Development of a pre-vascularized 3D scaffold-hydrogel composite graft using an arterio-venous loop for tissue engineering applications

Journal of Biomaterials Applications

Volumn 27, Issue 3, 2012, Pages 277-289

  Rath, Subha N ^a,b   Arkudas, Andreas ^b   Lam, Christopher Xf ^a   Olkowski, Radoslaw ^c   Polykandroitis, Elias ^b   Chróścicka, Anna ^c   Beier, Justus P ^b   Horch, Raymund E ^b   Hutmacher, Dietmar W ^d   Kneser, Ulrich ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c MEDICAL UNIVERSITY OF WARSAW   (Poland)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

angiogenesis; Arterio venous loop model; fibrin gel; hyaluronic acid; microvascular CT scanning; PLDLLA TCP PCL

Indexed keywords

ANGIOGENESIS; CT SCANNING; FIBRIN GELS; HYALURONIC ACIDS; LOOP MODELS; PLDLLA-TCP-PCL;

BLOOD VESSELS; COMPUTERIZED TOMOGRAPHY; CONTRAST MEDIA; DEGRADATION; HYDROGELS; ORGANIC ACIDS; RATS; TISSUE;

SCAFFOLDS (BIOLOGY);

TISSUE SCAFFOLD;

ANIMAL; ARTICLE; BLOOD VESSEL; GROWTH, DEVELOPMENT AND AGING; HYDROGEL; LEWIS RAT; MALE; RAT; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING;

ANIMALS; BLOOD VESSELS; HYDROGELS; MALE; MICROSCOPY, ELECTRON, SCANNING; RATS; RATS, INBRED LEW; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84865513944     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328211402243     Document Type: Article

References (36)

