Activation of autophagy through modulation of 5′-AMP-activated protein kinase protects pancreatic β-cells from high glucose

Biochemical Journal

Volumn 425, Issue 3, 2010, Pages 541-551

  Han, Diana ^a   Yang, Byungho ^a   Olson, L Karl ^b   Greenstein, Alexander ^a   Baek, Seung Hoon ^c   Claycombe, Kate J ^a   Goudreau, John L ^b,c,d   Yu, Seong Woon ^c,d   Kim, Eun Kyoung ^a,c  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c East Lansing   (United States)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

5 AMP activated protein kinase (AMPK); Autophagy; High glucose; Pancreatic cell

Indexed keywords

AMP-ACTIVATED PROTEIN KINASE; AUTOPHAGY; CASPASE-3 ACTIVATION; CELL FUNCTIONS; CELL SURVIVAL; GENETIC MANIPULATIONS; HIGH GLUCOSE; HYPERGLYCAEMIA; INSULIN SECRETION; LYSOSOMAL DEGRADATION; METABOLIC STRESS; MOLECULAR MECHANISM; PANCREATIC ISLET; PHYSIOLOGICAL FUNCTIONS; THERAPEUTIC TARGETS;

BIOELECTRIC POTENTIALS; CELL DEATH; GLUCOSE; PROTEINS;

ENZYME ACTIVITY;

CASPASE 3; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME INHIBITION; MALE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; AUTOPHAGY; CASPASE 3; CELL PROLIFERATION; CELL SURVIVAL; GLUCOSE; INSULIN-SECRETING CELLS; LYSOSOMES; MALE; MEMBRANE POTENTIALS; MITOCHONDRIAL MEMBRANES; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 74349115340     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090429     Document Type: Article

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