메뉴 건너뛰기




Volumn 21, Issue 14, 2007, Pages 4047-4058

Gα(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration

Author keywords

GPCR; MAPK; PI3K Akt; UTP; Wound healing

Indexed keywords

ALPHA3 INTEGRIN; NUCLEOTIDE; PURINERGIC P2Y2 RECEPTOR; SMALL INTERFERING RNA; URIDINE TRIPHOSPHATE;

EID: 36849012449     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7476com     Document Type: Article
Times cited : (42)

References (67)
  • 1
    • 0030934532 scopus 로고    scopus 로고
    • Wound healing-aiming for perfect skin regeneration
    • Martin, P. (1997) Wound healing-aiming for perfect skin regeneration. Science 276, 75-81
    • (1997) Science , vol.276 , pp. 75-81
    • Martin, P.1
  • 2
    • 0033517356 scopus 로고    scopus 로고
    • Cutaneous wound healing
    • Singer, A. J., and Clark, R. A. (1999) Cutaneous wound healing. N. Engl. J. Med. 341, 738-746
    • (1999) N. Engl. J. Med , vol.341 , pp. 738-746
    • Singer, A.J.1    Clark, R.A.2
  • 3
    • 13544259736 scopus 로고    scopus 로고
    • Cellular and molecular facets of keratinocyte reepithelization during wound healing
    • Santoro, M. M., and Gaudino, G. (2005) Cellular and molecular facets of keratinocyte reepithelization during wound healing. Exp. Cell Res. 304, 274-286
    • (2005) Exp. Cell Res , vol.304 , pp. 274-286
    • Santoro, M.M.1    Gaudino, G.2
  • 4
    • 0038676258 scopus 로고    scopus 로고
    • Regulation of wound healing by growth factors and cytokines
    • Werner, S., and Grose, R. (2003) Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 83, 835-870
    • (2003) Physiol. Rev , vol.83 , pp. 835-870
    • Werner, S.1    Grose, R.2
  • 6
    • 0346969816 scopus 로고    scopus 로고
    • Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing
    • Greig, A. V., James, S. E., McGrouther, D. A., Terenghi, G., and Burnstock, G. (2003b) Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing. Exp. Dermatol. 12, 860-871
    • (2003) Exp. Dermatol , vol.12 , pp. 860-871
    • Greig, A.V.1    James, S.E.2    McGrouther, D.A.3    Terenghi, G.4    Burnstock, G.5
  • 7
    • 0141457730 scopus 로고    scopus 로고
    • Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules
    • Lazarowski, E. R., Boucher, R. C., and Harden, T. K. (2003) Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol. Pharmacol. 64, 785-795
    • (2003) Mol. Pharmacol , vol.64 , pp. 785-795
    • Lazarowski, E.R.1    Boucher, R.C.2    Harden, T.K.3
  • 8
    • 34047114821 scopus 로고    scopus 로고
    • Wound-induced ATP release and EGF receptor activation in epithelial cells
    • Yin, J., Xu, K., Zhang, J., Kumar, A., and Yu, F. S. (2007) Wound-induced ATP release and EGF receptor activation in epithelial cells. J. Cell Sci. 120, 815-825
    • (2007) J. Cell Sci , vol.120 , pp. 815-825
    • Yin, J.1    Xu, K.2    Zhang, J.3    Kumar, A.4    Yu, F.S.5
  • 9
    • 30444450816 scopus 로고    scopus 로고
    • Purinergic signalling
    • Burnstock, G. (2006) Purinergic signalling. Br. J. Pharmacol. 147 Suppl 1, S172-181
    • (2006) Br. J. Pharmacol , vol.147 , Issue.SUPPL. 1
    • Burnstock, G.1
  • 10
    • 0036445493 scopus 로고    scopus 로고
    • P2X purinergic receptor antagonist accelerates skin barrier repair and prevents epidermal hyperplasia induced by skin barrier disruption
