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Volumn 25, Issue 5, 2014, Pages 274-282

G protein-coupled receptors and the regulation of autophagy

Author keywords

Amino acid sensing GPCRs; AMPK; Autophagy; GLP 1 receptor; MTORC1; Muscarinic receptor; adrenergic receptor

Indexed keywords

G PROTEIN COUPLED RECEPTOR;

EID: 84899489684     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2014.03.006     Document Type: Review
Times cited : (60)

References (101)
  • 1
    • 84866122688 scopus 로고    scopus 로고
    • Autophagy modulation as a potential therapeutic target for diverse diseases
    • Rubinsztein D.C., et al. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev. Drug Discov. 2012, 9:709-730.
    • (2012) Nat. Rev. Drug Discov. , vol.9 , pp. 709-730
    • Rubinsztein, D.C.1
  • 2
    • 84878532557 scopus 로고    scopus 로고
    • Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
    • Dibble C.C., Manning B.D. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat. Cell Biol. 2013, 6:555-564.
    • (2013) Nat. Cell Biol. , vol.6 , pp. 555-564
    • Dibble, C.C.1    Manning, B.D.2
  • 3
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang L., et al. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010, 6:467-478.
    • (2010) Cell Metab. , vol.6 , pp. 467-478
    • Yang, L.1
  • 4
    • 84873469666 scopus 로고    scopus 로고
    • Nutrient sensing, metabolism, and cell growth control
    • Yuan H.X., et al. Nutrient sensing, metabolism, and cell growth control. Mol. Cell 2013, 3:379-387.
    • (2013) Mol. Cell , vol.3 , pp. 379-387
    • Yuan, H.X.1
  • 5
    • 53749087941 scopus 로고    scopus 로고
    • Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi
    • Xue C., et al. Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiol. Rev. 2008, 6:1010-1032.
    • (2008) FEMS Microbiol. Rev. , vol.6 , pp. 1010-1032
    • Xue, C.1
  • 6
    • 84864541097 scopus 로고    scopus 로고
    • G protein-coupled receptors for energy metabolites as new therapeutic targets
    • Blad C.C., et al. G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat. Rev. Drug Discov. 2012, 8:603-619.
    • (2012) Nat. Rev. Drug Discov. , vol.8 , pp. 603-619
    • Blad, C.C.1
  • 7
    • 84880836560 scopus 로고    scopus 로고
    • Minireview: nutrient sensing by G protein-coupled receptors
    • Wauson E.M., et al. Minireview: nutrient sensing by G protein-coupled receptors. Mol. Endocrinol. 2013, 27:1188-1197.
    • (2013) Mol. Endocrinol. , vol.27 , pp. 1188-1197
    • Wauson, E.M.1
  • 8
    • 69549111756 scopus 로고    scopus 로고
    • Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients
    • Wellendorph P., et al. Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol. Pharmacol. 2009, 3:453-465.
    • (2009) Mol. Pharmacol. , vol.3 , pp. 453-465
    • Wellendorph, P.1
  • 9
    • 0037075555 scopus 로고    scopus 로고
    • An amino-acid taste receptor
    • Nelson G., et al. An amino-acid taste receptor. Nature 2002, 416:199-202.
    • (2002) Nature , vol.416 , pp. 199-202
    • Nelson, G.1
  • 10
    • 84896691815 scopus 로고    scopus 로고
    • Extrasensory perception: odorant and taste receptors beyond the nose and mouth
    • Foster S.R., et al. Extrasensory perception: odorant and taste receptors beyond the nose and mouth. Pharmacol. Ther. 2014, 142:41-61.
    • (2014) Pharmacol. Ther. , vol.142 , pp. 41-61
    • Foster, S.R.1
  • 11
    • 84866846953 scopus 로고    scopus 로고
    • The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy
    • Wauson E.M., et al. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol. Cell 2012, 6:851-862.
