Scaffold: A novel carrier for cell and drug delivery

Critical Reviews in Therapeutic Drug Carrier Systems

Volumn 29, Issue 1, 2012, Pages 1-63

  Garg, Tarun ^a   Singh, Onkar ^a   Arora, Saahil ^a   Murthy, R S R ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

Graft surgery; Implants; Prolonged drug delivery; Scaffold; Tissue engineering; Tissue regeneration

Indexed keywords

AGAR; ALGINIC ACID; BIOCERAMICS; BIOMATERIAL; CARRAGEENAN; CELLULOSE; CHITOSAN; CHONDROITIN SULFATE; COLLAGEN; DEXTRAN; ELASTIN; FIBRIN; GALACTOSE; GELATIN; GELLAN; HEPARIN; HYALURONIC ACID; MACROGOL; MICROSPHERE; POLY(ORTHO ESTER); POLYAMIDOAMINE; POLYANHYDRIDE; POLYBUTYLENE TEREPHTHALATE; POLYESTER; POLYMER; POLYPYRROLE; SILK FIBROIN; STARCH; TISSUE SCAFFOLD; UNINDEXED DRUG;

BINDING AFFINITY; BIOCOMPATIBILITY; BIODEGRADABILITY; CHEMICAL STRUCTURE; COMPOSITE MATERIAL; DRUG DELIVERY SYSTEM; ELECTROSPINNING; EMULSION; EMULSION TEMPLATING; FIBER BONDING; FIBER MESH TECHNIQUE; FREEZE DRYING; FUSED DEPOSITION MODELING; GAS FOAMING METHOD; HUMAN; HYDROGEL; KINETICS; MELT MOLDING TECHNIQUE; MEMBRANE; NONHUMAN; ORGAN PRINTING; PARTICULATE LEACHING METHOD; POROSITY; POWDER COMPACTION; PROCEDURES; RAPID PROTOTYPING; REVIEW; SELECTIVE LASER SINTERING; SOL GEL TECHNIQUE; SOYBEAN; STEREOLITHOGRAPHY; SUPERCRITICAL FLUID; THERMALLY INDUCED PHASE SEPARATION; TISSUE ENGINEERING;

EID: 84860375401     PISSN: 07434863     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevTherDrugCarrierSyst.v29.i1.10     Document Type: Review

References (363)

1. Saltzman WM, Olbricht WL. Building drug delivery into tissue engineering. Nat Rev Drug Discov. 2002;1:177-86.
2. Langer R. Biomaterials in drug delivery and tissue engineering: one laboratory's experience. Acc Chem Res. 2000;33:94-101.
3. Atala A. Tissue engineering and regenerative medicine: concepts for clinical application. Rejuvenation Res. 2004;7:15-31.
4. Bonassarl J, Vacanti CA. Tissue engineering: the first decade and beyond. J Cell Biochem Suppl. 1998;30:297-303.
5. Kretlow JD, Mikos AG. From material to tissue: biomaterial development, scaffold fabrication, and tissue engineering. AIChE J. 2008;54(12):3048-67.
6. Langer R, Vacanti JP. Tissue engineering. Science. 1993;260:920-6.
7. Freed LE, Vunjak-Novakovic G, Biron RJ, Eagles DB, Lesnoy DC, Barlow SK, Langer R. Biodegradable polymer scaffolds for tissue engineering. Nat Biotechnol. 1994;12:689-93.
8. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials. 2000;21:2529-43.
9. Papkov MS, Agashi K, Olaye A, shakesheff K, Domb AJ. Polymer carriers for drug delivery in tissue engineering. Adv Drug Deliv Rev. 2007;59:187-206.
10. Shea LD, Smiley E, Bonadio J, Mooney DJ. DNA delivery frompolymer matrices for tissue engineering. Nat Biotechnol. 1999;17:551-4.
11. Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev. 2002;43:3-12.
12. Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials. 2003;24:4337-51.
13. Lyons F, Partap S, O'Brien FJ. Part 1: scaffolds and surfaces. Technol Health Care. 2008;16:305-17.
14. Peter SJ, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG. Polymer concepts in tissue engineering. J Biomed Mater Res. 1998;43:422-7.
15. Chung HJ, Park TG. Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Adv Drug Deliv Rev. 2007;59:249-59.
16. Khang G, Lee SJ, Kim MS, Lee HB. Biomaterials: tissue engineering and scaffold. In Webster J (ed.). Encyclopedia of Medical Devices and Instrumentation, Vol 2; 2006:366-83.
17. Mandal BB, Kundu SC. Non-bioengineered high strength three-dimensional gland fibroin scaffolds from tropical non-mulberry silkworm for potential tissue engineering applications. Macromol Biosci. 2008;8:807-18.
18. Mandal BB, Kundu SC. Cell proliferation and migration in silk fibroin 3D scaffolds. Biomaterials. 2009;30:2956-65.
19. Mandal BB, Kundu SC. Osteogenic and adipogenic differentiation of rat bone marrow cells on nonmulberry and mulberry silk gland fibroin 3D scaffolds. Biomaterials. 2009;30:5019-30.
20. Widmer MS, Mikos AG. Fabrication of biodegradable polymer scaffolds. In: Patrick CW Jr, Mikos AG, McIntire LV, eds. Frontiers in Tissue Engineering; 1998:107-20.
21. Hench LL. Bioceramics. J Am Ceram Soc. 1998;81:1705-28.
22. Babensee JE, Mikos AG, Anderson JM, McIntire LV. Host response to tissue engineered devices. Adv Drug Del Rev. 1998;33:111-39.
23. Karande ST, Agrawal MC. Functions and requirement of synthetic scaffolds in tissue engineering. In: Laurencin CT, Nair LS (eds.). Nanotechnology and Tissue Engineering: The Scaffolds; 2008:53.
24. Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R. Novel approach to fabricate porous sponges of poly(d, l-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials. 1996;17: 1417-22.
25. Freyman TM, Yannas IV, Gibson LJ. Cellular materials as porous scaffolds for tissue engineering. Prog Mater Sci. 2001;46:273-82.
26. Ma PX. Biomimetic materials for tissue engineering. Adv Drug Deliv Rev. 2008;60:184-98.
27. Huang S, Fu X. Naturally derived materials-based cell and drug delivery systems in skin regeneration. J Control Release. 2010;142:149-59.
28. Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design variablesand applications. Biomaterials. 2003;24:4337-51.
29. Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev. 2002;43:3-12.
30. Kurisawa M, Yui N. Gelatin/dextran intelligent hydrogels for drug delivery: dualstimuli-responsive degradation in relation to miscibility in interpenetrating polymer networks. J Control Release. 1998;199:1547-54.
31. Augst AD, Kong HJ, Mooney DJ. Alginate hydrogels as biomaterials. Macromol Biosci. 2006;6:623-33.
32. Stile RA, Burghardt WR, Healy KE. Synthesis and characterization of injectable poly(N-isopropylacrylamide)-based hydrogels that support tissue formation in vitro. Macromolecules. 1999;32:7370-9.
33. Park KH, Yun K. Immobilization of Arg-Gly-Asp (RGD) sequence in a thermo-sensitive hydrogel for cell delivery using pheochromocytoma cells (PC12). J Biosci Bioeng. 2004;97:374-7.
34. Yoon JJ, Chung H, Park TG. Photo-crosslinkable and biodegradable Pluronic/heparin hydrogels for local and sustained delivery of angiogenic growth factor. J Biomed Mater Res. 2006;79:934-42.
35. Bryant SJ. Anseth KS. Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J Biomed Mater Res. 2003;64:70-9.
36. Burdicka JA, Ansetha KS. Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials. 2002;23:4315-23.
37. Williams CG, Kim TK, Taboas A, Malik A, Manson P, Elisseeff J. In vitro chondrogenesis of bone marrowderived mesenchymal stem cells in a photopolymerizing hydrogel. Tissue Eng. 2003;9:679-88.
38. Chenite A, Chaput C, Wang D, Combes C, Buschmann MD, Hoemann CD, Leroux JC, Atkinson BL, Binette F, Selmani A. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials. 2000;21:2155-61.
39. Jeong B, Lee KM, Gutowska A, An YH. Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering. Biomacromolecules. 2002;3:865-8.
40. Saim AB, Cao Y, Weng Y, Chang C, Vacanti MA, Vacanti CA, Eavey RD. Engineering autogenous cartilage in the shape of a helix using an injectable hydrogel scaffold. Laryngoscope. 2000;110:1694-7.
41. Tabata Y, Hijikata S, Muniruzzaman M, Ikada Y. Neovascularization effect of biodegradable gelatin microspheres incorporating basic fibroblast growth factor. J Biomater Sci Polym Ed. 1999;10:79-94.
42. Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev. 2003;55:329-47.
43. Park CJ, Clark SG, Lichtensteiger CA, Jamison RD, Johnson AJ. Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF. Acta Biomater. 2009;5:1926-36.
44. Clark RAF, Singer AJ. Wound repair: basic biology to tissue engineering. London: Academic Press; 2000.
45. Bradley M, Cullum N, Nelson EA, Petticrew M, Sheldon T, Torgerson D. Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds. Health Technol Assess. 1999;3:1-35.
46. Lee JE, Park JC, Lee HK, Oh SH, Suh H. Laminin modified infection-preventing collagen membrane containing silver sulfadiazine-hyaluronan microparticles. Artif Organs. 2002;26:521-8.
