Sphingolipids in colon cancer

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1841, Issue 5, 2014, Pages 773-782

  García Barros, Mónica ^a   Coant, Nicolas ^a   Truman, Jean Philip ^a   Snider, Ashley J ^b,c   Hannun, Yusuf A ^a  

^a Stony Brook Medicine   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Ceramide; Colorectal cancer; Dietary; Sphingolipids; Sphingosine; Sphingosine 1 phosphate

Indexed keywords

ALKALINE SPHINGOMYELIN PHOSPHODIESTERASE; ANTINEOPLASTIC AGENT; APC PROTEIN; BETA CATENIN; CERAMIDE GLUCOSYLTRANSFERASE; EXOGENOUS SPHINGOLIPID; INTESTINE ENZYME; LYASE; NEUTRAL CERAMIDASE; PHOSPHATASE; RECOMBINANT ENZYME; S 1 P LYASE; S 1 P LYASE ENZYME; S 1 P PHOSPHATASE; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE KINASE; UNCLASSIFIED DRUG; WNT PROTEIN;

BETA CATENIN PATHWAY; BIOLOGICAL ACTIVITY; CANCER CELL; CANCER MODEL; CANCER PATIENT; COLON CANCER; COLON CANCER CELL; DIET; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; HUMAN XENOGRAFT; LIPID METABOLISM; MOLECULAR INTERACTION; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WNT SIGNALING PATHWAY; XENOGRAFT;

CERAMIDE; COLORECTAL CANCER; DIETARY; SPHINGOLIPIDS; SPHINGOSINE; SPHINGOSINE-1-PHOSPHATE;

ANIMALS; CELL PHYSIOLOGICAL PHENOMENA; COLONIC NEOPLASMS; HOMEOSTASIS; HUMANS; SIGNAL TRANSDUCTION; SPHINGOLIPIDS;

EID: 84897954300     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.09.007     Document Type: Review

References (126)

1. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, and D.M. Parkin Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int. J. Cancer 127 12 2010 2893 2917 (Epub 2011/02/26)
2. Figures SACF 2013 American Cancer, Society Atlanta
3. L.E. Johns, and R.S. Houlston A systematic review and meta-analysis of familial colorectal cancer risk Am. J. Gastroenterol. 96 10 2001 2992 3003 (Epub 2001/11/06) (Pubitemid 32959544)
4. Y. Miyoshi, H. Ando, H. Nagase, I. Nishisho, A. Horii, and Y. Miki et al. Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients Proc. Natl. Acad. Sci. U. S. A. 89 10 1992 4452 4456 (Epub 1992/05/15)
5. J.D. Brensinger, S.J. Laken, M.C. Luce, S.M. Powell, G.H. Vance, and D.J. Ahnen et al. Variable phenotype of familial adenomatous polyposis in pedigrees with 3′ mutation in the APC gene Gut 43 4 1998 548 552 (Epub 1998/11/21) (Pubitemid 28462042)
6. V. Steinke, C. Engel, R. Buttner, H.K. Schackert, W.H. Schmiegel, and P. Propping Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome Deutsches Arzteblatt international 110 3 2013 32 38 (Epub 2013/02/16)
7. S. Seshagiri The burden of faulty proofreading in colon cancer Nat. Genet. 45 2 2013 121 122 (Epub 2013/01/30)
8. S. Yamaguchi, H. Ogata, D. Katsumata, M. Nakajima, T. Fujii, and S. Tsutsumi et al. MUTYH-associated colorectal cancer and adenomatous polyposis Surg. Today 2013 10.1007/s00595-013-0592-7 (Epub 2013/04/23)
9. P. Lichtenstein, N.V. Holm, P.K. Verkasalo, A. Iliadou, J. Kaprio, and M. Koskenvuo et al. Environmental and heritable factors in the causation of cancer - analyses of cohorts of twins from Sweden, Denmark, and Finland N. Engl. J. Med. 343 2 2000 78 85 (Epub 2000/07/13) (Pubitemid 30451850)
