Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 763-764, Issue , 2014, Pages 53-63

  Inturi, Swetha ^a   Tewari Singh, Neera ^a   Agarwal, Chapla ^a   White, Carl W ^b   Agarwal, Rajesh ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b University of Colorado Denver and Children s Hospital Colorado   (United States)

Author keywords

BO2; DNA double strand break (DSB) repair; HRR; NHEJ; Nitrogen mustard; NU7026; Rad51 inhibitor

Indexed keywords

BO 2; CELL PROTEIN; CHLORMETHINE; HISTONE H2AX; HOMOLOGOUS RECOMBINATION REPAIR PROTEIN; NONHOMOLOGOUS END JOINING PROTEIN; NU 7026; NUCLEOTIDYLTRANSFERASE INHIBITOR; PROTEIN KINASE INHIBITOR; PROTEIN P53; RAD51 PROTEIN; UNCLASSIFIED DRUG; 2-(MORPHOLIN-4-YL)BENZO(H)CHROMEN-4-ONE; BORON DERIVATIVE; BORON OXIDE; CHEMICAL WARFARE AGENT; CHROMONE DERIVATIVE; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; H2AX PROTEIN, MOUSE; HISTONE; MORPHOLINE DERIVATIVE; NUCLEAR PROTEIN; PRKDC PROTEIN, MOUSE; RAD51 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL GROWTH; CELL PROTECTION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; DRUG TARGETING; EPIDERMIS CELL; G2 PHASE CELL CYCLE CHECKPOINT; GENE ACTIVATION; GROWTH RETARDATION; KERATINOCYTE; M PHASE CELL CYCLE CHECKPOINT; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; SKIN INJURY; SKIN TOXICITY; TOXICITY TESTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE; PATHOLOGY; SKIN;

ANIMALS; BORON COMPOUNDS; CELL LINE; CHEMICAL WARFARE AGENTS; CHROMONES; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; G2 PHASE CELL CYCLE CHECKPOINTS; HISTONES; KERATINOCYTES; MECHLORETHAMINE; MICE; MORPHOLINES; NUCLEAR PROTEINS; RAD51 RECOMBINASE; SKIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84899146917     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2014.04.002     Document Type: Article

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