zhao L, Wang K, Yang T, Daun GW (2011b) Comparative analysis of a large dataset indicates that internal transcribed spacer (ITS) should be incorporated into the core barcode for seed plants. Proc Natl Acad Sci USA 108:19641-19646
197. Liang ZT, Qin MJ, Wang ZT, Huang Y, Wang NH (2002) Identification of Bupleurum L. plants by RAPD technology. Zhongcaoyào 33:1117-1119
198. Liang YZ, Xieb PS, Chan K (2004) Quality control of herbal medicines. J Chromatogr B 812:53-70
199. Lim W, Mudge KW et al (2007) Utilization of RAPD markers to assess genetic diversity of wild populations of North American ginseng (Panax quinquefolium). Planta Med 73:71-76
200. Lin J, Zhou X, Gao S, Wu W, Liu X, Sun X et al (2006) Authentication of Pinellia ternata and its adulterants based on PCR with specific primers. Planta Med 72:844-847
201. Lin WY, Chen LR, Lin TY (2008) Rapid authentication of Bupleurum species using an array of immobilized sequence-specific oligonucleotide probes. Planta Med 74:464-469
202. Litt M, Luty JA (1989) A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene. Am J Hum Genet 44:397-401
203. Little DP (2011) DNA barcode sequence identification incorporating taxonomic hierarchy and within taxon variability. PLoS One 6(8):e20552
204. Liu CX, Yaniv Z (2005) Research and development of new drugs originating from Chinese plants. In: Yaniv Z, Bachrach U (eds) Handbook of medicinal plants. Food Products-Haworth, pp 61-96
205. Liu Y, Cao H, Wang X (2001a) Application of gene technology in quality control of Chinese drugs (I) - identification of Pinellia ternata species from Yuncheng, Shandong using DNA sequencing. Chin J Pharm Anal 21:423-426
206. Liu Y, He B, Cao H (2001b) Application of gene technology in quality control of Chinese drugs (II) - identification of Chinese yam (Dioscorea polystachia rhizome) using DNA sequencing. Chin J Tradit Herb Drugs 32:113-117
207. Liu CS, Bai GB, Yan YN (2005) Studies on the botanical sources and DNA molecular identification of Herba Asari based on ITS sequence. Zhongguo Zhongyao Zazhi 30:329-332
208. Liu Y, Yan HF, Cao T, Ge XJ (2010a) Evaluation of 10 plant barcodes in Bryophyta (Mosses). J Systemat Evol 48(1):36-46
209. Liu Z, Chen K, Luo K, Pan H, Chen S (2010b) DNA barcoding in medicinal plants Caprifoliaceae. Zhongguo Zhongyao Zazhi 35(19):2527-2532
210. Liu C, Yu H, Chen L (2011) Framework for sustainable use of medicinal plants in China. Plant Divers Resour 33(1):65-68
211. Loh JP, Kiew R, Kee A, Gan LH, Gan YY (1999) Amplified fragment length polymorphism (AFLP) provides molecular markers for the identification of Caladium bicolor cultivars. Ann Bot (Lond) 84:155-161
212. Long C, Kakiuchi N, Takahashi A, Komatsu K, Cai S, Mikage M (2004) Phylogenetic analysis of the DNA sequence of the non-coding region of nuclear ribosomal DNA and chloroplast of Ephedra plants in China. Planta Med 70:1080-1084
213. Lopez-Pujol J, Zhao AM (2004) China: a rich flora needed of urgent conservation. Orsis 19:49-89
214. Lopez-Pujol J, Zhang FM, Song GE (2006) Plant biodiversity in China: richly varied, endangered, and in need of conservation. Biodivers Conserv 15:3983-4026
215. Lou SK, Wong KL, Li M et al (2010) An integrated web medicinal materials DNA database: MMDBD (Medicinal Materials DNA Barcode Database). BMC Genomics 11:402
216. Lowe CR (2000) Nanobiotechnology: the fabrication and applications of chemical and biological nanostructures. Curr Opin Struct Biol 10:428-434
217. Lu Y, Li CS, Dong Q (2008) Chinese herb related molecules of cancer-cell-apoptosis: a minireview of progress between Kanglaite injection and related genes. J Exp Clin Cancer Res 27:31
218. Lu KT, Lee HC, Liu FS et al (2009) Discriminating Astragali Radix from Hedysarum Radix in Chinese medicine preparations using nested PCR and DNA sequencing methods. J Food Drug Anal 17:380-385
219. Lu C, Zhang W, Peng X, Gu G, Chen M, Tang Z (2010a) Development of randomly amplified polymorphic DNA-sequence characterized amplified region marker for identification of Apocynum venetum LINN.from A. pictum SCHRENK. Biol Pharm Bull 33:522-526
220. Lu KT, Lee HC, Liu FS et al (2010b) Identification of Ginseng Radix in Chinese medicine preparations by nested PCR-DNA sequencing method and nested PCR-restriction fragment length polymorphism. J Food Drug Anal 18:58-63
221. Lum MR, Potter E, Dang T, Heber D, Hardy M, Hirsch AM (2005) Identification of botanicals and potential contaminants through RFLP and sequencing. Planta Med 71:841-846
222. Luo JP, Cao H, Liu YP (2002) DNA sequencing and molecular identification of Patchouli and its substitute wrinkled gianthyssop. Yao Xue Xue Bao 37:739-742
223. Luo YM, Zhang WM, Ding XY, Shen J, Bao SL, Chu BH et al (2006a) SNP marker and allelespecific diagnostic PCR for authenticating herbs of Perilla. Acta Pharm Sin 41:840-845
224. Luo YM, Zhang WM, Ding XY, Shen J, Bao SL, Chu BH, Mao SG (2006b) SNP marker and allele-specific diagnostic PCR for authenticating herbs of Perilla. Yao Xue Xue Bao 41(9):840-845
225. Luo K, Chen SL, Chen KL, Song JY, Yao H, Ma XY, Zhu YJ, Pang XH, Yu H, Li XW, Liu Z (2010) Assessment of candidate plant DNA barcodes using the Rutaceae family. Sci China Life Sci 53:701-708