47. Saltzman WM, Baldwin SP. Materials for protein delivery in tissue engineering. Adv Drug Deliv Rev. 1998;33:71-86.
48. Whang K. Engineering bone regeneration with bioabsorbable scaffolds with novel microarchitecture. Tissue Eng. 1999;5:35-51.
49. Caban AS, Pen MV, Roman J. Tailoring vancomycin release from x-TCP/agarose scaffolds. Eur J Pharm Sci. 2009;37:249-56.
50. Vepari C, Kaplan DL. Silk as a biomaterial. Prog Polym Sci. 2007;32(8-9):991-1007.
51. Altman GH, Diaz F, Jakuba C, Calabro T, Horan RL, Chen JL, Lu H, Richmond J, Kaplan DL. Silk based biomaterials. Biomaterials. 2003;24:401-16.
52. Mikos AG, Sarakinos G, Leite SM, Vacanti JP, Langer R. Laminated three-dimensional biodegradable foams for use in tissue engineering. Biomaterials. 1993;14:323-30.
53. Boland ED, Espy PG, Bowlin GL. Tissue engineering scaffolds. In: Wenk GE, Bowlin GL (Eds.). Encyclopaedia of Biomaterials and Biomedical Engineering. 2nd edition. London: Informa Healthcare; 2004: 1633-5.
54. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP. Preparation and characterization of poly(L-lactic acid) foams. Polymer. 1994;35:1068-77.
55. Lu L, Peter SJ, Lyman MD, Lai HL, Leite SM, Tamada JA, Uyama S, Vacanti JP, Langer R, Mikos AG. In vitro and in vivo degradation of porous poly(dl-lactic-co-glycolic acid) foams. Biomaterials. 2000;21: 1837-45.
56. Oh SH, Kang SG, Kim ES, Cho, Lee JH. Fabrication and characterization of hydrophilic poly(lactic-coglycolic acid)/poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate-leaching method. Biomaterials. 2003;2:4011-21.
57. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP. Preparation and Characterization of Poly(L-Lactic Acid) Foams. Polymer. 1994;35(5):1068-77.
58. Marra KG, Szem JW, Kumta PN, DiMilla PA, Weiss LE. In vitro analysis of biodegradable polymer blend/ hydroxyapatite composites for bone tissue engineering. J Biomed Mater Res. 1999;47:324-35.
59. Liu Q, de Wijn JR, van Blitterswijk CA. Composite biomaterials with chemical bonding between hydroxyapatite filler particles and PEG/PBT copylmer matrix. J Biomed Mater Res. 1998;40:490-7.
60. Yue H, Zhang L, Wang Y, Liang F, Guan L, Li S, Yan F, Nan X, Bai C, Lin F, Yan Y, Pei X. Proliferation and differentiation into endothelial cells of human bone marrow mesenchymal stem cells (MSCs) on poly DL-lactic-co-glycolic acid (PLGA) films. Chin Sci Bull. 2006;51:1328-33.
61. Leibmann-Vinson A, Hemperly JJ, Guarino RD, Spargo CA, Heidaran MA. Bioactive extracellular matrices: biological and biochemical evaluation. In: Lewandrowski K-U, Wise DL, Trantolo DJ, Gresser JD, Yaszemski MJ, Altobelli DE (Eds.). Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications. Boca Raton: CRC Press; 2002:709-64.
62. Plikk P, Målberg S, Albertsson AC. Design of resorbable porous tubular copolyester scaffolds for use in nerve regeneration. Biomacromolecules. 2009;10(5):1259-64.
63. Buckley CT, O Kelly KU. Regular scaffold fabrication techniques for Investigations in tissue engineering. In: Prendergast PJ, McHugh PE (Eds.). Topics in Bio-Mechanical Engineering. Trinity Centre for Bioengineering. Dublin: Trinity Centre for Bio-Engineering; 2004:147-67.
64. Nam YS, Yoon JJ, Park TG. A novel fabrication method for macroporous biodegradable polymer scaffolds using gas foaming salt as porogen additive. J Biomed Mater Res. 2000;53:1-7.
65. Yoon JJ, Park TG. Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts. J Biomed Mater Res. 2001;55:401-8.
66. Kanczler JM, Barry J, Ginty P, Howdle SM, Shakesheff KM, Oreffo ROC. Supercritical carbon dioxide generated vascular endothelial growth factor encapsulated poly(DL-lactic acid) scaffolds induce angiogenesis in vitro. Biochem Biophys Res Commun. 2007;352:135-41.
67. Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R. Novel approach to fabricate porous sponges of poly(D, L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials. 1996;17:1417-22.
68. Harris LD, Kim B, Mooney DJ. Open pore biodegradable matrices formed with gas foaming. J BiomedMater Res. 1998;42:396-402.
69. Li W, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J Biomed Mater Res. 2002;60:613-21.
70. Matthews JA, Wnek GE, Simpson DG, Bowlin GL. Electrospinning of collagen nanofibers. Biomacromolecules. 2002;3:232-8.
71. Kim SH, Nam YS, Lee TS, Park WH. Silk fibroin nanofiber: electrospinning, properties, and structure. Polym J. 2003;35:185-90.
72. Li WJ, Tuan RS. Fabrication and application of nanofibrous scaffolds in tissue engineering. Curr Protoc Cell Biol. 2009;Chapter 25:Unit 25.2.
73. Liang D, Hsiao BS, Chu B. Functional electrospun nanofibrous scaffolds for biomedical applications. Adv Drug Deliv Rev. 2007;59:1392-412.
74. Leong MF, Rasheed MZ, Lim TC, Chian KS. Invitro cell infiltration and invivo cell in filtration and vascularization in fibrous highly porous poly (D, L-Lactic acid) scaffold fabrication by electrospining technique. J Biomed Res A. 2008;91:231-40.
75. Baker BM, Gee AO, Metter RB, Nathan AS, Marklein RA, Burdick JA, Mauck RL. The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers. Biomaterials. 2008;29:2348-58.
76. Domingues ZR, Cortés ME, Gomes TA, Diniz HF, Freitas CS, Gomes JB, Faria AM, Sinisterra RD. Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with bcyclodextrin. Biomaterials. 2004;25:327-33.
77. Ulatowski-Jarza A, Andrzejewski D, Podbielska H, Maruszewski K, Strek W. Advantages of sol-gel technologies for biomedical applications. Proc SPIE. 1999;3567:50.
78. Di Nunzio S, Vitale-Brovarone C, Spriano S, Milanese D, Verne E, Bergo V, Maina G, Spinelli P. Silver containing bioactive glasses prepared by molten salt ionexchange. J Eur Ceram Soc. 2004;24:2935-42.
79. Kimakhe S, Bohic S, Larosse C, Reynaud A, Pilet P, Giumelli B, Heymann D, Daculsi G. Biological activities of sustained polymixin B release from calcium phosphate biomaterial prepared by dynamic compaction: an in vitro study. J Biomed Mater Res. 1999;47:18-27.
80. Nam YS, Park TG. Biodegradable polymeric microcellular foams by modified thermally induced phase separation method. Biomaterials. 1999;20:1783-90.
81. Smith LA, Beck JA, Ma PX. Nano fibrous scaffolds and their biological effects. In: Kumar C (Ed.). Tissue, Cell and Organ Engineering. Weinheim, Germany: Wiley-VCH; 2006:195.
82. Ma PX, Zhang R. Microtubular architecture of biodegradable polymer scaffolds. J Biomed Mater Res. 2001;56(4):469-77.
83. Boccaccini AR, Notingher I, Maquet V, Jerome R. Bioresorbable and bioactive composite materials based on polylactide foams filled with and coated by Bioglass particles for tissue engineering application. J Mater Sci Mater Med. 2003;14:443-50.
84. Nam YS, Park TG. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation. J Biomed Mater Res. 1999;47:8-17.
85. Thompson RC, Wake MC, Yasemski MJ, Mikos AG. Adv Polym Sci. 1995;122:245-74.
86. Kim B, Mooney DJ. Engineering smooth muscle tissue with a predefined structure. J Biomed Mater Res. 1998;41:322-32.
87. Cima LG, Vacanti JP, Vacanti C, Ingber D, Mooney D, Langer R. Tissue engineering by cell transplantation using degradable polymer substrates. J Biomech Eng. 1991;113(2):143-51.
88. Mikos AG, Bao Y, Cima LG, Ingber DE, Vacanti JP, Langer R. Preparation of poly (glycolic acid) bonded fiber structures for cell attachment and transplantation. J Biomed Mater Res. 1993;27(2):183-9.
89. Eberli D, Freitas FL, Atala A, Yoo JJ. Composite scaffolds for the engineering of hollow organs and tissues. Methods. 2009;47(2):109-15.
90. Moroni L, Hamann D, Paoluzzi L, Pieper J, de Wijn JR, Van Blitterswijk CA. Regenerating articular tissue by converging technologies. PLoS One. 2008;3(8):e3032.
91. Martins AM, Pham QP, Malafaya PB, Sousa RA, Gomes ME, Raphael RM, Kapser FK, Reis RL, Mikos AG. The role of lipase and alpha-amylase in the degradation of starch/poly(varepsilon-caprolactone) fiber meshes and the osteogenic differentiation of cultured marrow stromal cells. Tissue Eng Part A. 2009;15(2):295-305.