    • Denda, M., Inoue, K., Fuziwara, S., and Denda, S. (2002) P2X purinergic receptor antagonist accelerates skin barrier repair and prevents epidermal hyperplasia induced by skin barrier disruption. J. Invest. Dermatol. 119, 1034-1040
    • (2002) J. Invest. Dermatol , vol.119 , pp. 1034-1040
    • Denda, M.1    Inoue, K.2    Fuziwara, S.3    Denda, S.4
  • 11
    • 0038129501 scopus 로고    scopus 로고
    • Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes
    • Greig, A. V., Linge, C., Terenghi, G., McGrouther, D. A., and Burnstock, G. (2003a) Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. J. Invest. Dermatol. 120, 1007-1015
    • (2003) J. Invest. Dermatol , vol.120 , pp. 1007-1015
    • Greig, A.V.1    Linge, C.2    Terenghi, G.3    McGrouther, D.A.4    Burnstock, G.5
  • 12
    • 0345701260 scopus 로고    scopus 로고
    • Human keratinocytes express multiple P2Y-receptors: Evidence for functional P2Y1, P2Y2, and P2Y4 receptors
    • Burrell, H. E., Bowler, W. B., Gallagher, J. A., and Sharpe, G. R. (2003) Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. J. Invest. Dermatol. 120, 440-447
    • (2003) J. Invest. Dermatol , vol.120 , pp. 440-447
    • Burrell, H.E.1    Bowler, W.B.2    Gallagher, J.A.3    Sharpe, G.R.4
  • 13
    • 33745112861 scopus 로고    scopus 로고
    • ATP stimulates interleukin-6 production via P2Y receptors in human HaCaT keratinocytes
    • Yoshida, H., Kobayashi, D., Ohkubo, S., and Nakahata, N. (2006) ATP stimulates interleukin-6 production via P2Y receptors in human HaCaT keratinocytes. Eur. J. Pharmacol. 540, 1-9
    • (2006) Eur. J. Pharmacol , vol.540 , pp. 1-9
    • Yoshida, H.1    Kobayashi, D.2    Ohkubo, S.3    Nakahata, N.4
  • 14
    • 2942746282 scopus 로고    scopus 로고
    • Ca2+ waves in keratinocytes are transmitted to sensory neurons: The involvement of extracellular ATP and P2Y2 receptor activation
    • Koizumi, S., Fujishita, K., Inoue, K., Shigemoto-Mogami, Y., Tsuda, M., and Inoue, K. (2004) Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation. Biochem. J. 380, 329-338
    • (2004) Biochem. J , vol.380 , pp. 329-338
    • Koizumi, S.1    Fujishita, K.2    Inoue, K.3    Shigemoto-Mogami, Y.4    Tsuda, M.5    Inoue, K.6
  • 15
    • 0035177642 scopus 로고    scopus 로고
    • Purinoceptor-mediated calcium mobilization and proliferation in HaCaT keratinocytes
    • Lee, W. K., Choi, S. W., Lee, H. R., Lee, E. J., Lee, K. H., and Kim, H. O. (2001) Purinoceptor-mediated calcium mobilization and proliferation in HaCaT keratinocytes. J. Dermatol. Sci. 25, 97-105
    • (2001) J. Dermatol. Sci , vol.25 , pp. 97-105
    • Lee, W.K.1    Choi, S.W.2    Lee, H.R.3    Lee, E.J.4    Lee, K.H.5    Kim, H.O.6
  • 16
    • 33745745473 scopus 로고    scopus 로고
    • P2 receptors: Intracellular signaling
    • Erb, L., Liao, Z., Seye, C. I., and Weisman, G. A. (2006) P2 receptors: intracellular signaling. Plügers Arch. 452, 552-562
    • (2006) Plügers Arch , vol.452 , pp. 552-562
    • Erb, L.1    Liao, Z.2    Seye, C.I.3    Weisman, G.A.4
  • 18
    • 0029666263 scopus 로고    scopus 로고
    • P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells
    • Verghese, M. W., Kneisler, T. B., and Boucheron, J. A. (1996) P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells. J. Biol. Chem. 271, 15597-15601
    • (1996) J. Biol. Chem , vol.271 , pp. 15597-15601
    • Verghese, M.W.1    Kneisler, T.B.2    Boucheron, J.A.3