10. F. Radtke, and H. Clevers Self-renewal and cancer of the gut: two sides of a coin Science 307 5717 2005 1904 1909 (Epub 2005/03/26) (Pubitemid 40404692)
11. E. Sancho, E. Batlle, and H. Clevers Signaling pathways in intestinal development and cancer Annu. Rev. Cell Dev. Biol. 20 2004 695 723 (Epub 2004/10/12) (Pubitemid 39488655)
12. E.R. Fearon, and B. Vogelstein A genetic model for colorectal tumorigenesis Cell 61 5 1990 759 767 (Epub 1990/06/01)
13. L. Cheng, and M.D. Lai Aberrant crypt foci as microscopic precursors of colorectal cancer World J. Gastroenterol. 9 12 2003 2642 2649 (Epub 2003/12/12) (Pubitemid 38054431)
14. M.R. Nucci, C.R. Robinson, P. Longo, P. Campbell, and S.R. Hamilton Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa Hum. Pathol. 28 12 1997 1396 1407 (Epub 1998/01/07) (Pubitemid 28013636)
15. Y.A. Hannun Functions of ceramide in coordinating cellular responses to stress Science 274 5294 1996 1855 1859 (Epub 1996/12/13) (Pubitemid 26424756)
16. M.N. Nikolova-Karakashian, and K.A. Rozenova Ceramide in stress response Adv. Exp. Med. Biol. 688 2010 86 108 (Epub 2010/10/06)
17. B. Stancevic, and R. Kolesnick Ceramide-rich platforms in transmembrane signaling FEBS Lett. 584 9 2010 1728 1740 (Epub 2010/02/25)
18. M. El Alwani, B.X. Wu, L.M. Obeid, and Y.A. Hannun Bioactive sphingolipids in the modulation of the inflammatory response Pharmacol. Ther. 112 1 2006 171 183 (Epub 2006/06/09) (Pubitemid 44301491)
19. Y.A. Hannun, and L.M. Obeid Many ceramides J. Biol. Chem. 286 32 2011 27855 27862 (Epub 2011/06/23)
20. Y.A. Hannun, and L.M. Obeid Principles of bioactive lipid signalling: lessons from sphingolipids Nat. Rev. Mol. Cell Biol. 9 2 2008 139 150 (Epub 2008/01/25) (Pubitemid 351158911)
21. M. Maceyka, S. Milstien, and S. Spiegel Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling J. Lipid Res. 50 Suppl. 2009 S272 S276 (Epub 2008/11/07)
22. B. Ogretmen, and Y.A. Hannun Biologically active sphingolipids in cancer pathogenesis and treatment Nat. Rev. Cancer 4 8 2004 604 616 (Epub 2004/08/03) (Pubitemid 39025055)
23. Y.H. Zeidan, and Y.A. Hannun Translational aspects of sphingolipid metabolism Trends Mol. Med. 13 8 2007 327 336 (Epub 2007/06/26) (Pubitemid 47126985)
24. H. Furuya, Y. Shimizu, and T. Kawamori Sphingolipids in cancer Cancer Metastasis Rev. 30 3-4 2011 567 576 (Epub 2011/10/19)
25. S.A. Saddoughi, and B. Ogretmen Diverse functions of ceramide in cancer cell death and proliferation Adv. Cancer Res. 117 2013 37 58 (Epub 2013/01/08)
26. T.D. Mullen, Y.A. Hannun, and L.M. Obeid Ceramide synthases at the centre of sphingolipid metabolism and biology Biochem. J. 441 3 2012 789 802 (Epub 2012/01/18)
27. B. Henry, R. Ziobro, K.A. Becker, R. Kolesnick, and E. Gulbins Acid sphingomyelinase Handb. Exp. Pharmacol. 215 2013 77 88 (Epub 2013/04/13)
28. M.V. Airola, and Y.A. Hannun Sphingolipid metabolism and neutral sphingomyelinases Handb. Exp. Pharmacol. 215 2013 57 76 (Epub 2013/04/13)
29. J.C. Holthuis, and C. Luberto Tales and mysteries of the enigmatic sphingomyelin synthase family Adv. Exp. Med. Biol. 688 2010 72 85 (Epub 2010/10/06)
30. Y.Y. Liu, R.A. Hill, and Y.T. Li Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance Adv. Cancer Res. 117 2013 59 89 (Epub 2013/01/08)
