Biomaterial-based scaffolds-current status and future directions

Expert Opinion on Drug Delivery

Volumn 11, Issue 5, 2014, Pages 767-789

  Garg, Tarun ^a   Goyal, Amit K ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

Biomaterial based scaffold; Hydrogels; Microspheres; Nano fibre; Porous matrix

Indexed keywords

BIOMATERIAL; CIPROFLOXACIN; CLOTRIMAZOLE; CYANOCOBALAMIN; CYCLOPHANE DERIVATIVE; DICLOFENAC; FENRETINIDE; FLUOROURACIL; GENTAMICIN; IBUPROFEN; IMIDAZOLE DERIVATIVE; INDOMETACIN; INFLIXIMAB; INSULIN; LIDOCAINE; MEPACRINE; METFORMIN; MICROSPHERE; MOXIFLOXACIN; NANOFIBER; ORNIDAZOLE; POLYMER; PROPRANOLOL; RECOMBINANT DNA; RUTOSIDE; SILVER; SILVER IMIDAZOLE CYCLOPHANE; SIMVASTATIN; TACROLIMUS; TRICLOSAN; UNCLASSIFIED DRUG; TISSUE SCAFFOLD;

ADHESION; ADIPOSE DERIVED STEM CELL; ANTERIOR CRUCIATE LIGAMENT; BINDING AFFINITY; BIOCOMPATIBILITY; BIODEGRADABILITY; BONE DEFECT; CARDIOVASCULAR DISEASE; CARTILAGE; CARTILAGE CELL; CHEMICAL ANALYSIS; DENSITY; DIFFUSION; DRUG DELIVERY SYSTEM; EMBRYONIC STEM CELL; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; FLOW KINETICS; FOAMING; FREEZE DRYING; GAS; GEL; GELATION; GENE DELIVERY SYSTEM; HEART MUSCLE CELL; HUMAN; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; MELTING POINT; MESENCHYMAL STEM CELL; MORPHOLOGY; NANOFABRICATION; NONHUMAN; OSTEOBLAST; PANCREAS ISLET CELL; PC12 CELL LINE; PERIODONTAL DISEASE; POLYMERIZATION; POROSITY; REVIEW; SCANNING ELECTRON MICROSCOPY; SKELETAL MUSCLE SATELLITE CELL; SKIN DISEASE; SPRAY DRYING; STEM CELL; STRENGTH; SUPERCRITICAL FLUID; THERMAL ANALYSIS; TISSUE ENGINEERING; TUBERCULOSIS; WOUND DRESSING; CHEMISTRY; MEDICINAL CHEMISTRY; METHODOLOGY;

BIOCOMPATIBLE MATERIALS; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; HUMANS; MICROSPHERES; POLYMERS; POROSITY; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84899123590     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2014.891014     Document Type: Review

References (165)

1. Garg T, Singh S, Goyal AK. Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery. Crit Rev Ther Drug Carrier Syst 2013;30(5):369-409 . An excellent summary of the types of hydrogels.
2. Centola M, Abbruzzese F, Scotti C, et al. Scaffold-based delivery of a clinically relevant anti-angiogenic drug promotes the formation of in vivo stable cartilage. Tissue Eng Part A 2013;19(17-18):1960-71
3. Whang K, Goldstick TK, Healy KE. A biodegradable polymer scaffold for delivery of osteotropic factors. Biomaterials 2000;21(24):2545-51
4. Batrakova EV, Gendelman HE, Kabanov AV. Cell-mediated drug delivery. Expert Opin Drug Deliv 2011;8(4):415-33 . An excellent summary on cell mediated drug delivery systems.
5. Foged C, Nielsen HM. Cell-penetrating peptides for drug delivery across membrane barriers. Expert Opin Drug Deliv 2008;5(1):105-17 (Pubitemid 351234112)
6. Gerberich BG, Bhatia SK. Tissue scaffold surface patterning for clinical applications. Biotechnol J 2013;8(1):73-84 . An important article that discuss the clinical application of tissue scaffolds.
