-
1
-
-
84866122688
-
Autophagy modulation as a potential therapeutic target for diverse diseases
-
Rubinsztein D.C., et al. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev. Drug Discov. 2012, 9:709-730.
-
(2012)
Nat. Rev. Drug Discov.
, vol.9
, pp. 709-730
-
-
Rubinsztein, D.C.1
-
2
-
-
84878532557
-
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
-
Dibble C.C., Manning B.D. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat. Cell Biol. 2013, 6:555-564.
-
(2013)
Nat. Cell Biol.
, vol.6
, pp. 555-564
-
-
Dibble, C.C.1
Manning, B.D.2
-
3
-
-
77956400005
-
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
-
Yang L., et al. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010, 6:467-478.
-
(2010)
Cell Metab.
, vol.6
, pp. 467-478
-
-
Yang, L.1
-
4
-
-
84873469666
-
Nutrient sensing, metabolism, and cell growth control
-
Yuan H.X., et al. Nutrient sensing, metabolism, and cell growth control. Mol. Cell 2013, 3:379-387.
-
(2013)
Mol. Cell
, vol.3
, pp. 379-387
-
-
Yuan, H.X.1
-
5
-
-
53749087941
-
Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi
-
Xue C., et al. Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiol. Rev. 2008, 6:1010-1032.
-
(2008)
FEMS Microbiol. Rev.
, vol.6
, pp. 1010-1032
-
-
Xue, C.1
-
6
-
-
84864541097
-
G protein-coupled receptors for energy metabolites as new therapeutic targets
-
Blad C.C., et al. G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat. Rev. Drug Discov. 2012, 8:603-619.
-
(2012)
Nat. Rev. Drug Discov.
, vol.8
, pp. 603-619
-
-
Blad, C.C.1
-
7
-
-
84880836560
-
Minireview: nutrient sensing by G protein-coupled receptors
-
Wauson E.M., et al. Minireview: nutrient sensing by G protein-coupled receptors. Mol. Endocrinol. 2013, 27:1188-1197.
-
(2013)
Mol. Endocrinol.
, vol.27
, pp. 1188-1197
-
-
Wauson, E.M.1
-
8
-
-
69549111756
-
Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients
-
Wellendorph P., et al. Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol. Pharmacol. 2009, 3:453-465.
-
(2009)
Mol. Pharmacol.
, vol.3
, pp. 453-465
-
-
Wellendorph, P.1
-
9
-
-
0037075555
-
An amino-acid taste receptor
-
Nelson G., et al. An amino-acid taste receptor. Nature 2002, 416:199-202.
-
(2002)
Nature
, vol.416
, pp. 199-202
-
-
Nelson, G.1
-
10
-
-
84896691815
-
Extrasensory perception: odorant and taste receptors beyond the nose and mouth
-
Foster S.R., et al. Extrasensory perception: odorant and taste receptors beyond the nose and mouth. Pharmacol. Ther. 2014, 142:41-61.
-
(2014)
Pharmacol. Ther.
, vol.142
, pp. 41-61
-
-
Foster, S.R.1
-
11
-
-
84866846953
-
The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy
-
Wauson E.M., et al. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol. Cell 2012, 6:851-862.
-
(2012)
Mol. Cell
, vol.6
, pp. 851-862
-
-
Wauson, E.M.1
-
12
-
-
58149523270
-
Systemic regulation of starvation response in Caenorhabditis elegans
-
Kang C., Avery L. Systemic regulation of starvation response in Caenorhabditis elegans. Genes Dev. 2009, 1:12-17.
-
(2009)
Genes Dev.
, vol.1
, pp. 12-17
-
-
Kang, C.1
Avery, L.2
-
13
-
-
77956165390
-
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
-
Oh D.Y., et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 2010, 142:687-698.
-
(2010)
Cell
, vol.142
, pp. 687-698
-
-
Oh, D.Y.1
-
14
-
-
84858285593
-
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
-
Ichimura A., et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 2012, 483:350-354.