  • 22
    • 16844363317 scopus 로고    scopus 로고
    • P2Y receptors play a critical role in epithelial cell communication and migration
    • Klepeis, V. E., Weinger, I., Kaczmarek, E., and Trinkaus-Randall, V. (2004) P2Y receptors play a critical role in epithelial cell communication and migration. J. Cell Biochem. 93, 1115-1133
    • (2004) J. Cell Biochem , vol.93 , pp. 1115-1133
    • Klepeis, V.E.1    Weinger, I.2    Kaczmarek, E.3    Trinkaus-Randall, V.4
  • 23
    • 0037023645 scopus 로고    scopus 로고
    • Nucleotide receptors involved in UTP-induced rat arterial smooth muscle cell migration
    • Pillois, X., Chaulet, H., Belloc, I., Dupuch, F., Desgranges, C., and Gadeau, A. P. (2002) Nucleotide receptors involved in UTP-induced rat arterial smooth muscle cell migration. Circ. Res. 90, 678-681
    • (2002) Circ. Res , vol.90 , pp. 678-681
    • Pillois, X.1    Chaulet, H.2    Belloc, I.3    Dupuch, F.4    Desgranges, C.5    Gadeau, A.P.6
  • 24
    • 4644266185 scopus 로고    scopus 로고
    • UTP and diadenosine tetraphosphate accelerate wound healing in the rabbit cornea
    • Pintor, J., Bautista, A., Carracedo, G., and Peral, A. (2004) UTP and diadenosine tetraphosphate accelerate wound healing in the rabbit cornea. Ophthalmic. Physiol. Opt. 24, 186-193
    • (2004) Ophthalmic. Physiol. Opt , vol.24 , pp. 186-193
    • Pintor, J.1    Bautista, A.2    Carracedo, G.3    Peral, A.4
  • 25
    • 27644513711 scopus 로고    scopus 로고
    • P2Y nucleotide receptor interaction with alpha integrin mediates astrocyte migration
    • Wang, M., Kong, Q., Gonzalez, F. A., Sun, G., Erb, L., Seye, C., and Weisman, G. A. (2005) P2Y nucleotide receptor interaction with alpha integrin mediates astrocyte migration. J. Neurochem. 95, 630-640
    • (2005) J. Neurochem , vol.95 , pp. 630-640
    • Wang, M.1    Kong, Q.2    Gonzalez, F.A.3    Sun, G.4    Erb, L.5    Seye, C.6    Weisman, G.A.7
  • 27
    • 28244497054 scopus 로고    scopus 로고
    • The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration
    • Bagchi, S., Liao, Z., Gonzalez, F. A., Chorna, N. E., Seye, C. I., Weisman, G. A., and Erb, L. (2005) The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration. J. Biol. Chem. 280, 39050-39057
    • (2005) J. Biol. Chem , vol.280 , pp. 39050-39057
    • Bagchi, S.1    Liao, Z.2    Gonzalez, F.A.3    Chorna, N.E.4    Seye, C.I.5    Weisman, G.A.6    Erb, L.7
  • 28
    • 30044441160 scopus 로고    scopus 로고
    • P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation
    • Arthur, D. B., Akassoglou, K., and Insel, P. A. (2005) P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proc. Natl. Acad. Sci. U. S. A. 102, 19138-19143
    • (2005) Proc. Natl. Acad. Sci. U. S. A , vol.102 , pp. 19138-19143
    • Arthur, D.B.1    Akassoglou, K.2    Insel, P.A.3
  • 29
    • 10744232199 scopus 로고    scopus 로고
    • Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors
    • Liu, J., Liao, Z., Camden, J., Griffin, K. D., Garrad, R. C., Santiago-Perez, L. I., Gonzalez, F. A., Seye, C. I., Weisman, G. A., and Erb, L. (2004) Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors. J. Biol. Chem. 279, 8212-8218
    • (2004) J. Biol. Chem , vol.279 , pp. 8212-8218
    • Liu, J.1    Liao, Z.2    Camden, J.3    Griffin, K.D.4    Garrad, R.C.5    Santiago-Perez, L.I.6    Gonzalez, F.A.7    Seye, C.I.8    Weisman, G.A.9    Erb, L.10