    • (2012) Mol. Cell , vol.6 , pp. 851-862
    • Wauson, E.M.1
  • 12
    • 58149523270 scopus 로고    scopus 로고
    • Systemic regulation of starvation response in Caenorhabditis elegans
    • Kang C., Avery L. Systemic regulation of starvation response in Caenorhabditis elegans. Genes Dev. 2009, 1:12-17.
    • (2009) Genes Dev. , vol.1 , pp. 12-17
    • Kang, C.1    Avery, L.2
  • 13
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • Oh D.Y., et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 2010, 142:687-698.
    • (2010) Cell , vol.142 , pp. 687-698
    • Oh, D.Y.1
  • 14
    • 84858285593 scopus 로고    scopus 로고
    • Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
    • Ichimura A., et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 2012, 483:350-354.
    • (2012) Nature , vol.483 , pp. 350-354
    • Ichimura, A.1
  • 15
    • 84874271499 scopus 로고    scopus 로고
    • Omega-6 polyunsaturated fatty acids extend life span through the activation of autophagy
    • O'Rourke E.J., et al. Omega-6 polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2012, 4:429-440.
    • (2012) Genes Dev. , vol.4 , pp. 429-440
    • O'Rourke, E.J.1
  • 16
    • 84883028352 scopus 로고    scopus 로고
    • Beta-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation
    • Lizaso A., et al. beta-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation. Autophagy 2013, 9:1228-1243.
    • (2013) Autophagy , vol.9 , pp. 1228-1243
    • Lizaso, A.1
  • 17
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh R., et al. Autophagy regulates lipid metabolism. Nature 2009, 458:1131-1135.
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1
  • 18
    • 84894227163 scopus 로고    scopus 로고
    • Decreased autophagy in rat heart induced by anti-beta1-adrenergic receptor autoantibodies contributes to the decline in mitochondrial membrane potential
    • Wang L., et al. Decreased autophagy in rat heart induced by anti-beta1-adrenergic receptor autoantibodies contributes to the decline in mitochondrial membrane potential. PLoS ONE 2009, 8:e81296.
    • (2009) PLoS ONE , vol.8
    • Wang, L.1
  • 19
    • 78650277944 scopus 로고    scopus 로고
    • Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
    • Aranguiz-Urroz P., et al. Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation. Biochim. Biophys. Acta 2009, 1812:23-31.
    • (2009) Biochim. Biophys. Acta , vol.1812 , pp. 23-31
    • Aranguiz-Urroz, P.1
  • 20
    • 33645569464 scopus 로고    scopus 로고
    • Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx
    • You Y.J., et al. Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx. Cell Metab. 2006, 3:237-245.
    • (2006) Cell Metab. , vol.3 , pp. 237-245
    • You, Y.J.1
  • 21
    • 34548421950 scopus 로고    scopus 로고
    • Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
    • Kang C., et al. Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev. 2007, 17:2161-2171.
    • (2007) Genes Dev. , vol.17 , pp. 2161-2171
    • Kang, C.1
  • 22
    • 84884996310 scopus 로고    scopus 로고
    • Acetylcholine mediates AMPK-dependent autophagic cytoprotection in H9c2 cells during hypoxia/reoxygenation injury
    • Zhao M., et al. Acetylcholine mediates AMPK-dependent autophagic cytoprotection in H9c2 cells during hypoxia/reoxygenation injury. Cell. Physiol. Biochem. 2013, 3:601-613.
    • (2013) Cell. Physiol. Biochem. , vol.3 , pp. 601-613
    • Zhao, M.1
  • 23
    • 47749103323 scopus 로고    scopus 로고
    • Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression
    • Thornton C., et al. Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression. J. Biol. Chem. 2008, 283:17116-17122.
    • (2008) J. Biol. Chem. , vol.283 , pp. 17116-17122
    • Thornton, C.1
  • 24
    • 77952291363 scopus 로고    scopus 로고
    • The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism
    • Merlin J., et al. The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism. Cell. Signal. 2010, 7:1104-1113.