-
(2012)
Nature
, vol.483
, pp. 350-354
-
-
Ichimura, A.1
-
15
-
-
84874271499
-
Omega-6 polyunsaturated fatty acids extend life span through the activation of autophagy
-
O'Rourke E.J., et al. Omega-6 polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2012, 4:429-440.
-
(2012)
Genes Dev.
, vol.4
, pp. 429-440
-
-
O'Rourke, E.J.1
-
16
-
-
84883028352
-
Beta-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation
-
Lizaso A., et al. beta-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation. Autophagy 2013, 9:1228-1243.
-
(2013)
Autophagy
, vol.9
, pp. 1228-1243
-
-
Lizaso, A.1
-
17
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh R., et al. Autophagy regulates lipid metabolism. Nature 2009, 458:1131-1135.
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
-
18
-
-
84894227163
-
Decreased autophagy in rat heart induced by anti-beta1-adrenergic receptor autoantibodies contributes to the decline in mitochondrial membrane potential
-
Wang L., et al. Decreased autophagy in rat heart induced by anti-beta1-adrenergic receptor autoantibodies contributes to the decline in mitochondrial membrane potential. PLoS ONE 2009, 8:e81296.
-
(2009)
PLoS ONE
, vol.8
-
-
Wang, L.1
-
19
-
-
78650277944
-
Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
-
Aranguiz-Urroz P., et al. Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation. Biochim. Biophys. Acta 2009, 1812:23-31.
-
(2009)
Biochim. Biophys. Acta
, vol.1812
, pp. 23-31
-
-
Aranguiz-Urroz, P.1
-
20
-
-
33645569464
-
Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx
-
You Y.J., et al. Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx. Cell Metab. 2006, 3:237-245.
-
(2006)
Cell Metab.
, vol.3
, pp. 237-245
-
-
You, Y.J.1
-
21
-
-
34548421950
-
Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
-
Kang C., et al. Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev. 2007, 17:2161-2171.
-
(2007)
Genes Dev.
, vol.17
, pp. 2161-2171
-
-
Kang, C.1
-
22
-
-
84884996310
-
Acetylcholine mediates AMPK-dependent autophagic cytoprotection in H9c2 cells during hypoxia/reoxygenation injury
-
Zhao M., et al. Acetylcholine mediates AMPK-dependent autophagic cytoprotection in H9c2 cells during hypoxia/reoxygenation injury. Cell. Physiol. Biochem. 2013, 3:601-613.
-
(2013)
Cell. Physiol. Biochem.
, vol.3
, pp. 601-613
-
-
Zhao, M.1
-
23
-
-
47749103323
-
Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression
-
Thornton C., et al. Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression. J. Biol. Chem. 2008, 283:17116-17122.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 17116-17122
-
-
Thornton, C.1
-
24
-
-
77952291363
-
The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism
-
Merlin J., et al. The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism. Cell. Signal. 2010, 7:1104-1113.
-
(2010)
Cell. Signal.
, vol.7
, pp. 1104-1113
-
-
Merlin, J.1
-
25
-
-
84874207027
-
Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1alpha pathway
-
Sun L., et al. Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1alpha pathway. J. Cell. Physiol. 2013, 228:1238-1248.
-
(2013)
J. Cell. Physiol.
, vol.228
, pp. 1238-1248
-
-
Sun, L.1
-
26
-
-
0030013475
-
Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
-
Bullock B.P., et al. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 1996, 137:2968-2978.
-
(1996)
Endocrinology
, vol.137
, pp. 2968-2978
-
-
Bullock, B.P.1
-
27
-
-
84860204551
-
Cardiovascular biology of the incretin system
-
Ussher J.R., Drucker D.J. Cardiovascular biology of the incretin system. Endocr. Rev. 2012, 2:187-215.
-
(2012)
Endocr. Rev.
, vol.2
, pp. 187-215
-
-
Ussher, J.R.1
Drucker, D.J.2
-
28
-
-
84888203544
-
Incretin actions beyond the pancreas: lessons from knockout mice
-
Yabe D., Seino Y. Incretin actions beyond the pancreas: lessons from knockout mice. Curr. Opin. Pharmacol. 2013, 6:946-953.