92. Ikada Y. Scope of tissue engineering. In: Ikada Y (Ed.). Tissue Engineering, Volume 8: Fundamental and Applications. Waltham, MA: Academic Press; 2006:29.
93. Chen G, Ushida T, Tateishi T. Development of biodegradable porous scaffolds for tissue engineering. Mater Sci Eng C. 2002;17:63-9.
94. Chu TMG, Orton DG, Hollister SJ, Feinberg SE, Halloran JW. Mechanical and in vivo performance of Hydroxyapatite implants with controlled architectures. Biomaterials. 2002;23:1283-93.
95. Hollister SJ, Chu TM, Halloran JW, Feinberg SE. Design and manufacture of bone replacement scaffolds. In: Cowen S (ed.), Bone Mechanics. Boca Raton, FL: CRC Press, 2000, in press.
96. Hollister SJ, Maddox RD, Taboas JM. Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. Biomaterials. 2002;23(20):4095-103.
97. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials. 2000;21:2529-43.
98. Yang S, Leong K, Du Z, Chua C. The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques. Tissue Eng. 2002;8:1-11.
99. Sachlos E, Czernuszka JT. Making tissue engineering scaffolds work. Review: The application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cell Mater. 2003;5:29-39.
100. Cheah CM, Chue CK, Leong KF, Chue SW. Development of a tissue engineering scaffold structure library for rapid prototyping. Part 1: investigation and classification. Comput Sci Eng. 2004;21(4):291-301.
101. Hutmacher DW, Sittinger M, Risbud MV. Scaffold-based tissue engineering: rationale for computeraided design and solid free-form fabrication systems. Trends Biotechnol 2004;22(7):354-62.
102. Vladimir M, Thomas B, Thomas T, Gabor F, Roger RM. Organ printing: computer-aided jet-based 3D tissue engineering. Trends Biotechnol. 2003;21(4):157-61.
103. Maquet V, Jerome R. Design of macroporous biodegradable polymer scaffolds for cell transplantations. Mater Sci Forum. 1997;250:15-24.
104. Hutmacher DW. Scaffold in tissue engineering bone and cartilage. Biomaterials. 2000;21:2529-43.
105. Hutmacher DW. Scaffold design and fabrication technologies for engineering tissues: state of the art and future perspectives. J Biomat Sci Polym. 2001;12:107-24.
106. Partap S, Darr JA, Rehman IU, Jones JR. Supercritical carbon dioxide in water emulsion-templated synthesis of porous calcium alginate hydrogels. Adv Mater. 2006;18:501-4.
107. Barby D, Haq Z, inventors. Tough reinforced open porous polymer foams via concentrated emulsion templating,1982. European patent 60138.
108. Yulia L, Michael SS. Biodegradable porous polymers through emulsion templating. Macromolecules. 2009;42(5):1627-33.
109. Sravanthi R. Preparation and characterization of poly (e-caprolactone) PCL scaffolds for tissue engineering applications [Master's thesis]. Orissa, India: National Institute of Technology Roukela;2009:1-59.
110. Dietmarw H. Scaffold design and fabrication technologies for engineering tissues: state of the art and future perspectives. J Biomater Sci Polymer. 2001;(12):107-24.
111. Whang K, Thomas CH, Healy KE, Nuber G. A novel method to fabricate bioabsorbable scaffolds. Polymer. 1995;36:837-42.
112. Chen RR, Mooney DJ. Polymeric growth factor delivery strategies for tissue engineering. Pharm Res. 2003;20:1103-12.
113. Park TG, Jeong JH, Kim SW. Current status of polymeric gene delivery systems. Adv Drug Deliv Rev. 2006;58:467-86.
114. Shea LD, Smiley E, Bonadio J, Mooney DJ. DNA delivery from polymer matrices for tissue engineering. Nat Biotechnol. 1999;17:551-4.
115. Salvaya DM, Shea LD. Inductive tissue engineering with protein and DNA-releasing scaffolds. Mol Biosyst. 2006;2:36-48.
116. Huang Y, Riddle K, Rice KG, Mooney DJ. Long-term in vivo gene expression via delivery of PEI-DNA condensates from porous polymer scaffolds. Hum Gene Ther. 2005;16:609-17.
117. Jang J, Bengali Z, Houchin TL, Shea LD. Surface adsorption of DNA to tissue engineering scaffolds for efficient gene delivery. J Biomed Mater Res. 2006;77(A):50-8.
118. Yoon JJ, Kim JH, Park TG. Dexamethasone releasing biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method. Biomaterials. 2003;24:2323-9.
119. Malafaya PB, Silva GA, Reis RL. Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev. 2007;59:207-33.
120. Chevallay B, Herbage D. Collagen-based biomaterials as 3D scaffolds for cell cultures: application for tissue engineering and gene therapy. Med Biol Eng Comput. 2000;38:211-8.
121. Eyre DR. Collagen: molecular diversity in the body's protein scaffold. Science. 1980;207:1315-22.
122. Kemp PD. Tissue engineering and cell-populated collagen matrices methods. Mol Biol. 2000;139:287-93.
123. Lee CH, Singla A, Lee Y. Biomedical applications of collagen. Int J Pharmacogn. 2000;221:1-22.
124. Wong Po Foo C, Kaplan DL. Genetic engineering of fibrous proteins: spider dragline silk and collagen. Adv Drug Deliv Rev. 2002;54:1131-43.
125. Chunlin Y, Hillas PJ, Buez JA, Nokelainen M, Balan J, Tang J, Spiro R., Polarek JW. The application of recombinant human collagen in tissue engineering, BioDrugs. 2004;18:103-19.
126. Davidson PF, Levine L, Drake MP, Rubin A, Bump S. The serologic specificity of tropocollagen telopeptides. J Exp Med. 1967;126:331-46.
127. Lynn AK, Yannas IV, Bonfield W. Antigenicity and immunogenicity of collagen. J Biomed Mater Res B Appl Biomater. 2004;71(B):343-54.
128. Friess W. Collagen: biomaterial for drug delivery. Eur J Pharm Biopharm. 1998;45:113-36.
129. Baharvand H, Hashemi SM, Kazemi AS, Farrokhi A. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int J Dev Bio. 2006;50:645-52.
130. Young S, Wong M, Tabata Y, Mikos AG. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release. 2005;109:256-74.
131. Djagny KB, Wang Z, Xu S. Gelatin: a valuable protein for food and pharmaceutical industries: review. Crit Rev Food Sci Nutr. 2001;41:481-92.
132. Tabata Y, Ikada Y. Protein release from gelatin matrices. Adv Drug Deliv Rev 1998;31:287-301.
133. Yong P, Shiwu D, Yong H, Tongwei C, Changqing L, Zhengfeng Z, Zhou Y. Demineralized bone matrix gelatin as scaffold for tissue engineering. Afr J Microbiol Res. 2010;4(9):865-70.
134. Hinman MB, Jones JA, Lewis RV. Synthetic spider silk: a modular fiber. Trends Biotech. 2000;18:374-9.
135. Inoue S, Tanaka K, Arisaka F, Kimura S, Ohtomo K, Mizuno S. Silk friboin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain and P25, with a 6:6:1 molar ratio. J Biol Chem. 2000;275:40517-28.
136. Tamada Y. New process to form a silk fibroin porous 3-D structure. Biomacromolecules. 2005;6:3100-6.
137. Neidert MR, Lee ES, Oegema TR, Tranquillo RT. Enhanced fibrin remodeling in vitro with TGFbeta1, insulin and plasmin for improved tissue-equivalents. Biomaterials. 2002;23:3717-31.
138. Ehrbar M, Metters A, Zammaretti P, Hubbell JA, Zisch AH. Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. J Control Release. 2005;101:93-109.
139. Le Nihouannen D, Guehennec LL, Rouillon T, Pilet P, Bilban M, Layrolle P, Daculsi G. Microarchitecture of calcium phosphate granules and fibrin glue composites for bone tissue engineering. Biomaterials. 2006;27:2716-22.
140. Eyrich D, Brandl F, Appel B, Wiese H, Maier G, Wenzel M, Staudenmaier R, Goepferich A, Blunk T. Long-term stable fibrin gels for cartilage engineering. Biomaterials. 2007;28:55-65.
141. Hunter CJ, Mouw JK, Levenston ME. Dynamic compression of chondrocyte-seeded fibrin gels: effects on matrix accumulation and mechanical stiffness. Osteoarthr Cartil. 2004;12:117-30.
142. Perka C, Schultz O, Lindenhayn K, Spitzer RS, Muschik M, Sittinger M, Burmester GR. Joint cartilage repair with transplantation of embryonic chondrocytes embedded in collagen-fibrin matrices. Clin Exper Rheumatol. 2000;18:13-22.
143. Watson D, Sage A, Chang AA, Schumacher BL, Sah RL. Growth of human septal chondro-cytes in fibrin scaffolds. Am J Rhinol Allergy. 2010;24(1):19-22.
144. Lu Q, Ganesan K, Simionescu DT, Vyavahare NR. Novel porous aortic elastin and collagen scaffolds for tissue engineering. Biomaterials. 2004;25:5227-37.
145. Patel A, Fine B, Sandig M, Mequanint K. Elastin biosynthesis: the missing link in tissue-engineered blood vessels. Cardiovasc Res. 2006;71:40-9.
146. Scott AS, Patricia S, Koyal G, Jennifer M, Isaac AR, Gary LB. The use of natural polymers in tissue engineering: a focus on electrospun extracellular matrix analogues. Polymers. 2010;2:522-53.
