Evaluation of mucoadhesive hydrogels loaded with diclofenac sodium-chitosan microspheres for rectal administration

AAPS PharmSciTech

Volumn 11, Issue 4, 2010, Pages 1695-1702

  El Leithy, Eman S ^a   Shaker, Dalia S ^a   Ghorab, Mohamed K ^a   Abdel Rashid, Rania S ^a  

^a HELWAN UNIVERSITY   (Egypt)

Author keywords

carbopol 934; diclofenac sodium chitosan microspheres; histopathological study; HPMC; rectal mucoadhesive hydrogel

Indexed keywords

CARBOPOL 934; CHITOSAN; DICLOFENAC; GELLING AGENT; HYDROXYPROPYLMETHYLCELLULOSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; HISTOPATHOLOGY; HYDROGEL; KINETICS; MALE; MUCOADHESION; NONHUMAN; PH MEASUREMENT; PHYSICAL CHEMISTRY; POWDER; PRIORITY JOURNAL; RAT; RECTUM MUCOSA;

ADHESIVES; ADMINISTRATION, RECTAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHITOSAN; DICLOFENAC; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HYDROGELS; HYDROGEN-ION CONCENTRATION; MICROSPHERES; RHEOLOGY;

EID: 78651519684     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9544-3     Document Type: Article

References (30)