-
(2013)
Curr. Opin. Pharmacol.
, vol.6
, pp. 946-953
-
-
Yabe, D.1
Seino, Y.2
-
29
-
-
80053001967
-
GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy
-
Sharma S., et al. GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. PLoS ONE 2011, 6:e25269.
-
(2011)
PLoS ONE
, vol.6
-
-
Sharma, S.1
-
30
-
-
84872055241
-
A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity
-
Noyan-Ashraf M.H., et al. A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation 2013, 127:74-85.
-
(2013)
Circulation
, vol.127
, pp. 74-85
-
-
Noyan-Ashraf, M.H.1
-
31
-
-
84884273715
-
Liraglutide improves the survival of INS-1 cells by promoting macroautophagy
-
Jing Yin J., et al. Liraglutide improves the survival of INS-1 cells by promoting macroautophagy. Int. J. Endocrinol. Metab. 2013, 3:184-190.
-
(2013)
Int. J. Endocrinol. Metab.
, vol.3
, pp. 184-190
-
-
Jing Yin, J.1
-
32
-
-
84868273007
-
Nutrient sensing and signalling by the gut
-
Rasoamanana R., et al. Nutrient sensing and signalling by the gut. Proc. Nutr. Soc. 2012, 4:446-455.
-
(2012)
Proc. Nutr. Soc.
, vol.4
, pp. 446-455
-
-
Rasoamanana, R.1
-
33
-
-
74349115340
-
Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose
-
Han D., et al. Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose. Biochem. J. 2010, 425:541-551.
-
(2010)
Biochem. J.
, vol.425
, pp. 541-551
-
-
Han, D.1
-
34
-
-
52749094770
-
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
-
Jung H.S., et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab. 2008, 4:318-324.
-
(2008)
Cell Metab.
, vol.4
, pp. 318-324
-
-
Jung, H.S.1
-
35
-
-
65549152426
-
High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures
-
Costa G., et al. High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures. J. Neurosci. Res. 2009, 6:1375-1380.
-
(2009)
J. Neurosci. Res.
, vol.6
, pp. 1375-1380
-
-
Costa, G.1
-
36
-
-
84861012301
-
Extracellular nucleotides inhibit insulin receptor signaling, stimulate autophagy and control lipoprotein secretion
-
Chatterjee C., Sparks D.L. Extracellular nucleotides inhibit insulin receptor signaling, stimulate autophagy and control lipoprotein secretion. PLoS ONE 2012, 7:e36916.
-
(2012)
PLoS ONE
, vol.7
-
-
Chatterjee, C.1
Sparks, D.L.2
-
37
-
-
38549129745
-
P2 receptors in cardiovascular regulation and disease
-
Erlinge D., Burnstock G. P2 receptors in cardiovascular regulation and disease. Purinergic Signal. 2008, 4:1-20.
-
(2008)
Purinergic Signal.
, vol.4
, pp. 1-20
-
-
Erlinge, D.1
Burnstock, G.2
-
38
-
-
0042326762
-
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase
-
Tang X., et al. Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. Biochem. J. 2003, 374:137-143.
-
(2003)
Biochem. J.
, vol.374
, pp. 137-143
-
-
Tang, X.1
-
39
-
-
84894031924
-
Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation
-
Michel G., et al. Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation. J. Cell Sci. 2014, 127:773-787.
-
(2014)
J. Cell Sci.
, vol.127
, pp. 773-787
-
-
Michel, G.1
-
40
-
-
84873879360
-
Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells
-
Oubrahim H., et al. Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells. J. Biol. Chem. 2013, 288:2805-2815.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 2805-2815
-
-
Oubrahim, H.1
-
41
-
-
84871901272
-
Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling
-
Mercan F., et al. Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. Mol. Cell. Biol. 2013, 2:293-306.
-
(2013)
Mol. Cell. Biol.
, vol.2
, pp. 293-306
-
-
Mercan, F.1
-
42
-
-
84894594660
-
Gbetagamma interacts with mTOR and promotes its activation
-
Robles-Molina E., et al. Gbetagamma interacts with mTOR and promotes its activation. Biochem. Biophys. Res. Commun. 2014, 444:218-223.