226. Luo A, Zhang A, Ho SY, Xu W, Zhang Y, Shi W, Cameron SL, Zhu C (2011) Potential efficacy of mitochondrial genes for animal DNA barcoding: a case study using eutherian mammals. BMC Genomics 12:84
227. Ma GX, Xu GJ, Xu LS, Li MF (1995) Survey and identification of commercial example of Shihu (Dendrobium) (III). Chin Trad Herbal Drugs 26:370-372
228. Ma XQ, Duan JA, Zhu DY, Dong TT, Tsim KW (2000) Species identification of Radix Astragali (Huangqi) by DNA sequence of its 5S-rRNA spacer domain. Phytochemistry 54:363-368
229. Ma XQ, Zhu DY, Li SP, Dong TT, Tsim KW (2001) Authentic identification of stigma Croci (stigma of Crocus sativus) from its adulterants by molecular genetic analysis. Planta Med 67:183-186
230. Ma YS, Yu H, Li YY, Yan H, Cheng X (2008) a study of genetic structure of Stephania yunnanensis (Menispermaceae) by DALP. Biochem Genet 46:227-240
231. Ma XY, Xie CX, Liu C et al (2010) Species identification of medicinal pteridophytes by a DNA barcode marker, the chloroplast psbA-trnH intergenic region. Biol Pharm Bull 33(11):1919-1924
232. Maeda M, Uryu N, Murayama N, Ishii H, Ota M, Tsuji K, Inoko H (1990) A simple and rapid method for HLA-DP genotying by digestion of PCR-amplified DNA with allele specific restriction endonucleases. Hum Immunol 27:111-121
233. Makino R, Yazyu H, Kishimoto Y, Sekiya T, Hayashi K (1992) F-SSCP (fluorescence-based polymerase chain reaction-singlestrand conformation polymorphism (PCR-SSCP)) analysis. PCR Methods Appl 2:10-13
234. Malik A, Azam S, Hadi N, Hadi SM (2003) DNA degradation by water extract of green tea in the presence of copper ions: implications for anticancer properties. Phytother Res 17(4):358-363
235. Mardis ER (2008) The impact of next-generation sequencing technology on genetics. Trends Genet 24(3):133-141
236. Matsuyama S, Nishi K (2011) Genus identification of toxic plant by real-time PCR. Int J Legal Med 125(2):211-217
237. Mazzanti G, Battinelli L, Daniele C, Costantini S, Ciaralli L, Evandri MG (2008) Purity control of some Chinese crude herbal drugs marketed in Italy. Food Chem Toxicol 46:3043-3047
238. McDermott JM, Brandle U, Dutly F, Haemmerli UA, Keller S, Muller KE, Wolf MS (1994) Genetic variation in powdery mildew of barley: development of RAPD, SCAR and VNTR markers. Phytopathology 4:1316-1321
239. McIntyre M (1998) Chinese herbs: risk, side effects, and poisoning: the case for objective reporting and analysis reveals serious misrepresentation. J Altern Complement Med 4(1):15-16
240. Mills S, Bone K (2005) The essential guide to herbal safety. Churchill Livingstone, London
241. Mitchell D, Willerslev E, Hansen A (2005) Damage and repair of ancient DNA. Mutat Res 571:265-276
242. Mizukami H, Ohbayashi K, Kitamura Y, Ikenaga T (1993a) Restriction fragment length polymorphisms (RFLPs) of medicinal plants and crude drugs. I. RFLP probes allow clear identification of Duboisia interspecific hybrid genotypes in both fresh and dried tissues. Biol Pharm Bull 16:388-390
243. Mizukami H, Ohbayashi K, Umetsu K, Hiraoka N (1993b) Restriction fragment length polymorphism of medicinal plants and crude drugs. II. Analysis of Glehnia littoralis of different geographical origin. Biol Pharm Bull 16:611-612
244. Mizukami H, Okabe Y, Kohda H, Hiraoka N (2000) Identification of the crude drug Atractylodes rhizome (Byaku-jutsu) and Atractylodes lancea rhizome (So-jutsu) using chloroplast trnK sequence as a molecular marker. Biol Pharm Bull 23:589-594
245. Molina C, Kahl G (2002) Genomics of two banana pathogens, genetic diversity, diagnostics, and phylogeny of Mycosphaerella fijiensis and M. musicola. In: Jain SM (ed) Banana improvement, cellular and molecular biology, and induced mutations. FAO/IAEA, Vienna
246. Mondini L, Noorani A, Pagnotta MA (2009) Assessing plant genetic diversity by molecular tools. Diversity 1:19-35
247. Morgante M, Vogel J (1994) Compound microsatellite primers for the detection of genetic polymorphisms. US Patent Application 08/326456
248. Mori N, Moriguchi T, Nakamura C (1997) RFLP analysis of nuclear DNA for study of phylogeny and domestication of tetraploid wheat. Genes Genet Syst 72:153-161
249. Moritz C, Cicero C (2004) DNA barcoding: promise and pitfalls. PLoS Biol 2(10):e354
250. Mueller UG, Wolfenbarger L (1999) AFLP genotyping and fingerprinting. Trends Ecol Evol 14:389-394
251. Munthali M, Ford-Lloyd BV, Newbury HJ (1992) The random amplification of polymorphic DNA for fingerprinting plants. PCR Methods Appl 1:274-276
252. Nagamine K, Watanabe K, Ohtsuka K, Hase T, Notomi T (2001) Loop-mediated isothermal amplification reaction using a nondenatured template. Clin Chem 47:1742-1743
253. Nagamine K, Hase T, Notomi T (2002) Accelerated reaction by loop-mediated isothermal amplification using loop primers. Mol Cell Probes 16:223-229
254. Nakai R, Shoyama Y, Shiraishi S (1996) Genetic characterization of Epimedium species using random amplified polymorphic DNA (RAPD) and PCR-restriction fragment length polymorphism (RFLP) diagnosis. Biol Pharm Bull 19(1):67-70
255. Nalawade SM, Sagare AP, Lee CY et al (2003) Studies on tissue culture of Chinese medicinal plant resources in Taiwan and their sustainable utilization. Bot Bull Acad Sin 44:79-98
