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Volumn 263, Issue 1, 2009, Pages 12-19

Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering

Author keywords

Chemical warfare agents; Eyes; Lungs; Review; Skin; Sulfur mustard; Therapeutics

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CALMODULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MUSTARD GAS; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE;

EID: 67849111547     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.01.019     Document Type: Review
Times cited : (220)

References (114)
  • 1
    • 0023438459 scopus 로고
    • Mustard gas: clinical, toxicological, and mutagenic aspects based on modern experience
    • Aasted A., Darre E., and Wulf H.C. Mustard gas: clinical, toxicological, and mutagenic aspects based on modern experience. Ann. Plast. Surg. 19 (1987) 330-333
    • (1987) Ann. Plast. Surg. , vol.19 , pp. 330-333
    • Aasted, A.1    Darre, E.2    Wulf, H.C.3
  • 3
    • 33646183367 scopus 로고    scopus 로고
    • DNA damage responses and their many interactions with the replication fork
    • Andreassen P.R., Ho G.P., and D'Andrea A.D. DNA damage responses and their many interactions with the replication fork. Carcinogenesis 27 (2006) 883-892
    • (2006) Carcinogenesis , vol.27 , pp. 883-892
    • Andreassen, P.R.1    Ho, G.P.2    D'Andrea, A.D.3
  • 4
    • 0030574021 scopus 로고    scopus 로고
    • Calcineurin and mitochondrial function in glutamate-induced neuronal cell death
    • Ankarcrona M., Dypbukt J.M., Orrenius S., and Nicotera P. Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett. 394 (1996) 321-324
    • (1996) FEBS Lett. , vol.394 , pp. 321-324
    • Ankarcrona, M.1    Dypbukt, J.M.2    Orrenius, S.3    Nicotera, P.4
  • 8
    • 20044373718 scopus 로고    scopus 로고
    • The pharmacology, toxicology, and medical treatment of sulphur mustard poisoning
    • Balali-Mood M., and Hefazi M. The pharmacology, toxicology, and medical treatment of sulphur mustard poisoning. Fundam. Clin. Pharmacol. 19 (2005) 297-315
    • (2005) Fundam. Clin. Pharmacol. , vol.19 , pp. 297-315
    • Balali-Mood, M.1    Hefazi, M.2
  • 9
    • 33750061025 scopus 로고    scopus 로고
    • Comparison of early and late toxic effects of sulfur mustard in Iranian veterans
    • Balali-Mood M., and Hefazi M. Comparison of early and late toxic effects of sulfur mustard in Iranian veterans. Basic Clin. Pharmacol. Toxicol. 99 (2006) 273-282
    • (2006) Basic Clin. Pharmacol. Toxicol. , vol.99 , pp. 273-282
    • Balali-Mood, M.1    Hefazi, M.2
  • 11
    • 0022634961 scopus 로고
    • Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of poly (ADP-ribose) polymerase
    • Berger S.J., Sudar D.C., and Berger N.A. Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of poly (ADP-ribose) polymerase. Biochem. Biophys. Res. Commun. 134 (1986) 227-232
    • (1986) Biochem. Biophys. Res. Commun. , vol.134 , pp. 227-232
    • Berger, S.J.1    Sudar, D.C.2    Berger, N.A.3
  • 13
    • 0034578224 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) polymerase (PARP) in DNA repair in sulfur mustard-exposed normal human epidermal keratinocytes (NHEK)
    • Bhat K.R., Benton B.J., Rosenthal D.S., Smulson M.E., and Ray R. Role of poly(ADP-ribose) polymerase (PARP) in DNA repair in sulfur mustard-exposed normal human epidermal keratinocytes (NHEK). J. Appl. Toxicol. 20 1 (2000) S13-S17
    • (2000) J. Appl. Toxicol. , vol.20 , Issue.1
    • Bhat, K.R.1    Benton, B.J.2    Rosenthal, D.S.3    Smulson, M.E.4    Ray, R.5
  • 14
    • 0028906866 scopus 로고
    • Biological fate of sulphur mustard 1,1′-thiobis(2-chloroethane): identification of beta-lyase metabolites and hydrolysis products in human urine
    • Black R.M., and Read R.W. Biological fate of sulphur mustard 1,1′-thiobis(2-chloroethane): identification of beta-lyase metabolites and hydrolysis products in human urine. Xenobiotica 25 (1995) 167-173
    • (1995) Xenobiotica , vol.25 , pp. 167-173
    • Black, R.M.1    Read, R.W.2
  • 15
    • 0028940369 scopus 로고
    • Improved methodology for the detection and quantitation of urinary metabolites of sulphur mustard using gas chromatography-tandem mass spectrometry
    • Black R.M., and Read R.W. Improved methodology for the detection and quantitation of urinary metabolites of sulphur mustard using gas chromatography-tandem mass spectrometry. J. Chromatogr. B: Biomed. Appl. 665 (1995) 97-105
    • (1995) J. Chromatogr. B: Biomed. Appl. , vol.665 , pp. 97-105