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.444
, pp. 218-223
-
-
Robles-Molina, E.1
-
43
-
-
80053391464
-
CAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1
-
Ugland H., et al. cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy 2011, 7:1199-1211.
-
(2011)
Autophagy
, vol.7
, pp. 1199-1211
-
-
Ugland, H.1
-
44
-
-
42249106042
-
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
-
Williams A., et al. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat. Chem. Biol. 2008, 4:295-305.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 295-305
-
-
Williams, A.1
-
45
-
-
77955875002
-
Regulation of the autophagy protein LC3 by phosphorylation
-
Cherra S.J., et al. Regulation of the autophagy protein LC3 by phosphorylation. J. Cell Biol. 2010, 190:533-539.
-
(2010)
J. Cell Biol.
, vol.190
, pp. 533-539
-
-
Cherra, S.J.1
-
46
-
-
25444483066
-
Lithium induces autophagy by inhibiting inositol monophosphatase
-
Sarkar S., et al. Lithium induces autophagy by inhibiting inositol monophosphatase. J. Cell Biol. 2005, 170:1101-1111.
-
(2005)
J. Cell Biol.
, vol.170
, pp. 1101-1111
-
-
Sarkar, S.1
-
47
-
-
67549135655
-
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
-
Vicencio J.M., et al. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ. 2009, 7:1006-1017.
-
(2009)
Cell Death Differ.
, vol.7
, pp. 1006-1017
-
-
Vicencio, J.M.1
-
48
-
-
77952759763
-
Role of inositol trisphosphate receptors in autophagy in DT40 cells
-
Khan M.T., Joseph S.K. Role of inositol trisphosphate receptors in autophagy in DT40 cells. J. Biol. Chem. 2010, 285:16912-16920.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 16912-16920
-
-
Khan, M.T.1
Joseph, S.K.2
-
49
-
-
34247380330
-
Regulation of autophagy by the inositol trisphosphate receptor
-
Criollo A., et al. Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ. 2007, 5:1029-1039.
-
(2007)
Cell Death Differ.
, vol.5
, pp. 1029-1039
-
-
Criollo, A.1
-
50
-
-
84869876713
-
Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P(3) and IP(3)-receptors
-
Wong A., et al. Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P(3) and IP(3)-receptors. J. Mol. Cell. Cardiol. 2007, 54:19-24.
-
(2007)
J. Mol. Cell. Cardiol.
, vol.54
, pp. 19-24
-
-
Wong, A.1
-
51
-
-
76349114046
-
Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
-
Chang N.C., et al. Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J. 2007, 3:606-618.
-
(2007)
EMBO J.
, vol.3
, pp. 606-618
-
-
Chang, N.C.1
-
52
-
-
84887497763
-
2+ in quality control: an unresolved riddle critical to autophagy and mitophagy
-
2+ in quality control: an unresolved riddle critical to autophagy and mitophagy. Autophagy 2007, 9:1710-1719.
-
(2007)
Autophagy
, vol.9
, pp. 1710-1719
-
-
East, D.A.1
Campanella, M.2
-
53
-
-
0029867412
-
The metabolism of sphingo(glyco)lipids is correlated with the differentiation-dependent autophagic pathway in HT-29 cells
-
Ghidoni R., et al. The metabolism of sphingo(glyco)lipids is correlated with the differentiation-dependent autophagic pathway in HT-29 cells. Eur. J. Biochem. 1996, 237:454-459.
-
(1996)
Eur. J. Biochem.
, vol.237
, pp. 454-459
-
-
Ghidoni, R.1
-
54
-
-
0029036657
-
Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line
-
Houri J.J., et al. Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line. Biochem. J. 1995, 309:521-527.
-
(1995)
Biochem. J.