7. Rath SN, Arkudas A, Lam CX, et al. Development of a pre-vascularized 3D scaffold-hydrogel composite graft using an arterio-venous loop for tissue engineering applications. J Biomater Appl 2012;27(3):277-89
8. Loh XJ, Peh P, Liao S, et al. Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers. J Control Release 2010;143(2):175-82
9. Hutmacher D, Bowlin GL. Nano-fiber scaffold science and tissue engineering. Foreword. J Biomater Sci Polym Ed 2008;19(5):541-2
10. Tuzlakoglu K, Bolgen N, Salgado AJ, et al. Nano- and micro-fiber combined scaffolds: a new architecture for bone tissue engineering. J Mater Sci Mater Med 2005;16(12):1099-104 (Pubitemid 41803733)
11. Teles H, Vermonden T, Eggink G, et al. Hydrogels of collagen-inspired telechelic triblock copolymers for the sustained release of proteins. J Control Release 2010;147(2):298-303
12. Ashley GW, Henise J, Reid R, et al. Hydrogel drug delivery system with predictable and tunable drug release and degradation rates. Proc Natl Acad Sci USA 2013;110(6):2318-23
13. Johnson TD, Christman KL. Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction. Expert Opin Drug Deliv 2013;10(1):59-72
14. Huynh DP, Im GJ, Chae SY, et al. Controlled release of insulin from pH/ temperature-sensitive injectable pentablock copolymer hydrogel. J Control Release 2009;137(1):20-4
15. Kianfar F, Ayensu I, Boateng JS. Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system. Drug Dev Ind Pharm 2014;40(3):361-9
16. Cheng QY, Han BH. Supramolecular hydrogel based on graphene oxides for controlled release system. J Nanosci Nanotechnol 2013;13(2):755-60
17. Lee J, Oh YJ, Lee SK, et al. Facile control of porous structures of polymer microspheres using an osmotic agent for pulmonary delivery. J Control Release 2010;146(1):61-7
18. Zhang J, Tang Q, Xu X, et al. Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery. Int J Pharm 2013;448(1):168-74
19. Kim SE, Park JH, Cho YW, et al. Porous chitosan scaffold containing microspheres loaded with transforming growth factor-beta1: implications for cartilage tissue engineering. J Control Release 2003;91(3):365-74 (Pubitemid 36976767)
20. Jain RA, Rhodes CT, Railkar AM, et al. Controlled delivery of drugs from a novel injectable in situ formed biodegradable PLGA microsphere system. J Microencapsul 2000;17(3):343-62 (Pubitemid 30235007)
21. Parnami N, Garg T, Rath G, et al. Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. Artif Cells Nanomed Biotechnol 2013. [Epub ahead of print]
22. Hu Y, Zhang C, Zhang S, et al. Development of a porous poly(L-lactic acid)/hydroxyapatite/collagen scaffold as a BMP delivery system and its use in healing canine segmental bone defect. J Biomed Mater Res A 2003;67(2):591-8 (Pubitemid 37522466)
23. Kovacs EW, Hooker JM, Romanini DW, et al. Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system. Bioconjug Chem 2007;18(4):1140-7 (Pubitemid 47122635)
24. Niu X, Fan Y, Liu X, et al. Repair of bone defect in femoral condyle using microencapsulated chitosan, nanohydroxyapatite/collagen and poly (L-lactide)-based microsphere-scaffold delivery system. Artif Organs 2011;35(7):E119-28
25. Son JS, Appleford M, Ong JL, et al. Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres. J Control Release 2011;153(2):133-40
26. Garg T, Singh O, Arora S, et al. Scaffold: a novel carrier for cell and drug delivery. Crit Rev Ther Drug Carrier Syst 2012;29(1):1-63 . A good summary of different polymers used for fabrication of scaffolds.
27. Fatunmbi HO, Bruch MD. Characterization of the structural morphology of chemically modified silica prepared by surface polymerization of a mixture of long and short alkyl chains using 13C and 29Si NMR spectroscopy. Langmuir 2013;29(16):4974-87
28. Hu W, Jiang A, Jin L, et al. Effect of heat treatment on quality, thermal and pasting properties of sweet potato starch during yearlong storage. J Sci Food Agric 2011;91(8):1499-504
29. Brus C, Kleemann E, Aigner A, et al. Stabilization of oligonucleotidepolyethylenimine complexes by freezedrying: physicochemical and biological characterization. J Control Release 2004;95(1):119-31 (Pubitemid 38167686)
30. Junwei Z, Jinping L, Xiaojuan Q. Thermal stability analysis under embankment with asphalt pavement and cement pavement in permafrost regions. ScientificWorldJournal 2013;2013:549623
