Silibinin Attenuates Sulfur Mustard Analog-Induced Skin Injury by Targeting Multiple Pathways Connecting Oxidative Stress and Inflammation

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Tewari Singh, Neera ^a   Jain, Anil K ^a   Inturi, Swetha ^a   Agarwal, Chapla ^a   White, Carl W ^b   Agarwal, Rajesh ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b Children's Hospital Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; 5,5 DIMETHYL 2 (8 OCTANOIC ACID) 1 PYROLLINE N OXIDE; 8 OXO 2 DEOXYGUANOSINE; BIOLOGICAL MARKER; CYCLOOXYGENASE 2; DEOXYGUANOSINE DERIVATIVE; ETHYL 2 CHLOROETHYL SULFIDE; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MUSTARD GAS DERIVATIVE; MYELOPEROXIDASE; OCTANOIC ACID DERIVATIVE; SILIBININ; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CUTANEOUS PARAMETERS; DNA DAMAGE; DRUG EFFICACY; DRUG EXPOSURE; ENZYME ACTIVITY; EPIDERMAL THICKNESS; EPIDERMIS; FEMALE; HAIRLESS MOUSE; INFLAMMATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; SKIN BI FOLD THICKNESS; SKIN CELL; SKIN INJURY; SKIN TOXICITY; SKINFOLD THICKNESS;

ALDEHYDES; ANIMALS; ANTIDOTES; APOPTOSIS; CELLS, CULTURED; CHEMICAL WARFARE AGENTS; CYCLOOXYGENASE 2; DEOXYGUANOSINE; DNA DAMAGE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; MATRIX METALLOPROTEINASE 9; MICE; MICE, HAIRLESS; MUSTARD GAS; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SILYMARIN; SKIN;

EID: 84866910174     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046149     Document Type: Article

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