, vol.309
, pp. 521-527
-
-
Houri, J.J.1
-
55
-
-
0031560907
-
Evidence for a dual control of macroautophagic sequestration and intracellular trafficking of N-linked glycoproteins by the trimeric G(i3) protein in HT-29 cells
-
Ogier-Denis E., et al. Evidence for a dual control of macroautophagic sequestration and intracellular trafficking of N-linked glycoproteins by the trimeric G(i3) protein in HT-29 cells. Biochem. Biophys. Res. Commun. 1997, 235:166-170.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.235
, pp. 166-170
-
-
Ogier-Denis, E.1
-
56
-
-
0029905203
-
Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells
-
Ogier-Denis E., et al. Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells. J. Biol. Chem. 1996, 271:28593-28600.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 28593-28600
-
-
Ogier-Denis, E.1
-
57
-
-
0037742636
-
The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells
-
Pattingre S., et al. The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells. J. Biol. Chem. 2003, 278:20995-21002.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20995-21002
-
-
Pattingre, S.1
-
58
-
-
0033556037
-
Subcellular localization of the Galphai3 protein and G alpha interacting protein, two proteins involved in the control of macroautophagy in human colon cancer HT-29 cells
-
Petiot A., et al. Subcellular localization of the Galphai3 protein and G alpha interacting protein, two proteins involved in the control of macroautophagy in human colon cancer HT-29 cells. Biochem. J. 2003, 337:289-295.
-
(2003)
Biochem. J.
, vol.337
, pp. 289-295
-
-
Petiot, A.1
-
59
-
-
33745685061
-
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome
-
Slessareva J.E., et al. Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 2006, 126:191-203.
-
(2006)
Cell
, vol.126
, pp. 191-203
-
-
Slessareva, J.E.1
-
60
-
-
33847295750
-
An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver
-
Gohla A., et al. An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:3003-3008.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 3003-3008
-
-
Gohla, A.1
-
61
-
-
84870750816
-
G protein-coupled receptor-mediated activation of p110beta by Gbetagamma is required for cellular transformation and invasiveness
-
Dbouk H.A., et al. G protein-coupled receptor-mediated activation of p110beta by Gbetagamma is required for cellular transformation and invasiveness. Sci. Signal. 2012, 5:ra89.
-
(2012)
Sci. Signal.
, vol.5
-
-
Dbouk, H.A.1
-
62
-
-
78349244834
-
The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy
-
Dou Z., et al. The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. J. Cell Biol. 2010, 191:827-843.
-
(2010)
J. Cell Biol.
, vol.191
, pp. 827-843
-
-
Dou, Z.1
-
63
-
-
84876086849
-
Class IA PI3K p110beta subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation
-
Dou Z., et al. Class IA PI3K p110beta subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Mol. Cell 2013, 1:29-42.
-
(2013)
Mol. Cell
, vol.1
, pp. 29-42
-
-
Dou, Z.1
-
64
-
-
33644991114
-
Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras
-
Ballou L.M., et al. Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras. Biochem. J. 2006, 394:557-562.
-
(2006)
Biochem. J.
, vol.394
, pp. 557-562
-
-
Ballou, L.M.1
-
65
-
-
77949429043
-
Gq-coupled purinergic receptors inhibit insulin-like growth factor-I/phosphoinositide 3-kinase pathway-dependent keratinocyte migration
-
Taboubi S., et al. Gq-coupled purinergic receptors inhibit insulin-like growth factor-I/phosphoinositide 3-kinase pathway-dependent keratinocyte migration. Mol. Biol. Cell 2010, 6:946-955.
-
(2010)
Mol. Biol. Cell
, vol.6
, pp. 946-955
-
-
Taboubi, S.1
-
66
-
-
36849012449
-
G alpha(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration
-
Taboubi S., et al. G alpha(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration. FASEB J. 2007, 14:4047-4058.
-
(2007)
FASEB J.
, vol.14
, pp. 4047-4058
-
-
Taboubi, S.1
-
67
-
-
77953726944
-
Galpha16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling
-
Yeung W.W., Wong Y.H. Galpha16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling. Cell Signal. 2010, 9:1379-1387.
-
(2010)
Cell Signal.
