In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate

Biochemical and Biophysical Research Communications

Volumn 332, Issue 4, 2005, Pages 1053-1060

  Kim, Hyongbum ^a   Suh, Hwal ^b   Jo, Sangmee Ahn ^a   Kim, Hyun Woo ^b   Lee, Jung Min ^a   Kim, Eun Hae ^a   Reinwald, Yvonne ^a   Park, Sang Hyug ^c   Min, Byoung Hyun ^d   Jo, Inho ^a  

^a Korea National Institute of Health   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Ajou University   (South Korea)

^d Ajou University School of Medicine   (South Korea)

Author keywords

Alkaline phosphatase; Ascorbate 2 phosphate; Bone; Dexamethasone; Differentiation; Marrow stromal cells; Osteogenesis; Poly(D,L lactide co glycolide); Scaffolds; Tissue engineering

Indexed keywords

ALKALINE PHOSPHATASE; ASCORBIC ACID 2 PHOSPHATE; CALCIUM; DEXAMETHASONE;

ANIMAL EXPERIMENT; ARTICLE; BIODEGRADABILITY; BONE MARROW CELL; BONE MINERAL; CARTILAGE; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMPLANTATION; MOUSE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; STROMA CELL;

ALKALINE PHOSPHATASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASCORBIC ACID; BIOCOMPATIBLE MATERIALS; BONE AND BONES; BONE DEVELOPMENT; BONE MARROW CELLS; CALCIUM; CARTILAGE; CELLS, CULTURED; COLORING AGENTS; DEXAMETHASONE; GUIDED TISSUE REGENERATION; HUMANS; IN SITU HYBRIDIZATION; LACTIC ACID; MICE; MICE, INBRED BALB C; OSTEOGENESIS; PHENAZINES; POLYGLYCOLIC ACID; POLYMERS; STROMAL CELLS; TIME FACTORS; TISSUE ENGINEERING; UP-REGULATION;

EID: 20444395824     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.05.051     Document Type: Article

References (47)

