-
1
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
P.W. Ingham, and A.P. McMahon Hedgehog signaling in animal development: paradigms and principles Gene Dev. 15 2001 3059 3087
-
(2001)
Gene Dev.
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
2
-
-
84879414522
-
The mechanisms of Hedgehog signalling and its roles in development and disease
-
J. Briscoe, and P.P. Thérond The mechanisms of Hedgehog signalling and its roles in development and disease Nat. Rev. Mol. Cell Biol. 14 2013 416 429
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 416-429
-
-
Briscoe, J.1
Thérond, P.P.2
-
3
-
-
80053331930
-
Hedgehog signaling regulates nociceptive sensitization
-
D.T. Babcock, S. Shi, J. Jo, M. Shaw, H.B. Gutstein, and M.J. Galko Hedgehog signaling regulates nociceptive sensitization Curr. Biol. 21 2011 1525 1533
-
(2011)
Curr. Biol.
, vol.21
, pp. 1525-1533
-
-
Babcock, D.T.1
Shi, S.2
Jo, J.3
Shaw, M.4
Gutstein, H.B.5
Galko, M.J.6
-
4
-
-
84858637873
-
Sonic hedgehog, BOC, and synaptic development: New players for an old game
-
J. Courchet, and F. Polleux Sonic hedgehog, BOC, and synaptic development: new players for an old game Neuron 73 2012 1055 1058
-
(2012)
Neuron
, vol.73
, pp. 1055-1058
-
-
Courchet, J.1
Polleux, F.2
-
5
-
-
84867536639
-
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat
-
R. Teperino, S. Amann, M. Bayer, S.L. McGee, A. Loipetzberger, T. Connor, C. Jaeger, B. Kammerer, L. Winter, and G. Wiche Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat Cell 151 2012 414 426
-
(2012)
Cell
, vol.151
, pp. 414-426
-
-
Teperino, R.1
Amann, S.2
Bayer, M.3
McGee, S.L.4
Loipetzberger, A.5
Connor, T.6
Jaeger, C.7
Kammerer, B.8
Winter, L.9
Wiche, G.10
-
6
-
-
0036899614
-
Pathways and consequences: Hedgehog signaling in human disease
-
J.L. Mullor, and P. Sánchez Pathways and consequences: hedgehog signaling in human disease Trends Cell Biol. 12 2002 562 569
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 562-569
-
-
Mullor, J.L.1
Sánchez, P.2
-
7
-
-
84887512714
-
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
-
D. Amakye, Z. Jagani, and M. Dorsch Unraveling the therapeutic potential of the Hedgehog pathway in cancer Nat. Med. 19 2013 1410 1422
-
(2013)
Nat. Med.
, vol.19
, pp. 1410-1422
-
-
Amakye, D.1
Jagani, Z.2
Dorsch, M.3
-
8
-
-
77649337790
-
Hedgehog beyond medulloblastoma and basal cell carcinoma
-
S. Teglund, and R. Toftgård Hedgehog beyond medulloblastoma and basal cell carcinoma BBA-Rev. Cancer 2010 1805 181 208
-
(1805)
BBA-Rev. Cancer
, vol.2010
, pp. 181-208
-
-
Teglund, S.1
Toftgård, R.2
-
9
-
-
77955420936
-
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer
-
M.T. Barakat, E.W. Humke, and M.P. Scott Learning from Jekyll to control Hyde: hedgehog signaling in development and cancer Trends Mol. Med. 16 2010 337 348
-
(2010)
Trends Mol. Med.
, vol.16
, pp. 337-348
-
-
Barakat, M.T.1
Humke, E.W.2
Scott, M.P.3
-
10
-
-
77955287417
-
Hedgehog signaling update
-
M.M. Cohen Jr. Hedgehog signaling update Am. J. Med. Genet. A 152 2010 1875 1914
-
(2010)
Am. J. Med. Genet. A
, vol.152
, pp. 1875-1914
-
-
Cohen, Jr.M.M.1
-
11
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
R.L. Johnson, A.L. Rothman, J. Xie, L.V. Goodrich, J.W. Bare, J.M. Bonifas, A.G. Quinn, R.M. Myers, D.R. Cox, and E.H. Epstein Human homolog of patched, a candidate gene for the basal cell nevus syndrome Science 272 1996 1668 1671
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein, E.H.10
-
12
-
-
75749139262
-
Activation of the hedgehog-signaling pathway in human cancer and the clinical implications
-
L. Yang, G. Xie, Q. Fan, and J. Xie Activation of the hedgehog-signaling pathway in human cancer and the clinical implications Oncogene 29 2009 469 481
-
(2009)
Oncogene
, vol.29
, pp. 469-481
-
-
Yang, L.1
Xie, G.2
Fan, Q.3
Xie, J.4
-
13
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
C. Nüsslein-Volhard, and E. Wieschaus Mutations affecting segment number and polarity in Drosophila Nature 287 1980 795 801
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nüsslein-Volhard, C.1
Wieschaus, E.2
-
14
-
-
0030602796
-
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
-
J. Alcedo, M. Ayzenzon, T. Von Ohlen, M. Noll, and J.E. Hooper The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal Cell 86 1996 221 232
-
(1996)
Cell
, vol.86
, pp. 221-232
-
-
Alcedo, J.1
Ayzenzon, M.2
Von Ohlen, T.3
Noll, M.4
Hooper, J.E.5
-
15
-
-
0001133149
-
Cubitus interruptus, a new genovariation of the fourth chromosome of Drosophila melanogaster
-
G. Tiniakow, and E. Terentieva Cubitus interruptus, a new genovariation of the fourth chromosome of Drosophila melanogaster Genetics 18 1933 117 120
-
(1933)
Genetics
, vol.18
, pp. 117-120
-
-
Tiniakow, G.1
Terentieva, E.2
-
16
-
-
0025331133
-
Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila
-
T. Orenic, D. Slusarski, K. Kroll, and R. Holmgren Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila Gene Dev. 4 1990 1053 1067
-
(1990)
Gene Dev.
