Design and in vitro and in vivo characterization of mucoadhesive matrix pellets of metformin hydrochloride for oral controlled release: A technical note

Archives of Pharmacal Research

Volumn 35, Issue 3, 2012, Pages 487-498

  Ige, Pradum Pundlikrao ^a   Gattani, Surendra Ganeshlal ^b  

^a R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

^b H R PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

Design expert software; Hydroxy propyl methyl cellulose K200M; In vivo xray imaging study; Mucoadhesive gastro retentive drug delivery system; Pelletization; Scanning electron microscopy

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; METFORMIN; MICROCRYSTALLINE CELLULOSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED RELEASE FORMULATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG PELLET; EQUIPMENT; EX VIVO STUDY; IN VITRO STUDY; IN VIVO STUDY; MUCOADHESION; MUCOSA; NONHUMAN; PARTICLE SIZE; PELLET EXTRUSION; POROSITY; RABBIT; RADIOGRAPHY; SCANNING ELECTRON MICROSCOPE; SMALL INTESTINE; X RAY DIFFRACTION;

ADHESIVENESS; ADMINISTRATION, ORAL; ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DOSAGE FORMS; DRUG CARRIERS; DRUG COMPOUNDING; GASTRIC MUCOSA; GOATS; HYPOGLYCEMIC AGENTS; INTESTINAL MUCOSA; INTESTINE, SMALL; KINETICS; MALE; METFORMIN; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; POROSITY; RABBITS; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 84862896041     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0312-7     Document Type: Article

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