  • 30
    • 4143053858 scopus 로고    scopus 로고
    • The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1)
    • Seye, C. I., Yu, N., Gonzalez, F. A., Erb, L., and Weisman, G. A. (2004) The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1). J. Biol. Chem. 279, 35679-35686
    • (2004) J. Biol. Chem , vol.279 , pp. 35679-35686
    • Seye, C.I.1    Yu, N.2    Gonzalez, F.A.3    Erb, L.4    Weisman, G.A.5
  • 33
    • 0033594403 scopus 로고    scopus 로고
    • Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction
    • Watton, S. J., and Downward, J. (1999) Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. Curr. Biol. 9, 433-436
    • (1999) Curr. Biol , vol.9 , pp. 433-436
    • Watton, S.J.1    Downward, J.2
  • 34
  • 36
    • 16844381714 scopus 로고    scopus 로고
    • Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells
    • Pasquier, E., Honore, S., Pourroy, B., Jordan, M. A., Lehmann, M., Briand, C., and Braguer, D. (2005) Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells. Cancer Res. 65, 2433-2440
    • (2005) Cancer Res , vol.65 , pp. 2433-2440
    • Pasquier, E.1    Honore, S.2    Pourroy, B.3    Jordan, M.A.4    Lehmann, M.5    Briand, C.6    Braguer, D.7
  • 37
    • 14844338481 scopus 로고    scopus 로고
    • beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation
    • Barnes, W. G., Reiter, E., Violin, J. D., Ren, X. R., Milligan, G., and Lefkowitz, R. J. (2005) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J. Biol. Chem. 280, 8041-8050
    • (2005) J. Biol. Chem , vol.280 , pp. 8041-8050
    • Barnes, W.G.1    Reiter, E.2    Violin, J.D.3    Ren, X.R.4    Milligan, G.5    Lefkowitz, R.J.6
  • 38
    • 30044445078 scopus 로고    scopus 로고
    • Altered expression of G(q/ 11alpha) protein shapes mGlu1 and mGlu5 receptor-mediated single cell inositol 1,4,5-trisphosphate and Ca(2+) signaling
    • Atkinson, P. J., Young, K. W., Ennion, S. J., Kew, J. N., Nahorski, S. R., and Challiss, R. A. (2006) Altered expression of G(q/ 11alpha) protein shapes mGlu1 and mGlu5 receptor-mediated single cell inositol 1,4,5-trisphosphate and Ca(2+) signaling. Mol. Pharmacol. 69, 174-184
    • (2006) Mol. Pharmacol , vol.69 , pp. 174-184
    • Atkinson, P.J.1    Young, K.W.2    Ennion, S.J.3    Kew, J.N.4    Nahorski, S.R.5    Challiss, R.A.6
  • 39
    • 0035085802 scopus 로고    scopus 로고
    • Keratinocyte migration requires alpha2beta1 integrin-mediated interaction with the laminin 5 gamma2 chain
    • Decline, F., and Rousselle, P. (2001) Keratinocyte migration requires alpha2beta1 integrin-mediated interaction with the laminin 5 gamma2 chain. J. Cell Sci. 114, 811-823
    • (2001) J. Cell Sci , vol.114 , pp. 811-823
    • Decline, F.1    Rousselle, P.2
  • 40
    • 0031768408 scopus 로고    scopus 로고
    • Integrin ligation and PKC activation are required for migration of colon carcinoma cells
    • Rigot, V., Lehmann, M., Andre, F., Daemi, N., Marvaldi, J., and Luis, J. (1998) Integrin ligation and PKC activation are required for migration of colon carcinoma cells. J. Cell Sci. 111 (Pt 20), 3119-3127
    • (1998) J. Cell Sci , vol.111 , Issue.PART 20 , pp. 3119-3127
    • Rigot, V.1    Lehmann, M.2    Andre, F.3    Daemi, N.4    Marvaldi, J.5    Luis, J.6
  • 42
    • 0033603826 scopus 로고    scopus 로고