, vol.4
, pp. 1053-1067
-
-
Orenic, T.1
Slusarski, D.2
Kroll, K.3
Holmgren, R.4
-
17
-
-
0029784223
-
Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
-
M. van den Heuvel, and P.W. Ingham Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling Nature 382 1996 547 551
-
(1996)
Nature
, vol.382
, pp. 547-551
-
-
Van Den Heuvel, M.1
Ingham, P.W.2
-
18
-
-
0027756145
-
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
-
Y. Echelard, D.J. Epstein, B. St-Jacques, L. Shen, J. Mohler, J.A. McMahon, and A.P. McMahon Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity Cell 75 1993 1417 1430
-
(1993)
Cell
, vol.75
, pp. 1417-1430
-
-
Echelard, Y.1
Epstein, D.J.2
St-Jacques, B.3
Shen, L.4
Mohler, J.5
McMahon, J.A.6
McMahon, A.P.7
-
19
-
-
0027760995
-
Sonic hedgehog mediates the polarizing activity of the ZPA
-
R.D. Riddle, R.L. Johnson, E. Laufer, and C. Tabin Sonic hedgehog mediates the polarizing activity of the ZPA Cell 75 1993 1401 1416
-
(1993)
Cell
, vol.75
, pp. 1401-1416
-
-
Riddle, R.D.1
Johnson, R.L.2
Laufer, E.3
Tabin, C.4
-
20
-
-
0027749249
-
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
-
S. Krauss, J.-P. Concordet, and P. Ingham A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos Cell 75 1993 1431 1444
-
(1993)
Cell
, vol.75
, pp. 1431-1444
-
-
Krauss, S.1
Concordet, J.-P.2
Ingham, P.3
-
21
-
-
0029948270
-
Biochemical evidence that patched is the Hedgehog receptor
-
V. Marigo, R.A. Davey, Y. Zuo, J.M. Cunningham, and C.J. Tabin Biochemical evidence that patched is the Hedgehog receptor Nature 384 1996 176 179
-
(1996)
Nature
, vol.384
, pp. 176-179
-
-
Marigo, V.1
Davey, R.A.2
Zuo, Y.3
Cunningham, J.M.4
Tabin, C.J.5
-
22
-
-
0029791854
-
Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning
-
J.-P. Concordet, K.E. Lewis, J.W. Moore, L.V. Goodrich, R.L. Johnson, M.P. Scott, and P.W. Ingham Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning Development 122 1996 2835 2846
-
(1996)
Development
, vol.122
, pp. 2835-2846
-
-
Concordet, J.-P.1
Lewis, K.E.2
Moore, J.W.3
Goodrich, L.V.4
Johnson, R.L.5
Scott, M.P.6
Ingham, P.W.7
-
23
-
-
0011102935
-
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
-
D.M. Stone, M. Hynes, M. Armanini, T.A. Swanson, Q. Gu, R.L. Johnson, M.P. Scott, D. Pennica, A. Goddard, and H. Phillips The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog Nature 384 1996 129 134
-
(1996)
Nature
, vol.384
, pp. 129-134
-
-
Stone, D.M.1
Hynes, M.2
Armanini, M.3
Swanson, T.A.4
Gu, Q.5
Johnson, R.L.6
Scott, M.P.7
Pennica, D.8
Goddard, A.9
Phillips, H.10
-
24
-
-
0031560935
-
Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5
-
H. Akiyama, C. Shigeno, Y. Hiraki, C. Shukunami, H. Kohno, M. Akagi, J. Konishi, and T. Nakamura Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5 Biochem. Biophys. Res. Commun. 235 1997 142 147
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.235
, pp. 142-147
-
-
Akiyama, H.1
Shigeno, C.2
Hiraki, Y.3
Shukunami, C.4
Kohno, H.5
Akagi, M.6
Konishi, J.7
Nakamura, T.8
-
25
-
-
58149172091
-
Transducing the Hedgehog signal across the plasma membrane
-
Y. Zhao, C. Tong, and J. Jiang Transducing the Hedgehog signal across the plasma membrane Fly 1 2007 333 336
-
(2007)
Fly
, vol.1
, pp. 333-336
-
-
Zhao, Y.1
Tong, C.2
Jiang, J.3
-
26
-
-
67649972439
-
The hedgehog signaling pathway: Where did it come from?
-
G. Hausmann, C. von Mering, and K. Basler The hedgehog signaling pathway: where did it come from? PLoS Biol. 7 2009 e1000146
-
(2009)
PLoS Biol.
, vol.7
, pp. 1000146
-
-
Hausmann, G.1
Von Mering, C.2
Basler, K.3
-
27
-
-
84893003052
-
Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in drosophila hedgehog signaling
-
J. Fan, K. Jiang, Y. Liu, and J. Jia Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in drosophila hedgehog signaling PLoS One 8 2013 e79021
-
(2013)
PLoS One
, vol.8
, pp. 79021
-
-
Fan, J.1
Jiang, K.2
Liu, Y.3
Jia, J.4
-
28
-
-
79956308325
-
Mechanisms and functions of Hedgehog signalling across the metazoa
-
P.W. Ingham, Y. Nakano, and C. Seger Mechanisms and functions of Hedgehog signalling across the metazoa Nat. Rev. Genet. 12 2011 393 406
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 393-406
-
-
Ingham, P.W.1
Nakano, Y.2
Seger, C.3
-
29
-
-
0242581681
-
Hedgehog signalling in the mouse requires intraflagellar transport proteins
-
D. Huangfu, A. Liu, A.S. Rakeman, N.S. Murcia, L. Niswander, and K.V. Anderson Hedgehog signalling in the mouse requires intraflagellar transport proteins Nature 426 2003 83 87
-
(2003)
Nature
, vol.426
, pp. 83-87
-
-
Huangfu, D.1
Liu, A.2
Rakeman, A.S.3
Murcia, N.S.4
Niswander, L.5
Anderson, K.V.6
-
30
-
-
26644460824
-
Vertebrate Smoothened functions at the primary cilium
-
K.C. Corbit, P. Aanstad, V. Singla, A.R. Norman, D.Y. Stainier, and J.F. Reiter Vertebrate Smoothened functions at the primary cilium Nature 437 2005 1018 1021
-
(2005)
Nature
, vol.437
, pp. 1018-1021
-
-
Corbit, K.C.1
Aanstad, P.2
Singla, V.3
Norman, A.R.4
Stainier, D.Y.5
Reiter, J.F.6
-
31
-
-
77951101203
-
The primary cilium: A signalling centre during vertebrate development
-
S.C. Goetz, and K.V. Anderson The primary cilium: a signalling centre during vertebrate development Nat. Rev. Genet. 11 2010 331 344
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 331-344
-
-
Goetz, S.C.1
Anderson, K.V.2
-
32
-
-
0033598964
-
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
-
R. Burke, D. Nellen, M. Bellotto, E. Hafen, K.-A. Senti, B.J. Dickson, and K. Basler Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells Cell 99 1999 803 815
-
(1999)
Cell
, vol.99
, pp. 803-815
-
-
Burke, R.1
Nellen, D.2
Bellotto, M.3
Hafen, E.4
Senti, K.-A.5
Dickson, B.J.6
Basler, K.7
-
33
-
-
0037125938
-
Mouse dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling
-
T. Caspary, M.J. GarcIÍa-GarcIÍa, D. Huangfu, J.T. Eggenschwiler, M.R. Wyler, A.S. Rakeman, H.L. Alcorn, and K.V. Anderson Mouse dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling Curr. Biol. 12 2002 1628 1632
-
(2002)
Curr. Biol.