147. Gibbs BF, Zougman A, Masse R, Mulligan C. Production and characterization of bioactive peptides from soy hydrolysate and soyfermented food. Food Res Int. 2004;37:123-31.
148. Yannas IV, Burke JF, Gordon PL, Huang C, Rubenstein RH. Design of an artificial skin. Part II. Control of chemical composition. Biomaterials 1980; 14:107-31.
149. Schugens C, Maquet V, Grandfils C, Jerome R, Teyssie P. Polylactide macroporous biodegradable implants for cell transplantation. II. Preparation of polylactide foams by liquid-liquid phase separation. J Biomed Mater Res 1996; 30(4):449-61.
150. Bredt JF, Sach E, Brancazio D, Cima M, Curodeau A, Fan T. Three dimensional printing system. US Patent 1998, 5807437.
151. George M, Abraham TE. Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan-a review. J Control Release. 2006;114:1-14.
152. Khor E, Lim LY. Implantable applications of chitin and chitosan. Biomaterials. 2003;24:2339-49.
153. Abarrategi A, Lópiz-Morales Y, Ramos V, Civantos A, López-Durán L, Marco F, López-Lacomba JL. Chitosan scaffolds for osteochondral tissue regeneration. J Biomed Mater Res A. 2010;95(4);1132-41.
154. Morrison WR, Karkalas J. Starch. Carbohydrates. In: Dey PM, Harborne JB (Ed.). Methods in Plant Biochemistry. London: Academic Press Limited; 1989;2:323-52.
155. Poutanen K, Forssell P. Modification of starch properties with plasticizers. Trends Polym Sci. 1996;4:128-32.
156. Iva P, Paula M, Helena S, Rui L. Highly porous and interconnected starch-based scaffolds: production, characterization and surface modification. Mat Sci Eng C. 2010;30:981-9.
157. Yu-Ju L, Chi-Nan Y, Yu-Chen H, Yung-Chih W, Chun-Jen L, I-Ming C. Chondrocytes culture in three-dimensional porous alginate scaffolds enhanced cell proliferation, matrix synthesis and gene expression. J Biomed Mater Res A. 2009;88A(1):23-33.
158. Liao YH, Jones SA, Forbes B, Martin GP, Brown MB. Hyaluronan: pharmaceutical characterization and drug delivery. Drug Deliv. 2005;12:327-42.
159. Nishinari K, Takahashi R. Interaction in polysaccharide solutions and gels. Curr Opin Colloid Interface Sci. 2003;8:396-400.
160. Yadav AK, Mishra P, Agrawal GP. An insight on hyaluronic acid in drug targeting and drug delivery. J Drug Target. 2008;16:91-107.
161. Pan L, Ren Y, Cui F, Xu Q. Viability and differentiation of neural precursors on hyaluronic acid hydrogel scaffold. J Neurosci Res. 2009;87:3207-20.
162. Chung C, Burdick JA. Influence of three-dimensional hyaluronic acid microenvironments on mesenchymal stem cell chondrogenesis. Tissue Eng Part A. 2009;15:243-54.
163. Chung C, Erickson IE, Mauck RL, Burdick JA. Differential behavior of auricular and articular chondrocytes in hyaluronic acid hydrogels. Tissue Eng Part A. 2008;14:1121-31.
164. Lippiello L. Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes under simulated conditions of joint stress. Osteoarthr Cartil. 2003;11:335-42.
165. Lee CT, Kung PH, Lee YD. Preparation of poly(vinyl alcohol)-chondroitin sulfate hydrogel as matrices in tissue engineering. Carbohydr Polym. 2005;61:348-54.
166. Naessens M, Cerdobbel A, Soetaert W, Vandamme EJ. Leuconostoc dextransucrase and dextran: production, properties and applications. J Chem Technol Biotechnol. 2005;80:845-60.
167. Cascone MG, Barbani N, Cristallini C, Giusti P, Ciardelli G, Lazzeri L. Bioartificial polymeric materials based on polysaccharides. J Biomater Sci Polym Ed. 2001;12:267-81.
168. Hoffmann B, Seitz D, Mencke A, Kokott A, Ziegler G. Glutaraldehyde and oxidised dextran as crosslinker reagents for chitosan-based scaffolds for cartilage tissue engineering. J Mater Sci Mater Med. 2009;20(7):1495-503.
169. Rees DA. Structure, conformation and mechanism in the formation of polysaccharide gels and networks. Adv Carbohydr Chem. 1969;24:267-332.
170. Bao L, Yang W, Mao X, Mou S, Tang S. Agar/collagen membrane as skin dressing for wounds. Biomed Mater. 2008;3(4):044108.
171. Mangione MR, Giacomazza D, Bulone D, Martorana V, Cavallaro G, San Biagio PL. K+ and Na+ effects on the gelation properties of kcarrageenan. Biophys Chemist. 2005;113:129-35.
172. Bartkowiak A, Hunkeler D. Carrageenan-oligochitosan microcapsules: optimization of the formation process. Colloid Surf Biointerfaces. 2001;21:285-98.
173. Sjoberg H, Persson S, Caram-Lelham N. How interactions between drugs and agarose-carrageenan hydrogels influence the simultaneous transport of drugs. J Control Release. 1999;59:391-400.
174. Tapia C, Corbalan V, Costa E, Gai MN, Yazdani-Pedram M. Study of the release mechanism of diltiazem hydrochloride from matrices based on chitosan-alginate and chitosan-carrageenan mixtures. Biomacromolecules. 2005;6:2389-95.
175. Vlieghe P, Clerc T, Pannecouque C, Witvrouw M, De Clercq E, Salles JP, Kraus JL. Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities. J Med Chem. 2002;45:1275-83.
176. Santo VE, Frias AM, Carida M, Cancedda R, Gomes ME, Mano JF, Reis RL. Carrageenan-based hydrogels for the controlled delivery of PDGF-BB in bone tissue engineering applications. Biomacromolecules. 2009;10(6):1392-401.
177. Brown RM. Cellulose structure and biosynthesis: what is in store for the 21st century? J Polym Sci A Polym Chem. 2004;42:487-95.
178. Somerville C. Cellulose synthesis in higher plants. Annu Rev Cell Dev Biol. 2006;22:53-78.
179. Xing Q, Zhao F, Chen S, McNamara J, Decoster MA, Lvov YM. Porous biocompatible three-dimensional scaffolds of cellulose microfiber/gelatin composites for cell culture. Acta Biomater. 2010;6(6):2132-9.
180. Hong SR, Lee YM, Akaike T. Evaluation of a galactose-carrying gelatin sponge for hepatocytes culture and transplantation. J Biomed Mater Res A. 2003;67;733-41.
181. Mouriño V, Boccaccini AR. Bone tissue engineering therapeutics: controlled drug delivery in threedimensional scaffolds. J R Soc Interface. 2010;7:209-27.
182. Bhang SH, Lim JS, Choi CY, Kwon YK, Kim BS. The behavior of neural stem cells on biodegradable synthetic polymers. J Biomater Sci. 2007;18:223-39.
183. Chen F, Mao T, Tao K, Chen S, Ding G, Gu X. Injectable bone. Br J Oral Maxillofac Surg. 2003;41:240-3.
184. Benoit DS, Durney AR, Anseth KS. The effect of heparin-functionalized PEG hydrogels on threedimensional human mesenchymal stem cell osteogenic differentiation. Biomaterials. 2007;28: 66-77.
185. Chen GP, Ushida T, Tateishi T. Development of biodegradable porous scaffolds for tissue engineering. Mater Sci Eng C Biom Supram Syst. 2001;17:63-9.
186. Zhu YB, Chan-Park B, Chian KS. The growth improvement of porcine esophageal smooth muscle cells on collagen-grafted poly(DL-lactide-co glycolide) membrane. J Biomed Mater Res B Appl Biomater. 2005;75:193-9.
187. He S, Timmer M, Yaszemski MJ, Yasko AW, Engel PS, Mikos AG. Synthesis of biodegradable poly(propylene fumarate) networks with poly (propylene fumarate)-diacrylate macromers as crosslinking agents and characterization of their degradation products. Polymer. 2000;42:1251-60.
188. He SL, Yaszemski MJ, Yasko AW, Engel PS, Mikos AG. Injectable biodegradable polymer composites based on poly(propylene fumarate) crosslinked with poly(ethylene glycol)-dimethacrylate. Biomaterials. 2000;21:2389-94.
189. Vanblitterswijk GA, Vanderbrink J, Leenders H, Bakker D. The effect of Peo ratio on degradation, calcification and bone bonding of Peo/Pbt copolymer (polyactive). Cell Mater. 1993;3:23-36.
190. Radder AM, Leenders H, vanBlitterswijk CA. Application of porous PEO/PBT copolymers for bone replacement. J Biomed Mater Res. 1996;30:341-51.
191. Kose GT, Korkusuz F, Korkusuz P, Purali N, Ozkul A, Hasirci V. Bone generation on PHBV matrices: an in vitro study. Biomaterials. 2003;24:4999-5007.
192. Chen GQ, Wu Q. The application of polyhydroxyalkanoates as tissue engineering materials. Biomaterials. 2005;26:6565-78.
193. Williams SF, Martin DP, Horowitz DM, Peoples OP. PHA applications: addressing the price performance issue: I. Tissue engineering. Int J Biol Macromol. 1999;25:111-21.
