Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence

Biochemical Journal

Volumn 459, Issue 3, 2014, Pages 551-564

  Zelent, Bogumil ^a   Raimondo, Anne ^b   Barrett, Amy ^b   Buettger, Carol W ^a   Chen, Pan ^a   Gloyn, Anna L ^b   Matschinsky, Franz M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Allosteric regulation; Co operativity; Diabetes; Fructose phosphate ester; Glucokinase; Glucokinase regulatory protein; Metabolic regulation

Indexed keywords

ESTER; FRUCTOSE; FRUCTOSE 1 PHOSPHATE; FRUCTOSE PHOSPHATE; GLUCOKINASE; GLUCOKINASE REGULATORY PROTEIN; GLUCOSE; REGULATOR PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ABSORPTION; ALLOSTERISM; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLUORESCENCE; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; KINETICS; METABOLITE; MUTATION; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QUANTUM YIELD; STORAGE; TITRIMETRY; TRYPTOPHAN FLUORESCENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; FRUCTOSEPHOSPHATES; GLUCOKINASE; GLUCOSE; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTANT PROTEINS; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN REFOLDING; PROTEIN STABILITY; PROTEIN TRANSPORT; PROTEIN UNFOLDING; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

EID: 84898640681     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131363     Document Type: Article

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