    • (2010) Cell. Signal. , vol.7 , pp. 1104-1113
    • Merlin, J.1
  • 25
    • 84874207027 scopus 로고    scopus 로고
    • Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1alpha pathway
    • Sun L., et al. Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1alpha pathway. J. Cell. Physiol. 2013, 228:1238-1248.
    • (2013) J. Cell. Physiol. , vol.228 , pp. 1238-1248
    • Sun, L.1
  • 26
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • Bullock B.P., et al. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 1996, 137:2968-2978.
    • (1996) Endocrinology , vol.137 , pp. 2968-2978
    • Bullock, B.P.1
  • 27
    • 84860204551 scopus 로고    scopus 로고
    • Cardiovascular biology of the incretin system
    • Ussher J.R., Drucker D.J. Cardiovascular biology of the incretin system. Endocr. Rev. 2012, 2:187-215.
    • (2012) Endocr. Rev. , vol.2 , pp. 187-215
    • Ussher, J.R.1    Drucker, D.J.2
  • 28
    • 84888203544 scopus 로고    scopus 로고
    • Incretin actions beyond the pancreas: lessons from knockout mice
    • Yabe D., Seino Y. Incretin actions beyond the pancreas: lessons from knockout mice. Curr. Opin. Pharmacol. 2013, 6:946-953.
    • (2013) Curr. Opin. Pharmacol. , vol.6 , pp. 946-953
    • Yabe, D.1    Seino, Y.2
  • 29
    • 80053001967 scopus 로고    scopus 로고
    • GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy
    • Sharma S., et al. GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. PLoS ONE 2011, 6:e25269.
    • (2011) PLoS ONE , vol.6
    • Sharma, S.1
  • 30
    • 84872055241 scopus 로고    scopus 로고
    • A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity
    • Noyan-Ashraf M.H., et al. A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation 2013, 127:74-85.
    • (2013) Circulation , vol.127 , pp. 74-85
    • Noyan-Ashraf, M.H.1
  • 31
    • 84884273715 scopus 로고    scopus 로고
    • Liraglutide improves the survival of INS-1 cells by promoting macroautophagy
    • Jing Yin J., et al. Liraglutide improves the survival of INS-1 cells by promoting macroautophagy. Int. J. Endocrinol. Metab. 2013, 3:184-190.
    • (2013) Int. J. Endocrinol. Metab. , vol.3 , pp. 184-190
    • Jing Yin, J.1
  • 32
    • 84868273007 scopus 로고    scopus 로고
    • Nutrient sensing and signalling by the gut
    • Rasoamanana R., et al. Nutrient sensing and signalling by the gut. Proc. Nutr. Soc. 2012, 4:446-455.
    • (2012) Proc. Nutr. Soc. , vol.4 , pp. 446-455
    • Rasoamanana, R.1
  • 33
    • 74349115340 scopus 로고    scopus 로고
    • Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose
    • Han D., et al. Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose. Biochem. J. 2010, 425:541-551.
    • (2010) Biochem. J. , vol.425 , pp. 541-551
    • Han, D.1
  • 34
    • 52749094770 scopus 로고    scopus 로고
    • Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
    • Jung H.S., et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab. 2008, 4:318-324.
    • (2008) Cell Metab. , vol.4 , pp. 318-324
    • Jung, H.S.1
  • 35
    • 65549152426 scopus 로고    scopus 로고
    • High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures
    • Costa G., et al. High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures. J. Neurosci. Res. 2009, 6:1375-1380.
    • (2009) J. Neurosci. Res. , vol.6 , pp. 1375-1380
    • Costa, G.1
  • 36
    • 84861012301 scopus 로고    scopus 로고
    • Extracellular nucleotides inhibit insulin receptor signaling, stimulate autophagy and control lipoprotein secretion
    • Chatterjee C., Sparks D.L. Extracellular nucleotides inhibit insulin receptor signaling, stimulate autophagy and control lipoprotein secretion. PLoS ONE 2012, 7:e36916.
