Global fit analysis of glucose binding curves reveals a minimal model for kinetic cooperativity in human glucokinase

Biochemistry

Volumn 49, Issue 41, 2010, Pages 8902-8911

  Larion, Mioara ^a   Miller, Brian G ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; DYES; ENZYMES; GLYCEROL; KINETIC THEORY; LIGANDS; RATE CONSTANTS;

ANALYTICAL SOLUTIONS; BINARY COMPLEXES; BINDING CURVES; BLOOD GLUCOSE LEVEL; CONFORMATIONAL HETEROGENEITY; COOPERATIVITY; ENZYME CONFORMATIONS; GLOBAL FIT ANALYSIS; GLUCOKINASE; GLYCEROL CONCENTRATION; INCREASING VISCOSITY; INTRINSIC FLUORESCENCE; KINETIC ANALYSIS; KINETIC MODELS; MICHAELIS-MENTEN; MINIMAL MODEL; MONOMERIC ENZYMES; MULTIPLE CONFORMATIONS; THEORETICAL MODELS; TIME-DEPENDENT CHANGES; TRANSITION MODEL;

GLUCOSE;

GLUCOKINASE; GLUCOSE; GLYCEROL; GLUCOSE BLOOD LEVEL;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; FLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; VISCOSITY; CHEMICAL MODEL; CHEMISTRY; ENZYMOLOGY; GLUCOSE BLOOD LEVEL; HUMAN; KINETICS; METABOLISM; PANCREAS;

BLOOD GLUCOSE; GLUCOKINASE; GLYCEROL; HUMANS; KINETICS; MODELS, CHEMICAL; PANCREAS; VISCOSITY;

EID: 77957922049     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1008672     Document Type: Article

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