Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: Steady-state kinetic and cell-based analysis

Biochemical Journal

Volumn 441, Issue 3, 2012, Pages 881-887

  Bourbonais, Francis J ^a   Chen, Jing ^a   Huang, Cong ^a   Zhang, Yanwei ^a   Pfefferkorn, Jeffrey A ^a   Landro, James A ^a  

^a PFIZER INC   (United States)

Author keywords

Allosteric modulation; Glucokinase activator (GKA); Glucokinase regulatory protein (GKRP); Liver selective; Slow; Tight binding inhibition

Indexed keywords

6 [3 CYCLOPENTYL 2 [4 (TRIFLUOROMETHYL) 1H IMIDAZOL 1 YL]PROPANAMIDO]NICOTINIC ACID; ENZYME ACTIVATOR; GLUCOKINASE; GLUCOKINASE REGULATORY PROTEIN; GLUCOSE; RECOMBINANT ENZYME; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ASSAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MODIFICATION; HUMAN; IMAGE ANALYSIS; LIVER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE;

ALLOSTERIC REGULATION; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; DRUG AGONISM; ENZYME ACTIVATION; GLUCOKINASE; GLUCOSE; HEPATOCYTES; HUMANS; KINETICS; MODELS, BIOLOGICAL; PROTEIN CONFORMATION; RATS; SMALL MOLECULE LIBRARIES;

RATTUS;

EID: 84862908827     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110721     Document Type: Article

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