194. Gassner F, Owen AJ. Some properties of poly(3-hydroxybutyrate)-poly(3-hydroxyvalerate) blends. Polym Int. 1996;39:215-9.
195. Sun JY, Li HY, Chang J. Macroporous poly(3-hydroxybutyrateco-3 hydroxyvalerate) matrices for cartilage tissue engineering. Eur Polym J. 2005;541:2443-9.
196. Gao J, Crapo PM, Wang YD. Macroporous elastomeric scaffolds with extensive micropores for soft tissue engineering. Tissue Eng. 2006;12:917-25.
197. Radisic M, Park H, Chen F, Salazar-Lazzaro JE, Wang YD, Dennis R, Langer R, Freed LE, Vunjak-Novakovic G. Biomimetic approach to cardiac tissue engineering: oxygen carriers and channelled scaffolds. Tissue Eng. 2006;12:2077-91.
198. Sundback CA, Shyu JY, Wang YD, Faquin RS, Langer JP, Vacanti TA. Biocompatibility analysis of poly(glycerol sebacate) as a nerve guide material. Biomaterials. 2005;26:5454-64.
199. Ferruti P, Bianchi S, Ranucci E, Chiellini F, Caruso V. Novel poly (amido amine)-based hydrogels as scaffolds for tissue engineering. Macromol Biosci. 2005;5:613-22.
200. Hacker M, Tessmar J, Neubauer M, Blaimer A, Blunk T, Göpferich A, Schulz MB. Towards biomimetic scaffolds: anhydrous scaffold fabrication from biodegradable amine-reactive diblock copolymers. Biomaterials. 2003;24:4459-73.
201. Quirk RA, Chan WC, Davies MC, Tendler SJB, Shakesheff KM. Poly(L lysine)-GRGDS as a biomimetic surface modifier for poly(lactic acid). Biomaterials. 2001;22:865-72.
202. Barrera DA, Zylstra E, Lansbury PT, Langer R. Synthesis and Rgd peptide modification of a new biodegradable copolymer-poly(lactic acidco-lysine). J Am Chem Soc. 1993:11010-1.
203. Yamaoka T, Hotta Y, Kobayashi K, Kimura Y. Synthesis and properties of malic acid-containing functional polymers. Int J Biol Macromol. 1999;25:265-71.
204. Guan J, Stankus JJ, Wagner WR. Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications. Biomaterials. 2005;26:3961-71.
205. Pattison MA, Webster TJ, Haberstroh KM. Select bladder smooth muscle cell functions were enhanced on three-dimensional, nanostructured poly(ether urethane) scaffolds. J Biomater Sci Polym Ed. 2006;17:1317-32.
206. Bonzani IC, George JH, Stevens MM. Synthesis of two-component injectable polyurethanes for bone tissue engineering. Biomaterials. 2007;28:423-33.
207. Guan JJ, Stankus JJ, Wagner WR. Development of composite porous scaffolds based on collagen and biodegradable poly(ester urethane)urea. Cell Transplant. 2006;15:S17-S27.
208. Saim AB, Cao YL, Weng YL, Chang CN, Vacanti MA, Vacanti CA, Eavey RD. Engineering autogenous cartilage in the shape of a helix using an injectable hydrogel scaffold. Laryngoscope. 2000;110:1694-7.
209. Cao YL, Rodriguez A, Vacanti M, Ibarra C, Arevalo C, Vacanti CA. Comparative study of the use of poly(glycolic acid), calcium alginate and pluronics in the engineering of autologous porcine cartilage. J Biomater Sci Polym. 1998;9:475-87.
210. Gunatillake PA, Adhikari R. Biodegradable synthetic polymers for tissueengineering. Eur Cell Mater. 2003;5:1-16.
211. Martina M, Hutmacher DW. Biodegradable polymers applied in tissue engineering research: a review. Polym Int. 2007;57:145-57.
212. Ambrosio AM, Sahota JS, Runge C, Kurtz SM, Lakshmi S, Allcock HR, Laurencin CT. Novel polyphosphazene-hydroxyapatite composites as biomaterials. IEEE Eng Med Biol Mag. 2003;22: 19-26.
213. Lu Z, Yuan WZ, Yang Y, Tang XZ, Huang XB. Preparation and characterization of novel poly [cyclotriphosphazene-co-(4,4'-sulfonyldiphenol)] nanofiber matrices. Polym Int. 2006;55:1357-60.
214. Gunatillake P, Mayadunne R, Adhikari R. Recent developments in biodegradable synthetic polymers. Biotechnol Annu Rev. 2006;12:301-47.
215. George PM, Lyckman AV, LaVan DA, Hegde A, Leung Y, Avasare R, Testa C, Langer R, Sur M. Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics. Biomaterials. 2005;26:3511-9.
216. Richardson RT, Thompson B, Moulton S, Newbold C, Lum MG, Cameron A, Wallace G, Kapsa R, Clark G, O'leary S. The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons. Biomaterials. 2007;28:513-23.
217. Cho SH, Oh SH, Lee JH. Fabrication and characterization of porous alginate/polyvinyl alcohol hybrid scaffolds for 3D cell culture. J Biomater Sci Polym Ed. 2005;16(8):933-47.
218. Scott D, Fitzpatrick MA, Mazumder J, Lasowski F, Fitzpatrick LE, Sheardown H. PNIPAAmgrafted-collagen as an injectable, in situ gelling, bioactive cell delivery scaffold. Biomacromolecules. 2010;11(9):2261-7.
219. Hench LL. Bioceramics. J Am Ceram Soc. 1998;81:1705-28.
220. Hing KA. Bioceramic bone graft substitutes:Influence of porosity and chemistry. Int J Appl Ceram Technol. 2005;2:184-99.
221. Marino G, Rosso F, Cafiero G, Tortora C, Moraci M, Barbarisi M, Barbarisi A. Beta-tricalcium phosphate 3D scaffold promote alone osteogenic differentiation of human adipose stem cells: in vitro study. J Mater Sci Mater Med. 2010;21(1):353-63.
222. Yoon JJ, Kim JH, Park TG. Dexamethasone releasing biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method. Biomaterials. 2003;24:2323-2329.
223. Letic-Gavrilovic A, Piattelli A, Abe K. Nerve growth factor beta delivery via a collagen/hydroxyapatite composite and its effects on new bone growth. J Mater Sci Mater Med. 2003;14:95-102.
224. Xiao Y, Qian H, Young WG, Bartold PM. Tissue engineering for bone regeneration using differentiated alveolar bone cells in collagen scaffolds. Tissue Eng. 2003;9:1167-77.
225. Shih YRV, Chen CN, Tsai SW, Wang YJ, Lee OK. Growth of mesenchymal stem cells on electrospun type I collagen nanofibers. Stem Cells. 2006;24:2391-7.
226. Tabata Y, Ikada Y, Protein release from gelatin matrices. Adv Drug Deliv Rev. 1998;31:287-301.
227. Ren L, Osaka A, Yu B, Shi W, Ge DT, Chen S. Bioactive gelatin-siloxane hybrids as tissue engineering scaffolds. Solid State Phenom Sci Technol Hybrid Mat. 2006;111:13-8.
228. Payne RG, McGonigle JS, Yaszemski MJ, Yasko AW, Mikos AG. Development of an injectable, in situ crosslinkable, degradable polymeric carrier for osteogenic cell populations. Part 2. Viability of encapsulated marrow stromal osteoblasts cultured on crosslinking poly(propylene fumarate). Biomaterials. 2002;23:4373-80.
229. Payne RG, Yaszemski MJ, Yasko AW, Mikos AG. Development of an injectable, in situ crosslinkable, degradable polymeric carrier for osteogenic cell populations. Part 1. Encapsulation of marrow stromal osteoblasts in surface crosslinked gelatin microparticles. Biomaterials. 2002;23:4359-71.
230. Li C, Vepari C, Jin HJ, Kim HJ, Kaplan DL. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials. 2006;27:3115-24.
231. Fini M, Motta A, Torricelli P, Glavaresi G, Aldini NN, Tschon M, Giardino R, Migliareso C. The healing of confined critical size cancellous defects in the presence of silk fibroin hydrogel. Biomaterials. 2005;26:3527-36.
232. Schmoekel H, Schense JC, Weber FE, Gratz KW, Gnagi D, Müller R, Hubbell JA. Bone healing in the rat and dog with nonglycosylated BMP-2 demonstrating low solubility in fibrin matrices. J Orthop Res. 2004;22:376-81.
233. Delgado JJ, Evora C, Sanchez E, Baro M, Delgado A. Validation of a method for non-invasive in vivo measurement of growth factor release from a local delivery system in bone. J Control Release. 2006;114:223-9.
234. Lee JY, Nam SH, Im SY, Park YJ, Lee YM, Seol YJ, Chung CP, Lee SJ. Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials. J Control Release. 2002;78:187-97.
235. Silva GA, Costa FJ, Neves NM, Coutinho ACP, Reis R.L. Entrapment ability and release profile of corticosteroids from starch-based particles. J Biomed Mater Res. 2005;73:234-43.
236. Silva GA, Coutinho OP, Ducheyne P, Shapiro IM, Reis RL. The effect of starch and starch-bioactive glass composite microparticles on the adhesion and expression of the osteoblastic phenotype of a bone cell line. Biomaterials. 2007;28:326-34.
237. Silva GA, Coutinho OP, Ducheyne P, Shapiro IM, Reis RL. Starch based Micro-particles as vehicles for the delivery of active platelet-derived growth factor. Tissue Eng. 2007;16:200-20.