31. Tang J, Yao J, Shi J, et al. Synthesis, characterization, drug-loading capacity and safety of novel pH-independent amphiphilic amino acid copolymer micelles. Die Pharmazie 2012;67(9):756-64
32. Fu J, Wang D, Wang T, et al. High entrapment efficiency of chitosan/ polylactic acid/tripolyphotspate nanosized microcapsules for rapamycin by an emulsion-evaporation approach. J Biomed Nanotechnol 2010;6(6):725-8
33. Hwang K, Hwang PJ, Huan F, et al. Degree of swelling of the medial rectus muscle on CT images to differentiate old from new medial orbital wall fracture. J Craniofac Surg 2012;23(4):1174-5
34. Hagerstrom H, Edsman K. Interpretation of mucoadhesive properties of polymer gel preparations using a tensile strength method. J Pharm Pharmacol 2001;53(12):1589-99 (Pubitemid 34044247)
35. Lima AC, Sher P, Mano JF. Production methodologies of polymeric and hydrogel particles for drug delivery applications. Expert Opin Drug Deliv 2012;9(2):231-48
36. Aoshima M, Satoh A, Chantrell RW, et al. Rheological properties and orientational distributions of dilute ferromagnetic spherocylinder particle dispersions. Part II. Analysis for the two typical magnetic field directions. J Colloid Interface Sci 2002;253(2):455-64 (Pubitemid 35351923)
37. Koli JM, Basu S, Nayak BB, et al. Improvement of gel strength and melting point of fish gelatin by addition of coenhancers using response surface methodology. J Food Sci 2011;76(6):E503-9
38. Xu K, Hao Y. Determination of the density of human nuclear cataract lenses. Mol Med Rep 2013;8(5):1300-4
39. Codling DJ, Zheng G, Stait-Gardner T, et al. Diffusion studies of dihydroxybenzene isomers in water-alcohol systems. J Phys Chem B 2013;117(9):2734-41
40. Zachariadis GA, Tzollas NM, Nikolaou M, et al. Storage stability studies for tributyltin determination in human urine samples using headspace solid-phase microextraction and gas chromatography mass spectrometry. Biomed Chromatogr 2013;27(3):299-305
41. Petersen S, Hussner J, Reske T, et al. In vitro study of dual drug-eluting stents with locally focused sirolimus and atorvastatin release. J Mater Sci Mater Med 2013;24(11):2589-600
42. Xu Y, Wang Y, Li XM, et al. Study on the release of fenofibrate nanosuspension in vitro and its correlation with in situ intestinal and in vivo absorption kinetics in rats. Drug Dev Ind Pharm 2013. [Epub ahead of print]
43. Langdon SR, Westwood IM, van Montfort RL, et al. Scaffold-focused virtual screening: prospective application to the discovery of TTK inhibitors. J Chem Inf Model 2013;53(5):1100-12
44. Sohier J, Vlugt TJ, Cabrol N, et al. Dual release of proteins from porous polymeric scaffolds. J Control Release 2006;111(1-2):95-106 (Pubitemid 43292485)
45. Zervantonakis IK, Hughes-Alford SK, Charest JL, et al. Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci USA 2012;109(34):13515-20
46. Na SY, Oh SH, Song KS, et al. Hyaluronic acid/mildly crosslinked alginate hydrogel as an injectable tissue adhesion barrier. J Mater Sci Mater Med 2012;23(9):2303-13
47. Kumar PT, Lakshmanan VK, Anilkumar TV, et al. Flexible and microporous chitosan hydrogel/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation. ACS Appl Mater Interfaces 2012;4(5):2618-29
48. Deriase SF, Farahat LM, El-Batal AI. Optimization of process parameters for the continuous ethanol production by Kluyveromyces lactis immobilized cells in hydrogel copolymer carrier. Acta Microbiol Pol 2001;50(1):45-51 (Pubitemid 32537260)
49. Hadizadeh F, Moghadam MH, Mohajeri SA. Application of molecularly imprinted hydrogel for the preparation of lactose-free milk. J Sci Food Agric 2013;93(2):304-9
50. Mikos AG, Herring SW, Ochareon P, et al. Engineering complex tissues. Tissue Eng 2006;12(12):3307-39 . A good summary of research as well as clinical importance of biomaterial-based scaffolds. (Pubitemid 46037158)
51. Nath SD, Linh NT, Sadiasa A, et al. Encapsulation of simvastatin in PLGA microspheres loaded into hydrogel loaded BCP porous spongy scaffold as a controlled drug delivery system for bonetissue regeneration. J Biomater Appl 2013. [Epub ahead of print]
