-
1
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. 2012. mTOR signaling in growth control and disease. Cell 149:274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
2
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta S, Peterson TR, Sabatini DM. 2010. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell 40:310-322.
-
(2010)
Mol. Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
3
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptorindependent pathway that regulates the cytoskeleton
-
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument- Bromage H, Tempst P, Sabatini DM. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptorindependent pathway that regulates the cytoskeleton. Curr. Biol. 14: 1296-1302.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
4
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
5
-
-
67349217986
-
Molecular mechanisms of mTOR-mediated translational control
-
Ma XM, Blenis J. 2009. Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 10:307-318.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
6
-
-
13444259647
-
Regulation of cap-dependent translation by eIF4E inhibitory proteins
-
Richter JD, Sonenberg N. 2005. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433:477- 480.
-
(2005)
Nature
, vol.433
-
-
Richter, J.D.1
Sonenberg, N.2
-
7
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki K, Li Y, Xu T, Guan KL. 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17:1829- 1834.
-
(2003)
Genes Dev.
, vol.17
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
8
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. 2003. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13:1259-1268.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
9
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. 2010. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141:290-303.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
10
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar- Peled L, Sabatini DM. 2008. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320:1496-1501.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-peled, L.6
Sabatini, D.M.7
-
11
-
-
25444457577
-
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
Byfield MP, Murray JT, Backer JM. 2005. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 280: 33076-33082.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
12
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G. 2005. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc. Natl. Acad. Sci. U. S. A. 102:14238- 14243.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
Zwartkruis, F.J.11
Thomas, G.12
-
13
-
-
0031019664
-
An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells
-
Graves LM, He Y, Lambert J, Hunter D, Li X, Earp HS. 1997. An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells. J. Biol. Chem. 272:1920-1928.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 1920-1928
-
-
Graves, L.M.1
He, Y.2
Lambert, J.3
Hunter, D.4
Li, X.5
Earp, H.S.6
-
14
-
-
0037337449
-
Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex
-
Hannan KM, Thomas G, Pearson RB. 2003. Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex. Biochem. J. 370:469-477.
-
(2003)
Biochem. J.
, vol.370
, pp. 469-477
-
-
Hannan, K.M.1
Thomas, G.2
Pearson, R.B.3
-
15
-
-
0033604644
-
Shp-2 tyrosine phosphatase: signaling one cell or many
-
Feng GS. 1999. Shp-2 tyrosine phosphatase: signaling one cell or many. Exp. Cell Res. 253:47-54.
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 47-54
-
-
Feng, G.S.1
-
16
-
-
0038771965
-
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
-
Neel BG, Gu H, Pao L. 2003. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem. Sci. 28:284-293.
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 284-293
-
-
Neel, B.G.1
Gu, H.2
Pao, L.3
-
17
-
-
10744231884
-
Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation
-
Ferjoux G, Lopez F, Esteve JP, Ferrand A, Vivier E, Vely F, Saint- Laurent N, Pradayrol L, Buscail L, Susini C. 2003. Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation. Mol. Biol. Cell 14:3911-3928.
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 3911-3928
-
-
Ferjoux, G.1
Lopez, F.2
Esteve, J.P.3
Ferrand, A.4
Vivier, E.5
Vely, F.6
Saint-laurent, N.7
Pradayrol, L.8
Buscail, L.9
Susini, C.10
-
18
-
-
79953698416
-
The tyrosine phosphatase Shp-2 interacts with the dopamine D(1) receptor and triggers D(1)-mediated Erk signaling in striatal neurons
-
Fiorentini C, Mattanza C, Collo G, Savoia P, Spano P, Missale C. 2011. The tyrosine phosphatase Shp-2 interacts with the dopamine D(1) receptor and triggers D(1)-mediated Erk signaling in striatal neurons. J. Neurochem. 117:253-263.
-
(2011)
J. Neurochem.
, vol.117
, pp. 253-263
-
-
Fiorentini, C.1
Mattanza, C.2
Collo, G.3
Savoia, P.4
Spano, P.5
Missale, C.6
-
19
-
-
0142059890
-
Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling
-
Agazie YM, Hayman MJ. 2003. Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol. Cell. Biol. 23:7875- 7886.
-
(2003)
Mol. Cell. Biol.
, vol.23
-
-
Agazie, Y.M.1
Hayman, M.J.2
-
20
-
-
0032238275
-
Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway
-
Cleghon V, Feldmann P, Ghiglione C, Copeland TD, Perrimon N, Hughes DA, Morrison DK. 1998. Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. Mol. Cell 2:719-727.