, vol.12
, pp. 1628-1632
-
-
Caspary, T.1
Garciía-Garciía, M.J.2
Huangfu, D.3
Eggenschwiler, J.T.4
Wyler, M.R.5
Rakeman, A.S.6
Alcorn, H.L.7
Anderson, K.V.8
-
34
-
-
0033597141
-
Association of sterol-and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
-
A. Rietveld, S. Neutz, K. Simons, and S. Eaton Association of sterol-and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains J. Biol. Chem. 274 1999 12049 12054
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12049-12054
-
-
Rietveld, A.1
Neutz, S.2
Simons, K.3
Eaton, S.4
-
35
-
-
1842853184
-
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
-
M.-H. Chen, Y.-J. Li, T. Kawakami, S.-M. Xu, and P.-T. Chuang Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates Gene Dev. 18 2004 641 659
-
(2004)
Gene Dev.
, vol.18
, pp. 641-659
-
-
Chen, M.-H.1
Li, Y.-J.2
Kawakami, T.3
Xu, S.-M.4
Chuang, P.-T.5
-
36
-
-
0024468746
-
The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
-
J.E. Hooper, and M.P. Scott The Drosophila patched gene encodes a putative membrane protein required for segmental patterning Cell 59 1989 751 765
-
(1989)
Cell
, vol.59
, pp. 751-765
-
-
Hooper, J.E.1
Scott, M.P.2
-
37
-
-
0034682719
-
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
-
N. Denef, D. Neubüser, L. Perez, and S.M. Cohen Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened Cell 102 2000 521 531
-
(2000)
Cell
, vol.102
, pp. 521-531
-
-
Denef, N.1
Neubüser, D.2
Perez, L.3
Cohen, S.M.4
-
38
-
-
77956814604
-
Interactions between Hedgehog proteins and their binding partners come into view
-
P.A. Beachy, S.G. Hymowitz, R.A. Lazarus, D.J. Leahy, and C. Siebold Interactions between Hedgehog proteins and their binding partners come into view Gene Dev. 24 2010 2001 2012
-
(2010)
Gene Dev.
, vol.24
, pp. 2001-2012
-
-
Beachy, P.A.1
Hymowitz, S.G.2
Lazarus, R.A.3
Leahy, D.J.4
Siebold, C.5
-
39
-
-
0024440611
-
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
-
Y. Nakano, I. Guerrero, A. Hidalgo, A. Taylor, J. Whittle, and P. Ingham A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched Nature 341 1989 508 513
-
(1989)
Nature
, vol.341
, pp. 508-513
-
-
Nakano, Y.1
Guerrero, I.2
Hidalgo, A.3
Taylor, A.4
Whittle, J.5
Ingham, P.6
-
40
-
-
84861536500
-
Hedgehog secretion and signal transduction in vertebrates
-
K.E. Ryan, and C. Chiang Hedgehog secretion and signal transduction in vertebrates J. Biol. Chem. 287 2012 17905 17913
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 17905-17913
-
-
Ryan, K.E.1
Chiang, C.2
-
41
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
J. Taipale, M. Cooper, T. Maiti, and P. Beachy Patched acts catalytically to suppress the activity of Smoothened Nature 418 2002 892 896
-
(2002)
Nature
, vol.418
, pp. 892-896
-
-
Taipale, J.1
Cooper, M.2
Maiti, T.3
Beachy, P.4
-
42
-
-
84872508509
-
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
-
S. Mukhopadhyay, X. Wen, N. Ratti, A. Loktev, L. Rangell, S.J. Scales, and P.K. Jackson The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling Cell 152 2013 210 223
-
(2013)
Cell
, vol.152
, pp. 210-223
-
-
Mukhopadhyay, S.1
Wen, X.2
Ratti, N.3
Loktev, A.4
Rangell, L.5
Scales, S.J.6
Jackson, P.K.7
-
43
-
-
46849087764
-
Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice
-
K.J. Lavine, A. Kovacs, and D.M. Ornitz Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice J. Clin. Invest. 118 2008 2404 2414
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2404-2414
-
-
Lavine, K.J.1
Kovacs, A.2
Ornitz, D.M.3
-
44
-
-
46449127054
-
β-Arrestin-mediated localization of smoothened to the primary cilium
-
J.J. Kovacs, E.J. Whalen, R. Liu, K. Xiao, J. Kim, M. Chen, J. Wang, W. Chen, and R.J. Lefkowitz β-Arrestin-mediated localization of smoothened to the primary cilium Science 320 2008 1777 1781
-
(2008)
Science
, vol.320
, pp. 1777-1781
-
-
Kovacs, J.J.1
Whalen, E.J.2
Liu, R.3
Xiao, K.4
Kim, J.5
Chen, M.6
Wang, J.7
Chen, W.8
Lefkowitz, R.J.9
-
45
-
-
62449174504
-
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
-
Y. Wang, Z. Zhou, C.T. Walsh, and A.P. McMahon Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation Proc. Natl. Acad. Sci. U.S.A. 106 2009 2623 2628
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 2623-2628
-
-
Wang, Y.1
Zhou, Z.2
Walsh, C.T.3
McMahon, A.P.4
-
46
-
-
75549090700
-
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
-
L. Milenkovic, M.P. Scott, and R. Rohatgi Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium J. Cell Biol. 187 2009 365 374
-
(2009)
