Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk

Diabetologia

Volumn 55, Issue 1, 2012, Pages 114-122

  Rees, M G ^a,b   Wincovitch, S ^b   Schultz, J ^c   Waterstradt, R ^c   Beer, N L ^a   Baltrusch, S ^c   Collins, F S ^b   Gloyn, A L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Association study; Genetics; Glucokinase; Molecular mechanism

Indexed keywords

GLUCOKINASE; GLUCOKINASE REGULATORY PROTEIN; GLUCOSE; LEUCINE; PROLINE; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRANSFECTION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HELA CELL; HUMAN; HUMAN CELL; LIPOGENESIS; LIVER CELL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; RISK ASSESSMENT; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SUBSTITUTION; ANIMALS; CARRIER PROTEINS; CELL NUCLEUS; CELLS, CULTURED; CYTOSOL; DIABETES MELLITUS, TYPE 2; GENE LIBRARY; GLUCOKINASE; GLUCOSE; HELA CELLS; HEPATOCYTES; HUMANS; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MUTANT PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TRANSPORT; RATS; RECOMBINANT FUSION PROTEINS;

EID: 84856733126     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2348-5     Document Type: Article

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