256. NEPA National Environmental Protection Agency (1994) China biodiversity conservation action plan. China Environmental Science Press, Beijing
257. Newmaster SG, Fazekas AJ, Ragupathy S (2006) DNA barcoding in the land plants: evaluation of rbcL in a multigene tiered approach. Can J Bot 84:335-341
258. Newmaster SG, Fazekas AJ, Steeves RAD, Janovec J (2008) Testing candidate plant barcode regions with species of recent origin in the Myristicaceae. Mol Ecol Notes 8:480-490
259. Newton CR, Graham A, Heptinstall LE, Powell SJ, Summers C, Kalsheker N et al (1989) Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acids Res 17:2503-2516
260. Ng KY, Cheng CI, Xu HX (2009) Safety issues of Chinese medicine: a review of intoxication cases in Hong Kong. Chin Herb Med 1(1):29-39
261. Ngan F, Shaw P, But P, Wang J (1999) Molecular authentication of Panax species. Phytochemistry 50:787-791
262. Niu L, Mantri N, Li CG, Xue C, Wohlmuth H, Pang EC (2011) Detection of Panax quinquefolius in Panax ginseng using subtracted diversity array. J Sci Food Agric 18. doi:10.1002/jsfa.4319
263. Normile D (2003) The new face of traditional Chinese medicine. Science 299:188-190
264. Notomi T, Okayama H, Masubuchi H, Yonekawa T, Watanabe K, Amino N, Hase T (2000) Loopmediated isothermal amplification of DNA. Nucleic Acids Res 28(12):E63
265. Novak J, Grausgruber-Gröger S, Luka B (2007) DNA-based authentication of plant extracts. Food Res Int 40(3):388-392
266. Orita M, Iwahana H, Kanazawa H, Hayashi K, Sekiya T (1989) Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphism. Proc Natl Acad Sci USA 86:2766-2770
267. Paglia GE, Olivieri AM, Morgante M (1998) Towards second-generation STS (sequence-tagged sites) linkage maps in conifers, a genetic map of Norway spruce (Picea abies K.). Mol Gen Genet 258:466-478
268. Pang XH, Song JY, Zhu YJ, Xie CX, Chen SL (2010) Using DNA barcoding to identify species within Euphorbiaceae. Planta Med 76:1784-1786
269. Pang X, Songa J, Zhua Y, Xub H, Huanga L, Chena S (2011) Applying plant DNA barcodes for Rosaceae species identification. Cladistics 27:165-170
270. Paran I, Michelmore RW (1993) Development of reliable PCR based markers linked to downy mildew resistance genes in lettuce. Theor Appl Genet 85:985-993
271. Paran I, Kesseli R, Michelmore R (1991) Identification of restriction fragment-length-polymorphism and random amplified polymorphic DNA markers linked to downy mildew resistance genes in lettuce, using near isogenic lines. Genome 34:1021-1027
272. Passinho-Soares H, Felix D, Kaplan MA, Margis-Pinheiro M, Margis R (2006) Authentication of medicinal plant botanical identity by amplified fragmented length polymorphism dominant DNA marker: inferences from the Plectranthus genus. Planta Med 72:929-931
273. Pastinen T, Partanen J, Syvanen AC (1996) Multiplex, fluorescent, solid-phase minisequencing for efficient screening of DNA sequence variation. Clin Chem 42:1391-1397
274. Pastinen T, Raitio M, Lindroos K et al (2000) A system for specific, high-throughput genotyping by allele-specific primer extension on microarrays. Genome Res 10:1031-1042
275. Pei S (2001) Ethnobotanical approaches of traditional medicine studies: some experiences from Asia. Pharmaceutical Botany 39:74-79
276. Pei S (2002a) A brief review of ethnobotany and its curriculum development in China. In: Shinwari ZK, Hamilton A, Khan AA (eds) In: Proceedings of a Workshop on Curriculum Development in Applied Ethnobotany, Nathiagali, 2-4 May 2002. WWF-Pakistan, Lahore, Pakistan
277. Pei S (2002b) Ethnobotany and modernisation of Traditional Chinese Medicine. Paper at a Workshop onWise Practices and Experiential Learning in the Conservation and Management of Himalayan Medicinal Plants, Kathmandu, Nepal, 15-20 December 2002, supported by the Ministry of Forest and Soil Conservation, Nepal, the WWF-Nepal Program, MMAPPA and PPI
278. Pei-Gen X (2007) Ethnopharmacological investigation of Chinese medicinal plants. In: Chadwick DJ, Marsh J (eds) Etrnobotany and search for new drugs. Ciba Foundation Symposium 185 - Ethnobotany and the Search for New Drugs
279. Pennisi E (2007) Wanted: a barcode for plants. Science 318:190-191
280. Pereira F, Carneiro J, Amorim A (2008) Identification of species with DNA-based technology: current progress and challenges. Recent Pat DNA Gene Seq 2:187-200
281. Pharmacopoeia of the People's Republic of China (2005) State pharmacopoeia committee. Chemical Industry Publisher, Beijing, China
282. Pharmacopoeia of the People's Republic of China (2010) 2010 edn. China Medical Science and Technology Press, Beijing
283. Pirrung MC, Connors RV, Odenbaugh AL, Montague-Smith MP, Walcott NG, Tollett JJ (2000) The arrayed primer extension method for DNA microchip analysis. Molecular computation of satisfaction problems. J Am Chem Soc 122:1873-1882
284. Pirttilä AM, Hirsikorpi M, Kämäräinen T, Jaakola L, Hohtola A (2001) DNA isolation methods for medicinal and aromatic plants. Plant Mol Biol Rep 19:273a-f
285. Portis E, Acquadro A, Comino C, Lanteri S (2004) Analysis of DNA methylation during germination of pepper (Capsicum annuum L.) seeds using methylation-sensitive amplification polymorphism (MSAP). Plant Sci 166:169-178
