Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres

Journal of Controlled Release

Volumn 153, Issue 2, 2011, Pages 133-140

  Son, Jun Sik ^a   Appleford, Mark ^a   Ong, Joo L ^a   Wenke, Joseph C ^b   Kim, Jong Min ^c   Choi, Seok Hwa ^c   Oh, Daniel S ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b Army Institute of Surgical Research   (United States)

^c Chungbuk National University   (South Korea)

Author keywords

Dexamethasone; Drug delivery system; Hydroxyapatite; Microsphere; Poly(lactic co glycolic acid); Scaffold

Indexed keywords

BEAGLE DOG; BIOACTIVE MOLECULES; BIODEGRADABLE POLYMERIC MICROSPHERES; BONE FORMATION; BONE GRAFT SUBSTITUTES; BONE REGENERATION; BURST RELEASE; DEXAMETHASONES; DRUG DELIVERY SYSTEM; IN-VITRO; IN-VIVO; OSTEOGENESIS; PLGA MICROSPHERES; POLY(LACTIC-CO-GLYCOLIC ACID); POROUS HYDROXYAPATITE; RELEASE PROFILES; STEM CELL THERAPY; SUSTAINED RELEASE;

APATITE; BIOCERAMICS; BIODEGRADABLE POLYMERS; BONE; CALCIUM PHOSPHATE; DEFECTS; DRUG DELIVERY; DRUG PRODUCTS; HYDROXYAPATITE; SCAFFOLDS (BIOLOGY); STEM CELLS;

MICROSPHERES;

BIOCERAMICS; CALCIUM PHOSPHATE; DEXAMETHASONE; HYDROXYAPATITE; MICROSPHERE; POLYETHYLENEIMINE; POLYGLACTIN; TISSUE SCAFFOLD;

ANIMAL EXPERIMENT; ARTICLE; BONE DEFECT; BONE DEVELOPMENT; BONE GRAFT; BONE PROSTHESIS; BONE REGENERATION; CONTROLLED STUDY; DOG; DRUG DELIVERY SYSTEM; DRUG RELEASE; FEMUR; IMPLANTATION; MALE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; SURFACE CHARGE;

ANIMALS; BONE REGENERATION; DEXAMETHASONE; DOGS; DRUG DELIVERY SYSTEMS; DURAPATITE; GLUCOCORTICOIDS; LACTIC ACID; MALE; MICROSPHERES; POLYGLYCOLIC ACID; POROSITY; TISSUE SCAFFOLDS;

EID: 79960105126     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.03.010     Document Type: Article

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