, vol.9
, pp. 1379-1387
-
-
Yeung, W.W.1
Wong, Y.H.2
-
68
-
-
0034672063
-
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells
-
Ogier-Denis E., et al. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J. Biol. Chem. 2000, 275:39090-39095.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39090-39095
-
-
Ogier-Denis, E.1
-
69
-
-
80955177196
-
TFEB links autophagy to lysosomal biogenesis
-
Settembre C., et al. TFEB links autophagy to lysosomal biogenesis. Science 2011, 332:1429-1433.
-
(2011)
Science
, vol.332
, pp. 1429-1433
-
-
Settembre, C.1
-
70
-
-
84888153445
-
Autophagy proteins regulate ERK phosphorylation
-
Martinez-Lopez N., et al. Autophagy proteins regulate ERK phosphorylation. Nat. Commun. 2013, 4:2799.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2799
-
-
Martinez-Lopez, N.1
-
71
-
-
50049105823
-
The regulation of AMP-activated protein kinase by upstream kinases
-
Carling D., et al. The regulation of AMP-activated protein kinase by upstream kinases. Int. J. Obes. (Lond.) 2008, 32(Suppl. 4):S55-S59.
-
(2008)
Int. J. Obes. (Lond.)
, vol.32
, Issue.SUPPL. 4
-
-
Carling, D.1
-
72
-
-
50549100488
-
Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease
-
Hutchinson D.S., et al. Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease. Pharmacol. Ther. 2008, 119:291-310.
-
(2008)
Pharmacol. Ther.
, vol.119
, pp. 291-310
-
-
Hutchinson, D.S.1
-
73
-
-
84863393597
-
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
-
He C., et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature 2012, 481:511-515.
-
(2012)
Nature
, vol.481
, pp. 511-515
-
-
He, C.1
-
74
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung C.H., et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 2009, 7:1992-2003.
-
(2009)
Mol. Biol. Cell
, vol.7
, pp. 1992-2003
-
-
Jung, C.H.1
-
75
-
-
0035809160
-
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
-
Kihara A., et al. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 2001, 152:519-530.
-
(2001)
J. Cell Biol.
, vol.152
, pp. 519-530
-
-
Kihara, A.1
-
76
-
-
39049194057
-
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
-
Furuya N., et al. The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 2005, 1:46-52.
-
(2005)
Autophagy
, vol.1
, pp. 46-52
-
-
Furuya, N.1
-
77
-
-
68149139456
-
The autophagy effector Beclin 1: a novel BH3-only protein
-
Sinha S., Levine B. The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 2008, 27(Suppl. 1):S137-S148.
-
(2008)
Oncogene
, vol.27
, Issue.SUPPL. 1
-
-
Sinha, S.1
Levine, B.2
-
78
-
-
44949237240
-
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
-
Wei Y., et al. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 2008, 6:678-688.
-
(2008)
Mol. Cell
, vol.6
, pp. 678-688
-
-
Wei, Y.1
-
79
-
-
84880331368
-
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
-
Russell R.C., et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 2013, 7:741-750.
-
(2013)
Nat. Cell Biol.
, vol.7
, pp. 741-750
-
-
Russell, R.C.1
-
80
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan D.F., et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331:456-461.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
-
81
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim J., et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 2011, 2:132-141.
-
(2011)
Nat. Cell Biol.
, vol.2
, pp. 132-141
-
-
Kim, J.1
-
82
-
-
84872586081
-
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
-
Kim J., et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 2013, 152:290-303.
-
(2013)
Cell
, vol.152
, pp. 290-303
-
-
Kim, J.1
-
83
-
-
77951214016
-
Mammalian autophagy: core molecular machinery and signaling regulation
-
Yang Z., Klionsky D.J. Mammalian autophagy: core molecular machinery and signaling regulation. Curr. Opin. Cell Biol. 2010, 2:124-131.
-
(2010)
Curr. Opin. Cell Biol.
, vol.2
, pp. 124-131
-
-
Yang, Z.1
Klionsky, D.J.2
-
84
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
85
-
-
0018386209
-
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells
-
Reitzer L.J., et al. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem. 1979, 254:2669-2676.
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 2669-2676
-
-
Reitzer, L.J.1
-
86
-
-
43649093915
-
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
-
Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 2008, 4:393-402.