31. L.A. Heffernan-Stroud, and L.M. Obeid Sphingosine kinase 1 in cancer Adv. Cancer Res. 117 2013 201 235 (Epub 2013/01/08)
32. N. Bartke, and Y.A. Hannun Bioactive sphingolipids: metabolism and function J. Lipid Res. 50 Suppl. 2009 S91 S96 (Epub 2008/11/20)
33. C.R. Gault, L.M. Obeid, and Y.A. Hannun An overview of sphingolipid metabolism: from synthesis to breakdown Adv. Exp. Med. Biol. 688 2010 1 23 (Epub 2010/10/06)
34. D. Canals, and Y.A. Hannun Novel chemotherapeutic drugs in sphingolipid cancer research Handb. Exp. Pharmacol. 215 2013 211 238 (Epub 2013/04/13)
35. A.V. Alekseenko The potential role for sphingolipids in neuropathogenesis of Alzheimer's disease Biomeditsinskaia khimiia. 59 1 2013 25 50 (Epub 2013/05/09)
36. T. Hornemann, and T.S. Worgall Sphingolipids and atherosclerosis Atherosclerosis 226 1 2013 16 28 (Epub 2012/10/19)
37. K.A. Becker, B. Henry, R. Ziobro, J. Riethmuller, and E. Gulbins Lipids in cystic fibrosis Expert Rev. Respir. Med. 5 4 2011 527 535 (Epub 2011/08/24)
38. M. Flowers, G. Fabrias, A. Delgado, J. Casas, J.L. Abad, and M.C. Cabot C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth Breast Cancer Res. Treat. 133 2 2012 447 458 (Epub 2011/09/22)
39. T. Kawamori, T. Kaneshiro, M. Okumura, S. Maalouf, A. Uflacker, and J. Bielawski et al. Role for sphingosine kinase 1 in colon carcinogenesis FASEB J. 23 2 2009 405 414 (Epub 2008/10/01)
40. R.D. Duan, and A. Nilsson Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development Prog. Lipid Res. 48 1 2009 62 72 (Epub 2008/11/26)
41. E.M. Danielsen, and G.H. Hansen Lipid raft organization and function in the small intestinal brush border J. Physiol. Biochem. 64 4 2008 377 382 (Epub 2009/04/28)
42. J. Wu, F. Liu, A. Nilsson, and R.D. Duan Pancreatic trypsin cleaves intestinal alkaline sphingomyelinase from mucosa and enhances the sphingomyelinase activity Am. J. Physiol. Gastrointest. Liver Physiol. 287 5 2004 G967 G973 (Epub 2004/06/19)
43. E. Hertervig, A. Nilsson, M. Nilbert, and R.D. Duan Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation Int. J. Color. Dis. 18 4 2003 309 313 (Epub 2003/05/30) (Pubitemid 36790227)
44. E. Hertervig, A. Nilsson, Y. Cheng, and R.D. Duan Purified intestinal alkaline sphingomyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells J. Cancer Res. Clin. Oncol. 129 10 2003 577 582 (Epub 2003/08/16) (Pubitemid 37363597)
45. E. Hertervig, A. Nilsson, L. Nyberg, and R.D. Duan Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma Cancer 79 3 1997 448 453 (Epub 1997/02/01) (Pubitemid 27051767)
46. U. Sjoqvist, E. Hertervig, A. Nilsson, R.D. Duan, A. Ost, and B. Tribukait et al. Chronic colitis is associated with a reduction of mucosal alkaline sphingomyelinase activity Inflamm. Bowel Dis. 8 4 2002 258 263 (Epub 2002/07/20) (Pubitemid 34784978)
47. Y. Cheng, H.D. Tauschel, A. Nilsson, and R.D. Duan Ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in the rat colon Scand. J. Gastroenterol. 34 9 1999 915 920 (Epub 1999/10/16) (Pubitemid 29470572)
48. D. Andersson, J.J. Liu, A. Nilsson, and R.D. Duan Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase Anticancer. Res. 23 4 2003 3317 3322 (Epub 2003/08/21) (Pubitemid 36975429)