1. F. Rose, and R. Oreffo Bone tissue engineering: hope vs hype Biochem. Biophys. Res. Commun. 292 2002 1 7
2. T.W. Bauer, and G.F. Muschler Bone graft materials. An overview of the basic science Clin. Orthop. 2000 10 27
3. H.H. Xu, and C.G. Simon Jr. Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility Biomaterials 26 2005 1337 1348
4. A.R. Derubeis, and R. Cancedda Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances Ann. Biomed. Eng. 32 2004 160 165
5. A.I. Caplan, and S.P. Bruder Mesenchymal stem cells: building blocks for molecular medicine in the 21st century Trends Mol. Med. 7 2001 259 264
6. H. Petite, V. Viateau, W. Bensaid, A. Meunier, C. Pollak, M. Bourguignon, K. Oudina, L. Sedel, and G. Guillemin Tissue-engineered bone regeneration Nature 18 2000 959 962
7. Q. Shang, Z. Wang, W. Liu, Y. Shi, L. Cui, and Y. Cao Tissue-engineered bone repair of sheep cranial defects with autologous bone marrow stromal cells J. Craniofac. Surg. 6 2001 586 593 discussion 594-585
8. N.R. Jorgensen, Z. Henriksen, O.H. Sorensen, and R. Civitelli Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblasts Steroids 69 2004 219 226
9. S.L. Cheng, J.W. Yang, L. Rifas, S.F. Zhang, and L.V. Avioli Differentiation of human bone marrow osteogenic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone Endocrinology 134 1994 277 286
10. W. Huang, B. Carlsen, I. Wulur, G. Rudkin, K. Ishida, B. Wu, D.T. Yamaguchi, and T.A. Miller BMP-2 exerts differential effects on differentiation of rabbit bone marrow stromal cells grown in two-dimensional and three-dimensional systems and is required for in vitro bone formation in a PLGA scaffold Exp. Cell Res. 299 2004 325 334
11. D.L. Diefenderfer, A.M. Osyczka, G.C. Reilly, and P.S. Leboy BMP responsiveness in human mesenchymal stem cells Connect. Tissue Res. 44 Suppl. 1 2003 305 311
12. A.M. Osyczka, D.L. Diefenderfer, G. Bhargave, and P.S. Leboy Different effects of BMP-2 on marrow stromal cells from human and rat bone Cells Tissues Organs 176 2004 109 119
13. J. Kleeff, H. Maruyama, T. Ishiwata, H. Sawhney, H. Friess, M.W. Buchler, and M. Korc Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo Gastroenterology 116 1999 1202 1216
14. E.M. Langenfeld, S.E. Calvano, F. Abou-Nukta, S.F. Lowry, P. Amenta, and J. Langenfeld The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells Carcinogenesis 24 2003 1445 1454
15. Y. Jin, G.L. Tipoe, E.C. Liong, T.Y. Lau, P.C. Fung, and K.M. Leung Overexpression of BMP-2/4, -5 and BMPR-IA associated with malignancy of oral epithelium Oral Oncol. 37 2001 225 233
16. E.M. Langenfeld, and J. Langenfeld Bone morphogenetic protein-2 stimulates angiogenesis in developing tumors Mol. Cancer Res. 2 2004 141 149
17. R.D. Estensen, and L.W. Wattenberg Studies of chemopreventive effects of myo-inositol on benzo[a]pyrene-induced neoplasia of the lung and forestomach of female A/J mice Carcinogenesis 14 1993 1975 1977
18. H. Witschi, I. Espiritu, and D. Uyeminami Chemoprevention of tobacco smoke-induced lung tumors in A/J strain mice with dietary myo-inositol and dexamethasone Carcinogenesis 20 1999 1375 1378
19. H. Witschi, D. Uyeminami, D. Moran, and I. Espiritu Chemoprevention of tobacco-smoke lung carcinogenesis in mice after cessation of smoke exposure Carcinogenesis 21 2000 977 982
20. E. Fosslien Molecular pathology of cyclooxygenase-2 in neoplasia Ann. Clin. Lab. Sci. 30 2000 3 21
21. E.J. Frazza, and E.E. Schmitt A new absorbable suture J. Biomed. Mater. Res. 5 1971 43 58
22. C.M. Cowan, Y.Y. Shi, O.O. Aalami, Y.F. Chou, C. Mari, R. Thomas, N. Quarto, C.H. Contag, B. Wu, and M.T. Longaker Adipose-derived adult stromal cells heal critical-size mouse calvarial defects Nat. Biotechnol. 22 2004 560 567
23. H. Kim, H.W. Kim, and H. Suh Sustained release of ascorbate-2-phosphate and dexamethasone from porous PLGA scaffolds for bone tissue engineering using mesenchymal stem cells Biomaterials 24 2003 4671 4679
24. K. Ishizeki, H. Saito, T. Shinagawa, N. Fujiwara, and T. Nawa Histochemical and immunohistochemical analysis of the mechanism of calcification of Meckel's cartilage during mandible development in rodents J. Anat. 194 Pt 2 1999 265 277
