Hydrophilized 3D porous scaffold for effective plasmid DNA delivery

Journal of Biomedical Materials Research - Part A

Volumn 97 A, Issue 4, 2011, Pages 441-450

  Oh, Se Heang ^a   Kim, Tae Ho ^a   Jang, Sung Hwan ^a   Im, Gun Il ^b   Lee, Jin Ho ^a,c  

^a Hannam University   (South Korea)

^b Dongguk University Ilsan Hospital   (South Korea)

^c Biopol Corporation   (South Korea)

Author keywords

gene delivery; hydrophilization; mesenchymal stem cell; plasmid DNA; porous scaffold

Indexed keywords

GENE DELIVERY; HYDROPHILIZATION; MESENCHYMAL STEM CELL; PLASMID DNA; POROUS SCAFFOLD;

ADHESION; ANIMAL CELL CULTURE; BIOMOLECULES; CELL ADHESION; CELL CULTURE; DNA; DRUG THERAPY; GENE THERAPY; GENE TRANSFER; HYDROPHILICITY; LEACHING; NUCLEIC ACIDS; STEM CELLS; THREE DIMENSIONAL; TISSUE;

SCAFFOLDS (BIOLOGY);

MACROGOL; PLASMID DNA; POLOXAMER; POLYETHYLENEIMINE; POLYGLACTIN;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CYTOTOXICITY; GENE TARGETING; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HYDROPHILICITY; MESENCHYMAL STEM CELL; OXYGEN TRANSPORT; POROSITY; PRECIPITATION;

BONE MARROW CELLS; CELL DEATH; DNA; ELECTROPHORESIS, AGAR GEL; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTIC ACID; MESENCHYMAL STEM CELLS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; PLASMIDS; POLOXAMER; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYGLYCOLIC ACID; POROSITY; STATIC ELECTRICITY; TISSUE SCAFFOLDS; TRANSFECTION;

EID: 79955675084     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.33079     Document Type: Article

References (37)