    • (2012) PLoS ONE , vol.7
    • Chatterjee, C.1    Sparks, D.L.2
  • 37
    • 38549129745 scopus 로고    scopus 로고
    • P2 receptors in cardiovascular regulation and disease
    • Erlinge D., Burnstock G. P2 receptors in cardiovascular regulation and disease. Purinergic Signal. 2008, 4:1-20.
    • (2008) Purinergic Signal. , vol.4 , pp. 1-20
    • Erlinge, D.1    Burnstock, G.2
  • 38
    • 0042326762 scopus 로고    scopus 로고
    • Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase
    • Tang X., et al. Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. Biochem. J. 2003, 374:137-143.
    • (2003) Biochem. J. , vol.374 , pp. 137-143
    • Tang, X.1
  • 39
    • 84894031924 scopus 로고    scopus 로고
    • Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation
    • Michel G., et al. Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation. J. Cell Sci. 2014, 127:773-787.
    • (2014) J. Cell Sci. , vol.127 , pp. 773-787
    • Michel, G.1
  • 40
    • 84873879360 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells
    • Oubrahim H., et al. Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells. J. Biol. Chem. 2013, 288:2805-2815.
    • (2013) J. Biol. Chem. , vol.288 , pp. 2805-2815
    • Oubrahim, H.1
  • 41
    • 84871901272 scopus 로고    scopus 로고
    • Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling
    • Mercan F., et al. Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. Mol. Cell. Biol. 2013, 2:293-306.
    • (2013) Mol. Cell. Biol. , vol.2 , pp. 293-306
    • Mercan, F.1
  • 42
    • 84894594660 scopus 로고    scopus 로고
    • Gbetagamma interacts with mTOR and promotes its activation
    • Robles-Molina E., et al. Gbetagamma interacts with mTOR and promotes its activation. Biochem. Biophys. Res. Commun. 2014, 444:218-223.
    • (2014) Biochem. Biophys. Res. Commun. , vol.444 , pp. 218-223
    • Robles-Molina, E.1
  • 43
    • 80053391464 scopus 로고    scopus 로고
    • CAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1
    • Ugland H., et al. cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy 2011, 7:1199-1211.
    • (2011) Autophagy , vol.7 , pp. 1199-1211
    • Ugland, H.1
  • 44
    • 42249106042 scopus 로고    scopus 로고
    • Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
    • Williams A., et al. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat. Chem. Biol. 2008, 4:295-305.
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 295-305
    • Williams, A.1
  • 45
    • 77955875002 scopus 로고    scopus 로고
    • Regulation of the autophagy protein LC3 by phosphorylation
    • Cherra S.J., et al. Regulation of the autophagy protein LC3 by phosphorylation. J. Cell Biol. 2010, 190:533-539.
    • (2010) J. Cell Biol. , vol.190 , pp. 533-539
    • Cherra, S.J.1
  • 46
    • 25444483066 scopus 로고    scopus 로고
    • Lithium induces autophagy by inhibiting inositol monophosphatase
    • Sarkar S., et al. Lithium induces autophagy by inhibiting inositol monophosphatase. J. Cell Biol. 2005, 170:1101-1111.
    • (2005) J. Cell Biol. , vol.170 , pp. 1101-1111
    • Sarkar, S.1
  • 47
    • 67549135655 scopus 로고    scopus 로고
    • The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
    • Vicencio J.M., et al. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ. 2009, 7:1006-1017.
    • (2009) Cell Death Differ. , vol.7 , pp. 1006-1017
    • Vicencio, J.M.1
  • 48
    • 77952759763 scopus 로고    scopus 로고
    • Role of inositol trisphosphate receptors in autophagy in DT40 cells
    • Khan M.T., Joseph S.K. Role of inositol trisphosphate receptors in autophagy in DT40 cells. J. Biol. Chem. 2010, 285:16912-16920.