238. Gomes ME, Reis RL, Mikos AG. Bone tissue engineering constructs based on starch scaffolds and bone marrow cells cultured in a flow perfusion bioreactor. Mat Sci Forum. 2006;514-516: 980-4.
239. Xu XL, Lou J, Tang TT, Ng KW, Zhang JH, Yu CF, Dai KR. Evaluation of different scaffolds for BMP-2 genetic orthopedic tissue engineering. J Biomed Mater Res B Appl Biomater. 2005;75:289-303.
240. Pound JC, Green DW, Chaudhuri JB, Mann S, Roach HI, Oreffo ROC. Strategies to promote chondrogenesis and osteogenesis from human bone marrow cells and articular chondrocytes encapsulated in polysaccharide templates. Tissue Eng. 2006;12:2789-99.
241. Keskin DS, Tezcaner A, Korkusuz P, Korkusuz F, Hasirci V. Collagen-chondroitin sulfate-based PLLA-SAIB-coated rhBMP-2 delivery system for bone repair. Biomaterials. 2005;26:4023-34.
242. Park YJ, Lee YM, Lee JY, Seol YJ, Chung CP, Lee SJ. Controlled release of platelet-derived growth factor-BB from chondroitin sulfate-chitosan sponge for guided bone regeneration. J Control Release. 2000;67:385-94.
243. Chen FM, Wu ZF, Wang QT, Wu H, Zhang YJ, Nie X, Jin Y. Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics. Acta Pharmacol Sin. 2005;26:1093-103.
244. Chen FM, Zhao YM, Wu H, Deng ZH, Wang QT, Zhou W, Liu Q, Dong GY, Li K, Wu ZF, Jin Y. Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran-co-gelatin microspheres. J Control Release. 2006;114:209-22.
245. Kim H, Suh H, Jo SA, Kim HW, Lee JM. In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate. Biochem Biophys Res Commun. 2005;332:1053-60.
246. Xiang Z, Liao R, Kelly MS, Spector M. Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells. Tissue Eng. 2006;12:2467-78.
247. Neidert MR, Lee ES, Oegema TR, Tranquillo RT. Enhanced fibrin remodeling in vitro with TGF-beta1, insulin and plasmin for improved tissue-equivalents. Biomaterials. 2002;23:3717-31.
248. Mol A, van Lieshout MI, Dam-de Veen CG, Neuenschwander S, Hoerstrup SP, Baaijens FPT, Bouten CV. Fibrin as a cell carrier in cardiovascular tissue engineering applications. Biomaterials. 2005;26:3113-21.
249. Chandler LA, Gu DL, Ma CL, Gonzalez AM, Doukas J, Nguyen T, Pierce GF, Phillips ML. Matrix-enabled gene transfer for cutaneous wound repair. Wound Repair Regen. 2000;8:473-9.
250. Alemdaroglu C, Degim Z, Celebi N, Zor F, Ozturk S, Erdogan D. An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor. Burns. 2006;32:319-27.
251. Obara K, Ishihara M, Ishizuka T, Fujita M, Ozeki Y, Maehara T, Saito Y, Yura H, Matsui T, Hattori H, Kikuchi M, Kurita AL. Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice. Biomaterials. 2003;24:3437-44.
252. Pianigiani E, Andreassi A, Taddeucci P, Alessandrini C, Fimiani M, Andreassi L. A new model for studying differentiation and growth of epidermal cultures on hyaluronan-based carrier. Biomaterials. 1999;20: 1689-94.
253. Fujisato T, Sajiki T, Liu Q, Ikada Y. Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold. Biomaterials. 1996;17:155-62.
254. Franceschi LD, Grigolo B, Roseti L, Facchini A, Fini M, Giavaresi G, Tschon M, Giardino R. Transplantation of chondrocytes seeded on collagen-based scaffold in cartilage defects in rabbits. J Biomed Mater Res A. 2005;75:612-22.
255. Holland TA, Tabata Y, Mikos AG. Dual growth factor delivery from degradable oligo (poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering. J Control Release. 2005;101:111-25.
256. Park H, Temenoff JS, Holland TA, Tabata Y, Mikos AG. Delivery of TGF-beta1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials. 2005;26: 7095-103.
257. Awad HA, Wickham MQ, Leddy HA, Gimble JM, Guilak F. Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. Biomaterials 2004;25:3211-22.
258. Ito A, Mase A, Takizawa Y, Shinkai M, Honda H, Hata K, Ueda M, Kobayashi T. Transglutaminase-mediated gelatin matrices incorporating cell adhesion factors as a biomaterial for tissue engineering. J Biosci Bioeng. 2003;95:196-9.
259. Malda J, Kreijveld E, Temenoff JS, Blitterswijk CAV, Riesle J. Expansion of human nasal chondrocytes on macroporous microcarriers enhances redifferentiation. Biomaterials. 2003;24:5153-61.
260. Ponticiello MS, Schinagl RM, Kadiyala S, Barry FP. Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy. J Biomed Mater Res. 2000;52:246-55.
261. Wang Y, Kim UJ, Blasioli DJ, Kim HJ, Kaplan DL. In vitro cartilage tissue engineering with 3D porous aqueous-derived silk scaffolds and mesenchymal stem cells. Biomaterials. 2005;26:7082-94.
262. Perka C, Schultz O, Lindenhayn K, Spitze RS, Muschik M, Sittinger M, Burmester GR. Joint cartilage repair with transplantation of embryonic chondrocytes embedded in collagen-fibrin matrices. Clin Exper Rheumatol. 2000;18:13-22.
263. Eyrich D, Brandl F, Appel B, Wiese H, Maier G, Wenzel M, Staudenmaier R, Goepferich A, Blunk T. Longterm stable fibrin gels for cartilage engineering. Biomaterials. 2007;28:55-65.
264. Hunter CJ, Mouw JK, Levenston ME. Dynamic compression of chondrocyte-seeded fibrin gels: effects on matrix accumulation and mechanical stiffness. Osteoarthr Cartil. 2004;12:117-30.
265. Mouw JK, Case ND, Guldberg RE, Plaas AHK, Levenston ME. Variations in matrix composition and GAG fine structure among scaffolds for cartilage tissue engineering. Osteoarthr Cartil. 2005;13:828-36.
266. Ameer GA, Mahmood TA, Langer R. A biodegradable composite scaffold for cell transplantation. J Orthop Res. 2002;20:16-9.
267. Perka C, Spitzer RS, Lindenhayn K, Sittinger M, Schultz O. Matrixmixed culture: new methodology for chondrocyte culture and preparation of cartilage transplants. J Biomed Mater Res. 2000;49:305-11.
268. Guo T, Zhao J, Chang J, Ding Z, Hong H, Chen J, Zhang J. Porous chitosan-gelatin scaffold containing plasmid DNA encoding transforming growth factor-beta1 for chondrocytes proliferation. Biomaterials. 2006;27:1095-103.
269. Kim SE, Park JH, Cho YW, Chung H, Jeong SY, Lee EB, Kwon IC. Porous chitosan scaffold containing microspheres loaded with transforming growth factor-beta1: implications for cartilage tissue engineering. J Control Release. 2003;91:365-74.
270. Malafaya PB, Pedro A, Peterbauer A, Gabriel C, Redl H, Reis R. Chitosan particles agglomerated scaffolds for cartilage and osteochondral tissue engineering approaches with adipose tissue derived stem cells. J Mater Sci Mater Med. 2005;16:1077-085.
271. Gründer T, Gaissmaier C, Fritz J, Stoop R, Hortschansky P, Mollenhauer J, Aicher WK. Bone morphogenetic protein-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded inalginate beads. Osteoarthr Cartil. 2004;12:559-67.
272. Masuda K, Pfister BE, Sah RL, Thonar EJMA. Osteogenic protein-1 promotes the formation of tissue-engineered cartilage using the alginate-recovered-chondrocyte method. Osteoarthr Cartil. 2006;14:384-91.
273. Gaissmaier C, Fritz J, Krackhardt T, Flesch I, Aicher WK, Ashammakhi N. Effect of human platelet supernatant on proliferation and matrix synthesis of human articular chondrocytes in monolayer and threedimensional alginate cultures. Biomaterials. 2005;26:1953-60.
274. Akeda K, An HS, Okuma M, Attawia M, Miyamoto K, Thonar EJMA, Lenz ME, Sah RL, Masuda K. Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. Osteoarthr Cartil. 2006;14:1272-80.
275. Heywood HK, Bader DL, Lee DA. Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs. Tissue Eng. 2006;12:3487-96.
276. Dausse Y, Grossin L, Miralles G, Pelletier S, Mainard D, Hubert P, Baptiste D, Gillet P, Dellacherie E, Netter P, Payan E. Cartilage repair using new polysaccharidic biomaterials: macroscopic, histological and biochemical approaches in a rat model of cartilage defect. Osteoarthr Cartil. 2003;11: 16-28.
277. Marijnissen WJCM, van Osch GJVM, Aigner J, van der Veen SW, Hollander AP, Verwoerd-Verhoef HL, Verhaar JA. Alginate as a chondrocyte-delivery substance in combination with a non-woven scaffold for cartilage tissue engineering. Biomaterials. 2002;23:1511-7.
278. Cohen SB, Meirisch CM, Wilson HA, Diduch DR. The use of absorbable co-polymer pads with alginate and cells for articular cartilage repair in rabbits. Biomaterials. 2003;24:2653-60.