-
(2008)
Mol. Cell
, vol.4
, pp. 393-402
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
88
-
-
28544446058
-
Mitochondrial tumour suppressors: a genetic and biochemical update
-
Gottlieb E., Tomlinson I.P. Mitochondrial tumour suppressors: a genetic and biochemical update. Nat. Rev. Cancer 2005, 5:857-866.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 857-866
-
-
Gottlieb, E.1
Tomlinson, I.P.2
-
89
-
-
17844383964
-
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
-
Ramanathan A., et al. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:5992-5997.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 5992-5997
-
-
Ramanathan, A.1
-
90
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin V.R., et al. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9:425-434.
-
(2006)
Cancer Cell
, vol.9
, pp. 425-434
-
-
Fantin, V.R.1
-
91
-
-
0030921103
-
C-Myc transactivation of LDH-A: implications for tumor metabolism and growth
-
Shim H., et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:6658-6663.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
-
92
-
-
84858414020
-
Cellular metabolism and disease: what do metabolic outliers teach us?
-
DeBerardinis R.J., Thompson C.B. Cellular metabolism and disease: what do metabolic outliers teach us?. Cell 1997, 148:1132-1144.
-
(1997)
Cell
, vol.148
, pp. 1132-1144
-
-
DeBerardinis, R.J.1
Thompson, C.B.2
-
93
-
-
84861526009
-
Deconvoluting the context-dependent role for autophagy in cancer
-
White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer 2012, 6:401-410.
-
(2012)
Nat. Rev. Cancer
, vol.6
, pp. 401-410
-
-
White, E.1
-
94
-
-
84878219891
-
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
-
O'Hayre M., et al. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat. Rev. Cancer 2013, 6:412-424.
-
(2013)
Nat. Rev. Cancer
, vol.6
, pp. 412-424
-
-
O'Hayre, M.1
-
95
-
-
84894362626
-
Cardiomyocyte health: adapting to metabolic changes through autophagy
-
Kubli D.A., Gustafsson A.B. Cardiomyocyte health: adapting to metabolic changes through autophagy. Trends Endocrinol. Metab. 2014, 3:156-164.
-
(2014)
Trends Endocrinol. Metab.
, vol.3
, pp. 156-164
-
-
Kubli, D.A.1
Gustafsson, A.B.2
-
96
-
-
84875232070
-
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy
-
Papadakis M., et al. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat. Med. 2013, 3:351-357.
-
(2013)
Nat. Med.
, vol.3
, pp. 351-357
-
-
Papadakis, M.1
-
97
-
-
77957221783
-
Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury
-
Sala-Mercado J.A., et al. Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury. Circulation 2010, 122(Suppl.):S179-S184.
-
(2010)
Circulation
, vol.122
, Issue.SUPPL.
-
-
Sala-Mercado, J.A.1
-
98
-
-
71649084135
-
Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction
-
Buss S.J., et al. Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. J. Am. Coll. Cardiol. 2009, 25:2435-2446.
-
(2009)
J. Am. Coll. Cardiol.
, vol.25
, pp. 2435-2446
-
-
Buss, S.J.1
-
99
-
-
2342576807
-
GPCR expression in the heart; 'new' receptors in myocytes and fibroblasts
-
Tang C.M., Insel P.A. GPCR expression in the heart; 'new' receptors in myocytes and fibroblasts. Trends Cardiovasc. Med. 2004, 3:94-99.
-
(2004)
Trends Cardiovasc. Med.
, vol.3
, pp. 94-99
-
-
Tang, C.M.1
Insel, P.A.2
-
100
-
-
84887999195
-
An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases
-
Heng B.C., et al. An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases. Biotechnol. Adv. 2004, 8:1676-1694.
-
(2004)
Biotechnol. Adv.
, vol.8
, pp. 1676-1694
-
-
Heng, B.C.1
-
101
-
-
84869005068
-
Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β)
-
Ghislat G., et al. Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β). J Biol Chem 2012, 287:38625-38636.
-
(2012)
J Biol Chem
, vol.287
, pp. 38625-38636
-
-
Ghislat, G.1
|