    • Quantifying lamella dynamics of cultured cells by SACED, a new computer-assisted motion analysis
    • Hinz, B., Alt, W., Johnen, C., Herzog, V., and Kaiser, H. W. (1999) Quantifying lamella dynamics of cultured cells by SACED, a new computer-assisted motion analysis. Exp. Cell Res. 251, 234-243
    • (1999) Exp. Cell Res , vol.251 , pp. 234-243
    • Hinz, B.1    Alt, W.2    Johnen, C.3    Herzog, V.4    Kaiser, H.W.5
  • 43
    • 26244457628 scopus 로고    scopus 로고
    • Evidences that beta1 integrin and Rac1 are involved in the overriding effect of laminin on myelin-associated glycoprotein inhibitory activity on neuronal cells
    • Laforest, S., Milanini, J., Parat, F., Thimonier, J., and Lehmann, M. (2005) Evidences that beta1 integrin and Rac1 are involved in the overriding effect of laminin on myelin-associated glycoprotein inhibitory activity on neuronal cells. Mol. Cell Neurosci. 30, 418-428
    • (2005) Mol. Cell Neurosci , vol.30 , pp. 418-428
    • Laforest, S.1    Milanini, J.2    Parat, F.3    Thimonier, J.4    Lehmann, M.5
  • 45
    • 0041326890 scopus 로고    scopus 로고
    • Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin
    • Russell, A. J., Fincher, E. F., Millman, L., Smith, R., Vela, V., Waterman, E. A., Dey, C. N., Guide, S., Weaver, V. M., and Marinkovich, M. P. (2003) Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. J. Cell Sci. 116, 3543-3556
    • (2003) J. Cell Sci , vol.116 , pp. 3543-3556
    • Russell, A.J.1    Fincher, E.F.2    Millman, L.3    Smith, R.4    Vela, V.5    Waterman, E.A.6    Dey, C.N.7    Guide, S.8    Weaver, V.M.9    Marinkovich, M.P.10
  • 46
    • 4444361792 scopus 로고    scopus 로고
    • Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1
    • Choma, D. P., Pumiglia, K., and DiPersio, C. M. (2004) Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1. J. Cell Sci. 117, 3947-3959
    • (2004) J. Cell Sci , vol.117 , pp. 3947-3959
    • Choma, D.P.1    Pumiglia, K.2    DiPersio, C.M.3
  • 47
    • 2342472716 scopus 로고    scopus 로고
    • Focal adhesion and actin dynamics: A place where kinases and proteases meet to promote invasion
    • Carragher, N. O., and Frame, M. C. (2004) Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol. 14, 241-249
    • (2004) Trends Cell Biol , vol.14 , pp. 241-249
    • Carragher, N.O.1    Frame, M.C.2
  • 48
    • 33750472978 scopus 로고    scopus 로고
    • Regulation of epidermal homeostasis and repair by phosphoinositide 3-kinase
    • Pankow, S., Bamberger, C., Klippel, A., and Werner, S. (2006) Regulation of epidermal homeostasis and repair by phosphoinositide 3-kinase. J. Cell Sci. 119, 4033-4046
    • (2006) J. Cell Sci , vol.119 , pp. 4033-4046
    • Pankow, S.1    Bamberger, C.2    Klippel, A.3    Werner, S.4
  • 49
    • 0041629643 scopus 로고    scopus 로고
    • Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways
    • Haase, I., Evans, R., Pofahl, R., and Watt, F. M. (2003) Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways. J. Cell Sci. 116, 3227-3238
    • (2003) J. Cell Sci , vol.116 , pp. 3227-3238
    • Haase, I.1    Evans, R.2    Pofahl, R.3    Watt, F.M.4
  • 50
    • 30744433667 scopus 로고    scopus 로고
    • Beta2-adrenergic receptor activation delays wound healing