J. Cell Biol.
, vol.187
, pp. 365-374
-
-
Milenkovic, L.1
Scott, M.P.2
Rohatgi, R.3
-
47
-
-
79961010813
-
Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling
-
T. Evron, M. Philipp, J. Lu, A.R. Meloni, M. Burkhalter, W. Chen, and M.G. Caron Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling J. Biol. Chem. 286 2011 27676 27686
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 27676-27686
-
-
Evron, T.1
Philipp, M.2
Lu, J.3
Meloni, A.R.4
Burkhalter, M.5
Chen, W.6
Caron, M.G.7
-
48
-
-
79959804711
-
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened
-
Y. Chen, N. Sasai, G. Ma, T. Yue, J. Jia, J. Briscoe, and J. Jiang Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened PLoS Biol. 9 2011 e1001083
-
(2011)
PLoS Biol.
, vol.9
, pp. 1001083
-
-
Chen, Y.1
Sasai, N.2
Ma, G.3
Yue, T.4
Jia, J.5
Briscoe, J.6
Jiang, J.7
-
49
-
-
23144466931
-
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
-
A. Liu, B. Wang, and L.A. Niswander Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors Development 132 2005 3103 3111
-
(2005)
Development
, vol.132
, pp. 3103-3111
-
-
Liu, A.1
Wang, B.2
Niswander, L.A.3
-
50
-
-
33646869503
-
Multisite protein kinase A and glycogen synthase kinase 3β phosphorylation leads to Gli3 ubiquitination by SCFβTrCP
-
D. Tempé, M. Casas, S. Karaz, M.-F. Blanchet-Tournier, and J.-P. Concordet Multisite protein kinase A and glycogen synthase kinase 3β phosphorylation leads to Gli3 ubiquitination by SCFβTrCP Mol. Cell. Biol. 26 2006 4316 4326
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 4316-4326
-
-
Tempé, D.1
Casas, M.2
Karaz, S.3
Blanchet-Tournier, M.-F.4
Concordet, J.-P.5
-
51
-
-
77950463564
-
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
-
E.W. Humke, K.V. Dorn, L. Milenkovic, M.P. Scott, and R. Rohatgi The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins Gene Dev. 24 2010 670 682
-
(2010)
Gene Dev.
, vol.24
, pp. 670-682
-
-
Humke, E.W.1
Dorn, K.V.2
Milenkovic, L.3
Scott, M.P.4
Rohatgi, R.5
-
52
-
-
77958508124
-
A mechanism for vertebrate Hedgehog signaling: Recruitment to cilia and dissociation of SuFu-Gli protein complexes
-
H. Tukachinsky, L.V. Lopez, and A. Salic A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes J. Cell Biol. 191 2010 415 428
-
(2010)
J. Cell Biol.
, vol.191
, pp. 415-428
-
-
Tukachinsky, H.1
Lopez, L.V.2
Salic, A.3
-
53
-
-
33646270662
-
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
-
Y. Pan, C.B. Bai, A.L. Joyner, and B. Wang Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation Mol. Cell. Biol. 26 2006 3365 3377
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3365-3377
-
-
Pan, Y.1
Bai, C.B.2
Joyner, A.L.3
Wang, B.4
-
54
-
-
79952636214
-
Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo
-
J. Li, C. Wang, Y. Pan, Z. Bai, and B. Wang Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo Dev. Dyn. 240 2011 766 774
-
(2011)
Dev. Dyn.
, vol.240
, pp. 766-774
-
-
Li, J.1
Wang, C.2
Pan, Y.3
Bai, Z.4
Wang, B.5
-
55
-
-
84867678037
-
A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia
-
K.V. Dorn, C.E. Hughes, and R. Rohatgi A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia Dev. Cell 23 2012 823 835
-
(2012)
Dev. Cell
, vol.23
, pp. 823-835
-
-
Dorn, K.V.1
Hughes, C.E.2
Rohatgi, R.3
-
56
-
-
84868528041
-
Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2
-
C. Yang, W. Chen, Y. Chen, and J. Jiang Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2 Cell Res. 22 2012 1593 1604
-
(2012)
Cell Res.
, vol.22
, pp. 1593-1604
-
-
Yang, C.1
Chen, W.2
Chen, Y.3
Jiang, J.4
-
57
-
-
84871229068
-
The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia
-
J.A. Caparrós-Martín, M. Valencia, E. Reytor, M. Pacheco, M. Fernandez, A. Perez-Aytes, E. Gean, P. Lapunzina, H. Peters, and J.A. Goodship The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia Hum. Mol. Genet. 22 2013 124 139
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 124-139
-
-
Caparrós-Martín, J.A.1
Valencia, M.2
Reytor, E.3
Pacheco, M.4
Fernandez, M.5
Perez-Aytes, A.6
Gean, E.7
Lapunzina, P.8
Peters, H.9
Goodship, J.A.10
-
59
-
-
84874359079
-
GLI activation by atypical protein kinase C /λ regulates the growth of basal cell carcinomas
-
S.X. Atwood, M. Li, A. Lee, J.Y. Tang, and A.E. Oro GLI activation by atypical protein kinase C /λ regulates the growth of basal cell carcinomas Nature 494 2013 484 488
-
(2013)
Nature
, vol.494
, pp. 484-488
-
-
Atwood, S.X.1
Li, M.2
Lee, A.3
Tang, J.Y.4
Oro, A.E.5
-
60
-
-
0033170990
-
The RND permease superfamily: An ancient, ubiquitous and diverse family that includes human disease and development proteins
-
T.-T. Tseng, K.S. Gratwick, J. Kollman, D. Park, D.H. Nies, A. Goffeau, and M.H. Saier Jr. The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins J. Mol. Microbiol. Biotechnol. 1 1999 107 125
-
(1999)
J. Mol. Microbiol. Biotechnol.
, vol.1
, pp. 107-125
-
-
Tseng, T.-T.1
Gratwick, K.S.2
Kollman, J.3
Park, D.4
Nies, D.H.5
Goffeau, A.6
Saier, Jr.M.H.7
-
61
-
-
0036534286
-
The sterol-sensing domain: Multiple families, a unique role?