279. Cai S, Liu Y, Zheng Shu X, Prestwich GD. Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. Biomaterials. 2005;26:6054-67.
280. Lee JE, Kim KE, Kwon IC, Ahn HJ, Lee SH, Cho H, Kim JJ, Seong Sc, Lee MC. Effects of the controlled-released TGF-beta1 from chitosan microspheres on chondrocytes cultured in a collagen/ chitosan/ glycosaminoglycan scaffold. Biomaterials. 2004;25:4163-73.
281. Fan H, Hu Y, Zhang C, Li X, Lv R, Qin L, Zhu R. Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold. Biomaterials. 2006;27:4573-80.
282. Chang CH, Liu HC, Lin CC, Chou CH, Lin FH. Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering. Biomaterials. 2003;24:4853-8.
283. van Susante JLC, Pieper J, Buma P, Van Kuppevelt TH, Van Beuningen H, van Der Kraan PM, Veerkamp JH, van den Berg WB, Veth RPH. Linkage of chondroitin-sulfate to type I collagen scaffolds stimulates the bioactivity of seeded chondrocytes in vitro. Biomaterials. 2001;22:2359-69.
284. Stevens MM, Marini RP, Martin I, Langer R, Shastri VP. FGF-2 enhances TGF-beta1-induced periosteal chondrogenesis. J Orthop Res. 2004;22:1114-9.
285. Svensson A, Nicklasson E, Harrah T, Panilaitis B, Kaplan DL, Brittberg M, Gatenholm P. Bacterial cellulose as a potential scaffold for tissue engineering of cartilage. Biomaterials. 2005;26:419-31.
286. Koch S, Yao C, Grieb G, Prevel P, Noah EM, Steffens GCM. Enhancing angiogenesis in collagen matrices by covalent incorporation of VEGF. J Mater Sci Mater Med. 2006;17:735-41.
287. Pieper J, Hafmans T, van Wachem P, van Luyn M, Brouwer L, Veerkamp J, van Kuppevelt TH. Loading of collagen-heparan sulfate matrices with bFGF promotes angiogenesis and tissue regeneration in rats. J Biomed Mater Res. 2002;62:185-94.
288. Jeon O, Kang SW, Lim HW, Chung J, Kim BS. Long-term and zero-order release of basic fibroblast growth factor from heparinconjugated poly(l-lactide-co-glycolide) nanospheres and fibrin gel. Biomaterials. 2006;27:1598-607.
289. Jeon O, Ryu SH, Chung J, Kim BS. Control of basic fibroblast growth factor release from fibrin gel with heparin and concentrations of fibrinogen and thrombin. J Control Release. 2005;105:249-59.
290. Ehrbar M, Metters A, Zammaretti P, Hubbell JA, Zisch AH. Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. J Control Release. 2005;101:93-109.
291. Aper T, Schmidt A, Duchrow A, Bruch HP. Autologous blood vessels engineered from peripheral blood sample. Eur J Vasc Endovasc Surg. 2007;33:33-9.
292. Rowe SL, Lee S, Stegemann JP. Influence of thrombin concentration on the mechanical and morphological properties of cell-seeded fibrin hydrogels. Acta Biomaterialia. 2007;3:59-67.
293. Fujita M, Ishihara M, Simizu M, Obara K, Ishizuka T, Saito Y, Yura H, Morimoto Y, Takase B, Matsui T, Kikuchi M, Maehara T. Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogel. Biomaterials. 2004;25:699-706.
294. Fujita M, Ishihara M, Morimoto Y, Simizu M, Saito Y, Yura H, Matsui T, Takase B, Hattori H, KanataniY, Kikuchi M Maehara T. Efficacy of photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 in a rabbit model of chronic myocardial infarction. J Surg Res. 2005;126:27-33.
295. Santos MI, Fuchs S, Gomes ME, Unger RE, Reis RL, Kirkpatrick CJ. Response of micro-and macrovascular endothelial cells to starch-based fiber meshes for bone tissue engineering. Biomaterials. 2007;28:240-8.
296. Keshaw H, Forbes A, Day RM. Release of angiogenic growth factors from cells encapsulated in alginate beads with bioactive glass. Biomaterials. 2005;26:4171-9.
297. Yun YH, Goetz DJ, Yellen P, Chen WL. Hyaluronan microspheres for sustained gene delivery and sitespecific targeting. Biomaterials. 2004;25:147-57.
298. Turner NJ, Kielty CM, Walker MG, Canfield AE. A novel hyaluronan-based biomaterial (Hyaff-11) as a scaffold for endothelial cells in tissue engineered vascular grafts. Biomaterials. 2004;25:5955-64.
299. Liu Y, Yang H, Otaka K, Takatsuki H, Sakanishi A. Effects of vascular endothelial growth factor (VEGF) and chondroitin sulfate A on human monocytic THP-1 cell migration. Colloids Surf B Biointerfaces. 2005;43:216-20.
300. Vashi AV, Abberton KM, Thomas GP, Morrison WA, O'Connor AJ, Cooper-White JJ, Thompson EW. Adipose tissue engineering based on the controlled release of fibroblast growth factor-2 in a collagen matrix. Tissue Eng. 2006;12:3035-43.
301. Hemmrich K, Heimburg DV, Rendchen R, Bartolo CD, Milella E, Pallua N. Implantation of preadipocyteloaded hyaluronic acid-based scaffolds into nude mice to evaluate potential for soft tissue engineering. Biomaterials. 2005;26:7025-37.
302. Masuda T, Furue M, Matsuda T. Photocured, styrenated gelatin-based microspheres for de novo adipogenesis through corelease of basic fibroblast growth factor, insulin, and insulin-like growth factor I. Tissue Eng. 2004;10:523-35.
303. Kimura Y, Ozeki M, Inamoto T, Tabata Y. Adipose tissue engineering based on human preadipocytes combined with gelatin microspheres containing basic fibroblast growth factor. Biomaterials 2003;24:2513-21.
304. Gruber HE, Hoelscher GL, Leslie K, Ingram JA, Hanley EN. Threedimensional culture of human disc cells within agarose or a collagen sponge: assessment of proteoglycan production. Biomaterials. 2006;27:371-6.
305. Gruber HE, Leslie K, Ingram J, Norton HJ, Hanley EN. Cell-based tissue engineering for the intervertebral disc: in vitro studies of human disc cell gene expression and matrix production within selected cell carriers. Spine J. 2004;4:44-55.
306. Gruber H, Fisher E, Desai B, Stasky A, Hoelscher G, Hanley E. Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1. Exp Cell Res. 1997;235:13-21.
307. Sumita Y, Honda MJ, Ohara T, Tsuchiya S, Sagara H, Kagami H, Ueda M. Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering. Biomaterials. 2006;2:3238-48.
308. Zhang Y, Cheng X, Wang J, Wang Y, Shi B, Huang C, Yang X, Liu T. Novel chitosan/collagen scaffold containing transforming growth factor-beta1 DNA for periodontal tissue engineering. Biochem Biophys Res Commun. 2006;344:362-9.
309. Zhang Y, Wang Y, Shi B, Cheng X. A platelet-derived growth factor releasing chitosan/coral composite scaffold for periodontal tissue engineering. Biomaterials. 2007;28:1515-22.
310. Park YJ, Lee YM, Park SN, Sheen SY, Chung CP, Lee SJ. Platelet derived growth factor releasing chitosan sponge for periodontal bone regeneration. Biomaterials. 2000;21:153-9.
311. Prescott RS, Alsanea R, Fayad M, Johnson BR, Wenckus CS. In-vivo generation of dental pulp-like tissue using human pulpal stem cells, a collagen scaffold and dentin matrix protein 1 following subcutaneous transplantation in mice. J Endod. 2008;34(4):421-6.
312. Chen F, Zhao Y, Zhang R, Jin T. Periodontalregeneration using novel glycidyl methacrylated dextran (DexGMA)/ gelatin scaffolds containing microspheres loaded with bone morphogenetic proteins. J Control Release. 2007;121:81-90.
313. Danielsson C, Ruault S, Basset-Dardare A, Frey P. Modified collagen fleece, a scaffold for transplantation of human bladder smooth muscle cells. Biomaterials. 2006;27:1054-60.
314. Wang PC, Takezawa T. Reconstruction of renal glomerular tissue using collagen vitrigel scaffold. J Biosci Bioeng. 2005; 99:529-40.
315. Liu Y, Shu XZ, Prestwich GD. Osteochondral defect repair with autologous bone marrow derived mesenchymal stem cells in an injectable, in situ, cross-linked synthetic extracellular matrix. Tissue Eng. 2006;12: 3405-16.
316. Shao XX, Hutmacher DW, Ho ST, Goh JCH, Lee EH. Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits. Biomaterials. 2006;27:1071-80.
317. Chevrier A, Hoemann CD, Sun J, Buschmann MD. Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects. Osteoarthr Cartil. 2007;15:316-27.
318. Radice M, Brun P, Cortivo R, Scapinelli R, Battaliard C, Abatangelo G. Hyaluronan-based biopolymers as delivery vehicles for bone-marrow-derived mesenchymal progenitors. J Biomed Mater Res. 2000;50: 101-9.
319. Wang X, Wenk E, Zhang X, Meinel L, Vunjak-Novakovic G, Kaplan DL. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. J Control Release. 2009;134:81-90.