52. Kundu B, Lemos A, Soundrapandian C, et al. Development of porous HAp and beta-TCP scaffolds by starch consolidation with foaming method and drug-chitosan bilayered scaffold based drug delivery system. J Mater Sci Mater Med 2010;21(11):2955-69
53. Wang J, Cui W, Ye J, et al. A cellular delivery system fabricated with autologous BMSCs and collagen scaffold enhances angiogenesis and perfusion in ischemic hind limb. J Biomed Mater Res A 2012;100(6):1438-47
54. Yoon H, Kim G. A three-dimensional polycaprolactone scaffold combined with a drug delivery system consisting of electrospun nanofibers. J Pharm Sci 2011;100(2):424-30
55. Niwa T, Shimabara H, Danjo K. Novel spray freeze-drying technique using fourfluid nozzle-development of organic solvent system to expand its application to poorly water soluble drugs. Chem Pharm Bull (Tokyo) 2010;58(2):195-200
56. Hu C, Tercero C, Ikeda S, et al. Biodegradable porous sheet-like scaffolds for soft-tissue engineering using a combined particulate leaching of salt particles and magnetic sugar particles. J Biosci Bioeng 2013;116(1):126-31
57. Nam YS, Yoon JJ, Park TG. A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive. J Biomed Mater Res 2000;53(1):1-7 (Pubitemid 30056615)
58. Dhanda DS, Tyagi P, Mirvish SS, et al. Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose. J Control Release 2013;168(3):239-50
59. Oh SH, Park SC, Kim HK, et al. Degradation Behavior of 3D Porous Polydioxanone-b-Polycaprolactone Scaffolds Fabricated Using the Melt-Molding Particulate-Leaching Method. J Biomater Sci Polym Ed 2010. [Epub ahead of print]
60. Musumeci T, Bucolo C, Carbone C, et al. Polymeric nanoparticles augment the ocular hypotensive effect of melatonin in rabbits. Int J Pharm 2013;440(2):135-40
61. Blaker JJ, Knowles JC, Day RM. Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery. Acta Biomater 2008;4(2):264-72 (Pubitemid 351218102)
62. Yin A, Zhang K, McClure MJ, et al. Electrospinning collagen/chitosan/poly (L-lactic acid-co-epsilon-caprolactone) to form a vascular graft: mechanical and biological characterization. J Biomed Mater Res A 2013;101(5):1292-301
63. Zhang J, Sun Q, Liang R, et al. Microfiber Fabry-Perot interferometer fabricated by taper-drawing technique and its application as a radio frequency interrogated refractive index sensor. Opt Lett 2012;37(14):2925-7
64. Qi A, Chan P, Ho J, et al. Template-free synthesis and encapsulation technique for layer-by-layer polymer nanocarrier fabrication. ACS Nano 2011;5(12):9583-91
65. Tsuboi Y, Yoshida Y, Okada K, et al. Phase separation dynamics of aqueous solutions of thermoresponsive polymers studied by a laser T-jump technique. J Phys Chem B 2008;112(9):2562-5 (Pubitemid 351472961)
66. Endres T, Zheng M, Beck-Broichsitter M, et al. Optimising the self-assembly of siRNA loaded PEG-PCL-lPEI nano-carriers employing different preparation techniques. J Control Release 2012;160(3):583-91
67. Paquay YC, De Ruijter AE, van der Waerden JP, et al. A one stage versus two stage surgical technique. Tissue reaction to a percutaneous device provided with titanium fiber mesh applicable for peritoneal dialysis. ASAIO J 1996;42(6):961-7
68. Goncalves AP, Ogliari Ade O, Jardim Pdos S, et al. Chemical cleaning agents and bonding to glass-fiber posts. Braz Oral Res 2013;27(1):70-2
69. Sahni J, Raj S, Ahmad FJ, et al. Design and in vitro characterization of buccoadhesive drug delivery system of insulin. Indian J Pharm Sci 2008;70(1):61-5 (Pubitemid 351670570)
70. Konishi M, Tabata Y, Kariya M, et al. In vivo anti-tumor effect of dual release of cisplatin and adriamycin from biodegradable gelatin hydrogel. J Control Release 2005;103(1):7-19 (Pubitemid 40248557)
71. Attia J, Remita S, Jonic S, et al. Radiation-induced synthesis and cryo-TEM characterization of silver nanoshells on linoleate spherical micelles. Langmuir 2007;23(19):9523-6 (Pubitemid 47507969)
72. Guo BL, Gao QY. Preparation and properties of a pH/temperatureresponsive carboxymethyl chitosan/poly (N-isopropylacrylamide)semi-IPN hydrogel for oral delivery of drugs. Carbohydr Res 2007;342(16):2416-22
73. Zhang W, Zhang Z, Wang X. Investigation on surface molecular conformations and pervaporation performance of the poly(vinyl alcohol) (PVA) membrane. J Colloid Interface Sci 2009;333(1):346-53