-
P.E. Kuwabara, and M. Labouesse The sterol-sensing domain: multiple families, a unique role? Trends Genet. 18 2002 193 201
-
(2002)
Trends Genet.
, vol.18
, pp. 193-201
-
-
Kuwabara, P.E.1
Labouesse, M.2
-
62
-
-
80052521709
-
The hedgehog receptor patched is involved in cholesterol transport
-
M. Bidet, O. Joubert, B. Lacombe, M. Ciantar, R. Nehmé, P. Mollat, L. Brétillon, H. Faure, R. Bittman, and M. Ruat The hedgehog receptor patched is involved in cholesterol transport PLoS One 6 2011 e23834
-
(2011)
PLoS One
, vol.6
, pp. 23834
-
-
Bidet, M.1
Joubert, O.2
Lacombe, B.3
Ciantar, M.4
Nehmé, R.5
Mollat, P.6
Brétillon, L.7
Faure, H.8
Bittman, R.9
Ruat, M.10
-
63
-
-
33747332214
-
Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion
-
M.F. Bijlsma, C.A. Spek, D. Zivkovic, S. van de Water, F. Rezaee, and M.P. Peppelenbosch Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion PLoS Biol. 4 2006 e232
-
(2006)
PLoS Biol.
, vol.4
, pp. 232
-
-
Bijlsma, M.F.1
Spek, C.A.2
Zivkovic, D.3
Van De Water, S.4
Rezaee, F.5
Peppelenbosch, M.P.6
-
64
-
-
71449084811
-
Patched regulates Smoothened trafficking using lipoprotein-derived lipids
-
H. Khaliullina, D. Panáková, C. Eugster, F. Riedel, M. Carvalho, and S. Eaton Patched regulates Smoothened trafficking using lipoprotein-derived lipids Development 136 2009 4111 4121
-
(2009)
Development
, vol.136
, pp. 4111-4121
-
-
Khaliullina, H.1
Panáková, D.2
Eugster, C.3
Riedel, F.4
Carvalho, M.5
Eaton, S.6
-
65
-
-
77954949822
-
Role of lipid metabolism in smoothened derepression in hedgehog signaling
-
A. Yavari, R. Nagaraj, E. Owusu-Ansah, A. Folick, K. Ngo, T. Hillman, G. Call, R. Rohatgi, M.P. Scott, and U. Banerjee Role of lipid metabolism in smoothened derepression in hedgehog signaling Dev. Cell 19 2010 54 65
-
(2010)
Dev. Cell
, vol.19
, pp. 54-65
-
-
Yavari, A.1
Nagaraj, R.2
Owusu-Ansah, E.3
Folick, A.4
Ngo, K.5
Hillman, T.6
Call, G.7
Rohatgi, R.8
Scott, M.P.9
Banerjee, U.10
-
66
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
-
J.K. Chen, J. Taipale, M.K. Cooper, and P.A. Beachy Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened Gene Dev. 16 2002 2743 2748
-
(2002)
Gene Dev.
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
67
-
-
84878112106
-
Structure of the human smoothened receptor bound to an antitumour agent
-
C. Wang, H. Wu, V. Katritch, G.W. Han, X.-P. Huang, W. Liu, F.Y. Siu, B.L. Roth, V. Cherezov, and R.C. Stevens Structure of the human smoothened receptor bound to an antitumour agent Nature 497 2013 338 343
-
(2013)
Nature
, vol.497
, pp. 338-343
-
-
Wang, C.1
Wu, H.2
Katritch, V.3
Han, G.W.4
Huang, X.-P.5
Liu, W.6
Siu, F.Y.7
Roth, B.L.8
Cherezov, V.9
Stevens, R.C.10
-
68
-
-
84883051342
-
Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response
-
B.R. Myers, N. Sever, Y.C. Chong, J. Kim, J.D. Belani, S. Rychnovsky, J.F. Bazan, and P.A. Beachy Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response Dev. Cell 26 2013 346 357
-
(2013)
Dev. Cell
, vol.26
, pp. 346-357
-
-
Myers, B.R.1
Sever, N.2
Chong, Y.C.3
Kim, J.4
Belani, J.D.5
Rychnovsky, S.6
Bazan, J.F.7
Beachy, P.A.8
-
69
-
-
84887326705
-
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
-
S. Nachtergaele, D.M. Whalen, L.K. Mydock, Z. Zhao, T. Malinauskas, K. Krishnan, P.W. Ingham, D.F. Covey, C. Siebold, and R. Rohatgi Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling eLife 2 2013
-
(2013)
ELife
, vol.2
-
-
Nachtergaele, S.1
Whalen, D.M.2
Mydock, L.K.3
Zhao, Z.4
Malinauskas, T.5
Krishnan, K.6
Ingham, P.W.7
Covey, D.F.8
Siebold, C.9
Rohatgi, R.10
-
70
-
-
84883185477
-
Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling
-
D. Nedelcu, J. Liu, Y. Xu, C. Jao, and A. Salic Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling Nat. Chem. Biol. 9 2013 557 564
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 557-564
-
-
Nedelcu, D.1
Liu, J.2
Xu, Y.3
Jao, C.4
Salic, A.5
-
71
-
-
67449094358
-
The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling
-
P. Aanstad, N. Santos, K.C. Corbit, P.J. Scherz, L.A. Trinh, W. Salvenmoser, J. Huisken, J.F. Reiter, and D.Y. Stainier The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling Curr. Biol. 19 2009 1034 1039
-
(2009)
Curr. Biol.