49. D. Andersson, Y. Cheng, and R.D. Duan Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats J. Cancer Res. Clin. Oncol. 134 1 2008 101 107 (Epub 2007/07/03) (Pubitemid 350060690)
50. D.T. Rubin, and B.A. Lashner Will a 5-ASA a day keep the cancer (and dysplasia) away? Am. J. Gastroenterol. 100 6 2005 1354 1356 (Epub 2005/06/03) (Pubitemid 40904361)
51. D.L. Earnest, H. Holubec, R.K. Wali, C.S. Jolley, M. Bissonette, and A.K. Bhattacharyya et al. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid Cancer Res. 54 19 1994 5071 5074 (Epub 1994/10/01)
52. R.D. Duan Alkaline sphingomyelinase: an old enzyme with novel implications Biochim. Biophys. Acta 1761 3 2006 281 291 (Epub 2006/04/25)
53. Y. Fukuda, A. Kihara, and Y. Igarashi Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1 Biochem. Biophys. Res. Commun. 309 1 2003 155 160 (Epub 2003/08/29) (Pubitemid 36999771)
54. T. Kawamori, W. Osta, K.R. Johnson, B.J. Pettus, J. Bielawski, and T. Tanaka et al. Sphingosine kinase 1 is up-regulated in colon carcinogenesis FASEB J. 20 2 2006 386 388 (Epub 2005/12/02) (Pubitemid 46671180)
55. M. Kohno, M. Momoi, M.L. Oo, J.H. Paik, Y.M. Lee, and K. Venkataraman et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation Mol. Cell. Biol. 26 19 2006 7211 7223 (Epub 2006/09/19) (Pubitemid 44477697)
56. J. Liang, M. Nagahashi, E.Y. Kim, K.B. Harikumar, A. Yamada, and W.C. Huang et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer Cancer Cell 23 1 2013 107 120 (Epub 2013/01/01)
57. G.T. Eisenhoffer, P.D. Loftus, M. Yoshigi, H. Otsuna, C.B. Chien, and P.A. Morcos et al. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia Nature 484 7395 2012 546 549 (Epub 2012/04/17)
58. B. Oskouian, P. Sooriyakumaran, A.D. Borowsky, A. Crans, L. Dillard-Telm, and Y.Y. Tam et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer Proc. Natl. Acad. Sci. U. S. A. 103 46 2006 17384 17389 (Epub 2006/11/09) (Pubitemid 44788978)
59. B. Oskouian, and J. Saba Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again Cell Cycle 6 5 2007 522 527 (Epub 2007/03/16) (Pubitemid 46440422)
60. R.D. Duan, T. Bergman, N. Xu, J. Wu, Y. Cheng, and J. Duan et al. Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family J. Biol. Chem. 278 40 2003 38528 38536 (Epub 2003/07/30) (Pubitemid 37221748)
61. M. Olsson, R.D. Duan, L. Ohlsson, and A. Nilsson Rat intestinal ceramidase: purification, properties, and physiological relevance Am. J. Physiol. Gastrointest. Liver Physiol. 287 4 2004 G929 G937 (Epub 2004/06/26)
62. L. Ohlsson, C. Palmberg, R.D. Duan, M. Olsson, T. Bergman, and A. Nilsson Purification and characterization of human intestinal neutral ceramidase Biochimie 89 8 2007 950 960 (Epub 2007/05/04) (Pubitemid 47031431)
63. R.D. Duan, Y. Cheng, L. Yang, L. Ohlsson, and A. Nilsson Evidence for specific ceramidase present in the intestinal contents of rats and humans Lipids 36 8 2001 807 812 (Epub 2001/10/11) (Pubitemid 32924108)
64. P. Lundgren, A. Nilsson, and R.D. Duan Distribution and properties of neutral ceramidase activity in rat intestinal tract Dig. Dis. Sci. 46 4 2001 765 772 (Epub 2001/05/02) (Pubitemid 32373094)
65. M. Kono, J.L. Dreier, J.M. Ellis, M.L. Allende, D.N. Kalkofen, and K.M. Sanders et al. Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids J. Biol. Chem. 281 11 2006 7324 7331 (Epub 2005/12/29) (Pubitemid 43847501)