-
(1998)
Mol. Cell
, vol.2
, pp. 719-727
-
-
Cleghon, V.1
Feldmann, P.2
Ghiglione, C.3
Copeland, T.D.4
Perrimon, N.5
Hughes, D.A.6
Morrison, D.K.7
-
21
-
-
10744223870
-
Shp2 regulates SRC family kinase activity and ras/erk activation by controlling csk recruitment
-
Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T, Luo J, Thompson JA, Schraven BL, Philips MR, Neel BG. 2004. Shp2 regulates SRC family kinase activity and ras/erk activation by controlling csk recruitment. Mol. Cell 13:341-355.
-
(2004)
Mol. Cell
, vol.13
, pp. 341-355
-
-
Zhang, S.Q.1
Yang, W.2
Kontaridis, M.I.3
Bivona, T.G.4
Wen, G.5
Araki, T.6
Luo, J.7
Thompson, J.A.8
Schraven, B.L.9
Philips, M.R.10
Neel, B.G.11
-
22
-
-
33749577870
-
SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth
-
Fornaro M, Burch PM, Yang W, Zhang L, Hamilton CE, Kim JH, Neel BG, Bennett AM. 2006. SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J. Cell Biol. 175:87-97.
-
(2006)
J. Cell Biol.
, vol.175
, pp. 87-97
-
-
Fornaro, M.1
Burch, P.M.2
Yang, W.3
Zhang, L.4
Hamilton, C.E.5
Kim, J.H.6
Neel, B.G.7
Bennett, A.M.8
-
23
-
-
34147142287
-
SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway
-
Zito CI, Qin H, Blenis J, Bennett AM. 2007. SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. J. Biol. Chem. 282:6946- 6953.
-
(2007)
J. Biol. Chem.
, vol.282
-
-
Zito, C.I.1
Qin, H.2
Blenis, J.3
Bennett, A.M.4
-
24
-
-
77955808417
-
MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy
-
Shi H, Boadu E, Mercan F, Le AM, Flach RJ, Zhang L, Tyner KJ, Olwin BB, Bennett AM. 2010. MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy. FASEB J. 24:2985-2997.
-
(2010)
FASEB J.
, vol.24
, pp. 2985-2997
-
-
Shi, H.1
Boadu, E.2
Mercan, F.3
Le, A.M.4
Flach, R.J.5
Zhang, L.6
Tyner, K.J.7
Olwin, B.B.8
Bennett, A.M.9
-
25
-
-
0036091468
-
Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts
-
Kontaridis MI, Liu X, Zhang L, Bennett AM. 2002. Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Mol. Cell. Biol. 22:3875-3891.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3875-3891
-
-
Kontaridis, M.I.1
Liu, X.2
Zhang, L.3
Bennett, A.M.4
-
26
-
-
33144473897
-
Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling
-
Uhlen P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM. 2006. Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. Proc. Natl. Acad. Sci. U. S. A. 103:2160-2165.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 2160-2165
-
-
Uhlen, P.1
Burch, P.M.2
Zito, C.I.3
Estrada, M.4
Ehrlich, B.E.5
Bennett, A.M.6
-
27
-
-
0035094978
-
Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies
-
Lynch CJ. 2001. Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies. J. Nutr. 131:861S- 865S.
-
(2001)
J. Nutr.
, vol.131
-
-
Lynch, C.J.1
-
28
-
-
0141615891
-
Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR
-
Lynch CJ, Halle B, Fujii H, Vary TC, Wallin R, Damuni Z, Hutson SM. 2003. Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR. Am. J. Physiol. Endocrinol. Metab. 285:E854- E863.
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.285
-
-
Lynch, C.J.1
Halle, B.2
Fujii, H.3
Vary, T.C.4
Wallin, R.5
Damuni, Z.6
Hutson, S.M.7
-
29
-
-
56249147509
-
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
-
Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J. 2008. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc. Natl. Acad. Sci. U. S. A. 105:17414- 17419.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
-
-
Choo, A.Y.1
Yoon, S.O.2
Kim, S.G.3
Roux, P.P.4
Blenis, J.5
-
30
-
-
0030921502
-
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2
-
Saxton TM, Henkemeyer M, Gasca S, Shen R, Rossi DJ, Shalaby F, Feng GS, Pawson T. 1997. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 16:2352-2364.
-
(1997)
EMBO J.