, vol.19
, pp. 1034-1039
-
-
Aanstad, P.1
Santos, N.2
Corbit, K.C.3
Scherz, P.J.4
Trinh, L.A.5
Salvenmoser, W.6
Huisken, J.7
Reiter, J.F.8
Stainier, D.Y.9
-
72
-
-
84890897900
-
Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling
-
10.1038/ncomms3965 (Article number: 2965)
-
R. Rana, C.E. Carroll, H.-J. Lee, J. Bao, S. Marada, C.R. Grace, C.D. Guibao, S.K. Ogden, and J.J. Zheng Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling Nat. Commun. 4 2013 10.1038/ncomms3965 (Article number: 2965)
-
(2013)
Nat. Commun.
, vol.4
-
-
Rana, R.1
Carroll, C.E.2
Lee, H.-J.3
Bao, J.4
Marada, S.5
Grace, C.R.6
Guibao, C.D.7
Ogden, S.K.8
Zheng, J.J.9
-
73
-
-
84889604932
-
A novel site comes into sight
-
(2:e01680)
-
Y. Wang, and A.P. McMahon A novel site comes into sight eLife 2013 (2:e01680)
-
(2013)
ELife
-
-
Wang, Y.1
McMahon, A.P.2
-
74
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
R.L. Yauch, G.J. Dijkgraaf, B. Alicke, T. Januario, C.P. Ahn, T. Holcomb, K. Pujara, J. Stinson, C.A. Callahan, and T. Tang Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma Science 326 2009 572 574
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
Dijkgraaf, G.J.2
Alicke, B.3
Januario, T.4
Ahn, C.P.5
Holcomb, T.6
Pujara, K.7
Stinson, J.8
Callahan, C.A.9
Tang, T.10
-
75
-
-
0037195074
-
Small molecule modulation of Smoothened activity
-
J.K. Chen, J. Taipale, K.E. Young, T. Maiti, and P.A. Beachy Small molecule modulation of Smoothened activity Proc. Natl. Acad. Sci. U.S.A. 99 2002 14071 14076
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 14071-14076
-
-
Chen, J.K.1
Taipale, J.2
Young, K.E.3
Maiti, T.4
Beachy, P.A.5
-
76
-
-
69949084378
-
GDC-0449 - A potent inhibitor of the hedgehog pathway
-
K.D. Robarge, S.A. Brunton, G.M. Castanedo, Y. Cui, M.S. Dina, R. Goldsmith, S.E. Gould, O. Guichert, J.L. Gunzner, and J. Halladay GDC-0449 - a potent inhibitor of the hedgehog pathway Bioorg. Med. Chem. Lett. 19 2009 5576 5581
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 5576-5581
-
-
Robarge, K.D.1
Brunton, S.A.2
Castanedo, G.M.3
Cui, Y.4
Dina, M.S.5
Goldsmith, R.6
Gould, S.E.7
Guichert, O.8
Gunzner, J.L.9
Halladay, J.10
-
77
-
-
18644368453
-
Small-molecule modulators of Hedgehog signaling: Identification and characterization of Smoothened agonists and antagonists
-
M. Frank-Kamenetsky, X. Zhang, S. Bottega, O. Guicherit, H. Wichterle, H. Dudek, D. Bumcrot, F. Wang, S. Jones, and J. Shulok Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists J. Biol. 1 2002 10
-
(2002)
J. Biol.
, vol.1
, pp. 10
-
-
Frank-Kamenetsky, M.1
Zhang, X.2
Bottega, S.3
Guicherit, O.4
Wichterle, H.5
Dudek, H.6
Bumcrot, D.7
Wang, F.8
Jones, S.9
Shulok, J.10
-
78
-
-
79955820914
-
Vitamin D3 inhibits hedgehog signaling and proliferation in murine basal cell carcinomas
-
J.Y. Tang, T.Z. Xiao, Y. Oda, K.S. Chang, E. Shpall, A. Wu, P.-L. So, J. Hebert, D. Bikle, and E.H. Epstein Vitamin D3 inhibits hedgehog signaling and proliferation in murine basal cell carcinomas Cancer Prev. Res. 4 2011 744 751
-
(2011)
Cancer Prev. Res.
, vol.4
, pp. 744-751
-
-
Tang, J.Y.1
Xiao, T.Z.2
Oda, Y.3
Chang, K.S.4
Shpall, E.5
Wu, A.6
So, P.-L.7
Hebert, J.8
Bikle, D.9
Epstein, E.H.10
-
79
-
-
33645211374
-
Purmorphamine activates the Hedgehog pathway by targeting Smoothened
-
S. Sinha, and J.K. Chen Purmorphamine activates the Hedgehog pathway by targeting Smoothened Nat. Chem. Biol. 2 2006 29 30
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 29-30
-
-
Sinha, S.1
Chen, J.K.2
-
80
-
-
84856098531
-
Oxysterols are allosteric activators of the oncoprotein Smoothened
-
S. Nachtergaele, L.K. Mydock, K. Krishnan, J. Rammohan, P.H. Schlesinger, D.F. Covey, and R. Rohatgi Oxysterols are allosteric activators of the oncoprotein Smoothened Nat. Chem. Biol. 8 2012 211 220
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 211-220
-
-
Nachtergaele, S.1
Mydock, L.K.2
Krishnan, K.3
Rammohan, J.4
Schlesinger, P.H.5
Covey, D.F.6
Rohatgi, R.7
-
81
-
-
84865366865
-
High sensitivity measurements of active oxysterols with automated filtration/filter backflush-solid phase extraction-liquid chromatography-mass spectrometry
-
H. Roberg-Larsen, M.F. Strand, A. Grimsmo, P.A. Olsen, J.L. Dembinski, F. Rise, E. Lundanes, T. Greibrokk, S. Krauss, and S.R. Wilson High sensitivity measurements of active oxysterols with automated filtration/filter backflush-solid phase extraction-liquid chromatography-mass spectrometry J. Chromatogr. A 1255 2012 291 297
-
(2012)
J. Chromatogr. A
, vol.1255