    • Black, R.M.1    Read, R.W.2
  • 16
    • 67849087755 scopus 로고    scopus 로고
    • Comparison of sulfur mustard induced mechanism of cell damage in dependency of time course and cell type
    • Bloch W., Elischer A., Schriek M., Bohm K., Moghbeli F., Kehe K., Szinicz L., and Steinritz D. Comparison of sulfur mustard induced mechanism of cell damage in dependency of time course and cell type. Toxicology 233 (2007) 223
    • (2007) Toxicology , vol.233 , pp. 223
    • Bloch, W.1    Elischer, A.2    Schriek, M.3    Bohm, K.4    Moghbeli, F.5    Kehe, K.6    Szinicz, L.7    Steinritz, D.8
  • 17
    • 0030893676 scopus 로고    scopus 로고
    • Histopathological changes in Yucatan minipig skin following challenge with sulphur mustard. A sequential study of the first 24 hours following challenge
    • Brown R.F., and Rice P. Histopathological changes in Yucatan minipig skin following challenge with sulphur mustard. A sequential study of the first 24 hours following challenge. Int. J. Exp. Pathol. 78 (1997) 9-20
    • (1997) Int. J. Exp. Pathol. , vol.78 , pp. 9-20
    • Brown, R.F.1    Rice, P.2
  • 18
    • 0034814670 scopus 로고    scopus 로고
    • Physiology and pathophysiology of poly(ADP-ribosyl)ation
    • Bürkle A. Physiology and pathophysiology of poly(ADP-ribosyl)ation. Bioessays 23 (2001) 795-806
    • (2001) Bioessays , vol.23 , pp. 795-806
    • Bürkle, A.1
  • 19
    • 33751303107 scopus 로고    scopus 로고
    • Calcineurin inhibitors reduce nuclear localization of transcription factor NFAT in UV-irradiated keratinocytes and reduce DNA repair
    • Canning M.T., Nay S.L., Pena A.V., and Yarosh D.B. Calcineurin inhibitors reduce nuclear localization of transcription factor NFAT in UV-irradiated keratinocytes and reduce DNA repair. J. Mol. Histol. 37 (2006) 285-291
    • (2006) J. Mol. Histol. , vol.37 , pp. 285-291
    • Canning, M.T.1    Nay, S.L.2    Pena, A.V.3    Yarosh, D.B.4
  • 20
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 (2001) 37-40
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 21
    • 3242772143 scopus 로고    scopus 로고
    • Mitochondrial translocation of p53 and mitochondrial membrane potential (Delta Psi m) dissipation are early events in staurosporine-induced apoptosis of wild type and mutated p53 epithelial cells
    • Charlot J.F., Pretet J.L., Haughey C., and Mougin C. Mitochondrial translocation of p53 and mitochondrial membrane potential (Delta Psi m) dissipation are early events in staurosporine-induced apoptosis of wild type and mutated p53 epithelial cells. Apoptosis 9 (2004) 333-343
    • (2004) Apoptosis , vol.9 , pp. 333-343
    • Charlot, J.F.1    Pretet, J.L.2    Haughey, C.3    Mougin, C.4
  • 22
    • 0032942257 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase: a guardian of the genome that facilitates DNA repair by protecting against DNA recombination
    • Chatterjee S., Berger S.J., and Berger N.A. Poly(ADP-ribose) polymerase: a guardian of the genome that facilitates DNA repair by protecting against DNA recombination. Mol. Cell Biochem. 193 (1999) 23-30
    • (1999) Mol. Cell Biochem. , vol.193 , pp. 23-30
    • Chatterjee, S.1    Berger, S.J.2    Berger, N.A.3
  • 23
    • 27444446948 scopus 로고    scopus 로고
    • Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway
    • Clarke C.A., Bennett L.N., and Clarke P.R. Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway. J. Biol. Chem. 280 (2005) 35337-35345
    • (2005) J. Biol. Chem. , vol.280 , pp. 35337-35345
    • Clarke, C.A.1    Bennett, L.N.2    Clarke, P.R.3
  • 25
    • 67849086945 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity
    • Debiak M., Kehe K., and Bürkle A. Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity. Toxicology 263 (2009) 20-25
    • (2009) Toxicology , vol.263 , pp. 20-25
    • Debiak, M.1    Kehe, K.2    Bürkle, A.3
  • 26
    • 3142644823 scopus 로고    scopus 로고
    • An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytes
    • Dillman III J.F., McGary K.L., and Schlager J.J. An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytes. Toxicol. In Vitro 18 (2004) 593-599
    • (2004) Toxicol. In Vitro , vol.18 , pp. 593-599
    • Dillman III, J.F.1    McGary, K.L.2    Schlager, J.J.3
  • 27
    • 0035807079 scopus 로고    scopus 로고
    • Repair of DNA interstrand cross-links
    • Dronkert M.L., and Kanaar R. Repair of DNA interstrand cross-links. Mutat. Res. 486 (2001) 217-247
    • (2001) Mutat. Res. , vol.486 , pp. 217-247
    • Dronkert, M.L.1    Kanaar, R.2
  • 28