, vol.16
, pp. 2352-2364
-
-
Saxton, T.M.1
Henkemeyer, M.2
Gasca, S.3
Shen, R.4
Rossi, D.J.5
Shalaby, F.6
Feng, G.S.7
Pawson, T.8
-
31
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid- TOR signalling
-
Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D. 2002. Tsc tumour suppressor proteins antagonize amino-acid- TOR signalling. Nat. Cell Biol. 4:699-704.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
32
-
-
0037191045
-
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide- 3-OH kinase is mTOR independent
-
Jaeschke A, Hartkamp J, Saitoh M, Roworth W, Nobukuni T, Hodges A, Sampson J, Thomas G, Lamb R. 2002. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide- 3-OH kinase is mTOR independent. J. Cell Biol. 159:217-224.
-
(2002)
J. Cell Biol.
, vol.159
, pp. 217-224
-
-
Jaeschke, A.1
Hartkamp, J.2
Saitoh, M.3
Roworth, W.4
Nobukuni, T.5
Hodges, A.6
Sampson, J.7
Thomas, G.8
Lamb, R.9
-
33
-
-
1842525884
-
SHP-2 regulates the phosphatidylinositide 3=-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis
-
Ivins Zito C, Kontaridis MI, Fornaro M, Feng GS, Bennett AM. 2004. SHP-2 regulates the phosphatidylinositide 3=-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J. Cell. Physiol. 199:227-236.
-
(2004)
J. Cell. Physiol.
, vol.199
, pp. 227-236
-
-
Ivins Zito, C.1
Kontaridis, M.I.2
Fornaro, M.3
Feng, G.S.4
Bennett, A.M.5
-
34
-
-
13544270759
-
DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells
-
Ling Y, Maile LA, Badley-Clarke J, Clemmons DR. 2005. DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. J. Biol. Chem. 280:3151-3158.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 3151-3158
-
-
Ling, Y.1
Maile, L.A.2
Badley-clarke, J.3
Clemmons, D.R.4
-
35
-
-
0033761488
-
The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase
-
Maroun CR, Naujokas MA, Holgado-Madruga M, Wong AJ, Park M. 2000. The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol. Cell. Biol. 20: 8513-8525.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 8513-8525
-
-
Maroun, C.R.1
Naujokas, M.A.2
Holgado-madruga, M.3
Wong, A.J.4
Park, M.5
-
36
-
-
0037064549
-
Role of the SHP-2 tyrosine phosphatase in cytokineinduced signaling and cellular response
-
Qu CK. 2002. Role of the SHP-2 tyrosine phosphatase in cytokineinduced signaling and cellular response. Biochim. Biophys. Acta 1592: 297-301.
-
(2002)
Biochim. Biophys. Acta
, vol.1592
, pp. 297-301
-
-
Qu, C.K.1
-
37
-
-
70349248415
-
Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway
-
Altamirano F, Oyarce C, Silva P, Toyos M, Wilson C, Lavandero S, Uhlen P, Estrada M. 2009. Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. J. Endocrinol. 202:299-307.
-
(2009)
J. Endocrinol.
, vol.202
, pp. 299-307
-
-
Altamirano, F.1
Oyarce, C.2
Silva, P.3
Toyos, M.4
Wilson, C.5
Lavandero, S.6
Uhlen, P.7
Estrada, M.8
-
38
-
-
42649112409
-
2+/CaM signaling to hVps34
-
2+/CaM signaling to hVps34. Cell Metab. 7:456-465.
-
(2008)
Cell Metab.
, vol.7
, pp. 456-465
-
-
Gulati, P.1
Gaspers, L.D.2
Dann, S.G.3
Joaquin, M.4
Nobukuni, T.5
Natt, F.6
Kozma, S.C.7
Thomas, A.P.8
Thomas, G.9
-
39
-
-
0032548942
-
Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k
-
Conus NM, Hemmings BA, Pearson RB. 1998. Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k. J. Biol. Chem. 273:4776-4782.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 4776-4782
-
-
Conus, N.M.1
Hemmings, B.A.2
Pearson, R.B.3
-
41
-
-
37149029370
-
Calcium signaling
-
Clapham DE. 2007. Calcium signaling. Cell 131:1047-1058.
-
(2007)
Cell
, vol.131
, pp. 1047-1058
-
-
Clapham, D.E.1
-
42
-
-
0026009773
-
Ryanodine receptor protein is expressed during differentiation in the muscle cell lines BC3H1 and C2C12
-
Airey JA, Baring MD, Sutko JL. 1991. Ryanodine receptor protein is expressed during differentiation in the muscle cell lines BC3H1 and C2C12. Dev. Biol. 148:365-374.