, pp. 291-297
-
-
Roberg-Larsen, H.1
Strand, M.F.2
Grimsmo, A.3
Olsen, P.A.4
Dembinski, J.L.5
Rise, F.6
Lundanes, E.7
Greibrokk, T.8
Krauss, S.9
Wilson, S.R.10
-
82
-
-
33744788672
-
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
-
R.B. Corcoran, and M.P. Scott Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells Proc. Natl. Acad. Sci. U.S.A. 103 2006 8408 8413
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 8408-8413
-
-
Corcoran, R.B.1
Scott, M.P.2
-
83
-
-
77952703001
-
Identification of select glucocorticoids as Smoothened agonists: Potential utility for regenerative medicine
-
J. Wang, J. Lu, M.C. Bond, M. Chen, X.-R. Ren, H.K. Lyerly, L.S. Barak, and W. Chen Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine Proc. Natl. Acad. Sci. U.S.A. 107 2010 9323 9328
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 9323-9328
-
-
Wang, J.1
Lu, J.2
Bond, M.C.3
Chen, M.4
Ren, X.-R.5
Lyerly, H.K.6
Barak, L.S.7
Chen, W.8
-
84
-
-
84862582197
-
Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation
-
Y. Wang, A.C. Arvanites, L. Davidow, J. Blanchard, K. Lam, J.W. Yoo, S. Coy, L.L. Rubin, and A.P. McMahon Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation ACS Chem. Biol. 7 2012 1040 1048
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1040-1048
-
-
Wang, Y.1
Arvanites, A.C.2
Davidow, L.3
Blanchard, J.4
Lam, K.5
Yoo, J.W.6
Coy, S.7
Rubin, L.L.8
McMahon, A.P.9
-
85
-
-
84872417679
-
Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
-
J. Kim, B.T. Aftab, J.Y. Tang, D. Kim, A.H. Lee, M. Rezaee, J. Kim, B. Chen, E.M. King, and A. Borodovsky Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists Cancer Cell 23 2013 23 24
-
(2013)
Cancer Cell
, vol.23
, pp. 23-24
-
-
Kim, J.1
Aftab, B.T.2
Tang, J.Y.3
Kim, D.4
Lee, A.H.5
Rezaee, M.6
Kim, J.7
Chen, B.8
King, E.M.9
Borodovsky, A.10
-
86
-
-
77950492233
-
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
-
J. Kim, J.Y. Tang, R. Gong, J. Kim, J.J. Lee, K.V. Clemons, C.R. Chong, K.S. Chang, M. Fereshteh, and D. Gardner Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth Cancer Cell 17 2010 388 399
-
(2010)
Cancer Cell
, vol.17
, pp. 388-399
-
-
Kim, J.1
Tang, J.Y.2
Gong, R.3
Kim, J.4
Lee, J.J.5
Clemons, K.V.6
Chong, C.R.7
Chang, K.S.8
Fereshteh, M.9
Gardner, D.10
-
87
-
-
67349268463
-
Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
-
A.J. Brown, and W. Jessup Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis Mol. Aspects Med. 30 2009 111 122
-
(2009)
Mol. Aspects Med.
, vol.30
, pp. 111-122
-
-
Brown, A.J.1
Jessup, W.2
-
88
-
-
84862339778
-
A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma
-
J.G. McDonald, D.D. Smith, A.R. Stiles, and D.W. Russell A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma J. Lipid Res. 53 2012 1399 1409
-
(2012)
J. Lipid Res.
, vol.53
, pp. 1399-1409
-
-
McDonald, J.G.1
Smith, D.D.2
Stiles, A.R.3
Russell, D.W.4
-
89
-
-
0038209538
-
The detection of 20 (S)-hydroxycholesterol in extracts of rat brains and human placenta by a gas chromatograph/mass spectrometry technique
-
Y.Y. Lin, M. Welch, and S. Lieberman The detection of 20 (S)-hydroxycholesterol in extracts of rat brains and human placenta by a gas chromatograph/mass spectrometry technique J. Steroid Biochem. Mol. Biol. 85 2003 57 61
-
(2003)
J. Steroid Biochem. Mol. Biol.
, vol.85
, pp. 57-61
-
-
Lin, Y.Y.1
Welch, M.2
Lieberman, S.3
-
90
-
-
0001113998
-
Cholesterol oxidation in meat products during cooking and frozen storage
-
J.E. Pie, K. Spahis, and C. Seillan Cholesterol oxidation in meat products during cooking and frozen storage J. Agric. Food Chem. 39 1991 250 254
-
(1991)
J. Agric. Food Chem.
, vol.39
, pp. 250-254
-
-
Pie, J.E.1
Spahis, K.2
Seillan, C.3
-
91
-
-
84874115170
-
Five decades with oxysterols
-
I. Björkhem Five decades with oxysterols Biochimie 95 2013 448 454
-
(2013)
Biochimie
, vol.95
, pp. 448-454
-
-
Björkhem, I.1
-
92
-
-
0028816863
-
Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry
-
S. Dzeletovic, O. Breuer, E. Lund, and U. Diczfalusy Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry Anal. Biochem. 225 1995 73 80
-
(1995)
Anal. Biochem.
, vol.225
, pp. 73-80
-
-
Dzeletovic, S.1
Breuer, O.2
Lund, E.3
Diczfalusy, U.4
-
94
-
-
34147118488
-
Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols
-
K. Karu, M. Hornshaw, G. Woffendin, K. Bodin, M. Hamberg, G. Alvelius, J. Sjövall, J. Turton, Y. Wang, and W.J. Griffiths Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols J. Lipid Res. 48 2007 976 987
-
(2007)