66. Y.Y. Liu, T.Y. Han, A.E. Giuliano, and M.C. Cabot Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells J. Biol. Chem. 274 2 1999 1140 1146 (Epub 1999/01/05)
67. A. Lucci, W.I. Cho, T.Y. Han, A.E. Giuliano, D.L. Morton, and M.C. Cabot Glucosylceramide: a marker for multiple-drug resistant cancers Anticancer. Res. 18 1B 1998 475 480 (Epub 1998/05/06) (Pubitemid 28174859)
68. Y.Y. Liu, T.Y. Han, A.E. Giuliano, and M.C. Cabot Ceramide glycosylation potentiates cellular multidrug resistance FASEB J. 15 3 2001 719 730 (Epub 2001/03/22) (Pubitemid 32245990)
69. O. Kovbasnjuk, R. Mourtazina, B. Baibakov, T. Wang, C. Elowsky, and M.A. Choti et al. The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer Proc. Natl. Acad. Sci. U. S. A. 102 52 2005 19087 19092 (Epub 2005/12/21) (Pubitemid 43049570)
70. Y. Uchida, S. Murata, M. Schmuth, M.J. Behne, J.D. Lee, and S. Ichikawa et al. Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress J. Lipid Res. 43 8 2002 1293 1302 (Epub 2002/08/15) (Pubitemid 34988177)
71. H. Vesper, E.M. Schmelz, M.N. Nikolova-Karakashian, D.L. Dillehay, D.V. Lynch, and A.H. Merrill Jr. Sphingolipids in food and the emerging importance of sphingolipids to nutrition J. Nutr. 129 7 1999 1239 1250 (Epub 1999/07/08) (Pubitemid 29304970)
72. P.K. Dudeja, R. Dahiya, and T.A. Brasitus The role of sphingomyelin synthetase and sphingomyelinase in 1,2-dimethylhydrazine-induced lipid alterations of rat colonic plasma membranes Biochim. Biophys. Acta 863 2 1986 309 312 (Epub 1986/12/16) (Pubitemid 17219342)
73. R. Dahiya, P.K. Dudeja, and T.A. Brasitus Premalignant alterations in the glycosphingolipids of small intestinal mucosa of rats treated with 1,2-dimethylhydrazine Lipids 23 5 1988 445 451 (Epub 1988/05/01)
74. E.H. Ahn, and J.J. Schroeder Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells Exp. Biol. Med. (Maywood) 227 5 2002 345 353 (Epub 2002/04/27)
75. D. Hartmann, J. Lucks, S. Fuchs, S. Schiffmann, Y. Schreiber, and N. Ferreiros et al. Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth Int. J. Biochem. Cell Biol. 44 4 2012 620 628 (Epub 2012/01/11)
76. M. Fillet, C. Cren-Olive, A.F. Renert, J. Piette, F. Vandermoere, and C. Rolando et al. Differential expression of proteins in response to ceramide-mediated stress signal in colon cancer cells by 2-D gel electrophoresis and MALDI-TOF-MS J. Proteome Res. 4 3 2005 870 880 (Epub 2005/06/15) (Pubitemid 40863276)
77. K. Koizumi, S. Shimizu, K.T. Koizumi, K. Nishida, C. Sato, and K. Ota et al. Rapid isolation and lipid characterization of plasma membranes from normal and malignant lymphoid cells of mouse Biochim. Biophys. Acta 649 2 1981 393 403 (Epub 1981/12/07) (Pubitemid 12223639)
78. W.J. Van Blitterswijk, H. Hilkmann, and T. Hengeveld Differences in membrane lipid composition and fluidity of transplanted GRSL lymphoma cells, depending on their site of growth in the mouse Biochim. Biophys. Acta 778 3 1984 521 529 (Epub 1984/12/19) (Pubitemid 15150782)
79. S.A. Morad, J.P. Madigan, J.C. Levin, N. Abdelmageed, R. Karimi, and D.W. Rosenberg et al. Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53 Biochem. Pharmacol. 85 8 2013 1057 1065 (Epub 2013/01/29)