-
(1991)
Dev. Biol.
, vol.148
, pp. 365-374
-
-
Airey, J.A.1
Baring, M.D.2
Sutko, J.L.3
-
43
-
-
42949163670
-
c-Met must translocate to the nucleus to initiate calcium signals
-
Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH. 2008. c-Met must translocate to the nucleus to initiate calcium signals. J. Biol. Chem. 283:4344-4351.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 4344-4351
-
-
Gomes, D.A.1
Rodrigues, M.A.2
Leite, M.F.3
Gomez, M.V.4
Varnai, P.5
Balla, T.6
Bennett, A.M.7
Nathanson, M.H.8
-
44
-
-
0037178898
-
Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium
-
Pusl T, Wu JJ, Zimmerman TL, Zhang L, Ehrlich BE, Berchtold MW, Hoek JB, Karpen SJ, Nathanson MH, Bennett AM. 2002. Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J. Biol. Chem. 277:27517-27527.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 27517-27527
-
-
Pusl, T.1
Wu, J.J.2
Zimmerman, T.L.3
Zhang, L.4
Ehrlich, B.E.5
Berchtold, M.W.6
Hoek, J.B.7
Karpen, S.J.8
Nathanson, M.H.9
Bennett, A.M.10
-
45
-
-
0028971813
-
Phosphoinositide-specific phospholipase C and mitogenic signaling
-
Noh DY, Shin SH, Rhee SG. 1995. Phosphoinositide-specific phospholipase C and mitogenic signaling. Biochim. Biophys. Acta 1242:99-113.
-
(1995)
Biochim. Biophys. Acta
, vol.1242
, pp. 99-113
-
-
Noh, D.Y.1
Shin, S.H.2
Rhee, S.G.3
-
46
-
-
0028283331
-
Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins
-
Jiang H, Wu D, Simon MI. 1994. Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins. J. Biol. Chem. 269:7593-7596.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 7593-7596
-
-
Jiang, H.1
Wu, D.2
Simon, M.I.3
-
47
-
-
0025793981
-
Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq
-
Smrcka AV, Hepler JR, Brown KO, Sternweis PC. 1991. Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq. Science 251:804-807.
-
(1991)
Science
, vol.251
, pp. 804-807
-
-
Smrcka, A.V.1
Hepler, J.R.2
Brown, K.O.3
Sternweis, P.C.4
-
48
-
-
0025860413
-
Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins
-
Taylor SJ, Chae HZ, Rhee SG, Exton JH. 1991. Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins. Nature 350:516-518.
-
(1991)
Nature
, vol.350
, pp. 516-518
-
-
Taylor, S.J.1
Chae, H.Z.2
Rhee, S.G.3
Exton, J.H.4
-
49
-
-
0030936370
-
Proteintyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway
-
Yu Z, Ahmad S, Schwartz J-L, Banville D, Shen S-H. 1997. Proteintyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway. J. Biol. Chem. 272:7519-7524.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7519-7524
-
-
Yu, Z.1
Ahmad, S.2
Schwartz, J.L.3
Banville, D.4
Shen, S.H.5
-
50
-
-
3042857429
-
Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation
-
Faenza I, Bavelloni A, Fiume R, Santi P, Martelli AM, Maria Billi A, Lo Vasco VR, Manzoli L, Cocco L. 2004. Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation. J. Cell Physiol. 200:291-296.
-
(2004)
J. Cell Physiol.
, vol.200
, pp. 291-296
-
-
Faenza, I.1
Bavelloni, A.2
Fiume, R.3
Santi, P.4
Martelli, A.M.5
Maria Billi, A.6
Lo Vasco, V.R.7
Manzoli, L.8
Cocco, L.9
-
51
-
-
0028899789
-
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
-
Blommaart EF, Luiken JJ, Blommaart PJ, van Woerkom GM, Meijer AJ. 1995. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J. Biol. Chem. 270:2320-2326.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 2320-2326
-
-
Blommaart, E.F.1
Luiken, J.J.2
Blommaart, P.J.3
van Woerkom, G.M.4
Meijer, A.J.5
-
52
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720-5728.
-
(2000)
EMBO J.
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
54
-
-
79952104568
-
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
-
Howell JJ, Manning BD. 2011. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol. Metab. 22:94- 102.
-
(2011)
Trends Endocrinol. Metab.