    • Pullar, C. E., Grahn, J. C., Liu, W., and Isseroff, R. R. (2006) Beta2-adrenergic receptor activation delays wound healing. FASEB J. 20, 76-86
    • (2006) FASEB J , vol.20 , pp. 76-86
    • Pullar, C.E.1    Grahn, J.C.2    Liu, W.3    Isseroff, R.R.4
  • 52
    • 0038604436 scopus 로고    scopus 로고
    • PP2A activation by beta2-adrenergic receptor agonists: Novel regulatory mechanism of keratinocyte migration
    • Pullar, C. E., Chen, J., and Isseroff, R. R. (2003) PP2A activation by beta2-adrenergic receptor agonists: novel regulatory mechanism of keratinocyte migration. J. Biol. Chem. 278, 22555-22562
    • (2003) J. Biol. Chem , vol.278 , pp. 22555-22562
    • Pullar, C.E.1    Chen, J.2    Isseroff, R.R.3
  • 53
    • 33644988355 scopus 로고    scopus 로고
    • The beta 2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms
    • Pullar, C. E., and Isseroff, R. R. (2006) The beta 2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms. J. Cell Sci. 119, 592-602
    • (2006) J. Cell Sci , vol.119 , pp. 592-602
    • Pullar, C.E.1    Isseroff, R.R.2
  • 54
    • 0036682506 scopus 로고    scopus 로고
    • Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors
    • Idzko, M., Dichmann, S., Ferrari, D., Di Virgilio, F., la Sala, A., Girolomoni, G., Panther, E., and Norgauer, J. (2002) Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Blood 100, 925-932
    • (2002) Blood , vol.100 , pp. 925-932
    • Idzko, M.1    Dichmann, S.2    Ferrari, D.3    Di Virgilio, F.4    la Sala, A.5    Girolomoni, G.6    Panther, E.7    Norgauer, J.8
  • 55
    • 0038156223 scopus 로고    scopus 로고
    • ATP gradients inhibit the migratory capacity of specific human dendritic cell types: Implications for P2Y11 receptor signaling
    • Schnurr, M., Toy, T., Stoitzner, P., Cameron, P., Shin, A., Beecroft, T., Davis, I. D., Cebon, J., and Maraskovsky, E. (2003) ATP gradients inhibit the migratory capacity of specific human dendritic cell types: implications for P2Y11 receptor signaling. Blood 102, 613-620
    • (2003) Blood , vol.102 , pp. 613-620
    • Schnurr, M.1    Toy, T.2    Stoitzner, P.3    Cameron, P.4    Shin, A.5    Beecroft, T.6    Davis, I.D.7    Cebon, J.8    Maraskovsky, E.9
  • 56
    • 0343395802 scopus 로고    scopus 로고
    • Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures
    • Lenz, G., Goncalves, D., Luo, Z., Avruch, J., Rodnight, R., and Neary, J. T. (2001) Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures. J. Neurochem. 77, 1001-1009
    • (2001) J. Neurochem , vol.77 , pp. 1001-1009
    • Lenz, G.1    Goncalves, D.2    Luo, Z.3    Avruch, J.4    Rodnight, R.5    Neary, J.T.6
  • 57
    • 1542329707 scopus 로고    scopus 로고
    • Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells
    • Czajkowski, R., Banachewicz, W., Ilnytska, O., Drobot, L. B., and Baranska, J. (2004) Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells. Br. J. Pharmacol. 141, 497-507
    • (2004) Br. J. Pharmacol , vol.141 , pp. 497-507
    • Czajkowski, R.1    Banachewicz, W.2    Ilnytska, O.3    Drobot, L.B.4    Baranska, J.5
  • 58
    • 0034681369 scopus 로고    scopus 로고
    • Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblasts
    • Ballou, L. M., Cross, M. E., Huang, S., McReynolds, E. M., Zhang, B. X., and Lin, R. Z. (2000) Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblasts. J. Biol. Chem. 275, 4803-4809
    • (2000) J. Biol. Chem , vol.275 , pp. 4803-4809