286. Preeti C, Kalpana J, Bhushan P (2006) DNA microarrays in herbal drug research. Advance Access Publication
287. Preeti C, Kalpana J, Bhushan P (2006b) DNA microarrays in herbal drug research. Evid Based Complement Altern Med 3(4):447-457
288. Provan J, Biss PM, McMee D, Mathews S (2004) Universal primers for the amplification of chloroplast microsatellites in grasses (Poaceae). Mol Ecol Notes: Primer Note
289. Qi JJ, Li XE et al (2008) Genetic relationships among Rehmannia glutinosa cultivars and varieties. Planta Med 74:1846-1852
290. Qian L, Ding G et al (2008) Molecular authentication of Dendrobium loddigesii Rolfe by amplification refractory mutation system (ARMS). Planta Med 74:470-473
291. Qin J, Leung FC, Fung Y, Zhu D, Lin B (2005) Rapid authentication of ginseng species using microchip electrophoresis with laser-induced fluorescence detection. Anal Bioanal Chem 381:812-819
292. Reyna-Lopez GE, Simpson J, Ruiz-Herrera J (1997) Differences in DNA methylation patterns are detectable during the dimorphic transition of fungi by amplification of restriction polymorphism. Mol Gen Genet 253:703-710
293. Robba L, Russell SJ, Barker GL, Brodie J (2006) Assessing the use of the mitochondrial cox1 marker for use in DNA barcoding of Red algae (Rhodophyta). Am J Bot 93(8):1101-1108
294. Saar DE, Polans NO, Sörensen PD, Duvall MR (2001) Angiosperm DNA contamination by endophytic fungi: detection and methods of avoidance. Plant Mol Biol Rep 19:249-260
295. Sahin FP, Yamashita H et al (2007) DNA authentication of Plantago herb based on nucleotide sequences of 18S-28S rRNA internal transcribed Spacer region. Biol Pharm Bull 30:1265-1270
296. Sarwat M, Das S et al (2008) Analysis of genetic diversity through AFLP, SAMPL, ISSR and RAPD markers in Tribulus terrestris, a medicinal herb. Plant Cell Rep 27:519-528
297. Sasaki Y, Nagumo S (2007) Rapid identification of Curcuma longa and C. aromatica by LAMP. Biol Pharm Bull 30:2229-2230
298. Sasaki Y, Fushimi H et al (2002) Sequence analysis of Chinese and Japanese Curcuma drugs on the 18S rRNA gene and trnK gene and the application of amplification-refractory mutation system analysis for their authentication. Biol Pharm Bull 25:1593-1599
299. Sasaki Y, Komatsu K, Nagumo S (2008) Rapid detection of Panax ginseng by loop-mediated isothermal amplification and its application to authentication of Ginseng. Biol Pharm Bull 31(9):1806-1808
300. Sasaki Y, Fujimoto T, Aragane M, Yasuda I, Nagumo S (2009) Rapid and sensitive detection of Lophophora williamsii by loop-mediated isothermal amplification. Biol Pharm Bull 32(5):887-891
301. Sass C, Little DP, Stevenson DW, Specht CD (2007) DNA barcoding in the Cycadales: testing the potential of proposed barcoding markers for species identification of Cycads. PLoS One 2:e1154
302. Schadt EE, Turner S, Kasarskis A (2010) A window into third-generation sequencing. Hum Mol Genet 19:R227-R240
303. Schena M, Heller RA et al (1998) Microarrays: biotechnology's discovery platform for functional genomics. Trends Biotechnol 16(7):301-306
304. Schippmann U, Leaman DJ, Cunningham AB (2002) Impact of cultivation and gathering of medicinal plants on biodiversity: global trends and issues. Inter-Department Working Group on Biology Diversity for Food and Agriculture, Food and Agricultural Organisation of the United Nations, Rome, Italy
305. Schouten JP, McElgunn CJ, Waaijer R, Zwijnenburg D, Diepvens F, Pals G (2002) Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res 30(12):e57
306. Schuler GD, Boguski MS, Stewart EA et al (1996) A gene map of the human genome. Science 274:540-546
307. Semagn K, Bjørnstad A, Ndjiondjop MN (2006) An overview of molecular marker methods for plants. Afr J Biotechnol 5:2540-2568
308. SEPA State Environmental Protection Administration (1998) China's biodiversity: a country study. China Environmental Science Press, Beijing
309. Shan X, Blake TK, Talbert LE (1999) Conversion of AFLP markers to sequence-specific PCR markers in barley and wheat. Theor Appl Genet 98:1072-1078
310. Shaw PC, Ngan FN, But PPH, Wang J (2002) Molecular markers in Chinese medicinal materials. In: Shaw PC, But PPH (eds) Authentication of Chinese medicinal material by DNA technology. World Scientific Publishing, Singapore
311. Shaw J, Lickey EB, Schilling EE, Small RL (2007) Comparison of whole chloroplast genome sequences to choose noncoding regions for phylogenetic studies in angiosperms: the tortoise and the hare III. Am J Bot 94(3):275-288
312. Shaw PC, Wong KKL, Chan AWK, Wong WC, But PPH (2009) Patent applications for using DNA technologies to authenticate medicinal herbal material. J Chin Med 4:1-11
313. Shen Y, Wu BL (2009) Designing a simple multiplex ligation-dependent probe amplification (MLPA) assay for rapid detection of copy number variants in the genome. J Genet Genomics 36(4):257-265
314. Shen J, Ding XY, Ding G, Liu DY, Tang F, He J (2006) Studies on population difference of Dendrobium officinale II establishment and optimization of the method of ISSR fingerprinting marker. Zhongguo Zhongyao Zazhi 31:291-294