, vol.22
-
-
Howell, J.J.1
Manning, B.D.2
-
55
-
-
79958285227
-
PLCbeta1-SHP-2 complex, PLCbeta1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling? J
-
Calo LA, Bordin L, Davis PA, Pagnin E, Dal Maso L, Rossi GP, Pessina AC, Clari G. 2011. PLCbeta1-SHP-2 complex, PLCbeta1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling? J. Biomed. Sci. 18:38.
-
(2011)
Biomed. Sci.
, vol.18
, pp. 38
-
-
Calo, L.A.1
Bordin, L.2
Davis, P.A.3
Pagnin, E.4
Dal Maso, L.5
Rossi, G.P.6
Pessina, A.C.7
Clari, G.8
-
56
-
-
61449235398
-
Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy
-
Choo AY, Blenis J. 2009. Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle 8:567-572.
-
(2009)
Cell Cycle
, vol.8
, pp. 567-572
-
-
Choo, A.Y.1
Blenis, J.2
-
57
-
-
0033118334
-
Molecular tinkering of G protein-coupled receptors: an evolutionary success
-
Bockaert J, Pin JP. 1999. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 18:1723-1729.
-
(1999)
EMBO J.
, vol.18
, pp. 1723-1729
-
-
Bockaert, J.1
Pin, J.P.2
-
58
-
-
77954244300
-
Broad-spectrum amino acid-sensing class C G-protein coupled receptors: molecular mechanisms, physiological significance and options for drug development
-
Conigrave AD, Hampson DR. 2010. Broad-spectrum amino acid-sensing class C G-protein coupled receptors: molecular mechanisms, physiological significance and options for drug development. Pharmacol. Ther. 127: 252-260.
-
(2010)
Pharmacol. Ther.
, vol.127
, pp. 252-260
-
-
Conigrave, A.D.1
Hampson, D.R.2
-
59
-
-
84866846953
-
The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy
-
Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, Deberardinis RJ, Cobb MH. 2012. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol. Cell 47:851- 862.
-
(2012)
Mol. Cell
, vol.47
-
-
Wauson, E.M.1
Zaganjor, E.2
Lee, A.Y.3
Guerra, M.L.4
Ghosh, A.B.5
Bookout, A.L.6
Chambers, C.P.7
Jivan, A.8
Mcglynn, K.9
Hutchison, M.R.10
Deberardinis, R.J.11
Cobb, M.H.12
-
60
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH, Kim S. 2012. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149:410-424.
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
Kim, G.4
Kwon, N.H.5
Kim, H.K.6
Ha, S.H.7
Ryu, S.H.8
Kim, S.9
-
62
-
-
79952797615
-
Identification of PTPsigma as an autophagic phosphatase
-
Martin KR, Xu Y, Looyenga BD, Davis RJ, Wu CL, Tremblay ML, Xu HE, MacKeigan JP. 2011. Identification of PTPsigma as an autophagic phosphatase. J. Cell Sci. 124:812- 819.
-
(2011)
J. Cell Sci.
, vol.124
-
-
Martin, K.R.1
Xu, Y.2
Looyenga, B.D.3
Davis, R.J.4
Wu, C.L.5
Tremblay, M.L.6
Xu, H.E.7
Mackeigan, J.P.8
-
63
-
-
77949673935
-
PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
-
Banno R, Zimmer D, De Jonghe BC, Atienza M, Rak K, Yang W, Bence KK. 2010. PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. J. Clin. Invest. 120:720-734.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 720-734
-
-
Banno, R.1
Zimmer, D.2
De Jonghe, B.C.3
Atienza, M.4
Rak, K.5
Yang, W.6
Bence, K.K.7
-
64
-
-
43449123047
-
Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase
-
Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S. 2008. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am. J. Pathol. 172:1312- 1324.
-
(2008)
Am. J. Pathol.
, vol.172
-
-
Krajewska, M.1
Banares, S.2
Zhang, E.E.3
Huang, X.4
Scadeng, M.5
Jhala, U.S.6
Feng, G.S.7
Krajewski, S.8
-
65
-
-
58249115040
-
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death
-
Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS. 2009. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol. Cell. Biol. 29:378-388.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 378-388
-
-
Princen, F.1
Bard, E.2
Sheikh, F.3
Zhang, S.S.4
Wang, J.5
Zago, W.M.6
Wu, D.7
Trelles, R.D.8
Bailly-maitre, B.9
Kahn, C.R.10
Chen, Y.11
Reed, J.C.12
Tong, G.G.13
Mercola, M.14
Chen, J.15
Feng, G.S.16
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