1. Arkudas A, Tjiawi J, Bleiziffer O, Grabinger L, Polykandriotis E, Beier JP, et al. Fibrin gel-immobilized VEGF and bFGF efficiently stimulate angiogenesis in the AV loop model. Mol Med. 2007 ; 13: 480-487
2. Folkman JH, Hochberg M. Self regulation of growth in three dimensions. J Exp Med. 1973 ; 138: 745-753
3. Hutmacher DW, Horch RE, Loessner D, Rizzi S, Sieh S, Reichert JC, et al. Translating tissue engineering technology platforms into cancer research. J Cell Mol Med. 2009 ; 13: 1417-1427
4. Steffens L, Wenger A, Stark G, Finkenzeller G. In vivo engineering of a human vasculature for bone tissue engineering applications. J Cell Mol Med. 2009 ; 13: 3380-3386
5. Kneser U, Schaefer DJ, Polykandriotis E, Horch RE. Tissue engineering of bone: the reconstructive surgeon's point of view. J Cell Mol Med. 2006 ; 10: 7-19
6. Lokmic Z, Stillaert F, Morrison WA, Thompson EW, Mitchell GM. An arteriovenous loop in a protected space generates a permanent, highly vascular, tissue-engineered construct. FASEB J. 2007 ; 21: 511-522
7. Tanaka Y, Sung KC, Tsutsumi A, Ohba S, Ueda K, Morrison WA. Tissue engineering skin flaps: which vascular carrier, arteriovenous shunt loop or arteriovenous bundle, has more potential for angiogenesis and tissue generation?. Plast Reconstr Surg. 2003 ; 112: 1636-1644
8. Polykandriotis E, Euler S, Arkudas A, Pryymachuk G, Beier JP, Greil P, et al. Regression and persistence: remodelling in a tissue engineered axial vascular assembly. J Cell Mol Med. 2009 ; 13: 4166-4175
9. Sung H, Meredith C, Johnson C, Galis Z. The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. Biomaterials. 2004 ; 25: 5735-5742
10. Rezwan K, Chen Q, Blaker J, Boccaccini A. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials. 2006 ; 27: 3413-3431
11. Schmidmaier G, Wildemann B, Bail H, Lucke M, Fuchs T, Stemberger A, et al. Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-ß1) from a biodegradable poly (d, l-lactide) coating of osteosynthetic implants accelerates fracture healing in rats. Bone. 2001 ; 28: 341-350
12. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials. 2000 ; 21: 2529-2543
13. Shor L, Güçeri S, Chang R, Gordon J, Kang Q, Hartsock L, et al. Precision extruding deposition (PED) fabrication of polycaprolactone (PCL) scaffolds for bone tissue engineering. Biofabrication. 2009 ; 1: 015003-015003
14. Heidemann W, Jeschkeit S, Ruffieux K, Fischer J, Wagner M, Krüger G, et al. Degradation of poly (d, l) lactide implants with or without addition of calciumphosphates in vivo. Biomaterials. 2001 ; 22: 2371-2381
15. Endres M, Hutmacher DW, Salgado AJ, Kaps C, Ringe J, Reis RL, et al. Osteogenic induction of human bone marrow-derived mesenchymal progenitor cells in novel synthetic polymer-hydrogel matrices. Tissue Eng. 2003 ; 9: 689-702
16. Ferreira L, Gerecht S, Fuller J, Shieh H, Vunjak-Novakovic G, Langer R. Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells. Biomaterials. 2007 ; 28: 2706-2717
17. Hoffman A. Hydrogels for biomedical applications. Adv Drug Deliv Rev. 2002 ; 54: 3-12
18. Hong L, Tabata Y, Miyamoto S, Yamamoto M, Yamada K, Hashimoto N, et al. Bone regeneration at rabbit skull defects treated with transforming growth factor-beta 1 incorporated into hydrogels with different levels of biodegradability. J Neurosurg. 2000 ; 92: 315-325
19. Arnander C, Westermark A, Veltheim R, Docherty-Skogh AC, Hilborn J, Engstrand T. Three-dimensional technology and bone morphogenetic protein in frontal bone reconstruction. J Craniofac Surg. 2006 ; 17: 275-279
20. Toole BP, Hascall VC. Hyaluronan and tumor growth. Am J Pathol. 2002 ; 161: 745-747
21. Shu XZ, Liu Y, Palumbo FS, Luo Y. In situ crosslinkable hyaluronan hydrogels for tissue engineering. Biomaterials. 2004 ; 25: 1339-1348
22. Lam C, Olkowski R, Swieszkowski W, Tan K, Gibson I, Hutmacher D. Mechanical and in vitro evaluations of composite PLDLLA/TCP scaffolds for bone engineering. Virtual Phys Prototyping. 2008 ; 3: 193-197
23. Kneser U, Polykandriotis E, Ohnolz J, Heidner K, Grabinger L, Euler S, et al. Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Tissue Eng. 2006 ; 12: 1721-1731
24. Polykandriotis E, Arkudas A, Beier JP, Hess A, Greil P, Papadopoulos T, et al. Intrinsic axial vascularization of an osteoconductive bone matrix by means of an arteriovenous vascular bundle. Plast Reconstr Surg. 2007 ; 120: 855-868
25. Arkudas A, Pryymachuk G, Hoereth T, Beier J, Polykandriotis E, Bleiziffer O, et al. Dose-finding study of fibrin gel-immobilized vascular endothelial growth factor 165 and basic fibroblast growth factor in the arteriovenous loop rat model. Tissue Eng Pt A. 2009 ; 15: 2501-2511
26. Athanasiou KA, Zhu C, Lanctot DR, Agrawal CM, Wang X. Fundamentals of biomechanics in tissue engineering of bone. Tissue Eng. 2000 ; 6: 361-381
27. Slivka MA, Leatherbury NC, Kieswetter K, Niederauer GG. Porous, resorbable, fiber-reinforced scaffolds tailored for articular cartilage repair. Tissue Eng. 2001 ; 7: 767-780
28. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 2005 ; 26: 5474-5491
29. Temenoff J, Park H, Jabbari E, Conway D, Sheffield T, Ambrose C, et al. Thermally cross-linked oligo (poly (ethylene glycol) fumarate) hydrogels support osteogenic differentiation of encapsulated marrow stromal cells in vitro. Biomacromolecules. 2004 ; 5: 5-10
30. Smith JD, Chen A, Ernst LA, Waggoner AS, Campbell PG. Immobilization of aprotinin to fibrinogen as a novel method for controlling degradation of fibrin gels. Bioconjugate Chem. 2007 ; 18: 695-701
31. Vanderhooft JL, Mann BK, Prestwich GD. Synthesis and characterization of novel thiol-reactive poly(ethylene glycol) cross-linkers for extracellular-matrix-mimetic. Biomacromolecules. 2007 ; 8: 2883-2889
32. Peled E, Boss J, Bejar J, Zinman C, Seliktar D. A novel poly (ethylene glycol)-fibrinogen hydrogel for tibial segmental defect repair in a rat model. J Biomed Mater Res A. 2007 ; 80: 874-884
33. Le Nihouannen D, Guehennec LL, Rouillon T, Pilet P, Bilban M, Layrolle P, et al. Micro-architecture of calcium phosphate granules and fibrin glue composites for bone tissue engineering. Biomaterials. 2006 ; 27: 2716-2722
34. Schliephake H, Weich H, Dullin C, Gruber R, Frahse S. Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid-An experimental study in rats. Biomaterials. 2008 ; 29: 103-110
35. Riley CM, Fuegy PW, Firpo MA, Shu XZ, Prestwich GD, Peattie RA. Stimulation of in vivo angiogenesis using dual growth factor-loaded crosslinked glycosaminoglycan hydrogels. Biomaterials. 2006 ; 27: 5935-5943
36. Terheyden H, Menzel C, Wang H, Springer IN, Rueger DR, Acil Y. Prefabrication of vascularized bone grafts using recombinant human osteogenic protein-1-part 3: dosage of rhOP-1, the use of external and internal scaffolds. Int J Oral Maxillofac Surg. 2004 ; 33: 164-172