74. Khademhosseini A, Langer R. Microengineered hydrogels for tissue engineering. Biomaterials 2007;28(34):5087-92 (Pubitemid 47488484)
75. Olive D, Mawas C. Therapeutic applications of anti-CD4 antibodies. Crit Rev Ther Drug Carrier Syst 1993;10(1):29-63 (Pubitemid 23107932)
76. Rolland JP, Maynor BW, Euliss LE, et al. Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials. J Am Chem Soc 2005;127(28):10096-100 (Pubitemid 40995455)
77. Kloxin AM, Kasko AM, Salinas CN, et al. Photodegradable hydrogels for dynamic tuning of physical and chemical properties. Science 2009;324(5923):59-63
78. Panda P, Ali S, Lo E, et al. Stop-flow lithography to generate cell-laden microgel particles. Lab Chip 2008;8(7):1056-61 (Pubitemid 351904833)
79. Nava-Arzaluz MG, Pinon-Segundo E, Ganem-Rondero A, et al. Single emulsion-solvent evaporation technique and modifications for the preparation of pharmaceutical polymeric nanoparticles. Recent Pat Drug Deliv Formul 2012;6(3):209-23
80. Pinon-Segundo E, Nava-Arzaluz MG, Lechuga-Ballesteros D. Pharmaceutical polymeric nanoparticles prepared by the double emulsion- solvent evaporation technique. Recent Pat Drug Deliv Formul 2012;6(3):224-35
81. Campistol JM, Bernard D, Papastoitsis G, et al. Polymerization of normal and intact beta 2-microglobulin as the amyloidogenic protein in dialysis-amyloidosis. Kidney Int 1996;50(4):1262-7 (Pubitemid 26342833)
82. van Dijken JW, Horstedt P, Waern R. Directed polymerization shrinkage versus a horizontal incremental filling technique: interfacial adaptation in vivo in Class II cavities. Am J Dent 1998;11(4):165-72 (Pubitemid 128505196)
83. Genc L, Demirel M, Guler E, et al. Microencapsulation of ketorolac tromethamine by means of a coacervation-phase separation technique induced by the addition of non-solvent. J Microencapsul 1998;15(1):45-53 (Pubitemid 28031789)
84. Monajjemzadeh F, Valizadeh H, Alasty P, et al. Spray drying as a fast and simple technique for the preparation of extended release dipyridamole (DYP) microparticles in a fixed dose combination (FDC) product with aspirin. Drug Res (Stuttg) 2013. [Epub ahead of print]
85. Liang L, Horvat M, Cernichiari E, et al. Simple solvent extraction technique for elimination of matrix interferences in the determination of methylmercury in environmental and biological samples by ethylation-gas chromatography-cold vapor atomic fluorescence spectrometry. Talanta 1996;43(11):1883-8 (Pubitemid 26352163)
86. Ahmad MZ, Akhter S, Ahmad I, et al. In vitro and in vivo evaluation of Assam Bora rice starch-based bioadhesive microsphere as a drug carrier for colon targeting. Expert Opin Drug Deliv 2012;9(2):141-9
87. Goyal G, Garg T, Malik B, et al. Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug Deliv 2013. [Epub ahead of print]
88. Ige PP, Gattani SG. Design and in vitro and in vivo characterization of mucoadhesive matrix pellets of metformin hydrochloride for oral controlled release: a technical note. Arch Pharm Res 2012;35(3):487-98
89. Wang M, Coffer JL, Dorraj K, et al. Sustained antibacterial activity from triclosan-loaded nanostructured mesoporous silicon. Mol Pharm 2010;7(6):2232-9
90. Asghar LF, Chandran S. Design and evaluation of matrices of Eudragit with polycarbophil and carbopol for colon-specific delivery. J Drug Target 2008;16(10):741-57
91. Phaechamud T. Variables influencing drug release from layered matrix system comprising hydroxypropyl methylcellulose. AAPS PharmSciTech 2008;9(2):668-74
92. Fernandez-Carballido A, Pastoriza P, Barcia E, et al. PLGA/PEG-derivative polymeric matrix for drug delivery system applications: characterization and cell viability studies. Int J Pharm 2008;352(1-2):50-7 (Pubitemid 351273913)
93. Phaechamud T, Ritthidej GC. Sustained-release from layered matrix system comprising chitosan and xanthan gum. Drug Dev Ind Pharm 2007;33(6):595-605 (Pubitemid 47035891)
94. Sweet JL, Pillay V, Choonara YE. Design and development of a novel controlled release PLGA alginate-pectinate polyspheric drug delivery system. Drug Deliv 2007;14(5):309-18 (Pubitemid 47027043)
95. Chung TW, Yang MC, Tsai WJ. A fibrin encapsulated liposomes-in-chitosan matrix (FLCM) for delivering water-soluble drugs. Influences of the surface properties of liposomes and the crosslinked fibrin network. Int J Pharm 2006;311(1-2):122-9