    • (2010) J. Biol. Chem. , vol.285 , pp. 16912-16920
    • Khan, M.T.1    Joseph, S.K.2
  • 49
    • 34247380330 scopus 로고    scopus 로고
    • Regulation of autophagy by the inositol trisphosphate receptor
    • Criollo A., et al. Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ. 2007, 5:1029-1039.
    • (2007) Cell Death Differ. , vol.5 , pp. 1029-1039
    • Criollo, A.1
  • 50
    • 84869876713 scopus 로고    scopus 로고
    • Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P(3) and IP(3)-receptors
    • Wong A., et al. Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P(3) and IP(3)-receptors. J. Mol. Cell. Cardiol. 2007, 54:19-24.
    • (2007) J. Mol. Cell. Cardiol. , vol.54 , pp. 19-24
    • Wong, A.1
  • 51
    • 76349114046 scopus 로고    scopus 로고
    • Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
    • Chang N.C., et al. Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J. 2007, 3:606-618.
    • (2007) EMBO J. , vol.3 , pp. 606-618
    • Chang, N.C.1
  • 52
    • 84887497763 scopus 로고    scopus 로고
    • 2+ in quality control: an unresolved riddle critical to autophagy and mitophagy
    • 2+ in quality control: an unresolved riddle critical to autophagy and mitophagy. Autophagy 2007, 9:1710-1719.
    • (2007) Autophagy , vol.9 , pp. 1710-1719
    • East, D.A.1    Campanella, M.2
  • 53
    • 0029867412 scopus 로고    scopus 로고
    • The metabolism of sphingo(glyco)lipids is correlated with the differentiation-dependent autophagic pathway in HT-29 cells
    • Ghidoni R., et al. The metabolism of sphingo(glyco)lipids is correlated with the differentiation-dependent autophagic pathway in HT-29 cells. Eur. J. Biochem. 1996, 237:454-459.
    • (1996) Eur. J. Biochem. , vol.237 , pp. 454-459
    • Ghidoni, R.1
  • 54
    • 0029036657 scopus 로고
    • Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line
    • Houri J.J., et al. Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line. Biochem. J. 1995, 309:521-527.
    • (1995) Biochem. J. , vol.309 , pp. 521-527
    • Houri, J.J.1
  • 55
    • 0031560907 scopus 로고    scopus 로고
    • Evidence for a dual control of macroautophagic sequestration and intracellular trafficking of N-linked glycoproteins by the trimeric G(i3) protein in HT-29 cells
    • Ogier-Denis E., et al. Evidence for a dual control of macroautophagic sequestration and intracellular trafficking of N-linked glycoproteins by the trimeric G(i3) protein in HT-29 cells. Biochem. Biophys. Res. Commun. 1997, 235:166-170.
    • (1997) Biochem. Biophys. Res. Commun. , vol.235 , pp. 166-170
    • Ogier-Denis, E.1
  • 56
    • 0029905203 scopus 로고    scopus 로고
    • Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells
    • Ogier-Denis E., et al. Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells. J. Biol. Chem. 1996, 271:28593-28600.
    • (1996) J. Biol. Chem. , vol.271 , pp. 28593-28600
    • Ogier-Denis, E.1
  • 57
    • 0037742636 scopus 로고    scopus 로고
    • The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells
    • Pattingre S., et al. The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells. J. Biol. Chem. 2003, 278:20995-21002.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20995-21002
    • Pattingre, S.1
  • 58
    • 0033556037 scopus 로고    scopus 로고
    • Subcellular localization of the Galphai3 protein and G alpha interacting protein, two proteins involved in the control of macroautophagy in human colon cancer HT-29 cells
    • Petiot A., et al. Subcellular localization of the Galphai3 protein and G alpha interacting protein, two proteins involved in the control of macroautophagy in human colon cancer HT-29 cells. Biochem. J. 2003, 337:289-295.