J. Lipid Res.
, vol.48
, pp. 976-987
-
-
Karu, K.1
Hornshaw, M.2
Woffendin, G.3
Bodin, K.4
Hamberg, M.5
Alvelius, G.6
Sjövall, J.7
Turton, J.8
Wang, Y.9
Griffiths, W.J.10
-
95
-
-
14944348447
-
A new LC/APCI-MS method for the determination of cholesterol oxidation products in food
-
K. Raith, C. Brenner, H. Farwanah, G. Müller, K. Eder, and R.H. Neubert A new LC/APCI-MS method for the determination of cholesterol oxidation products in food J. Chromatogr. A 1067 2005 207 211
-
(2005)
J. Chromatogr. A
, vol.1067
, pp. 207-211
-
-
Raith, K.1
Brenner, C.2
Farwanah, H.3
Müller, G.4
Eder, K.5
Neubert, R.H.6
-
97
-
-
53049101328
-
Discovering oxysterols in plasma: A window on the metabolome
-
W.J. Griffiths, M. Hornshaw, G. Woffendin, S.F. Baker, A. Lockhart, S. Heidelberger, M. Gustafsson, J. Sjovall, and Y. Wang Discovering oxysterols in plasma: a window on the metabolome J. Proteome Res. 7 2008 3602 3612
-
(2008)
J. Proteome Res.
, vol.7
, pp. 3602-3612
-
-
Griffiths, W.J.1
Hornshaw, M.2
Woffendin, G.3
Baker, S.F.4
Lockhart, A.5
Heidelberger, S.6
Gustafsson, M.7
Sjovall, J.8
Wang, Y.9
-
98
-
-
64749098311
-
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS
-
A. Honda, K. Yamashita, T. Hara, T. Ikegami, T. Miyazaki, M. Shirai, G. Xu, M. Numazawa, and Y. Matsuzaki Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS J. Lipid Res. 50 2009 350 357
-
(2009)
J. Lipid Res.
, vol.50
, pp. 350-357
-
-
Honda, A.1
Yamashita, K.2
Hara, T.3
Ikegami, T.4
Miyazaki, T.5
Shirai, M.6
Xu, G.7
Numazawa, M.8
Matsuzaki, Y.9
-
99
-
-
80051471394
-
Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: Monitoring of cholesterol autoxidation
-
K. Karu, J. Turton, Y. Wang, and W.J. Griffiths Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation Chem. Phys. Lipids 164 2011 411 424
-
(2011)
Chem. Phys. Lipids
, vol.164
, pp. 411-424
-
-
Karu, K.1
Turton, J.2
Wang, Y.3
Griffiths, W.J.4
-
100
-
-
79952140449
-
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry
-
J. Clark, K.E. Anderson, V. Juvin, T.S. Smith, F. Karpe, M.J. Wakelam, L.R. Stephens, and P.T. Hawkins Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry Nat. Methods 8 2011 267 272
-
(2011)
Nat. Methods
, vol.8
, pp. 267-272
-
-
Clark, J.1
Anderson, K.E.2
Juvin, V.3
Smith, T.S.4
Karpe, F.5
Wakelam, M.J.6
Stephens, L.R.7
Hawkins, P.T.8
-
101
-
-
78650425264
-
Development and optimization of an LC-MS/MS-based method for simultaneous quantification of vitamin D2, vitamin D3, 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3
-
J. Adamec, A. Jannasch, J. Huang, E. Hohman, J.C. Fleet, M. Peacock, M.G. Ferruzzi, B. Martin, and C.M. Weaver Development and optimization of an LC-MS/MS-based method for simultaneous quantification of vitamin D2, vitamin D3, 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 J. Sep. Sci. 34 2011 11 20
-
(2011)
J. Sep. Sci.
, vol.34
, pp. 11-20
-
-
Adamec, J.1
Jannasch, A.2
Huang, J.3
Hohman, E.4
Fleet, J.C.5
Peacock, M.6
Ferruzzi, M.G.7
Martin, B.8
Weaver, C.M.9
-
102
-
-
84862815337
-
Determination of serum aldosterone by liquid chromatography and tandem mass spectrometry: A liquid-liquid extraction method for the ABSCIEX API-5000 mass spectrometry system
-
J.G. Van Der Gugten, J. Dubland, H.-F. Liu, A. Wang, C. Joseph, and D.T. Holmes Determination of serum aldosterone by liquid chromatography and tandem mass spectrometry: a liquid-liquid extraction method for the ABSCIEX API-5000 mass spectrometry system J. Clin. Pathol. 65 2012 457 462
-
(2012)
J. Clin. Pathol.
, vol.65
, pp. 457-462
-
-
Van Der Gugten, J.G.1
Dubland, J.2
Liu, H.-F.3
Wang, A.4
Joseph, C.5
Holmes, D.T.6
-
103
-
-
84860128607
-
Liquid chromatography-tandem mass spectrometry analysis of human adrenal vein corticosteroids before and after adrenocorticotropic hormone stimulation
-
Y. Nakamura, J. Rege, F. Satoh, R. Morimoto, M.R. Kennedy, C.N. Ahlem, S. Honma, H. Sasano, and W.E. Rainey Liquid chromatography-tandem mass spectrometry analysis of human adrenal vein corticosteroids before and after adrenocorticotropic hormone stimulation Clin. Endocrinol. 76 2012 778 784
-
(2012)
Clin. Endocrinol.
, vol.76
, pp. 778-784
-
-
Nakamura, Y.1
Rege, J.2
Satoh, F.3
Morimoto, R.4
Kennedy, M.R.5
Ahlem, C.N.6
Honma, S.7
Sasano, H.8
Rainey, W.E.9
-
104
-
-
84889071668
-
Mass spectrometry imaging for dissecting steroid intracrinology within target tissues
-
D.F. Cobice, C.L. Mackay, R.J. Goodwin, A. McBride, P.R. Langridge-Smith, S.P. Webster, B.R. Walker, and R. Andrew Mass spectrometry imaging for dissecting steroid intracrinology within target tissues Anal. Chem. 85 2013 11576 11584
-
(2013)
Anal. Chem.
, vol.85
, pp. 11576-11584
-
-
Cobice, D.F.1
Mackay, C.L.2
Goodwin, R.J.3
McBride, A.4
Langridge-Smith, P.R.5
Webster, S.P.6
Walker, B.R.7
Andrew, R.8
-
105
-
-
80051471752
-
Pathways of cholesterol oxidation via non-enzymatic mechanisms
-
L. Iuliano Pathways of cholesterol oxidation via non-enzymatic mechanisms Chem. Phys. Lipids 164 2011 457 468
-
(2011)
Chem. Phys. Lipids
, vol.164
, pp. 457-468
-
-
Iuliano, L.1
|