1. H Matsuda H Arima 1999 Cyclodextrins in transdermal and rectal delivery Adv Drug Deliv Rev 36 81 99 1:CAS:528:DyaK1MXksFeguw%3D%3D 10.1016/S0169- 409X(98)00056-8 10837710 (Pubitemid 29074478)
2. T Uchida Y Toida S Sakakibara Y Miyanaga H Tanaka M Nishikata, et al. 2001 Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers Chem Pharm Bull Tokyo 49 1261 6 1:CAS:528:DC%2BD3MXnt1Cksbk%3D 10.1248/cpb.49.1261 11605651 (Pubitemid 33035633)
3. NA Peppas PA Buri 1985 Surface interfacial and molecular aspects of polymer bioadhesion on soft tissues J Control Release 2 257 75 1:CAS:528:DyaL28Xls1anug%3D%3D 10.1016/0168-3659(85)90050-1
4. S Nagaoka R Akashi 1990 Low friction hydrophilic surface for medical devices Biomaterials 11 419 24 1:CAS:528:DyaK3MXht1WmtQ%3D%3D 10.1016/0142-9612(90)90098-B 2207232 (Pubitemid 20300837)
5. MG Dodov K Goracinova M Simonoska S Trajkovic-Jolevska JT Ribarska MD Mitevska 2005 Formulation and evaluation of diazepam hydrogel for rectal administration Acta Pharm 55 251 61 1:CAS:528:DC%2BD2MXht1altrzL 16375836
6. N Kurosawa E Owada K Ito K Ueda A Takahashi T Kikuiri 1985 Bioavailability of nifedipine suppository in healthy subjects Int J Pharm 27 81 8 1:CAS:528:DyaL28XisVWntg%3D%3D 10.1016/0378-5173(85)90187-5 (Pubitemid 15246924)
7. T Kawaguchi T Hasegawa K Juni T Seki 1991 Rectal absorption of Zidovudine Int J Pharm 77 71 4 1:CAS:528:DyaK38Xks1WgtA%3D%3D 10.1016/0378-5173(91)90303-6
8. DJ Morgan Y McCormick W Cosolo L Roller J Zalcberg 1992 Prolonged release of morphine alkaloid from a lipophilic suppository base in vitro and in vivo Int J Clin Pharmacol Ther Toxicol 30 576 81 1:CAS:528:DyaK3sXhslGlsLc%3D 1473873
9. C Kim S Lee H Choi M Lee Z Gao I Kim, et al. 1998 Trials of in situ-gelling and mucoadhesive acetaminophen liquid suppository in human subjects Int J Pharm 174 201 7 1:CAS:528:DyaK1cXmsFGnurk%3D 10.1016/S0378-5173(98)00258- 0 (Pubitemid 28487004)
10. A Schneeweis CC Müller-Goymann 2000 Controlled release of solid-reversed-micellar-solution (SRMS) suppositories containing metoclopramide-HCl Int J Pharm 196 193 6 1:CAS:528:DC%2BD3cXhtl2qt7Y%3D 10.1016/S0378-5173(99)00419-6 10699716 (Pubitemid 30105741)
11. Y Azechi K Ishikawa N Mizuno K Takahashi 2000 Sustained release of diclofenac from polymer-containing suppository and the mechanism involved Drug Dev Ind Pharm 26 1177 83 1:CAS:528:DC%2BD3cXnvVSnurw%3D 10.1081/DDC-100100989 11068691
12. H Shiohira M Fujii N Koizumi M Kondoh Y Watanabe 2009 Novel chronotherapeutic rectal aminophylline delivery system for therapy of asthma Int J Pharm 379 119 24 1:CAS:528:DC%2BD1MXhtVaqs7rJ 10.1016/j.ijpharm.2009.06.017 19555748
13. C Hk JH Jung JM Ryu SJ Yoon YK Oh CK Kim 1998 Development of in-situ gelling and mucoadhesive acetaminophen liquid suppository Int J Pharm 165 33 44 10.1016/S0378-5173(97)00386-4 (Pubitemid 28218342)
14. M Yun H Choi J Jung C Kim 1999 Development of a thermo-reversible insulin liquid suppository with bioavailability enhancement Int J Pharm 189 137 45 1:CAS:528:DyaK1MXmvVaqtLk%3D 10.1016/S0378-5173(99)00227-6 10536242 (Pubitemid 29481749)
15. F Fawaz A Koffi M Guyot P Millet 2004 Comparative in vitro-in vivo study of two quinine rectal gel formulations Int J Pharm 280 151 62 1:CAS:528:DC%2BD2cXlslGhsL8%3D 10.1016/j.ijpharm.2004.05.002 15265555 (Pubitemid 38950912)
16. CS Yong CH Yang J Rhee B Lee D Kim D Kim, et al. 2004 Enhanced rectal bioavailability of ibuprofen in rats by poloxamer 188 and menthol Int J Pharm 269 169 76 1:CAS:528:DC%2BD3sXpvFektL8%3D 10.1016/j.ijpharm.2003.09.013 14698588 (Pubitemid 38032832)
17. J Ryu S Chung M Lee C Kim C Shim 1999 Increased bioavailability of propranolol in rats by retaining thermally gelling liquid suppositories in the rectum J Control Release 59 163 72 1:CAS:528:DyaK1MXjtVyktbs%3D 10.1016/S0168-3659(98)00189-8 10332051 (Pubitemid 29199922)
18. DL French BO Häglund KJ Himmelstein JW Mauger 1995 Controlled release of substituted benzole and naphthoic acids using carbopol® gels: measurement of drug concentration profiles and correlation to release rate kinetics Pharm Res 12 1513 20 1:CAS:528:DyaK2MXosleru7c%3D 10.1023/A: 1016295723253 8584491
19. A Berthold K Cremer J Kreuter 1996 Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs J Contemp Relig 39 17 25 1:CAS:528: DyaK28XjtFSktL8%3D
20. VL Gonçalves MCM Laranjeira VT Fávere Polímeros 2005 Effect of crosslinking agents on chitosan microspheres in controlled release of diclofenac sodium Ciênc Tecnol 15 1 6 12
21. ES El-Leithy DS Shaker MK Ghorab D Abdel-Rashid 2010 Optimization and characterization of Diclofenac sodium microspheres prepared by modified coacervation Drug Discov Ther 4 3 208 16 1:CAS:528:DC%2BC3cXhtV2nt73J
22. SS Abd El Hady ND Mortada GA Awad NM Zaki RA Taha 2003 Development of in situ gelling and mucoadhesive mebeverine hydrochloride solution for rectal administration Saudi Pharm J 11 4 159 71
23. KC Gupta MNV Ravi Kumar 2000 Drug release behavior of beads and microgranules of chitosan Biomaterials 21 1115 9 1:CAS:528:DC%2BD3cXjtFWlsrg%3D 10.1016/S0142-9612(99)00263-X 10817263 (Pubitemid 30173149)
24. J Siepmann NA Peppas 2001 Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC) Adv Drug Deliv Rev 48 139 57 1:CAS:528:DC%2BD3MXjtlaqsrk%3D 10.1016/S0169-409X(01)00112-0 11369079 (Pubitemid 32434400)
25. MS El-Samaligy SA Yahia EB Basalious 2004 Formulation and evaluation of diclofenac sodium buccoadhesive discs Int J Pharm 286 27 39 1:CAS:528: DC%2BD2cXovVSksbo%3D 10.1016/j.ijpharm.2004.07.033 15501000 (Pubitemid 39410471)
26. EJ van Hoogdalem C Vermeij-Kerrs AG de Boer DD Breimer 1990 Topical effects of absorption enhancing agents on the rectal mucosa of rats in vivo J Pharm Sci 79 866 70 10.1002/jps.2600791004 2280353
27. EE Hassan JM Gallo 1990 A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength Pharm Res 7 491 5 1:CAS:528:DyaK3cXltVehtbk%3D 10.1023/A:1015812615635 1694990
28. SA Bravo MC Lamas CJ Salomón 2002 In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices J Pharm Pharm Sci 5 213 9 1:CAS:528:DC%2BD38Xot1Ojsrg%3D 12553888
29. J Sujja-areevath DL Munday PJ Cox KA Khan 1996 Release characteristics of diclofenac sodium from encapsulated natural gum mini-matrix formulations Int J Pharm 139 53 62 1:CAS:528:DyaK28XkvFWgsb0%3D 10.1016/0378-5173(96)04573-5 (Pubitemid 26276267)
30. Hunt G, Kearney P, Kellaway IW. Mucoadhesive polymers in drug delivery systems. In: Johnson P, Lloyd-Jones JG, editors. Drug delivery systems: fundamentals and techniques. Ann Arbor: VCH; 1987. p. 180-99.