    • 0030915587 scopus 로고    scopus 로고
    • Intracellular ATP levels determine cell death fate by apoptosis or necrosis
    • Eguchi Y., Shimizu S., and Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. 57 (1997) 1835-1840
    • (1997) Cancer Res. , vol.57 , pp. 1835-1840
    • Eguchi, Y.1    Shimizu, S.2    Tsujimoto, Y.3
  • 29
    • 49649103587 scopus 로고    scopus 로고
    • Expanded roles for Chk1 in genome maintenance
    • Enders G.H. Expanded roles for Chk1 in genome maintenance. J. Biol. Chem. 283 (2008) 17749-17752
    • (2008) J. Biol. Chem. , vol.283 , pp. 17749-17752
    • Enders, G.H.1
  • 30
    • 33749178260 scopus 로고    scopus 로고
    • Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response
    • Festjens N., Vanden B.T., and Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim. Biophys. Acta 1757 (2006) 1371-1387
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 1371-1387
    • Festjens, N.1    Vanden, B.T.2    Vandenabeele, P.3
  • 31
    • 34250687555 scopus 로고    scopus 로고
    • Inhibition of sulfur mustard-induced cytotoxicity and inflammation by the macrolide antibiotic roxithromycin in human respiratory epithelial cells
    • Gao X., Ray R., Xiao Y., Barker P.E., and Ray P. Inhibition of sulfur mustard-induced cytotoxicity and inflammation by the macrolide antibiotic roxithromycin in human respiratory epithelial cells. BMC Cell Biol. 8 (2007) 17
    • (2007) BMC Cell Biol. , vol.8 , pp. 17
    • Gao, X.1    Ray, R.2    Xiao, Y.3    Barker, P.E.4    Ray, P.5
  • 32
    • 0034949086 scopus 로고    scopus 로고
    • Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases
    • Gobeil S., Boucher C.C., Nadeau D., and Poirier G.G. Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases. Cell Death Differ. 8 (2001) 588-594
    • (2001) Cell Death Differ. , vol.8 , pp. 588-594
    • Gobeil, S.1    Boucher, C.C.2    Nadeau, D.3    Poirier, G.G.4
  • 33
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green D.R., and Kroemer G. The pathophysiology of mitochondrial cell death. Science 305 (2004) 626-629
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 35
    • 0022370660 scopus 로고
    • Sulfur mustard lowers nicotinamide adenine dinucleotide concentrations in human skin grafted to athymic nude mice
    • Gross C.L., Meier H.L., Papirmeister B., Brinkley F.B., and Johnson J.B. Sulfur mustard lowers nicotinamide adenine dinucleotide concentrations in human skin grafted to athymic nude mice. Toxicol. Appl. Pharmacol. 81 (1985) 85-90
    • (1985) Toxicol. Appl. Pharmacol. , vol.81 , pp. 85-90
    • Gross, C.L.1    Meier, H.L.2    Papirmeister, B.3    Brinkley, F.B.4    Johnson, J.B.5
  • 36
    • 0027420576 scopus 로고
    • Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard
    • Gross C.L., Innace J.K., Hovatter R.C., Meier H.L., and Smith W.J. Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard. Cell Biol. Toxicol. 9 (1993) 201-213
    • (1993) Cell Biol. Toxicol. , vol.9 , pp. 201-213
    • Gross, C.L.1    Innace, J.K.2    Hovatter, R.C.3    Meier, H.L.4    Smith, W.J.5
  • 37
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden M.S., and Ghosh S. Shared principles in NF-kappaB signaling. Cell 132 (2008) 344-362
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 38
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 39
    • 0033119126 scopus 로고    scopus 로고
    • Activation of poly [ADP ribose] polymerase in endothelial cells and keratinocytes: role in an in vitro model of sulfur mustard-mediated vesication
    • Hinshaw D.B., Lodhi I.J., Hurley K.B., and Dabrowska M.I. Activation of poly [ADP ribose] polymerase in endothelial cells and keratinocytes: role in an in vitro model of sulfur mustard-mediated vesication. Toxicol. Appl. Pharmacol. 156 (1999) 17-29
    • (1999) Toxicol. Appl. Pharmacol. , vol.156 , pp. 17-29
    • Hinshaw, D.B.1    Lodhi, I.J.2    Hurley, K.B.3    Dabrowska, M.I.4
  • 40
    • 0032540247 scopus 로고    scopus 로고
    • Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide
    • Hirako Y., Usukura J., Uematsu J., Hashimoto T., Kitajima Y., and Owaribe K. Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide. J. Biol. Chem. 273 (1998) 9711-9717
    • (1998) J. Biol. Chem. , vol.273 , pp. 9711-9717
    • Hirako, Y.1    Usukura, J.2    Uematsu, J.3    Hashimoto, T.4    Kitajima, Y.5    Owaribe, K.6
  • 41
    • 0345732755 scopus 로고    scopus 로고
    • The 97-kDa (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini
    • Hirako Y., Nishizawa Y., Sitaru C., Opitz A., Marcus K., Meyer H.E., Butt E., Owaribe K., and Zillikens D. The 97-kDa (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini. J. Invest. Dermatol. 121 (2003) 1554-1556
    • (2003) J. Invest. Dermatol. , vol.121 , pp. 1554-1556
    • Hirako, Y.1    Nishizawa, Y.2    Sitaru, C.3    Opitz, A.4    Marcus, K.5    Meyer, H.E.6    Butt, E.7    Owaribe, K.8    Zillikens, D.9
  • 42
    • 14244269334 scopus 로고    scopus 로고
    • Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks
    • Ismail I.H., Nystrom S., Nygren J., and Hammarsten O. Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks. J. Biol. Chem. 280 (2005) 4649-4655
    • (2005) J. Biol. Chem. , vol.280 , pp. 4649-4655
    • Ismail, I.H.1    Nystrom, S.2    Nygren, J.3    Hammarsten, O.4
  • 43
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome C-mediated apoptosis
    • Jiang X., and Wang X. Cytochrome C-mediated apoptosis. Annu. Rev. Biochem. 73 (2004) 87-106
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 44
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: the control of NF-κB activity
    • Karin M., and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18 (2000) 621-663
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 45
    • 25844459154 scopus 로고    scopus 로고
    • NF-κB: linking inflammation and immunity to cancer development and progression
    • Karin M., and Greten F.R. NF-κB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5 (2005) 749-759
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 46
    • 0027255417 scopus 로고
    • Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis
    • Kaufmann S.H., Desnoyers S., Ottaviano Y., Davidson N.E., and Poirier G.G. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 53 (1993) 3976-3985
    • (1993) Cancer Res. , vol.53 , pp. 3976-3985
    • Kaufmann, S.H.1    Desnoyers, S.2    Ottaviano, Y.3    Davidson, N.E.4    Poirier, G.G.5
  • 47
    • 26044437901 scopus 로고    scopus 로고
    • Medical aspects of sulphur mustard poisoning
    • Kehe K., and Szinicz L. Medical aspects of sulphur mustard poisoning. Toxicology 214 (2005) 198-209
    • (2005) Toxicology , vol.214 , pp. 198-209
    • Kehe, K.1    Szinicz, L.2
  • 48
    • 0034575045 scopus 로고    scopus 로고
    • Sulfur mustard induces apoptosis and necrosis in SCL II cells in vitro
    • Kehe K., Reisinger H., and Szinicz L. Sulfur mustard induces apoptosis and necrosis in SCL II cells in vitro. J. Appl. Toxicol. 20 (2000) S81-S86
    • (2000) J. Appl. Toxicol. , vol.20
    • Kehe, K.1    Reisinger, H.2    Szinicz, L.3
  • 50
    • 67849098319 scopus 로고    scopus 로고
    • Sulfur mustard activates ATM signalling pathway to stabilize p53 and induce cell cycle arrest and apoptosis in human keratinocytes
    • Kehe K., Emmler J., Steinritz D., Reichl F.X., Kreppel H., and Szinicz L. Sulfur mustard activates ATM signalling pathway to stabilize p53 and induce cell cycle arrest and apoptosis in human keratinocytes. Naunyn Schmiedebergs Arch. Pharmacol. 372 1 (2006) 109-110
    • (2006) Naunyn Schmiedebergs Arch. Pharmacol. , vol.372 , Issue.1 , pp. 109-110
    • Kehe, K.1    Emmler, J.2    Steinritz, D.3    Reichl, F.X.4    Kreppel, H.5    Szinicz, L.6
  • 51
    • 45849118741 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells
    • Kehe K., Raithel K., Kreppel H., Jochum M., Worek F., and Thiermann H. Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells. Arch. Toxicol. 82 (2007) 461-470
    • (2007) Arch. Toxicol. , vol.82 , pp. 461-470
    • Kehe, K.1    Raithel, K.2    Kreppel, H.3    Jochum, M.4    Worek, F.5    Thiermann, H.6
  • 52
    • 61349103777 scopus 로고    scopus 로고
    • Sulfur mustard-strategies for the development of improved medical therapy
    • Kehe K., Balszuweit F., Emmler J., Kreppel H., Jochum M., and Thiermann H. Sulfur mustard-strategies for the development of improved medical therapy. Eplasty 8 (2008) 312-332
    • (2008) Eplasty , vol.8 , pp. 312-332
    • Kehe, K.1    Balszuweit, F.2    Emmler, J.3    Kreppel, H.4    Jochum, M.5    Thiermann, H.6
  • 53
    • 33748683582 scopus 로고    scopus 로고
    • Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation
    • Korkmaz A., Yaren H., Topal T., and Oter S. Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation. Arch. Toxicol. 80 (2006) 662-670
    • (2006) Arch. Toxicol. , vol.80 , pp. 662-670
    • Korkmaz, A.1    Yaren, H.2    Topal, T.3    Oter, S.4
  • 54
    • 0031918742 scopus 로고    scopus 로고