    • Ballou, L.M.1    Cross, M.E.2    Huang, S.3    McReynolds, E.M.4    Zhang, B.X.5    Lin, R.Z.6
  • 60
    • 3042819385 scopus 로고    scopus 로고
    • Galphaq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells
    • Ueda, H., Morishita, R., Narumiya, S., Kato, K., and Asano, T. (2004) Galphaq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells. Exp. Cell Res. 298, 207-217
    • (2004) Exp. Cell Res , vol.298 , pp. 207-217
    • Ueda, H.1    Morishita, R.2    Narumiya, S.3    Kato, K.4    Asano, T.5
  • 61
    • 0034624060 scopus 로고    scopus 로고
    • Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits
    • Bommakanti, R. K., Vinayak, S., and Simonds, W. F. (2000) Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits. J. Biol. Chem. 275, 38870-38876
    • (2000) J. Biol. Chem , vol.275 , pp. 38870-38876
    • Bommakanti, R.K.1    Vinayak, S.2    Simonds, W.F.3
  • 62
    • 33646710125 scopus 로고    scopus 로고
    • Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade
    • Wu, E. H., Tam, B. H., and Wong, Y. H. (2006) Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade. FEBS J. 273, 2388-2398
    • (2006) FEBS J , vol.273 , pp. 2388-2398
    • Wu, E.H.1    Tam, B.H.2    Wong, Y.H.3
  • 63
    • 0141890280 scopus 로고    scopus 로고
    • Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion
    • Howes, A. L., Arthur, J. F., Zhang, T., Miyamoto, S., Adams, J. W., Dorn, I. G., Woodcock, E. A., and Brown, J. H. (2003) Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. J. Biol. Chem. 278, 40343-40351
    • (2003) J. Biol. Chem , vol.278 , pp. 40343-40351
    • Howes, A.L.1    Arthur, J.F.2    Zhang, T.3    Miyamoto, S.4    Adams, J.W.5    Dorn, I.G.6    Woodcock, E.A.7    Brown, J.H.8
  • 64
    • 27444440633 scopus 로고    scopus 로고
    • Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins
    • Hubbard, K. B., and Hepler, J. R. (2006) Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Cell Signal 18, 135-150
    • (2006) Cell Signal , vol.18 , pp. 135-150
    • Hubbard, K.B.1    Hepler, J.R.2
  • 65
    • 33644991114 scopus 로고    scopus 로고
    • Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras
    • Ballou, L. M., Chattopadhyay, M., Li, Y., Scarlata, S., and Lin, R. Z. (2006) Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras. Biochem. J. 394, 557-562
    • (2006) Biochem. J , vol.394 , pp. 557-562
    • Ballou, L.M.1    Chattopadhyay, M.2    Li, Y.3    Scarlata, S.4    Lin, R.Z.5
  • 66
    • 0038268664 scopus 로고    scopus 로고
    • Activated G alpha q inhibits p110 alpha phosphatidylinositol 3-kinase and Akt
    • Ballou, L. M., Lin, H. Y., Fan, G., Jiang, Y. P., and Lin, R. Z. (2003) Activated G alpha q inhibits p110 alpha phosphatidylinositol 3-kinase and Akt. J. Biol. Chem. 278, 23472-23479
    • (2003) J. Biol. Chem , vol.278 , pp. 23472-23479
    • Ballou, L.M.1    Lin, H.Y.2    Fan, G.3    Jiang, Y.P.4    Lin, R.Z.5
  • 67
    • 0346101775 scopus 로고    scopus 로고
    • Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq
    • Fan, G., Ballou, L. M., and Lin, R. Z. (2003) Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq. J. Biol. Chem. 278, 52432-52436
    • (2003) J. Biol. Chem , vol.278 , pp. 52432-52436
    • Fan, G.1    Ballou, L.M.2    Lin, R.Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.