315. Shi HM, Wang J, Wang MY, Tu PF, Li XB (2009) Identification of Cistanche species by chemical and inter-simple sequence repeat fingerprinting. Biol Pharm Bull 32:142-146
316. Shim YH, Choi JH, Park CD et al (2003) Molecular differentiation of Panax species by RAPD analysis. Arch Pharm Res 26:601-605
317. Shneyer VS (2009) DNA Barcoding is a new approach in comparative genomics of plants. Russ J Genet 45(11):1267-1278
318. Silva LM, Montes De Oca H, Diniz CR, Fortes-Dias CL (2001) Fingerprinting of cell lines by directed amplification of minisatellite-region DNA (DAMD). Braz J Med Biol Res 34:1405-1410
319. Siow YL, Gong Y, Au-Yeung KK, Woo CW, Choy PC (2005) Emerging issues in traditional Chinese medicine. Can J Physiol Pharmacol 83:321-334
320. Slanc P, Ravnikar M, Strukelj B (2006) Identification of individual herbal drugs in tea mixtures using restriction analysis of ITS DNA and real-time PCR. Pharmazie 61(11):912-915
321. Smillie TJ, Khan IA (2010) A comprehensive approach to identifying and authenticating botanical products. Clin Pharmacol Ther 87:175-186
322. Society of Japanese Pharmacopoeia (2001) Japanese pharmacopoeia (English version), 14th edn. Junkudo Book Shop, Tokyo
323. Somers DJ, Demmon G (2002) Identification of repetitive, genome-specific probes in crucifer oilseed species. Genome 45:485-492
324. Song H, Buhay JE, Whiting MF, Crandall KA (2008) Many species in one: DNA barcoding overestimates the number of species when nuclear mitochondrial pseudogenes are coamplified. Proc Natl Acad Sci USA 105(36):13486-13491
325. Song JY, Yao H, Li Y, Li XW, Lin YL, Liu C, Han JP, Xie CX, Chen SL (2009) Authentication of the family Polygonaceae in Chinese pharmacopoeia by DNA barcoding technique. J Ethnopharmacol 124:434-439
326. Song Z, Li X, Wang H, Wang J (2010) Genetic diversity and population structure of Salvia miltiorrhiza Bge in China revealed by ISSR and SRAP. Genetica 138:241-249
327. Soumaya R, Dakhlaoui-Dkhil S, Salem AOM, Zehdi-Azouzi S, Rhouma A, Marrakchi M, Trifi M (2008) Genetic diversity and phylogenic relationships in date-palms (Phoenix dactylifera L.) as assessed by random amplified microsatellite polymorphism markers (RAMPOs). Scientia Hort 117:53-57
328. Squirrell J, Hollingsworth PM, Woodhead M, Russell J, Lowe AJ, Gibby M, Powell W (2003) How much effort is required to isolate nuclear microsatellites from plants? Mol Ecol 12:1339-1348
329. Srivastava J, Lambert J, Vietmeyer N (1996) Medicinal plants: an expanding role in development [M]. World Bank Publications, Washington, DC
330. Sucher JN, Carles MC (2008) Genome-based approaches to the authentication of medicinal plants. Planta Med 74:603-623
331. Sucher NJ, Hennel JR, Carles MC (2012) Plant DNA fingerprinting and barcoding. Methods Mol Biol 862:13-22
332. Sun Y, Fung KP, Leung PC, Shi D, Shaw PC (2004) Characterization of medicinal Epimedium species by 5S rRNA gene spacer sequencing. Planta Med 70:287-288
333. Sun Y, Fung KP, Leung PC, Shaw PC (2005) A phylogenetic analysis of Epimedium (Berberidaceae) based on nuclear ribosomal DNA sequences. Mol Phylogenet Evol 35(1):287-291
334. Sun Y, Shaw PC, Fung KP (2007) Molecular authentication of Radix Puerariae Lobatae and Radix Puerariae Thomsonii by ITS and 5S rRNA spacer sequencing. Biol Pharm Bull 30:173-175
335. Sun ZY, Gao T, Yao H, Shi LC, Zhu YJ, Chen SL (2010) Identification of Lonicera japonica and its related species using the DNA barcoding method. Plant Med. doi:10.1055/s-0030-1250324
336. Sze SCW, Song JX, Wong RNS, Feng YB, Ng TB, Tong Y, Zhang KYB (2008) Application of SCAR (sequence characterized amplified region) analysis to authenticate Lycium barbarum (wolfberry) and its adulterants. Biotech Applied Biochem 51:15-21
337. Taberlet P et al (2007) Power and limitations of the chloroplast trnL (UAA) intron for plant DNA barcoding. Nucleic Acids Res 35:e14
338. Takamiya T, Wongsawad P, Tajima N, Shioda N, Lu JF, Wen CL, Wu JB, Handa T, Iijima H, Kitanaka S, Yukawa T (2011) Identification of Dendrobium species used for herbal medicines based on ribosomal DNA internal transcribed spacer sequence. Biol Pharm Bull 34(5):779-82
339. Techaprasan J, Klinbunga S, Jenjittiku T (2008) Genetic relationships and species authentication of Boesenbergia (Zingiberaceae) in Thailand based on AFLP and SSCP analyses. Biochem Syst Ecol 36(5-6):408-441
340. Ten Kate K, Laird S (1999) The commercial use of biodiversity: access to genetic resources and benefit-sharing. Commission of the European Communities and Earthscan, London, p 398
341. Theerakulpisut P, Kanawapee N, Maensiri D, Bunnag S, Chantaranothai P (2008) Development of species-specific SCAR markers for identification of three medicinal species of Phyllanthus. J Syst Evol 46:614-621
342. Thorne RF (2002) How many species of seed plants are there? Taxon 51:511-522
343. Trau D, Lee TM, Lao AI, Lenigk R, Hsing IM, Ip NY et al (2002) Genotyping on a complementary metal oxide semiconductor silicon polymerase chain reaction chip with integrated DNA microarray. Anal Chem 74:3168-3173
344. Trifi-Farah N, Marrakchi M (2001) Hedysarum phylogeny mediated by RFLP analysis of nuclear ribosomal DNA. Gen Res Crop Evol 48:339-345