    • The mitochondrial death/life regulator in apoptosis and necrosis
    • Kroemer G., Dallaporta B., and Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 60 (1998) 619-642
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 619-642
    • Kroemer, G.1    Dallaporta, B.2    Resche-Rigon, M.3
  • 55
    • 0035857792 scopus 로고    scopus 로고
    • Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes
    • Kumar O., Sugendran K., and Vijayaraghavan R. Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes. Chem. Biol. Interact. 134 (2001) 1-12
    • (2001) Chem. Biol. Interact. , vol.134 , pp. 1-12
    • Kumar, O.1    Sugendran, K.2    Vijayaraghavan, R.3
  • 56
    • 0014202447 scopus 로고
    • Interstrand cross-linking of DNA by difunctional alkylating agents
    • Lawley P.D., and Brookes P. Interstrand cross-linking of DNA by difunctional alkylating agents. J. Mol. Biol. 25 (1967) 143-160
    • (1967) J. Mol. Biol. , vol.25 , pp. 143-160
    • Lawley, P.D.1    Brookes, P.2
  • 57
    • 0014674093 scopus 로고
    • Inactivation of bacteriophage t7 by mono- and difunctional sulfur mustards in relation to cross-linking and depurination of bacteriophage DNA
    • Lawley P.D., Lethbridge J.H., Edwards P.A., and Shooter K.V. Inactivation of bacteriophage t7 by mono- and difunctional sulfur mustards in relation to cross-linking and depurination of bacteriophage DNA. J. Mol. Biol. 39 (1969) 181-198
    • (1969) J. Mol. Biol. , vol.39 , pp. 181-198
    • Lawley, P.D.1    Lethbridge, J.H.2    Edwards, P.A.3    Shooter, K.V.4
  • 58
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB regulation in the immune system
    • Li Q., and Verma I.M. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2 (2002) 725-734
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 59
    • 0030033259 scopus 로고    scopus 로고
    • Bis(2-chloroethyl)sulfide (BCES) disturbs the progression of rat keratinocytes through the cell cycle
    • Lin P.P., Bernstein I.A., and Vaughan F.L. Bis(2-chloroethyl)sulfide (BCES) disturbs the progression of rat keratinocytes through the cell cycle. Toxicol. Lett. 84 (1996) 23-32
    • (1996) Toxicol. Lett. , vol.84 , pp. 23-32
    • Lin, P.P.1    Bernstein, I.A.2    Vaughan, F.L.3
  • 60
    • 0031046452 scopus 로고    scopus 로고
    • Protection of A549 cells against the toxic effects of sulphur mustard by hexamethylenetetramine
    • Lindsay C.D., and Hambrook J.L. Protection of A549 cells against the toxic effects of sulphur mustard by hexamethylenetetramine. Hum. Exp. Toxicol. 16 (1997) 106-114
    • (1997) Hum. Exp. Toxicol. , vol.16 , pp. 106-114
    • Lindsay, C.D.1    Hambrook, J.L.2
  • 61
    • 0030730317 scopus 로고    scopus 로고
    • Monoisopropylglutathione ester protects A549 cells from the cytotoxic effects of sulphur mustard
    • Lindsay C.D., Hambrook J.L., and Lailey A.F. Monoisopropylglutathione ester protects A549 cells from the cytotoxic effects of sulphur mustard. Hum. Exp. Toxicol. 16 (1997) 636-644
    • (1997) Hum. Exp. Toxicol. , vol.16 , pp. 636-644
    • Lindsay, C.D.1    Hambrook, J.L.2    Lailey, A.F.3
  • 62
    • 47549108069 scopus 로고    scopus 로고
    • The use of doxycycline as a protectant against sulphur mustard in HaCaT cells
    • Lindsay C.D., Gentilhomme E., and Mathieu J.D. The use of doxycycline as a protectant against sulphur mustard in HaCaT cells. J. Appl. Toxicol. 28 (2008) 665-673
    • (2008) J. Appl. Toxicol. , vol.28 , pp. 665-673
    • Lindsay, C.D.1    Gentilhomme, E.2    Mathieu, J.D.3
  • 64
    • 0021726899 scopus 로고
    • Formation of O6-ethylthioethyldeoxyguanosine from the reaction of chloroethyl ethyl sulfide with deoxyguanosine
    • Ludlum D.B., Tong W.P., Mehta J.R., Kirk M.C., and Papirmeister B. Formation of O6-ethylthioethyldeoxyguanosine from the reaction of chloroethyl ethyl sulfide with deoxyguanosine. Cancer Res. 44 (1984) 5698-5701
    • (1984) Cancer Res. , vol.44 , pp. 5698-5701
    • Ludlum, D.B.1    Tong, W.P.2    Mehta, J.R.3    Kirk, M.C.4    Papirmeister, B.5
  • 65
    • 0022931469 scopus 로고
    • Formation of O6-ethylthioethylguanine in DNA by reaction with the sulfur mustard, chloroethyl sulfide, and its apparent lack of repair by O6-alkylguanine-DNA alkyltransferase
    • Ludlum D.B., Kent S., and Mehta J.R. Formation of O6-ethylthioethylguanine in DNA by reaction with the sulfur mustard, chloroethyl sulfide, and its apparent lack of repair by O6-alkylguanine-DNA alkyltransferase. Carcinogenesis 7 (1986) 1203-1206
    • (1986) Carcinogenesis , vol.7 , pp. 1203-1206
