Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery

International Journal of Pharmaceutics

Volumn 448, Issue 1, 2013, Pages 168-174

  Zhang, Jifen ^a   Tang, Qin ^a   Xu, Xiaoyu ^a   Li, Na ^a  

^a SOUTHWEST UNIVERSITY   (China)

Author keywords

Chitosan microspheres; Curcumin; Lipophilic compound; Phytosomes; Sustained release

Indexed keywords

CHITOSAN; CURCUMIN; GLYCYRRHETINIC ACID PHOSPHOLIPID COMPLEX; MICROSPHERE;

ANIMAL EXPERIMENT; ARTICLE; COMPLEX FORMATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; DRUG RETENTION; DRUG SCREENING; DRUG SOLUBILITY; GELATION; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MAXIMUM PLASMA CONCENTRATION; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; RAT;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHITOSAN; CURCUMIN; DRUG DELIVERY SYSTEMS; MICROSPHERES; PARTICLE SIZE; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84875925584     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.03.021     Document Type: Article

References (32)

1. P. Anand, S.G. Thomas, A.B. Kunnumakkara, A.B. Kunnumakkara, and C. Sundaram Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature Biochem. Pharm. 76 2008 590 1611
2. A. Anitha, S. Maya, N. Deepa, K.P. Chennazhi, S.V. Nair, H. Tamura, and R. Jayakumar Efficient water soluble O-carboxymethyl chitosan nanocarrier for the delivery of curcumin to cancer cells Carbohyd. Polym. 83 2011 452 461
3. G. Began, E. Sudharshan, K. Udaya Sankar, and A.G. Appu Rao Interaction of curcumin with phosphatidylcholine: a spectrofluorometric study J. Agric. Food Chem. 47 1999 4992 4997 (Pubitemid 30016929)
4. X.Q. Cai, Y.X. Luan, Y. Jiang, A.X. Song, W. Shao, Z.H. Li, and Z.X. Zhao Huperzine A-phospholipid complex-loaded biodegradable thermosensitive polymer gel for controlled drug release Int. J. Pharm. 433 2012 102 111
5. C.G. Chen, T.D. Johnston, H. Jeon, R. Gedaly, P.P. McHugh, T.G. Burke, and D. Ranjanm An in vitro study of liposomal curcumin: stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells Int. J. Pharm. 366 2009 133 139
6. A.L. Cheng, C.H. Hsu, J.K. Lin, M.M. Hsu, Y.F. Ho, and T.S. Shen Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions Anticancer Res. 21 2001 2895 2900
7. J. Cui, B. Yu, Y. Zhao, W.W. Zhu, H.L. Li, H.X. Lou, and G.X. Zhai Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems Int. J. Pharm. 371 2009 148 155
8. P. Dadhaniya, C. Patel, J. Muchhara, N. Bhadja, N. Mathuria, K. Vachhani, and M.G. Sonib Safety assessment of a solid lipid curcumin particle preparation: acute and subchronic toxicity studies Food Chem. Toxicol. 49 2011 1834 1842
9. R.K. Das, N. Kasoju, and U. Bora Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells Nanomed. Nanotechnol. Biol. Med. 6 2010 153 160
10. M. Dasha, F. Chiellini, R.M. Ottenbrite, and E. Chiellini Chitosan-A versatile semisynthetic polymer in biomedical applications Prog. Polym. Sci. 36 2011 981 1014
11. S.S. Feng, G. Ruan, and Q.T. Li Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM) Biomaterials 25 2004 5181 5189 (Pubitemid 38510404)
12. T.H. Kim, H.H. Jiang, Y.S. Youn, C.W. Park, K.K. Tak, S. Lee, H. Kim, S.Y. Jon, X.Y. Chen, and K.C. Lee Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity Int. J. Pharm. 403 2011 285 291