    • (2003) Biochem. J. , vol.337 , pp. 289-295
    • Petiot, A.1
  • 59
    • 33745685061 scopus 로고    scopus 로고
    • Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome
    • Slessareva J.E., et al. Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 2006, 126:191-203.
    • (2006) Cell , vol.126 , pp. 191-203
    • Slessareva, J.E.1
  • 60
    • 33847295750 scopus 로고    scopus 로고
    • An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver
    • Gohla A., et al. An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:3003-3008.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 3003-3008
    • Gohla, A.1
  • 61
    • 84870750816 scopus 로고    scopus 로고
    • G protein-coupled receptor-mediated activation of p110beta by Gbetagamma is required for cellular transformation and invasiveness
    • Dbouk H.A., et al. G protein-coupled receptor-mediated activation of p110beta by Gbetagamma is required for cellular transformation and invasiveness. Sci. Signal. 2012, 5:ra89.
    • (2012) Sci. Signal. , vol.5
    • Dbouk, H.A.1
  • 62
    • 78349244834 scopus 로고    scopus 로고
    • The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy
    • Dou Z., et al. The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. J. Cell Biol. 2010, 191:827-843.
    • (2010) J. Cell Biol. , vol.191 , pp. 827-843
    • Dou, Z.1
  • 63
    • 84876086849 scopus 로고    scopus 로고
    • Class IA PI3K p110beta subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation
    • Dou Z., et al. Class IA PI3K p110beta subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Mol. Cell 2013, 1:29-42.
    • (2013) Mol. Cell , vol.1 , pp. 29-42
    • Dou, Z.1
  • 64
    • 33644991114 scopus 로고    scopus 로고
    • Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras
    • Ballou L.M., et al. Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras. Biochem. J. 2006, 394:557-562.
    • (2006) Biochem. J. , vol.394 , pp. 557-562
    • Ballou, L.M.1
  • 65
    • 77949429043 scopus 로고    scopus 로고
    • Gq-coupled purinergic receptors inhibit insulin-like growth factor-I/phosphoinositide 3-kinase pathway-dependent keratinocyte migration
    • Taboubi S., et al. Gq-coupled purinergic receptors inhibit insulin-like growth factor-I/phosphoinositide 3-kinase pathway-dependent keratinocyte migration. Mol. Biol. Cell 2010, 6:946-955.
    • (2010) Mol. Biol. Cell , vol.6 , pp. 946-955
    • Taboubi, S.1
  • 66
    • 36849012449 scopus 로고    scopus 로고
    • G alpha(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration
    • Taboubi S., et al. G alpha(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration. FASEB J. 2007, 14:4047-4058.
    • (2007) FASEB J. , vol.14 , pp. 4047-4058
    • Taboubi, S.1
  • 67
    • 77953726944 scopus 로고    scopus 로고
    • Galpha16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling
    • Yeung W.W., Wong Y.H. Galpha16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling. Cell Signal. 2010, 9:1379-1387.
    • (2010) Cell Signal. , vol.9 , pp. 1379-1387
    • Yeung, W.W.1    Wong, Y.H.2
  • 68
    • 0034672063 scopus 로고    scopus 로고
    • Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells
    • Ogier-Denis E., et al. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J. Biol. Chem. 2000, 275:39090-39095.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39090-39095
    • Ogier-Denis, E.1
  • 69
    • 80955177196 scopus 로고    scopus 로고
    • TFEB links autophagy to lysosomal biogenesis
    • Settembre C., et al. TFEB links autophagy to lysosomal biogenesis. Science 2011, 332:1429-1433.