80. E.H. Ahn, and J.J. Schroeder Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide Anticancer. Res. 30 7 2010 2881 2884 (Epub 2010/08/05)
81. F. Scarlatti, C. Bauvy, A. Ventruti, G. Sala, F. Cluzeaud, and A. Vandewalle et al. Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1 J. Biol. Chem. 279 18 2004 18384 18391 (Epub 2004/02/19) (Pubitemid 38623254)
82. E.A. Sweeney, C. Sakakura, T. Shirahama, A. Masamune, H. Ohta, and S. Hakomori et al. Sphingosine and its methylated derivative N, N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines Int. J. Cancer 66 3 1996 358 366 (Epub 1996/05/03) (Pubitemid 26166198)
83. D. Dindo, F. Dahm, Z. Szulc, A. Bielawska, L.M. Obeid, and Y.A. Hannun et al. Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells Mol. Cancer Ther. 5 6 2006 1520 1529 (Epub 2006/07/05) (Pubitemid 44070489)
84. T. Sugawara, N. Zaima, A. Yamamoto, S. Sakai, R. Noguchi, and T. Hirata Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells Biosci. Biotechnol. Biochem. 70 12 2006 2906 2912 (Epub 2006/12/08) (Pubitemid 46021548)
85. V. Thamilselvan, W. Li, B.E. Sumpio, and M.D. Basson Sphingosine-1- phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism In Vitro Cell. Dev. Biol. 38 4 2002 246 253 (Epub 2002/08/29) (Pubitemid 34975850)
86. B. Visentin, J.A. Vekich, B.J. Sibbald, A.L. Cavalli, K.M. Moreno, and R.G. Matteo et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages Cancer Cell 9 3 2006 225 238 (Epub 2006/03/15) (Pubitemid 43357948)
87. D.E. Modrak, W. Lew, D.M. Goldenberg, and R. Blumenthal Sphingomyelin potentiates chemotherapy of human cancer xenografts Biochem. Biophys. Res. Commun. 268 2 2000 603 606 Epub 2000/02/19 (Pubitemid 30119668)
88. J.W. Kok, R.J. Veldman, K. Klappe, H. Koning, C.M. Filipeanu, and M. Muller Differential expression of sphingolipids in MRP1 overexpressing HT29 cells Int. J. Cancer 87 2 2000 172 178 (Epub 2000/06/22) (Pubitemid 30434341)
89. C.A. Benedict, and C.F. Ware TRAIL: not just for tumors anymore? J. Exp. Med. 209 11 2012 1903 1906 (Epub 2012/10/24)
90. C. Voelkel-Johnson, Y.A. Hannun, and A. El-Zawahry Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein Mol. Cancer Ther. 4 9 2005 1320 1327 (Epub 2005/09/20)
91. S. White-Gilbertson, T. Mullen, C. Senkal, P. Lu, B. Ogretmen, and L. Obeid et al. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells Oncogene 28 8 2009 1132 1141 (Epub 2009/01/13)
92. M. Selzner, A. Bielawska, M.A. Morse, H.A. Rudiger, D. Sindram, and Y.A. Hannun et al. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer Cancer Res. 61 3 2001 1233 1240 (Epub 2001/02/28) (Pubitemid 32174448)
93. R.J. Veldman, K. Klappe, D. Hoekstra, and J.W. Kok Metabolism and apoptotic properties of elevated ceramide in HT29rev cells Biochem. J. 331 Pt 2 1998 563 569 (Epub 1998/06/11)
94. A. Colell, A. Morales, J.C. Fernandez-Checa, and C. Garcia-Ruiz Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-alpha-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3 FEBS Lett. 526 1-3 2002 135 141 (Pubitemid 35245708)
95. A.S. Jaiswal, and S. Narayan Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells J. Cancer Res. Clin. Oncol. 130 12 2004 695 703 (Epub 2004/09/02)