96. Chang NJ, Lam CF, Lin CC, et al. Transplantation of autologous endothelial progenitor cells in porous PLGA scaffolds create a microenvironment for the regeneration of hyaline cartilage in rabbits. Osteoarthritis Cartilage 2013;21(10):1613-22
97. He X, Dziak R, Yuan X, et al. BMP2 genetically engineered MSCs and EPCs promote vascularized bone regeneration in rat critical-sized calvarial bone defects. PLoS One 2013;8(4):e60473
98. Phull MK, Eydmann T, Roxburgh J, et al. Novel macro-microporous gelatin scaffold fabricated by particulate leaching for soft tissue reconstruction with adipose-derived stem cells. J Mater Sci Mater Med 2013;24(2):461-7
99. Hwang HD, Cho HJ, Balakrishnan P, et al. Cross-linked hyaluronic acid-based flexible cell delivery system: application for chondrogenic differentiation. Colloids Surf B Biointerfaces 2012;91:106-13
100. Lee GS, Park JH, Shin US, et al. Direct deposited porous scaffolds of calcium phosphate cement with alginate for drug delivery and bone tissue engineering. Acta Biomater 2011;7(8):3178-86
101. Oh SH, Kim TH, Jang SH, et al. Hydrophilized 3D porous scaffold for effective plasmid DNA delivery. J Biomed Mater Res A 2011;97(4):441-50
102. Singh D, Tripathi A, Nayak V, et al. Proliferation of chondrocytes on a 3-d modelled macroporous poly(hydroxyethyl methacrylate)-gelatin cryogel. J Biomater Sci Polym Ed 2011;22(13):1733-51
103. Pasquinelli G, Orrico C, Foroni L, et al. Mesenchymal stem cell interaction with a non-woven hyaluronan-based scaffold suitable for tissue repair. J Anat 2008;213(5):520-30
104. Sarojini H, Medepalli K, Terry DA, et al. Localized delivery of DNA to the cells by viral collagen-loaded silica colloidal crystals. BioTechniques 2007;43(2):213-14; 16-8, 20-1
105. Grenier S, Sandig M, Mequanint K. Polyurethane biomaterials for fabricating 3D porous scaffolds and supporting vascular cells. J Biomed Mater Res A 2007;82(4):802-9 (Pubitemid 47312895)
106. Hidalgo-Bastida LA, Barry JJ, Everitt NM, et al. Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering. Acta Biomater 2007;3(4):457-62 (Pubitemid 46865782)
107. Madhaiyan K, Sridhar R, Sundarrajan S, et al. Vitamin B12 loaded polycaprolactone nanofibers: a novel transdermal route for the water soluble energy supplement delivery. Int J Pharm 2013;444(1-2):70-6
108. Chen M, Gao S, Dong M, et al. Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. ACS Nano 2012;6(6):4835-44
109. Sundar SS, Sangeetha D. Fabrication and evaluation of electrospun collagen/poly (N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery. J Mater Sci Mater Med 2012;23(6):1421-30
110. Montero RB, Vial X, Nguyen DT, et al. bFGF-containing electrospun gelatin scaffolds with controlled nano-architectural features for directed angiogenesis. Acta Biomater 2012;8(5):1778-91
111. Li L, Chu CC. Nitroxyl radical incorporated electrospun biodegradable poly(ester Amide) nanofiber membranes. J Biomater Sci Polym Ed 2009;20(3):341-61
112. Jia B, Zhou J, Zhang L. Electrospun nano-fiber mats containing cationic cellulose derivatives and poly (vinyl alcohol) with antibacterial activity. Carbohydr Res 2011;346(11):1337-41
113. Hwang S, Jeong S. Electrospun nano composites of poly(vinyl pyrrolidone)/ nano-silver for antibacterial materials. J Nanosci Nanotechnol 2011;11(1):610-13
114. Nguyen TH, Kim YH, Song HY, et al. Nano Ag loaded PVA nano-fibrous mats for skin applications. J Biomed Mater Res Appl Biomater 2011;96(2):225-33
115. Mutsuga M, Narita Y, Yamawaki A, et al. Development of novel drug-eluting biodegradable nano-fiber for prevention of postoperative pulmonary venous obstruction. Interact Cardiovasc Thorac Surg 2009;8(4):402-6; discussion 06-7
116. Melaiye A, Sun Z, Hindi K, et al. Silver (I)-imidazole cyclophane gem-diol complexes encapsulated by electrospun tecophilic nanofibers: formation of nanosilver particles and antimicrobial activity. J Am Chem Soc 2005;127(7):2285-91 (Pubitemid 40270533)
117. Manning CN, Schwartz AG, Liu W, et al. Controlled delivery of mesenchymal stem cells and growth factors using a nanofiber scaffold for tendon repair. Acta Biomater 2013;9(6):6905-14
118. Xie J, Willerth SM, Li X, et al. The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. Biomaterials 2009;30(3):354-62