345. Tsoi PY, Wu HS, Wong MS, Chen SL, Fong WF, Xiao PG et al (2003) Genotyping and species identification of Fritillaria by DNA chip technology. Acta Pharm Sin 4:185-190
346. Um JY, Chung HS, Kim MS, Na HJ, Kwon HJ, Kim JJ, Lee KM, Lee SJ, Lim JP, Do KR, Hwang WJ, Lyu YS, An NH, Kim HM (2001) Molecular authentication of Panax ginseng species by RAPD analysis and PCR-RFLP. Biol Pharm Bull 24:872-875
347. Valdes AM, Slatkin M, Freimer NB (1993) Allele frequencies at microsatellite loci - the stepwise mutation model revisited. Genetics 133:737-749
348. Varshney RV, Graner A, Sorrells ME (2005) Genic microsatellite markers in plants: features and applications. Trends Biotechnol 23:28-55
349. Vences M, Thomas M, Bonett RM, Vieites DR (2005) Deciphering amphibian diversity through DNA barcoding: chances and challenges. Philos Trans R Soc London Ser B 360:1859-1868
350. Vijayan K, Tsou CH (2010) DNA barcoding in plants: taxonomy in a new perspective. Curr Sci 99(11):1513-1541
351. Virgilio M, Backeljau T, Nevado Band De Meyer M (2010) Comparative performances of DNA barcoding across insect orders. BMC Bioinformatics 11:206
352. Vos P, Hogers R, Bleeker M, Reijans M, Van De Lee T, Hornes M, Frijters A, Pot J, Peleman J, Kuiper M, Zabeau M (1995) AFLP: a new technique for DNA fingerprinting. Nucleic Acids Res 23:4407-4414
353. Wagner H, Bauer R, Melchart D, Xiao PG, Staudinger A (2011) Chromatographic fingerprint analysis of herbal medicines: thin-layer and high performance liquid chromatography of Chinese drugs, Vol I and Vol II, 2nd edn. Springer, Wien
354. Wang H, Wang Q (2005) Analysis of rDNA ITS sequences of Radix et Rhizoma Salviae miltiorrhizae and plants of Salvia L. Chin Tradit Herb Drugs 36:1381-1385
355. Wang P, Huang F, Zhou L, Cao L, Liang S, Xu H, Liu J (2000) Analysis of Amomun villosum species and some adulterants of Zingiberaceae by RAPD. Zhong Yao Cai 23:71-74
356. Wang J, Ha WY, Ngan FN, But PP, Shaw PC (2001) Application of sequence characterized amplified region (SCAR) analysis to authenticate Panax species and their adulterants. Planta Med 67:781-783
357. Wang CZ, Li P, Ding JY, Jin GQ, Yuan CS (2005) Identification of Fritillaria pallidiflora using diagnostic PCR and PCR-RFLP based on nuclear ribosomal DNA internal transcribed spacer sequences. Planta Med 71:384-386
358. Wang CZ, Li P, Ding JY et al (2007a) Simultaneous identification of Bulbus Fritillariae cirrhosae using PCR-RFLP analysis. Phytomedicine 14:628-632
359. Wang MW, Hao XJ, Chen KX (2007b) Biological screening of natural products and drug innovation in China. Philos Trans R Soc Lond B Biol Sci 362(1482):1093-1105
360. Wang Y, Li XE, Li XD, Qi JJ, Sun P, Zhou LL (2008) Analysis of genetic diversity of wild Rehmannia glutinosa by using RAPD and ISSR markers. Zhongguo Zhongyao Zazhi 33(22):2591-2595
361. Wang HZ, Wu ZX, Lu JJ et al (2009) Molecular diversity and relationships among Cymbidium goeringii cultivars based on inter-simple sequence repeat (ISSR) markers. Genetica 136(3):391-399
362. Wang HT, Sun H, Kwon WS, Jin H, Yang DC (2010a) A PCR-based SNP marker for specific authentication of Korean ginseng (Panax ginseng) cultivar "Chunpoong". Mol Biol Rep 37:1053-1057
363. Wang W, Wu Y, Yan Y, Ermakova M, Kerstetter R et al (2010b) DNA barcoding of the Lemnaceae, a family of aquatic monocots. BMC Plant Biol 10(1):205
364. Ward RD, Hanner R, Hebert PDN (2009) The campaign to DNA barcode all fishes, FISH-BOL. J Fish Biol 74:329-356
365. Watanabe A, Araki S, Kobari S, Sudo H, Tsuchida T, Uno T et al (1998) In vitro propagation, restriction fragment length polymorphism, and random amplified polymorphic DNA analyses of Angelica plants. Plant Cell Rep 18:187-192
366. Waugh J (2007) DNA barcoding in animal species: progress, potential and pitfalls. Bioessays 29(2):188-197
367. Weising K, Gardner RC (1999) A set of conserved PCR primers for the analysis of simple sequence repeat polymorphisms in chloroplast genomes of dicotyledonous angiosperms. Genome 42:9-11
368. Weising K, Kahl G (1998) Hybridization-based microsatellite fingerprinting of plants. In: Caetano-Anolles G, Gresshoff PM (eds) DNA markers: protocols, applications, and overviews. Wiley, New York, pp 238-243
369. Weising K, Bybom H, Wolff K, Kahl G (2005) DNA fingerprinting in plants. Principles, methods, and application, 2nd edn. Taylor and Francis, Boca Raton
370. Welsh J, McClelland M (1990) Fingerprinting genomes using PCR with arbitrary primers. Nucleic Acids Res 18:7213-7218
371. Winter E, Pfaff T, Udupa SM, Hiittel B, Sharma PC, Sahi S, Arreguin-Espinoza R, Weigand F, Muehlbauer FJ, Kahl G (1999) Characterization and mapping of sequence-tagged microsatellite sites in the chickpea (Cicer arietinum L.) genome. Mol Gen Genet 262:90-101
372. Witsenboer H, Vogel J, Michelmore RW (1997) Identification, genetic localization, and allelic diversity of selectively amplified polymorphic loci in lettuce and wild relatives (Lactuca spp.). Genome 40:923-936
373. Wolfe KH, Li WH, Sharp PM (1987) Rates of nucleotide substitution vary greatly among plant mitochondrial, chloroplast, and nuclear DNAs. Proc Natl Acad Sci USA 84(24):9054-9058
