Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis

Diabetologia

Volumn 42, Issue 10, 1999, Pages 1175-1186

  Davis, E A ^a   Cuesta Munoz A ^a   Raoul, M ^a   Buettger, C ^a   Sweet, I ^a   Moates, M ^b   Magnuson, M A ^b   Matschinsky, F M ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Diabetes Research Center   (United States)

Author keywords

Beta cell; Glucokinase; Glucose threshold; Insulin secretion; Mathematical model; MODY 2

Indexed keywords

GLUCOKINASE; GLUCOSE; MUTANT PROTEIN; RECOMBINANT ENZYME;

ARTICLE; ENZYME ANALYSIS; ENZYME DEFECT; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STABILITY; ESCHERICHIA COLI; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPOGLYCEMIA; MATURITY ONSET DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; SYNDROME; THERMOSTABILITY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATE; BLOOD GLUCOSE; CARRIER PROTEINS; ENZYME ACTIVATION; ENZYME STABILITY; GLUCOKINASE; GLUCOSE; GLUTATHIONE TRANSFERASE; HOMEOSTASIS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN; MODELS, BIOLOGICAL; MUTATION; PROTEINS; RECOMBINANT FUSION PROTEINS; SYNDROME;

EID: 0032875616     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051289     Document Type: Article

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