25. M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosaca, M.A. Moorman, D.W. Simonetti, S. Craig, and D.R. Marshak Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
26. A.G. Mikos, M.D. Lyman, L.E. Freed, and R. Langer Wetting of poly(l-lactic acid) and poly(dl-lactic-co-glycolic acid) foams for tissue culture Biomaterials 15 1994 55 58
27. D.H. Cho, Y.J. Choi, S.A. Jo, and I. Jo Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: evidence for involvement of peroxisome proliferator-activated receptor (PPAR) gamma-dependent and PPARgamma-independent signaling pathways J. Biol. Chem. 279 2004 2499 2506
28. S.A. Kuznetsov, P.H. Krebsbach, K. Satomura, J. Kerr, M. Riminucci, D. Benayahu, and P.G. Robey Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo J. Bone Miner. Res. 12 1997 1335 1347
29. P.F. Jacobsen, and J. Daly A method for distinguishing human and mouse cells in solid tumors using in situ hybridization Exp. Mol. Pathol. 61 1994 212 220
30. B. Berner, S. Dinh, Fundamental concepts in controlled release, in Treatise on controlled drug delivery, in: A. Kydonieus, (Ed.), Marcel Dekker, New York, 1992. pp. 1-35.
31. S.P. Bruder, M.C. Horowitz, J.D. Mosca, and S.E. Haynesworth Monoclonal antibodies reactive with human osteogenic cell surface antigens Bone 21 1997 225 235
32. R.M. Porter, W.R. Huckle, and A.S. Goldstein Effect of dexamethasone withdrawal on osteoblastic differentiation of bone marrow stromal cells J. Cell Biochem. 90 2003 13 22
33. H. Schacke, W.D. Docke, and K. Asadullah Mechanisms involved in the side effects of glucocorticoids Pharmacol. Ther. 96 2002 23 43
34. J.Y. Zhang, B.A. Doll, E.J. Beckman, and J.O. Hollinger Three-dimensional biocompatible ascorbic acid-containing scaffold for bone tissue engineering Tissue Eng. 9 2003 1143 1157
35. J.C. Geesin, J.S. Gordon, and R.A. Berg Regulation of collagen synthesis in human dermal fibroblasts by the sodium and magnesium salts of ascorbyl-2-phosphate Skin Pharmacol. 6 1993 65 71
36. V.I. Sikavitsas, G.N. Bancroft, and A.G. Mikos Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor J. Biomed. Mater. Res. 62 2002 136 148
37. N. Jaiswal, S.E. Haynesworth, A.I. Caplan, and S.P. Bruder Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro J. Cell Biochem. 64 1997 295 312
38. A. Al-Khaldi, N. Eliopoulos, D. Martineau, L. Lejeune, K. Lachapelle, and J. Galipeau Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neoangiogenic response in vivo Gene Ther. 10 2003 621 629
39. T. Kinnaird, E. Stabile, M.S. Burnett, M. Shou, C.W. Lee, S. Barr, S. Fuchs, and S.E. Epstein Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms Circulation 109 2004 1543 1549
40. T.K. Sampath, J.C. Maliakal, P.V. Hauschka, W.K. Jones, H. Sasak, R.F. Tucker, K.H. White, J.E. Coughlin, M.M. Tucker, and R.H. Pang Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro J. Biol. Chem. 267 1992 20352 20362
41. Y. Chen, K.M. Cheung, H.F. Kung, J.C. Leong, W.W. Lu, and K.D. Luk In vivo new bone formation by direct transfer of adenoviral-mediated bone morphogenetic protein-4 gene Biochem. Biophys. Res. Commun. 298 2002 121 127
42. C.A. Simmons, E. Alsberg, S. Hsiong, W.J. Kim, and D.J. Mooney Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells Bone 35 2004 562 569
43. L. Attisano, and J.L. Wrana Signal transduction by the TGF-beta superfamily Science 296 2002 1646 1647
44. R. Quarto, G. Campanile, R. Cancedda, and B. Dozin Thyroid hormone, insulin, and glucocorticoids are sufficient to support chondrocyte differentiation to hypertrophy: a serum-free analysis J. Cell Biol. 119 1992 989 995
45. M. Takigawa, T. Takano, K. Nakagawa, M. Sakuda, and F. Suzuki Hydrocortisone stimulation of proliferation and glycosaminoglycan synthesis in rabbit craniofacial chondrocytes in vitro Arch. Oral Biol. 33 1988 893 899
46. T. Fujita, R. Fukuyama, H. Enomoto, and T. Komori Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2 J. Cell Biochem. 93 2004 374 383
47. H.A. Awad, Y.D. Halvorsen, J.M. Gimble, and F. Guilak Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells Tissue Eng. 9 2003 1301 1312