374. Wong KL, Wang J, But PPH, Shaw PC (2001) Application of ctyochrome b DNA sequences for the authentication of endangered snake species. Forensic Sci Int 139:49-55
375. Wu H, Lien EJ, Lien LL (2003) Chemical and pharmacological investigations of Epimedium species: a survey. Prog Drug Res 60:1-57
376. Wu W, Zheng YL, Chen L, Wei YM, Yang RW, Yan ZH (2005) Evaluation of genetic relationships in the genus Houttuynia Thunb. In China based on RAPD and ISSR markers. Biochem Syst Ecol 33:1141-1157
377. Xia Q, Zhao KJ, Huang ZG, Zhang P, Dong TT, Li SP et al (2005) Molecular genetic and chemical assessment of Rhizoma Curcumae in China. J Agric Food Chem 53:6019-6026
378. Xia T, Chen S, Chen S, Zhang D, Zhang D, Gao Q et al (2007) ISSR analysis of genetic diversity of the Qinghai-Tibet plateau endemic Rhodiola chrysanthemifolia (Crassulaceae). Biochem Syst Ecol 35:209-214
379. Xiao PG (1994) Ethnopharmacological investigation of Chinese medicinal plants. Ciba Found Symp 185:169-173
380. Xiao PG, Yong P (1998) Ethnopharmacology and research on medicinal plants in China. In: Prendergast HDV, Etkin NL, Harris DR, Houghton PJ (eds) Plants for food and medicine. Proceedings from a Joint Conference of the Society for Economic Botany and the International Society for Ethnopharmacology, London, Royal Botanic Gardens, Kew, UK, pp 31-39
381. Xiong LZ, Xu CG, Saghai-Maroof MA, Zhang QF (1999) Pattern of cytosine methylation in an elite rice hybrid and its potential lines, detected by a methylationsensitive amplification polymorphism technique. Mol Gen Genet 261:439-446
382. Xu M, Li X, Korban SS (2000) AFLP-Based detection of DNA methylation. Plant Mol Biol Rep 18:361-368
383. Xu M, Huaracha E, Korban SS (2001) Development of sequence-characterized amplified regions (SCARs) from amplified fragment length polymorphism (AFLP) markers tightly linked to the Vf gene in apple. Genome 44:63-70
384. Xu H, Wang Z, Ding X, Zhou K, Xu L (2006) Differentiation of Dendrobium species used as "Huangcao Shihu" by rDNA ITS sequence analysis. Planta Med 72:89-92
385. Xue D (1997) China's national report on implementation of the Convention on Biological Diversity. China Environmental Science Press, Beijing
386. Xue CY, Xue HG (2008) Application of real-time scorpion PCR for authentication and quantification of the traditional chinese medicinal plant Drynaria fortunei. Planta Med 74:e765-e770
387. Xue CY, Li DZ, Lu JM, Yang JB, Liu JQ (2006a) Molecular authentication of the traditional Tibetan medicinal plant Swertia mussotii. Planta Med 72:1223-1226
388. Xue HG, Zhou SD, He XJ, Yu Y (2006b) Molecular authentication of the traditional Chinese medicinal plant Euphorbia pekinensis. Planta Med 73:91-93
389. Xue CY, Li DZ, Wang QZ (2008a) Identification and quantification of the traditional Chinese medicinal plant Gentiana macrophylla using Taqman real-time PCR. Planta Med 74(15):1842-1845
390. Xue HG, Wang H, Li DZ, Xue CY, Wang QZ (2008b) Differentiation of the traditional Chinese medicinal plants Euphorbia humifusa and E. maculata from adulterants by TaqMan real-time polymerase chain reaction. Planta Med 74:302-304
391. Yamaji H, Fukuda T, Yokoyama J, Pak JH, Zhou C, Yang C et al (2007) Reticulate evolution and phylogeography in Asarum sect. asiasarum (Aristolochiaceae) documented in internal transcribed spacer sequences (ITS) of nuclear ribosomal DNA. Mol Phylogenet Evol 44:863-884
392. Yamasaki M, Sato A, Shimomura K, Saito K, Murakoshi I (1994) Genetic relationships among Glycyrrhiza plants determined by RADP and RFLP analyses. Biol Pharm Bull 17:1529-1531
393. Yamazaki M, Sato A, Saito K, Murakoshi I (1993) Molecular phylogeny based on RFLP and its relation with alkaloid patterns in Lupinus plants. Biol Pharm Bull 16:1182-1184
394. Yang HY, Chen CF (1998) Pharmacology and toxicology of herbal medicine: subacute toxicity of commonly used Chinese drugs. J Toxicol Sci 23(Suppl 2):229-233
395. Yang ZY, Ling Z (2010) Screening potential DNA barcode regions in Amomum (Zingiberaceae). Acta Bot Yunnan 32(5):393-400
396. Yang M, Zhang D, Liu J, Zheng J (2001) A molecular marker that is specific to medicinal rhubarb based on chloroplast trnL/trnF sequences. Planta Med 67:784-786
397. Yang DY, Hirotoshi F, Shao-Qing C, Katsuko K (2004) Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and amplification refractory mutation system (ARMS) analyses of medicinally used rheum species and their application for identification of Rhei rhizoma. Biol Pharm Bull 27:661-669
398. Yang ZY, Chao Z, Huo KK, Wu BY, Pan SL (2006) Nuclear ribosomal DNA internal transcribed spacer 1 sequences of 4 Leonurus species. Nan Fang Yi Ke Da Xue Xue Bao 26:1593-1595
399. Yang ZY, Chao Z et al (2007) ITS sequence analysis used for molecular identification of the Bupleurum species from northwestern China. Phytomedicine 14:416-422
400. Yao H, Zhao Z, Chen DF, Chen JK, Zhou TS (2008) ISSR primer screening and preliminary evaluation of genetic diversity in wild populations of Glycyrrhiza uralensis. Biol Plantarum 052(1):117-120
401. Yao H, Song J, Liu C, Luo K, Han J et al (2010) Use of ITS2 region as the universal DNA barcode for plants and animals. PLoS One 5(10):e13102