96. S. Nemoto, M. Nakamura, Y. Osawa, S. Kono, Y. Itoh, and Y. Okano et al. Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation J. Biol. Chem. 284 16 2009 10422 10432 (Epub 2009/02/26)
97. S. Schiffmann, S. Ziebell, J. Sandner, K. Birod, K. Deckmann, and D. Hartmann et al. Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide Biochem. Pharmacol. 80 11 2010 1632 1640 (Epub 2010/08/26)
98. D. Chauvier, H. Morjani, and M. Manfait Ceramide involvement in homocamptothecin- and camptothecin-induced cytotoxicity and apoptosis in colon HT29 cells Int. J. Oncol. 20 4 2002 855 863 (Epub 2002/03/15)
99. B.J. Maurer, L. Melton, C. Billups, M.C. Cabot, and C.P. Reynolds Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl) retinamide and modulators of ceramide metabolism J. Natl. Cancer Inst. 92 23 2000 1897 1909 (Epub 2000/12/07) (Pubitemid 32036920)
100. H. Wang, B.J. Maurer, Y.Y. Liu, E. Wang, J.C. Allegood, and S. Kelly et al. N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing Mol. Cancer Ther. 7 9 2008 2967 2976 (Epub 2008/09/16)
101. M. Rahmaniyan, R.W. Curley Jr., L.M. Obeid, Y.A. Hannun, and J.M. Kraveka Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide J. Biol. Chem. 286 28 2011 24754 24764 (Epub 2011/05/06)
102. S. Martin, D.C. Phillips, K. Szekely-Szucs, L. Elghazi, F. Desmots, and J.A. Houghton Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae Cancer Res. 65 24 2005 11447 11458 (Epub 2005/12/17) (Pubitemid 41821702)
103. D.L. Dillehay, S.K. Webb, E.M. Schmelz, and A.H. Merrill Jr. Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice J. Nutr. 124 5 1994 615 620 (Epub 1994/05/01) (Pubitemid 24157280)
104. E.M. Schmelz, D.L. Dillehay, S.K. Webb, A. Reiter, J. Adams, and A.H. Merrill Jr. Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis Cancer Res. 56 21 1996 4936 4941 (Epub 1996/11/01) (Pubitemid 26374432)
105. E.M. Schmelz, A.S. Bushnev, D.L. Dillehay, D.C. Liotta, and A.H. Merrill Jr. Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones Nutr. Cancer 28 1 1997 81 85 (Epub 1997/01/01) (Pubitemid 27287632)
106. E.M. Schmelz, A.S. Bushnev, D.L. Dillehay, M.C. Sullards, D.C. Liotta, and A.H. Merrill Jr. Ceramide-beta-d-glucuronide: synthesis, digestion, and suppression of early markers of colon carcinogenesis Cancer Res. 59 22 1999 5768 5772 (Epub 1999/12/03)
107. L.A. Lemonnier, D.L. Dillehay, M.J. Vespremi, J. Abrams, E. Brody, and E.M. Schmelz Sphingomyelin in the suppression of colon tumors: prevention versus intervention Arch. Biochem. Biophys. 419 2 2003 129 138 (Epub 2003/11/01) (Pubitemid 37329979)
108. H. Symolon, E.M. Schmelz, D.L. Dillehay, and A.H. Merrill Jr. Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CF1 mice and ApcMin/+ mice J. Nutr. 134 5 2004 1157 1161 (Epub 2004/04/29) (Pubitemid 38619956)
109. J.H. Exon, and E.H. South Effects of sphingomyelin on aberrant colonic crypt foci development, colon crypt cell proliferation and immune function in an aging rat tumor model Food Chem. Toxicol. 41 4 2003 471 476 (Epub 2003/03/05) (Pubitemid 36259785)
110. S.J. Baker, A.C. Preisinger, J.M. Jessup, C. Paraskeva, S. Markowitz, and J.K. Willson et al. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis Cancer Res. 50 23 1990 7717 7722 (Epub 1990/12/01)