    • (2011) Science , vol.332 , pp. 1429-1433
    • Settembre, C.1
  • 70
    • 84888153445 scopus 로고    scopus 로고
    • Autophagy proteins regulate ERK phosphorylation
    • Martinez-Lopez N., et al. Autophagy proteins regulate ERK phosphorylation. Nat. Commun. 2013, 4:2799.
    • (2013) Nat. Commun. , vol.4 , pp. 2799
    • Martinez-Lopez, N.1
  • 71
    • 50049105823 scopus 로고    scopus 로고
    • The regulation of AMP-activated protein kinase by upstream kinases
    • Carling D., et al. The regulation of AMP-activated protein kinase by upstream kinases. Int. J. Obes. (Lond.) 2008, 32(Suppl. 4):S55-S59.
    • (2008) Int. J. Obes. (Lond.) , vol.32 , Issue.SUPPL. 4
    • Carling, D.1
  • 72
    • 50549100488 scopus 로고    scopus 로고
    • Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease
    • Hutchinson D.S., et al. Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease. Pharmacol. Ther. 2008, 119:291-310.
    • (2008) Pharmacol. Ther. , vol.119 , pp. 291-310
    • Hutchinson, D.S.1
  • 73
    • 84863393597 scopus 로고    scopus 로고
    • Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
    • He C., et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature 2012, 481:511-515.
    • (2012) Nature , vol.481 , pp. 511-515
    • He, C.1
  • 74
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • Jung C.H., et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 2009, 7:1992-2003.
    • (2009) Mol. Biol. Cell , vol.7 , pp. 1992-2003
    • Jung, C.H.1
  • 75
    • 0035809160 scopus 로고    scopus 로고
    • Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
    • Kihara A., et al. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 2001, 152:519-530.
    • (2001) J. Cell Biol. , vol.152 , pp. 519-530
    • Kihara, A.1
  • 76
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    • Furuya N., et al. The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 2005, 1:46-52.
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1
  • 77
    • 68149139456 scopus 로고    scopus 로고
    • The autophagy effector Beclin 1: a novel BH3-only protein
    • Sinha S., Levine B. The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 2008, 27(Suppl. 1):S137-S148.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Sinha, S.1    Levine, B.2
  • 78
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    • Wei Y., et al. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 2008, 6:678-688.
    • (2008) Mol. Cell , vol.6 , pp. 678-688
    • Wei, Y.1
  • 79
    • 84880331368 scopus 로고    scopus 로고
    • ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
    • Russell R.C., et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 2013, 7:741-750.
    • (2013) Nat. Cell Biol. , vol.7 , pp. 741-750
    • Russell, R.C.1
  • 80
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan D.F., et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331:456-461.
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1
  • 81
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J., et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 2011, 2:132-141.
    • (2011) Nat. Cell Biol. , vol.2 , pp. 132-141
    • Kim, J.1
  • 82
    • 84872586081 scopus 로고    scopus 로고
    • Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
    • Kim J., et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 2013, 152:290-303.
    • (2013) Cell , vol.152 , pp. 290-303
    • Kim, J.1
  • 83
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: core molecular machinery and signaling regulation
    • Yang Z., Klionsky D.J. Mammalian autophagy: core molecular machinery and signaling regulation. Curr. Opin. Cell Biol. 2010, 2:124-131.
    • (2010) Curr. Opin. Cell Biol. , vol.2 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 84
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 85
    • 0018386209 scopus 로고
    • Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells
    • Reitzer L.J., et al. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem. 1979, 254:2669-2676.
    • (1979) J. Biol. Chem. , vol.254 , pp. 2669-2676
    • Reitzer, L.J.1
  • 86
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 2008, 4:393-402.