13. M. Machluf, O. Regev, Y. Peled, J. Kost, and S. Cohen Characterization of microencapsulated liposome systems for the controlled delivery of liposome-associated macromolecules J. Control. Rel. 43 1996 35 45 (Pubitemid 26393606)
14. R.K. Maheshwari, A.K. Singh, J. Gaddipati, and R.C. Srimal Multiple biological activities of curcumin: a short review Life Sci. 78 2006 2081 2087
15. K. Maiti, K. Mukherjee, A. Gantait, B.P. Saha, and P.K. Mukherjee Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats Int. J. Pharm. 330 2007 155 163 (Pubitemid 46097368)
16. M.H. Pan, T.M. Huang, and J.K. Lin Biotransformation of curcumin through reduction and glucuronidation in mice Drug Metab. Dispos. 27 1999 486 494
17. A. Paradkar, A.A. Ambike, B.K. Jadhav, and K.R. Mahadik Characterization of curcumin-PVP solid dispersion obtained by spray drying Int. J. Pharm. 271 2004 281 286 (Pubitemid 38210105)
18. Q. Peng, Z.R. Zhang, T. Gong, G.Q. Chen, and X. Sun A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles Biomaterials 33 2012 1583 1588
19. A.S. Saraf Applications of novel drug delivery system for herbal formulations Fitoterapia 81 2010 680 689
20. S. Senel, M.J. Kremer, S. Kas, P.W. Wertz, A.A. Hincal, and C.A. Squier Enhancing effect of chitosan on peptide drug delivery across buccal mucosa Biomaterials 21 2000 2067 2071 (Pubitemid 30488077)
21. S. Setthacheewakul, S. Mahattanadul, N. Phadoongsombut, W. Pichayakorn, and R. Wiwattanapatapee Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats Eur. J. Pharm. Biopharm. 76 2010 475 485
22. J. Shaikh, D.D. Ankola, V. Beniwal, D. Singh, and M.N.V. Ravi Kumar Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer Eur. J. Pharm. Sci. 37 2009 223 230
23. R.A. Sharma, S.A. Euden, S.L. Platton, D.N. Cooke, A. Shafayat, and H.R. Hewitt Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance Clin. Cancer Res. 10 2004 6847 6854 (Pubitemid 39383033)
24. R.A. Sharma, W.P. Steward, and A.J. Gescher Pharmacokinetics and pharmacodynamics of curcumin Adv. Exp. Med. Biol. 595 2007 453 470
25. Z.M. Song, R.L. Feng, M. Sun, C.Y. Guo, Y. Gao, L.B. Li, and G.X. Zhai Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: preparation, pharmacokinetics and distribution in vivo J. Colloid Interf. Sci. 354 2011 116 123
26. K. Sou, S. Inenaga, S. Takeoka, and E. Tsuchida Loading of curcumin into macrophages using lipid-based nanoparticles Int. J. Pharm. 352 2008 287 293
27. R.M. Srivastava, S. Singh, S.K. Dubey, K. Misra, and A. Khar Immunomodulatory and therapeutic activity of curcumin Int. Immunopharm. 11 2011 331 341
28. R.J.H. Stenekes, A.E. Loebis, C.M. Fernandes, D.J.A. Crommelin, and W.E. Hennink Controlled release of liposomes from biodegradable dextran microspheres: a novel delivery concept Pharma. Res. 17 2000 690 695 (Pubitemid 30670634)
29. M. Thanou, J.C. Verhoef, and H.E. Junginger Oral drug absorption enhancement by chitosan and its derivatives Adv. Drug Deliv. Rev. 52 2001 117 126 (Pubitemid 33079167)
30. H.H. Tonnesen, M. Masson, and T. Loftsson Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability Int. J. Pharm. 244 2002 127 135 (Pubitemid 35245453)
31. M.M. Yallapu, M. Jaggi, and S.C. Chauhan Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells Colloids Surf. B: Biointerface 79 2010 113 125
32. K.Y. Yang, L.C. Lin, T.Y. Tseng, S.C. Wang, and T.H. Tsai Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 853 2007 183 189