Novel spray freeze-drying technique using four-fluid nozzle-development of organic solvent system to expand its application to poorly water soluble drugs

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 2, 2010, Pages 195-200

  Niwa, Toshiyuki ^a   Shimabara, Hiroko ^a   Danjo, Kazumi ^a  

^a MEIJO UNIVERSITY   (Japan)

Author keywords

Acetonitrile; Four fluid nozzle; Liquid nitrogen; Porous microparticle; Spray freeze drying

Indexed keywords

ACETONITRILE; CYCLOSPORIN A; DRUG CARRIER; LIQUID NITROGEN; ORGANIC SOLVENT; PHENYTOIN;

AEROSOL; AQUEOUS SOLUTION; ARTICLE; DRUG FORMULATION; DRUG INDUSTRY; FREEZE DRYING; FREEZING; INTERMETHOD COMPARISON; MICROSCOPY; MORPHOLOGICAL TRAIT; NEBULIZER; PARTICLE SIZE; PHYSICAL CHEMISTRY; POLYMERIZATION; POROSITY; SOLUBILITY; SPRAY DRYING; SURFACE PROPERTY; SUSPENSION; TECHNIQUE;

ACETONITRILES; ANTICONVULSANTS; CYCLOSPORINE; FREEZE DRYING; IMMUNOSUPPRESSIVE AGENTS; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; PHENYTOIN; POROSITY; SOLUBILITY; WATER;

EID: 76149106514     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.195     Document Type: Article

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