320. Fuchs S, Motta A, Migliaresi C, Kirkpatrick CJ. Outgrowth endothelial cells isolated and expanded from human peripheral blood progenitor cells for endothelialization as a potential source of autologous of silk fibroin biomaterials. Biomaterials. 2006;27:5399-408.
321. Unger RE, Peters K, Wolf M, Motta A, Migliaresi C, Kirkpatrick CJ. Endothelialization of a non-woven silk fibroin net for use in tissue engineering: growth and gene regulation of hunian endothelial cells. Biomaterials. 2004;25:5137-46.
322. Min BM, Lee G, Kim SH, Nam YS, Lee TS. Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro. Biomaterials. 2004;25: 1289-97.
323. Li B, Brown KV, Wenke JC. Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect mode. J Control Release. 2010;145:221-30.
324. Tigh RS, Gümüsderelioglu M. Dexamethasone releasing chitosan scaffold for cartilage development. Eur Cell Mater. 2006;12:73.
325. Lv Q, Feng Q, Hu K, Cui F. Three-dimensional fibroin/collagen scaffolds derived from aqueous solution and the use for HepG2 culture. Polymer. 2005;46:12662-9.
326. Balakrishnan B, Jayakrishnan A. Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds. Biomaterials. 2005;26:3941-51.
327. Altman GH, Horan RL, Lu HH, Moreau JE, Martin I, Richmond JC, Kaplan DL. Silk matrix for tissue engineered anterior cruciate ligaments. Biomaterials. 2002;23:4131-41.
328. Taylor SJ, McDonald JW, Sakiyama-Elbert SE. Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury. J Control Release. 2004;98:281-94.
329. Taylor SJ, Rosenzweig ES, McDonald JW, Sakiyama-Elbert SE. Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injury. J Control Release. 2006;113:226-35.
330. Willerth SM, Arendas KJ, Gottlieb DI, Sakiyama-Elbert SE. Optimization of fibrin scaffolds for differentiation of murine embryonicstem cells into neural lineage cells. Biomaterials. 2006;27:5990-6003.
331. Lee AC, Yu VM, Lowe JB, Brenner MJ, Hunter DA, Mackinnon SE, Sakiyama-Elbert SE. Controlled release of nerve growth factor enhances sciatic nerve regeneration. Exp Neurol. 2003;184: 295-303.
332. Sakiyama-Elbert SE, Hubbell JA. Controlled release of nerve growth factor from a heparin-containing fibrinbased cell in growth matrix. J Control Release. 2000;69:149-58.
333. Sakiyama-Elbert SE, Hubbell JA. Development of fibrin derivatives for controlled release of heparin-binding growth factors. J Control Release. 2000;65:389-402.
334. Goraltchouk A, Scanga V, Morshead CM, Shoichet MS. Incorporation of protein-eluting microspheres into biodegradable nerve guidance channels for controlled release. J Control Release. 2006;110:400-7.
335. Vogelin E, Baker JM, Gates J, Dixit V, Constantinescu MA, Jones NF. Effects of local continuous release of brain derived neurotrophic factor (BDNF) on peripheral nerve regeneration in a rat model. Exp Neurol. 2006;199:348-53.
336. Simpson NE, Stabler CL, Simpson CP, Sambanis A, Constantinidis I. The role of the CaCl2-guluronic acid interaction on alginate encapsulated betaTC3 cells. Biomaterials. 2004;25:2603-10.
337. Bloch K, Lozinsky VI, Galaev IY, Yavriyanz K, Vorobeychik M, Azarov D, Damshkain LG, Mattiasson B, Vardi P. Functional activity of insulinoma cells (INS-1E) and pancreatic islets cultured in agarose cryogel sponges. J Biomed Mater Res A. 2005;75:802-9.
338. Flanagan TC, Wilkins B, Black A, Jockenhoevel S, Smith TJ, Pandit AS. A collagen-glycosaminoglycan coculture model for heart valve tissue engineering applications. Biomaterials. 2006;27:2233-46.
339. Zhao DE, Li RB, Liu WY, Wang G, Yu SQ, Zhang CW, Chen WS, Zhou GX. Tissue-engineered heart valve on acellular aortic valve scaffold: in-vivo study. Asian Cardiovasc Thorac Ann. 2003;11:153-6.
340. Lee CT, Kung PH, Lee YD. Preparation of poly(vinyl alcohol)-chondroitin sulfate hydrogel as matrices in tissue engineering. Carbohydr Polym. 2005;6:348-54.
341. Levesque SG, Shoichet MS. Synthesis of cell-adhesive dextran hydrogels and macroporous scaffolds. Biomaterials. 2006;27:5277-85.
342. Alaminos M, Del Carmen Sanchez-Quevdo M, Munoz-Avila JI, Serrano D, Medialdea S, Carreras I, Campos A. Construction of a complete rabbit cornea substitute using a fibrin-agarose scaffold. Invest Ophthalmol Vis Sci. 2007;47:3311-17.
343. Mao G, Chen G, Bai H, Song T, Wang Y. The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells. Biomaterials. 2009;30: 1706-14.
344. Salvay DM, Rives CB, Zhang X, Chen F, Kaufman DB, Lowe WL Jr, Shea LD. Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation. Transplantation. 2008;85(10):1456-64.
345. Park JS, Woo DG, Sun BK, Chung H. In vitro and in vivo test of PEG/PCL-based hydro gel scaffold for cell delivery application. J Control Release. 2007;124:51-9.
346. Defail AJ, Edington HD, Mathhews S, Lee W, Marra K. Controlled release of bioactive doxorubicin from microspheres embedded within gelatin scaffolds. J Biomed Mater Res A. 2006;79:954-62.
347. Venkatesan P, Puvvada N, Dash R, Prashanth BN, Sarkar D, Azab B, Pathak A, Kundu SC, Fisher PB, Mandal M. The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer. Biomaterials. 2011;32:3794-806.
348. Feng K, Sun H, Bradley MA, Dupler EJ, Giannobile WV, Ma PX. Novel antibacterial nanofibrous PLLA scaffolds. J Control Release. 2010;146:363-9.
349. Zhang Y, Zhang M. Calcium phosphate/chitosan composite scaffolds for controlled in vitro antibiotic drug release. J Biomed Mater Res. 2002;62:378-86.
350. Vallet-Regi M, Ragel CV, Arcos D, Clavel-Sainz M, Meseguer-Olmo L. Mé todos para la obtención de implantes bioactivos ú tiles como sistemas de liberacióncontrolada. Spanish patent no. P22001-01386.2181593. 2001.
351. Zhu Y, Kaskel S. Comparison of the in vitro bioactivity and drug release property of mesoporous bioactive glasses (MBGs) and bioactive glasses (BGs) scaffolds. Microporous Mesoporous Mater. 2009;118:176-82.
352. Shi X, Wang Y, Rena L, Zhao N, Gong Y, Wang D. Novel mesoporous silica-based antibiotic releasing scaffold for bone repair. Acta Biomater. 2009;5:1697-707.
353. Domingues ZR, Cortés ME, Gomes TA, Diniz HF, Freitas CS, Gomes JB, Faria AM, Sinisterra RD. Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with b-cyclodextrin. Biomaterials. 2004;25:327-33.
354. Cabañas MV, Peña J, Román J, Vallet-Regí M. Tailoring vancomycin release from x-TCP/agarose scaffolds. Eur J Pharm Sci. 2009;37:249-56.
355. Kimakhe S, Bohic S, Larosse C, Reynaud A, Pilet P, Giumelli B, Heymann D, Daculsi G. Biological activities of sustained polymixin B release from calcium phosphate biomaterial prepared by dynamic compaction: an in vitro study. J Biomed Mater Res. 1999;47:18-27.
356. Miyai T, Ito A, Tamazawa G, Matsuno T, Sogo Y, Nakamura C, Yamazaki A, Satoh T. Antibioticloaded poly-e-caprolactone and porous b-tricalcium phosphate composite for treating osteomyelitis. Biomaterials. 2008;29:350-8.
357. Castro C, Evora C, Baro M, Soriano I, Sánchez E. Two-month ciprofloxacin implants for multibacterial bone infections. Eur J Pharm Sci. 2005;60:401-6.
358. Di Nunzio S, Verné E. Process for the production of silver-containing prosthetic devices. Italian patent no. PCT/EP2005/056391. 2005.
359. Duarte AR, Mano JF, Reis RL. A Dexamethasone-loaded scaffolds prepared by supercritical-assisted phase inversion. Acta Biomater. 2009;5:2054-62.
360. Duarte AR, Mano JF, Reis RL. Preparation of chitosan scaffolds loaded with dexamethasone for tissue engineering applications using supercritical fluid technology. Eur Polym J. 2009;45:141-8.
361. Mortera R, Onida B, Fiorilli S, Cauda V, Vitale-Brovarone C, Baino F, Verne E, Garrone E. Synthesis and characterization of MCM-41 spheres inside bioactive glass-ceramic scaffold. Chem Eng J. 2007;137:54-61.
362. Nieto A, Balas F, Colilla M, Manzano M, Vallet-Regí M. Functionalization degree of SBA-15 as key factor to modulate sodium alendronate dosage. Microporous Mesoporous Mater. 2008;116:4-13.
363. Fauchex C. Controlled release of bisphosphonate from a calcium phosphate biomaterial inhibits osteoclastic resorption in vitro. J Biomed Mater Res A. 2009;86:46-56.