119. Lee JY, Nam SH, Im SY, et al. Enhanced bone formation by controlled growth factor delivery from chitosanbased biomaterials. J Control Release 2002;78(1-3):187-97
120. Kim H, Suh H, Jo SA, et al. In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate. Biochem Biophys Res Commun 2005;332(4):1053-60 (Pubitemid 40798192)
121. Wang X, Wenk E, Zhang X, et al. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. J Control Release 2009;134(2):81-90
122. Prescott RS, Alsanea R, Fayad MI, et al. In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod 2008;34(4):421-6
123. Mao GH, Chen GA, Bai HY, et al. The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells. Biomaterials 2009;30(9):1706-14
124. Cooper JA, Lu HH, Ko FK, et al. Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation. Biomaterials 2005;26(13):1523-32 (Pubitemid 39441385)
125. Park JS, Woo DG, Sun BK, et al. In vitro and in vivo test of PEG/PCL-based hydrogel scaffold for cell delivery application. J Control Release 2007;124(1-2):51-9 (Pubitemid 350103733)
126. Nanjwade BK, Deshmukh RV, Gaikwad KR, et al. Formulation and evaluation of micro hydrogel of Moxifloxacin hydrochloride. Eur J Drug Metab Pharmacokinet 2012;37(2):117-23
127. Pignatello R, Basile L, Puglisi G. Chitosan glutamate hydrogels with local anesthetic activity for buccal application. Drug Deliv 2009;16(3):176-81
128. Singh B, Sharma N. Mechanistic implication for cross-linking in sterculiabased hydrogels and their use in GIT drug delivery. Biomacromolecules 2009;10(9):2515-32
129. Chaturvedi K, Ganguly K, Nadagouda MN, et al. Polymeric hydrogels for oral insulin delivery. J Control Release 2013;165(2):129-38
130. El-Leithy ES, Shaker DS, Ghorab MK, et al. Evaluation of mucoadhesive hydrogels loaded with diclofenac sodium-chitosan microspheres for rectal administration. AAPS PharmSciTech 2010;11(4):1695-702
131. Chang JY, Oh YK, Kong HS, et al. Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis. J Control Release 2002;82(1):39-50
132. Almeida JS, Benvegnu DM, Boufleur N, et al. Hydrogels containing rutin intended for cutaneous administration: efficacy in wound healing in rats. Drug Dev Ind Pharm 2012;38(7):792-9
133. Fukui T, Ii M, Shoji T, et al. Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing. J Bone Miner Res 2012;27(5):1118-31
134. Das A, Wadhwa S, Srivastava AK. Cross-linked guar gum hydrogel discs for colon-specific delivery of ibuprofen: formulation and in vitro evaluation. Drug Deliv 2006;13(2):139-42 (Pubitemid 43162310)
135. Vaghani SS, Patel MM, Satish CS, et al. Synthesis and characterization of carboxymethyl chitosan hydrogel: application as pH-sensitive delivery for nateglinide. Curr Drug Deliv 2012;9(6):628-36
136. Moshaverinia A, Xu X, Chen C, et al. Dental mesenchymal stem cells encapsulated in an alginate hydrogel codelivery microencapsulation system for cartilage regeneration. Acta Biomater 2013;9(12):9343-50
137. Zustiak SP, Pubill S, Ribeiro A, et al. Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds as a cell delivery vehicle: characterization of PC12 cell response. Biotechnol Prog 2013;29(5):1255-64
138. Ding K, Yang Z, Zhang YL, et al. Injectable thermosensitive chitosan/ beta-glycerophosphate/collagen hydrogel maintains the plasticity of skeletal muscle satellite cells and supports their in vivo viability. Cell Biol Int 2013;37(9):977-87
139. Wang L, Rao RR, Stegemann JP. Delivery of mesenchymal stem cells in chitosan/collagen microbeads for orthopedic tissue repair. Cells Tissues Organs 2013;197(5):333-43
140. Hassan W, Dong Y, Wang W. Encapsulation and 3D culture of human adipose-derived stem cells in an in-situ crosslinked hybrid hydrogel composed of PEG-based hyperbranched copolymer and hyaluronic acid. Stem Cell Res Ther 2013;4(2):32
141. Halberstadt C, Robbins N, McCoy DW, et al. Formulation of selected renal cells for implantation into a kidney. Methods Mol Biol 2013;1001:279-87
142. Mothe AJ, Tam RY, Zahir T, et al. Repair of the injured spinal cord by transplantation of neural stem cells in a hyaluronan-based hydrogel. Biomaterials 2013;34(15):3775-83
143. Popa EG, Caridade SG, Mano JF, et al. Chondrogenic potential of injectable kappa-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications. J Tissue Eng Regen Med 2013. [Epub ahead of print]