    • (2008) Mol. Cell , vol.4 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 88
    • 28544446058 scopus 로고    scopus 로고
    • Mitochondrial tumour suppressors: a genetic and biochemical update
    • Gottlieb E., Tomlinson I.P. Mitochondrial tumour suppressors: a genetic and biochemical update. Nat. Rev. Cancer 2005, 5:857-866.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 857-866
    • Gottlieb, E.1    Tomlinson, I.P.2
  • 89
    • 17844383964 scopus 로고    scopus 로고
    • Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
    • Ramanathan A., et al. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:5992-5997.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 5992-5997
    • Ramanathan, A.1
  • 90
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin V.R., et al. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9:425-434.
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1
  • 91
    • 0030921103 scopus 로고    scopus 로고
    • C-Myc transactivation of LDH-A: implications for tumor metabolism and growth
    • Shim H., et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:6658-6663.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 6658-6663
    • Shim, H.1
  • 92
    • 84858414020 scopus 로고    scopus 로고
    • Cellular metabolism and disease: what do metabolic outliers teach us?
    • DeBerardinis R.J., Thompson C.B. Cellular metabolism and disease: what do metabolic outliers teach us?. Cell 1997, 148:1132-1144.
    • (1997) Cell , vol.148 , pp. 1132-1144
    • DeBerardinis, R.J.1    Thompson, C.B.2
  • 93
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer 2012, 6:401-410.
    • (2012) Nat. Rev. Cancer , vol.6 , pp. 401-410
    • White, E.1
  • 94
    • 84878219891 scopus 로고    scopus 로고
    • The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
    • O'Hayre M., et al. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat. Rev. Cancer 2013, 6:412-424.
    • (2013) Nat. Rev. Cancer , vol.6 , pp. 412-424
    • O'Hayre, M.1
  • 95
    • 84894362626 scopus 로고    scopus 로고
    • Cardiomyocyte health: adapting to metabolic changes through autophagy
    • Kubli D.A., Gustafsson A.B. Cardiomyocyte health: adapting to metabolic changes through autophagy. Trends Endocrinol. Metab. 2014, 3:156-164.
    • (2014) Trends Endocrinol. Metab. , vol.3 , pp. 156-164
    • Kubli, D.A.1    Gustafsson, A.B.2
  • 96
    • 84875232070 scopus 로고    scopus 로고
    • Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy
    • Papadakis M., et al. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat. Med. 2013, 3:351-357.
    • (2013) Nat. Med. , vol.3 , pp. 351-357
    • Papadakis, M.1
  • 97
    • 77957221783 scopus 로고    scopus 로고
    • Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury
    • Sala-Mercado J.A., et al. Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury. Circulation 2010, 122(Suppl.):S179-S184.
    • (2010) Circulation , vol.122 , Issue.SUPPL.
    • Sala-Mercado, J.A.1
  • 98
    • 71649084135 scopus 로고    scopus 로고
    • Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction
    • Buss S.J., et al. Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. J. Am. Coll. Cardiol. 2009, 25:2435-2446.
    • (2009) J. Am. Coll. Cardiol. , vol.25 , pp. 2435-2446
    • Buss, S.J.1
  • 99
    • 2342576807 scopus 로고    scopus 로고
    • GPCR expression in the heart; 'new' receptors in myocytes and fibroblasts
    • Tang C.M., Insel P.A. GPCR expression in the heart; 'new' receptors in myocytes and fibroblasts. Trends Cardiovasc. Med. 2004, 3:94-99.
    • (2004) Trends Cardiovasc. Med. , vol.3 , pp. 94-99
    • Tang, C.M.1    Insel, P.A.2
  • 100
    • 84887999195 scopus 로고    scopus 로고
    • An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases
    • Heng B.C., et al. An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases. Biotechnol. Adv. 2004, 8:1676-1694.
    • (2004) Biotechnol. Adv. , vol.8 , pp. 1676-1694
    • Heng, B.C.1
  • 101
    • 84869005068 scopus 로고    scopus 로고
    • Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β)
    • Ghislat G., et al. Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β). J Biol Chem 2012, 287:38625-38636.
    • (2012) J Biol Chem , vol.287 , pp. 38625-38636
    • Ghislat, G.1


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