1. Karande TS, Ong JL, Agrawal CM,. Diffusion in musculoskeletal tissue engineering scaffolds: Design issues related to porosity, permeability, architecture, and nutrient mixing. Ann Biomed Eng 2004; 32: 1728-1743. (Pubitemid 40121305)
2. Shin H, Jo S, Mikos AG,. Biomimetic materials for tissue engineering. Biomaterials 2003; 24: 4353-4364. (Pubitemid 36960133)
3. Ratner BD, Bryant SJ,. Biomaterials: Where we have been and where we are going. Annu Rev Biomed Eng 2004; 6: 41-75. (Pubitemid 39209492)
4. Wang S, Cui W, Bei J,. Bulk and surface modifications of polylactide. Anal Bioanal Chem 2005; 381: 547-556. (Pubitemid 40379327)
5. Howard D, Buttery LD, Shakesheff KM, Roberts SJ,. Tissue engineering: strategies, stem cells and scaffolds. J Anat 2008; 213: 66-72. (Pubitemid 352044397)
6. Richardson TP, Peters MC, Ennett AB, Mooney DJ,. Polymeric system for dual growth factor delivery. Nat Biotechnol 2001; 19: 1029-1034. (Pubitemid 33041886)
7. Hu Y, Zhang C, Zhang S, Xiong Z, Xu J,. Development of a porous poly(L -lactic acid)/hydroxyapatite/collagen scaffold as a BMP delivery system and its use in healing canine segmental bone defect. J Biomed Mater Res 2003; 67A: 591-598. (Pubitemid 37522466)
8. Capito RM, Spector M,. Collagen scaffolds for nonviral IGF-1 gene delivery in articular cartilage tissue engineering. Gene Ther 2007; 14: 721-732. (Pubitemid 46585653)
9. Bonadio J, Smiley E, Patil P, Goldstein S,. Localized, direct plasmid gene delivery in vivo: Prolonged therapy results in reproducible tissue regeneration. Nat Med 1999; 5: 753-759. (Pubitemid 29318608)
10. Agrawal CM, Ray RB,. Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. J Biomed Mater Res 2001; 55: 141-150. (Pubitemid 32198496)
11. Fu K, Kilbanov AM, Langer R,. Protein stability in controlled-release systems. Nat Biotechnol 2000; 18: 24-25. (Pubitemid 30041164)
12. Saul JM, Linnes MP, Ratner BD, Giachelli CM, Pun SH,. Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression. Biomaterials 2007; 28: 4705-4716. (Pubitemid 47260703)
13. Capito RM, Spector M,. Scaffold-based articular cartilage repair. IEEE Eng Med Biol Mag 2003; 22: 42-50. (Pubitemid 38005030)
14. Jang JH, Houchin TL, Shea LD,. Gene delivery from polymeric scaffolds for tissue engineering. Exp Rev Med Dev 2004; 1: 127-138. (Pubitemid 40220424)
15. Shea LD, Smiley E, Bonadio J, Mooney DJ,. Controllable DNA delivery from polymer matrices. Nat Biotechnol 1999; 17: 551-554. (Pubitemid 29262917)
16. Chun KW, Cho KC, Kim SH, Jeong JH, Park TG,. Controlled release of plasmid DNA from biodegradable scaffolds fabricated using a thermally-induced phase-separation method. J Biomater Sci Polym Ed 2004; 15: 1341-1353. (Pubitemid 39654326)
17. Jang JH, Shea LD,. Controllable delivery of non-viral DNA from porous scaffolds. J Control Release 2003; 86: 157-168. (Pubitemid 35469122)
18. Rives CB, des Rieux A, Zelivyanskaya M, Stock SR, Lowe WL Jr, Shea LD,. Layered PLG scaffolds for in vivo plasmid delivery. Biomaterials 2009; 30: 394-401.
19. Luu YK, Kim K, Hsiao BS, Chu B, Hadjiargyrou M,. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J Control Release 2003; 89: 341-353. (Pubitemid 36507026)
20. Ando S, Putnam D, Pack DW, Langer R,. PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J Pharm Sci 1999; 88: 126-130. (Pubitemid 29037379)
21. Blacklock J, You YZ, Zhou QH, Mao G, Oupickà D,. Gene delivery in vitro and in vivo from bioreducible multilayered polyelectrolyte films of plasmid DNA. Biomaterials 2009; 30: 939-950.
22. De Laporte L, Shea LD,. Matrices and scaffolds for DNA delivery in tissue engineering. Adv Drug Deliv Rev 2007; 59: 292-307. (Pubitemid 46879971)
23. Lei Y, Segura T,. DNA delivery from matrix metalloproteinase degradable poly(ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells. Biomaterials 2009; 30: 254-265.
24. Huang YC, Connell M, Park Y, Mooney DJ,. Rice KG Fabrication and in vitro testing of polymeric delivery system for condensed DNA. J Biomed Mater Res 2003; 67A: 1384-1392. (Pubitemid 37522753)
25. Kostarelos K,. Rational design and engineering of delivery systems for therapeutics: Biomedical exercises in colloid and surface science. Adv Colloid Interface Sci 2003; 106: 147-168.
26. Hong JW, Park JH, Huh KM, Chung H, Kwon IC, Jeong SY,. PEGylated polyethylenimine for in vivo local gene delivery based on lipiodolized emulsion system. J Control Release 2004; 99: 167-176. (Pubitemid 39165742)
27. Yang J, Shi G, Bei J, Wang S, Cao Y, Shang Q, Yang Q, Wang W,. Fabrication and surface modification of macroporous poly-(L -lactic acid) and poly(L -lactic-co-glycolic acid) (70/30) cell scaffolds for human skin fibroblast cell culture. J Biomed Mater Res 2002; 62: 438-446. (Pubitemid 35332208)
28. Oh SH, Kang SG, Cho SH, Kim ES, Lee JH,. Fabrication and characterization of hydrophilic poly(lactic-co-glycolic acid)/poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate-leaching method. Biomaterials 2003; 24: 4011-4021. (Pubitemid 36794405)
29. Sagara K, Kim SW,. A new synthesis of galactose-poly(ethylene glycol)-polyethylenimine for gene delivery to hepatocytes. J Control Release 2002; 79: 271-281. (Pubitemid 34164179)
30. Tang GP, Zeng JM, Gao SJ, Ma YX, Shi L, Li Y, Too HP, Wang S,. Polyethylene glycol modified polyethylenimine for improved CNS gene transfer: Effects of PEGylation extent. Biomaterials 2003; 24: 2351-2362. (Pubitemid 36434055)
31. Zhang X, Pan SR, Hu HM, Wu GF, Feng M, Zhang W, Luo X,. Poly(ethylene glycol)-block-polyethylenimine copolymers as carriers for gene delivery: Effects of PEG molecular weight and PEGylation degree. J Biomed Mater Res 2008; 84A: 795-804. (Pubitemid 351237797)
32. Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos AG, Langer R,. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res 1993; 27: 11-23. (Pubitemid 23002763)
33. Lee JH, Lee HB,. A wettability gradient as a tool to study protein adsorption and cell adhesion on polymer surfaces. J Biomater Sci Polym Ed 1993; 4: 467-481.
34. Lee JH, Khang G, Lee JW, Lee HB,. Interaction of different types of cells on polymer surfaces with wettability gradient. J Colloid Interface Sci 1998; 205: 323-330. (Pubitemid 28421946)
35. Lee JH, Lee SJ, Khang G, Lee HB,. The effect of fluid shear stress on endothelial cell adhesiveness to polymer surfaces with wettability gradient. J Colloid Interface Sci 2000; 230: 84-90.
36. Oh SH, Cho SH, Kim ES, Lee JH,. Preparation and characterization of PLGA scaffolds with uniform porosity and hydrophilicity. Biomater Res 2002; 6: 89-98.
37. Luo D, Woodrow-Mumford K, Belcheva N, Saltzman MW,. Controlled DNA delivery systems. Pharm Res 1999; 16: 1300-1308. (Pubitemid 29393622)