144. Mathieu E, Lamirault G, Toquet C, et al. Intramyocardial delivery of mesenchymal stem cell-seeded hydrogel preserves cardiac function and attenuates ventricular remodeling after myocardial infarction. PLoS One 2012;7(12):e51991
145. Zamora DO, Natesan S, Christy RJ. Constructing a collagen hydrogel for the delivery of stem cell-loaded chitosan microspheres. J Vis Exp 2012;64:e3624
146. Md Lutful A, Jesmeen T, Sutradhar KB, et al. Development and in vitro evaluation of diclofenac sodium loaded mucoadhesive microsphere with natural gum for sustained delivery. Curr Drug Deliv 2013;10(6):765-70
147. Guo YJ, Long T, Chen W, et al. Bactericidal property and biocompatibility of gentamicin-loaded mesoporous carbonated hydroxyapatite microspheres. Mater Sci Eng C Mater Biol Appl 2013;33(7):3583-91
148. He P, Liu H, Tang Z, et al. Poly(ester amide) blend microspheres for oral insulin delivery. Int J Pharm 2013;455(1-2):259-66
149. Falconi M, Focaroli S, Teti G, et al. Novel PLA microspheres with hydrophilic and bioadhesive surfaces for the controlled delivery of fenretinide. J Microencapsul 2013;31(1):41-8
150. Gokhale KS, Jonnalagadda S. Preparation and evaluation of sustained release infliximab microspheres. PDA J Pharm Sci Technol 2013;67(3):255-66
151. Shahzad MK, Ubaid M, Raza M, et al. The formulation of flurbiprofen loaded microspheres using hydroxypropylmethycellulose and ethylcellulose. Adv Clin Exp Med 2013;22(2):177-83
152. Pagar KP, Vavia PR. Naltrexone-loaded poly[La-(Glc-Leu)] polymeric microspheres for the treatment of alcohol dependence: in vitro characterization and in vivo biocompatibility assessment. Pharm Dev Technol 2014;19(4):385-94
153. Ramasamy T, Ruttala HB, Shanmugam S, et al. Eudragit-coated aceclofenac-loaded pectin microspheres in chronopharmacological treatment of rheumatoid arthritis. Drug Deliv 2013;20(2):65-77
154. Jiang T, Wu C, Gao Y, et al. Preparation of novel porous starch microsphere foam for loading and release of poorly water soluble drug. Drug Dev Ind Pharm 2014;40(2):252-9
155. Mohanraj K, Sethuraman S, Krishnan UM. Development of poly (butylene succinate) microspheres for delivery of levodopa in the treatment of Parkinson's disease. J Biomed Mater Res B Appl Biomater 2013;101(5):840-7
156. Moshaverinia A, Ansari S, Chen C, et al. Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering. Biomaterials 2013;34(28):6572-9
157. Ahearne M, Kelly DJ. A comparison of fibrin, agarose and gellan gum hydrogels as carriers of stem cells and growth factor delivery microspheres for cartilage regeneration. Biomed Mater 2013;8(3):035004
158. Skop NB, Calderon F, Levison SW, et al. Heparin crosslinked chitosan microspheres for the delivery of neural stem cells and growth factors for central nervous system repair. Acta Biomater 2013;9(6):6834-43
159. Sukarto A, Yu C, Flynn LE, et al. Co-delivery of adipose-derived stem cells and growth factor-loaded microspheres in RGD-grafted N-methacrylate glycol chitosan gels for focal chondral repair. Biomacromolecules 2012;13(8):2490-502
160. Huang S, Lu G, Wu Y, et al. Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair. J Dermatol Sci 2012;66(1):29-36
161. Zhou Y, Yan Z, Zhang H, et al. Expansion and delivery of adiposederived mesenchymal stem cells on three microcarriers for soft tissue regeneration. Tissue Eng Part A 2011;17(23-24):2981-97
162. Yang Y, Dreessen de Gervai P, Sun J, et al. MRI studies of cryoinjury infarction in pig hearts: ii. Effects of intrapericardial delivery of adiposederived stem cells (ADSC) embedded in agarose gel. NMR Biomed 2012;25(2):227-35
163. Bian L, Zhai DY, Tous E, et al. Enhanced MSC chondrogenesis following delivery of TGF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Biomaterials 2011;32(27):6425-34
164. Natesan S, Baer DG, Walters TJ, et al. Adipose-derived stem cell delivery into collagen gels using chitosan microspheres. Tissue Eng Part A 2010;16(4):1369-84
165. Llano R, Epstein S, Zhou R, et al. Intracoronary delivery of mesenchymal stem cells at high flow rates after myocardial infarction improves distal coronary blood flow and decreases mortality in pigs. Catheter Cardiovasc Interv 2009;73(2):251-7