    • Ludlum, D.B.1    Kent, S.2    Mehta, J.R.3
  • 67
    • 33745398211 scopus 로고
    • + content in cultured human epidermal kerationocytes exposed to sulfur mustard (HD)
    • + content in cultured human epidermal kerationocytes exposed to sulfur mustard (HD). Proc. Med. Biol. Rev. (1991) 101-104
    • (1991) Proc. Med. Biol. Rev. , pp. 101-104
    • Martens, M.E.1
  • 68
    • 40549118516 scopus 로고    scopus 로고
    • + depletion in the mechanism of sulfur mustard-induced metabolic injury
    • + depletion in the mechanism of sulfur mustard-induced metabolic injury. Cutan. Ocul. Toxicol. 27 (2008) 41-53
    • (2008) Cutan. Ocul. Toxicol. , vol.27 , pp. 41-53
    • Martens, M.E.1    Smith, W.J.2
  • 70
    • 0030770629 scopus 로고    scopus 로고
    • Caveolin versus calmodulin counterbalancing allosteric modulators of endothelial nitric oxide synthase
    • Michel J.B., Feron O., Sase K., Prabhakar P., and Michel T. Caveolin versus calmodulin counterbalancing allosteric modulators of endothelial nitric oxide synthase. J. Biol. Chem. 272 (1997) 25907-25912
    • (1997) J. Biol. Chem. , vol.272 , pp. 25907-25912
    • Michel, J.B.1    Feron, O.2    Sase, K.3    Prabhakar, P.4    Michel, T.5
  • 71
    • 33947397515 scopus 로고    scopus 로고
    • Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor kappaB responses and cell death are altered by caffeic acid phenethyl ester: a potential role for antioxidant/electrophilic response-element signaling
    • Minsavage G.D., and Dillman III J.F. Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor kappaB responses and cell death are altered by caffeic acid phenethyl ester: a potential role for antioxidant/electrophilic response-element signaling. J. Pharmacol. Exp. Ther. 321 (2007) 202-212
    • (2007) J. Pharmacol. Exp. Ther. , vol.321 , pp. 202-212
    • Minsavage, G.D.1    Dillman III, J.F.2
  • 72
    • 0029670560 scopus 로고    scopus 로고
    • 2+ signalling in sulphur mustard-exposed normal human epidermal keratinocytes
    • 2+ signalling in sulphur mustard-exposed normal human epidermal keratinocytes. Chem. Biol. Interact. 100 (1996) 85-93
    • (1996) Chem. Biol. Interact. , vol.100 , pp. 85-93
    • Mol, M.A.1    Smith, W.J.2
  • 73
    • 0024524043 scopus 로고
    • + levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard
    • + levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard. Toxicol. Appl. Pharmacol. 98 (1989) 159-165
    • (1989) Toxicol. Appl. Pharmacol. , vol.98 , pp. 159-165
    • Mol, M.A.1    van de Ruit, A.M.2    Kluivers, A.W.3
  • 74
    • 0032844328 scopus 로고    scopus 로고
    • Immunohistochemical characterization of the basement membrane epitopes in bis(2-chloroethyl) sulfide-induced toxicity in mouse ear skin
    • Monteiro-Riviere N.A., Inman A.O., Babin M.C., and Casillas R.P. Immunohistochemical characterization of the basement membrane epitopes in bis(2-chloroethyl) sulfide-induced toxicity in mouse ear skin. J. Appl. Toxicol. 19 (1999) 313-328
    • (1999) J. Appl. Toxicol. , vol.19 , pp. 313-328
    • Monteiro-Riviere, N.A.1    Inman, A.O.2    Babin, M.C.3    Casillas, R.P.4
  • 75
  • 77
    • 0033735840 scopus 로고    scopus 로고
    • Efficient protection of human bronchial epithelial cells against sulfur and nitrogen mustard cytotoxicity using drug combinations
    • Rappeneau S., Baeza-Squiban A., Marano F., and Calvet J. Efficient protection of human bronchial epithelial cells against sulfur and nitrogen mustard cytotoxicity using drug combinations. Toxicol. Sci. 58 (2000) 153-160
    • (2000) Toxicol. Sci. , vol.58 , pp. 153-160
    • Rappeneau, S.1    Baeza-Squiban, A.2    Marano, F.3    Calvet, J.4
  • 78
    • 0028913992 scopus 로고
    • Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membrane
    • Ray R., Legere R.H., Majerus B.J., and Petrali J.P. Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membrane. Toxicol. Appl. Pharmacol. 131 (1995) 44-52
    • (1995) Toxicol. Appl. Pharmacol. , vol.131 , pp. 44-52
    • Ray, R.1    Legere, R.H.2    Majerus, B.J.3    Petrali, J.P.4
  • 79
    • 13244275399 scopus 로고    scopus 로고
    • A convenient fluorometric method to study sulfur mustard-induced apoptosis in human epidermal keratinocytes monolayer microplate culture
    • Ray R., Hauck S., Kramer R., and Benton B. A convenient fluorometric method to study sulfur mustard-induced apoptosis in human epidermal keratinocytes monolayer microplate culture. Drug Chem. Toxicol. 28 (2005) 105-116
    • (2005) Drug Chem. Toxicol. , vol.28 , pp. 105-116