402. Ye Q, Qiu YX, Quo YQ, Chen JX, Yang SZ, Zhao MS, Fu CX (2006) Species-specific SCAR markers for authentication of Sinocalycanthus chinensis. J Zhejiang Univ Sci B 7:868-872
403. Ying XC, Zhu D, Wang Q, Zhong WQ (2009) Application of Light Cycler polymerase chain reaction and melting curve analysis to the authentication of the traditional Chinese medicinal plant Cimicifuga foetida. Planta Med 75(8):873-874
404. Yip PY, Kwan HS (2006) Molecular identification of Astragalus membranaceus at the species and locality levels. J Ethnopharmacol 106:222-229
405. Yip PY, Chau CF, Mak CY, Kwan HS (2007) DNA methods for identification of Chinese medicinal materials. J Chin Med 2:1-19
406. Zabeau M, Vos P (1993) Selective restriction fragment amplification: a general method for DNA fingerprinting. European Patent Application number 92402629.7. Publication number 0534858A1
407. Zane L, Bargelloni L, Patarnello T (2002) Strategies for microsatellite isolation: a review. Mol Ecol 11:1-16
408. Zerega NJC, Mori S, Lindqvist C, Zheng Q, Motley TJ (2002) Using amplified fragment length polymorphisms (AFLP) to identify black cohosh (Actaea racemosa). Econ Bot 56:154-164
409. Zhang R, Zhang B, Ye H (1997) Identification of the Chinese herbs of Indigoferae L. by RAPD analysis. Hongguo Zhong Yao Za Zhi 22:72-73
410. Zhang YB, Ngan FN, Wang ZT, Wang J, But PPH, Shaw PC (1999) Differentiation of Codonopsis pilosula using random amplified polymorphic DNA. Planta Med 65:57-60
411. Zhang KYB, Leung HW et al (2001a) Differentiation of Lycium barbarum from its related Lycium species using random amplified polymorphic DNA. Planta Med 67:379-381
412. Zhang M, Huang HR, Liao SM, Gao JY (2001b) Cluster analysis of Dendrobium by RAPD and design of specific primer for Dendrobium candidum. Zhongguo Zhong Yao Za Zhi 26:442-447
413. Zhang YB, Wang J, Wang ZT, But PP, Shaw PC (2003) DNA microarray for identification of the herb of Dendrobium species from Chinese medicinal formulations. Planta Med 69:1172-1174
414. Zhang M, Zhang DZ, Xu XH, Zhang T, Wang ZT (2005a) 5S rRNA gene spacer sequences from Ligularia medicinal plants and the identification of HPAs-containing species. Chin J Nat Med 3:38-40
415. Zhang T, Xu LS, Wang ZT, Zhou KY, Zhang N, Shi YF (2005b) Molecular identification of medicinal plants: Dendrobium chrysanthum, Dendrobium fimbriatum and their morphologically allied species by PCR-RFLP analyses. Yao Xue Xue Bao 40:728-733
416. Zhang YB, Shaw PC, Sze CW, Wang ZT, Tong Y (2007) Molecular authentication of Chinese herbal materials. J Food Drug Anal 15:1-9
417. Zhang JM, Wang JX, Xia T, Zhou SL (2009) DNA barcoding: species delimitation in tree peonies. Sci China C Life Sci 52(6):568-578
418. Zhao ZZ, Li TYS (2004) Hong Kong commonly confused Chinese medicines. Chinese Medicine Merchants Association, Hong Kong
419. Zhao KJ, Dong TT, Cui XM, Tu PF, Tsim KW (2003a) Genetic distinction of radix adenophorae from its adulterants by the DNA sequence of 5S-rRNA spacer domains. Am J Chin Med 31:919-926
420. Zhao KJ, Dong TT, Tu PF, Song ZH, Lo CK, Tsim KW (2003b) Molecular genetic and chemical assessment of radix Angelica (Danggui) in China. J Agric Food Chem 51:2576-2583
421. Zhao Z, Hu Y, Liang Z, Yuen J, Jiang Z, Leung KSY (2006) Authentication is fundamental for standardization of Chinese medicines. Planta Med 72:865-874
422. Zhao YP, Qiu YX et al (2007a) Authentication of Actinidia macrosperma using PCR-RFLP based on trnK sequences. Bot Studies 48:239-242
423. Zhao ZL, Leng CH et al (2007b) Identification of Dryopteris crassirhizoma and the adulterant species based on cpDNA rbcL and translated amino acid sequences. Planta Med 73:1230-1233
424. Zhao ZZ, Yuen JPS, Wu J, Yu T, Huang W, Zhao ZZ, Li TYS (2007c) Easily confused Chinese medicines in Hong Kong. Ann Acad Med 35(11):764-769
425. Zhen-Yan Y, Ling Z (2010) Screening potential DNA barcode regions in Amomum (Zingiberaceae). Acta Bot Yunnan 32(5):393-400
426. Zhou Z, Bebeli PJ et al (1997) Direct amplification of minisatellite-region DNA with VNTR core sequences in the genus Oryza. Theor Appl Genet 95:942-949
427. Zhu YP (2002) Toxicity of the Chinese herb mu tong (Aristolochia manshuriensis). What history tells us. Adverse Drug React Toxicol Rev 21(4):171-177
428. Zhu S, Fushimi H, Cai S, Komatsu K (2003) Phylogenetic relationship in the genus Panax: inferred from chloroplast trnK gene and nuclear 18S rRNA gene sequences. Planta Med 69:647-653
429. Zhu S, Fushimi H, Cai S, Komatsu K (2004) Species identification from Ginseng drugs by multiplex amplification refractory mutation system (MARMS). Planta Med 70:189-192
430. Zhu S, Hirotoshi Fushimi H, Komatsu K (2008) Development of a DNA microarray for authentication of ginseng drugs based on 18S rRNA gene sequence. J Agric Food Chem 56(11):3953-3959
431. Zhu YJ, Sl C, Hui Y et al (2010) DNA barcoding the medicinal plants of the genus Paris. Yaoxue Xuebao 45(3):376-382
432. Zietkiewicz E, Rafalski A, Labuda D (1994) Genome fingerprinting by simple sequence repeat (SSR)-anchored polymerase chain reaction amplification. Genomics 20(2):176-183
433. Zuo YJ, Chen ZJ, Kondo K et al (2011) DNA barcoding of Panax species. Planta Med 77(2):182-187