A novel site comes into sight: Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway

eLife

Volumn 2013, Issue 2, 2013, Pages

  Wang, Yu ^a,b   McMahon, Andrew P ^c  

^a INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; OXYSTEROL; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN;

ARTICLE; CHEMICAL PHENOMENA; COMPUTER MODEL; CRYSTAL STRUCTURE; DEGENERATIVE DISEASE; HUMAN; LIPID OXIDATION; MEMBRANE POTENTIAL; NONHUMAN; PHARMACOLOGICAL PROCEDURES; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 84889604932     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.01680     Document Type: Article

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