111. Y. Hu, R.K. Le Leu, D. Belobrajdic, and G.P. Young The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model: wild-type and p53 +/- mice Mol. Nutr. Food Res. 52 5 2008 558 566 (Epub 2008/03/08)
112. H. Symolon, A. Bushnev, Q. Peng, H. Ramaraju, S.G. Mays, and J.C. Allegood et al. Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer Mol. Cancer Ther. 10 4 2011 648 657 (Epub 2011/03/15)
113. H. Nojiri, H. Yamana, G. Shirouzu, T. Suzuki, and H. Isono Glycotherapy for cancer: remodeling of ganglioside pattern as an effective approach for cancer therapy Cancer Detect. Prev. 26 2 2002 114 120 (Epub 2002/07/10) (Pubitemid 36016908)
114. D.E. Modrak, M.D. Rodriguez, D.M. Goldenberg, W. Lew, and R.D. Blumenthal Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts Int. J. Oncol. 20 2 2002 379 384 (Epub 2002/01/15)
115. S. Schiffmann, T.J. Maier, I. Wobst, A. Janssen, H. Corban-Wilhelm, and C. Angioni et al. The anti-proliferative potency of celecoxib is not a class effect of coxibs Biochem. Pharmacol. 76 2 2008 179 187 (Epub 2008/06/13)
116. H. Clevers, and R. Nusse Wnt/beta-catenin signaling and disease Cell 149 6 2012 1192 1205 (Epub 2012/06/12)
117. H. Clevers Wnt/beta-catenin signaling in development and disease Cell 127 3 2006 469 480 (Epub 2006/11/04)
118. J. Pepperl, G. Reim, U. Luthi, A. Kaech, G. Hausmann, and K. Basler Sphingolipid depletion impairs endocytic traffic and inhibits Wingless signaling Mech. Dev. 130 9-10 2013 493 505
119. N.C. Lucki, S. Bandyopadhyay, E. Wang, A.H. Merrill, and M.B. Sewer Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression Mol. Endocrinol. 26 2 2012 228 243 (Epub 2012/01/21)
120. Y.Y. Liu, V. Gupta, G.A. Patwardhan, K. Bhinge, Y. Zhao, and J. Bao et al. Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling Mol. Cancer 9 2010 145 (Epub 2010/06/15)
121. N. Marchesini, J.A. Jones, and Y.A. Hannun Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma Biochim. Biophys. Acta 1771 12 2007 1418 1428 (Epub 2007/11/13)
122. E. Matsuzaki, S. Hiratsuka, T. Hamachi, F. Takahashi-Yanaga, Y. Hashimoto, and K. Higashi et al. Sphingosine-1-phosphate promotes the nuclear translocation of beta-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines Bone 55 2 2013 315 324
123. I. Ahmed, P. Chandrakesan, O. Tawfik, L. Xia, S. Anant, and S. Umar Critical roles of Notch and Wnt/beta-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection Infect. Immun. 80 9 2012 3107 3121 (Epub 2012/06/20)
124. E.M. Schmelz, P.C. Roberts, E.M. Kustin, L.A. Lemonnier, M.C. Sullards, and D.L. Dillehay et al. Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids Cancer Res. 61 18 2001 6723 6729 (Epub 2001/09/18) (Pubitemid 32896494)
125. K.W. Simon, P.C. Roberts, M.J. Vespremi, S. Manchen, and E.M. Schmelz Regulation of beta-catenin and connexin-43 expression: targets for sphingolipids in colon cancer prevention Mol. Nutr. Food Res. 53 3 2009 332 340 (Epub 2008/10/08)
126. M. Luchtenborg, M.P. Weijenberg, G.M. Roemen, A.P. de Bruine, P.A. van den Brandt, and M.H. Lentjes et al. APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study Carcinogenesis 25 7 2004 1219 1226 (Epub 2004/02/21) (Pubitemid 38968050)