    • Ray, R.1    Hauck, S.2    Kramer, R.3    Benton, B.4
  • 80
    • 45549091196 scopus 로고    scopus 로고
    • Role of NF-kappaB/RelA and MAPK pathways in keratinocytes in response to sulfur mustard
    • Rebholz B., Kehe K., Ruzicka T., and Rupec R.A. Role of NF-kappaB/RelA and MAPK pathways in keratinocytes in response to sulfur mustard. J. Invest. Dermatol. 128 (2008) 1626-1632
    • (2008) J. Invest. Dermatol. , vol.128 , pp. 1626-1632
    • Rebholz, B.1    Kehe, K.2    Ruzicka, T.3    Rupec, R.A.4
  • 81
    • 67849113956 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 expression and release from skin fibroblasts interacting with keratinocytes: Upregulation in response to sulphur mustard
    • Ries C., Popp T., Egea V., Kehe K., and Jochum M. Matrix metalloproteinase-9 expression and release from skin fibroblasts interacting with keratinocytes: Upregulation in response to sulphur mustard. Toxicology 263 (2009) 26-61
    • (2009) Toxicology , vol.263 , pp. 26-61
    • Ries, C.1    Popp, T.2    Egea, V.3    Kehe, K.4    Jochum, M.5
  • 82
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • Roos W.P., and Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol. Med. 12 (2006) 440-450
    • (2006) Trends Mol. Med. , vol.12 , pp. 440-450
    • Roos, W.P.1    Kaina, B.2
  • 86
    • 67849131217 scopus 로고    scopus 로고
    • Signaling molecules in sulfur mustard-induced cutaneous injury
    • Ruff A.L., and Dillman J.F. Signaling molecules in sulfur mustard-induced cutaneous injury. Eplasty 8 (2007) e2
    • (2007) Eplasty , vol.8
    • Ruff, A.L.1    Dillman, J.F.2
  • 87
    • 0034567094 scopus 로고    scopus 로고
    • Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin
    • Sabourin C.L., Petrali J.P., and Casillas R.P. Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin. J. Biochem. Mol. Toxicol. 14 (2000) 291-302
    • (2000) J. Biochem. Mol. Toxicol. , vol.14 , pp. 291-302
    • Sabourin, C.L.1    Petrali, J.P.2    Casillas, R.P.3
  • 88
    • 0036952731 scopus 로고    scopus 로고
    • Cytokine, chemokine, and matrix metalloproteinase response after sulfur mustard injury to weanling pig skin
    • Sabourin C.L., Danne M.M., Buxton K.L., Casillas R.P., and Schlager J.J. Cytokine, chemokine, and matrix metalloproteinase response after sulfur mustard injury to weanling pig skin. J. Biochem. Mol. Toxicol. 16 (2002) 263-272
    • (2002) J. Biochem. Mol. Toxicol. , vol.16 , pp. 263-272
    • Sabourin, C.L.1    Danne, M.M.2    Buxton, K.L.3    Casillas, R.P.4    Schlager, J.J.5
  • 89
    • 0033998195 scopus 로고    scopus 로고
    • Effect of intracellular calcium modulation on sulfur mustard cytotoxicity in cultured human neonatal keratinocytes
    • Sawyer T.W., and Hamilton M.G. Effect of intracellular calcium modulation on sulfur mustard cytotoxicity in cultured human neonatal keratinocytes. Toxicol. In Vitro 14 (2000) 149-157
    • (2000) Toxicol. In Vitro , vol.14 , pp. 149-157
    • Sawyer, T.W.1    Hamilton, M.G.2
  • 90
    • 0030296415 scopus 로고    scopus 로고
    • Protective effect of an inhibitor of nitric oxide synthase on sulphur mustard toxicity in vitro
    • Sawyer T.W., Lundy P.M., and Weiss M.T. Protective effect of an inhibitor of nitric oxide synthase on sulphur mustard toxicity in vitro. Toxicol. Appl. Pharmacol. 141 (1996) 138-144
    • (1996) Toxicol. Appl. Pharmacol. , vol.141 , pp. 138-144
    • Sawyer, T.W.1    Lundy, P.M.2    Weiss, M.T.3
  • 91
    • 0029115193 scopus 로고
    • Ultraviolet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-alpha in the formation of sunburn cells
    • Schwarz A., Bhardwaj R., Aragane Y., Mahnke K., Riemann H., Metze D., Luger T.A., and Schwarz T. Ultraviolet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-alpha in the formation of sunburn cells. J. Invest. Dermatol. 104 (1995) 922-927
    • (1995) J. Invest. Dermatol. , vol.104 , pp. 922-927
    • Schwarz, A.1    Bhardwaj, R.2    Aragane, Y.3    Mahnke, K.4    Riemann, H.5    Metze, D.6    Luger, T.A.7    Schwarz, T.8
  • 92
    • 0035930396 scopus 로고    scopus 로고
    • Mitochondrial and nuclear DNA damage induced by sulphur mustard in keratinocytes
    • Shahin S., Cullinane C., and Gray P.J. Mitochondrial and nuclear DNA damage induced by sulphur mustard in keratinocytes. Chem. Biol. Interact. 138 (2001) 231-245
    • (2001) Chem. Biol. Interact. , vol.138 , pp. 231-245
    • Shahin, S.1    Cullinane, C.2    Gray, P.J.3
  • 94
    • 0024368696 scopus 로고
    • Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes
    • Shi Y.F., Sahai B.M., and Green D.R. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature 339 (1989) 625-626
    • (1989) Nature , vol.339 , pp. 625-626
    • Shi, Y.F.1    Sahai, B.M.2    Green, D.R.3
  • 95
    • 0036121272 scopus 로고    scopus 로고
    • Apoptosome: the cellular engine for the activation of caspase-9
    • Shi Y. Apoptosome: the cellular engine for the activation of caspase-9. Structure 10 (2002) 285-288
    • (2002) Structure , vol.10 , pp. 285-288
    • Shi, Y.1
  • 96
    • 0030895188 scopus 로고    scopus 로고
    • Immunohistochemical localization of nitric oxide synthase in normal human skin: expression of endothelial-type and inducible-type nitric oxide synthase in keratinocytes
    • Shimizu Y., Sakai M., Umemura Y., and Ueda H. Immunohistochemical localization of nitric oxide synthase in normal human skin: expression of endothelial-type and inducible-type nitric oxide synthase in keratinocytes. J. Dermatol. 24 (1997) 80-87
    • (1997) J. Dermatol. , vol.24 , pp. 80-87
    • Shimizu, Y.1    Sakai, M.2    Umemura, Y.3    Ueda, H.4
  • 99
    • 6244275503 scopus 로고
    • On dichloroethylsulfide (mustard gas) IV. The mechanism of absorption by the skin
    • Smith H.W., Clowes G.H.A., and Marshall E.K. On dichloroethylsulfide (mustard gas) IV. The mechanism of absorption by the skin. J. Pharmacol. Exp. Ther. 13 (1919) 1-30
    • (1919) J. Pharmacol. Exp. Ther. , vol.13 , pp. 1-30
    • Smith, H.W.1    Clowes, G.H.A.2    Marshall, E.K.3
  • 101
    • 0031081132 scopus 로고    scopus 로고
    • Histopathologic features seen with different animal models following cutaneous sulfur mustard exposure
    • Smith K.J., Casillas R., Graham J., Skelton H.G., Stemler F., and Hackley Jr. B.E. Histopathologic features seen with different animal models following cutaneous sulfur mustard exposure. J. Dermatol. Sci. 14 (1997) 126-135
    • (1997) J. Dermatol. Sci. , vol.14 , pp. 126-135
    • Smith, K.J.1    Casillas, R.2    Graham, J.3    Skelton, H.G.4    Stemler, F.5    Hackley Jr., B.E.6
  • 103
    • 0036022402 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update
    • Soldani C., and Scovassi A.I. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis 7 (2002) 321-328
    • (2002) Apoptosis , vol.7 , pp. 321-328
    • Soldani, C.1    Scovassi, A.I.2
  • 104
    • 33744477102 scopus 로고    scopus 로고
    • Mechanisms of doxycycline-induced cytotoxicity on human bronchial epithelial cells
    • Sourdeval M., Lemaire C., Brenner C., Boisvieux-Ulrich E., and Marano F. Mechanisms of doxycycline-induced cytotoxicity on human bronchial epithelial cells. Front. Biosci. 11 (2006) 3036-3048
    • (2006) Front. Biosci. , vol.11 , pp. 3036-3048
    • Sourdeval, M.1    Lemaire, C.2    Brenner, C.3    Boisvieux-Ulrich, E.4    Marano, F.5
  • 105
    • 33747384627 scopus 로고    scopus 로고
    • Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis
    • Sourdeval M., Lemaire C., Deniaud A., Taysse L., Daulon S., Breton P., Brenner C., Boisvieux-Ulrich E., and Marano F. Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis 11 (2006) 1545-1559
    • (2006) Apoptosis , vol.11 , pp. 1545-1559
    • Sourdeval, M.1    Lemaire, C.2    Deniaud, A.3    Taysse, L.4    Daulon, S.5    Breton, P.6    Brenner, C.7    Boisvieux-Ulrich, E.8    Marano, F.9
  • 108
    • 0242656497 scopus 로고    scopus 로고
    • Death receptor-induced cell killing
    • Thorburn A. Death receptor-induced cell killing. Cell Signal. 16 (2004) 139-144
    • (2004) Cell Signal. , vol.16 , pp. 139-144
    • Thorburn, A.1
  • 109
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation
    • Viatour P., Merville M.P., Bours V., and Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem. Sci. 30 (2005) 43-52
    • (2005) Trends Biochem. Sci. , vol.30 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 111
    • 0032401880 scopus 로고    scopus 로고
    • Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation
    • Wright S.C., Wang H., Wei Q.S., Kinder D.H., and Larrick J.W. Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation. Cancer Res. 58 (1998) 5570-5576
    • (1998) Cancer Res. , vol.58 , pp. 5570-5576
    • Wright, S.C.1    Wang, H.2    Wei, Q.S.3    Kinder, D.H.4    Larrick, J.W.5
  • 113
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., and Korsmeyer S.J. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 (1995) 285-291
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 114


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