-
1
-
-
0023179255
-
Farber's disease: a fine structural study
-
Abenoza P., and Sibley R.K. Farber's disease: a fine structural study. Ultrastruct Pathol 11 (1987) 397-403
-
(1987)
Ultrastruct Pathol
, vol.11
, pp. 397-403
-
-
Abenoza, P.1
Sibley, R.K.2
-
2
-
-
31144453620
-
Effects of cyclooxygenase-1 and -2 inhibition on gastric acid secretion and cardiovascular functions in rats
-
Adami M., Coppelli G., Guaita E., Pozzoli C., Menozzi A., Giovannini E., et al. Effects of cyclooxygenase-1 and -2 inhibition on gastric acid secretion and cardiovascular functions in rats. Pharmacology 76 (2005) 84-92
-
(2005)
Pharmacology
, vol.76
, pp. 84-92
-
-
Adami, M.1
Coppelli, G.2
Guaita, E.3
Pozzoli, C.4
Menozzi, A.5
Giovannini, E.6
-
3
-
-
85047692516
-
Signalling pathways of the TNF superfamily: a double-edged sword
-
Aggarwal B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3 (2003) 745-756
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 745-756
-
-
Aggarwal, B.B.1
-
5
-
-
10644260243
-
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720
-
Allende M.L., Sasaki T., Kawai H., Olivera A., Mi Y., van Echten-Deckert G., et al. Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem 279 (2004) 52487-52492
-
(2004)
J Biol Chem
, vol.279
, pp. 52487-52492
-
-
Allende, M.L.1
Sasaki, T.2
Kawai, H.3
Olivera, A.4
Mi, Y.5
van Echten-Deckert, G.6
-
6
-
-
0032530455
-
Tumor necrosis factor receptor-associated factors (TRAFs)-a family of adapter proteins that regulates life and death
-
Arch R.H., Gedrich R.W., and Thompson C.B. Tumor necrosis factor receptor-associated factors (TRAFs)-a family of adapter proteins that regulates life and death. Genes Dev 12 (1998) 2821-2830
-
(1998)
Genes Dev
, vol.12
, pp. 2821-2830
-
-
Arch, R.H.1
Gedrich, R.W.2
Thompson, C.B.3
-
7
-
-
0027501020
-
Interleukin-1 receptor antagonist
-
Arend W.P. Interleukin-1 receptor antagonist. Adv Immunol 54 (1993) 167-227
-
(1993)
Adv Immunol
, vol.54
, pp. 167-227
-
-
Arend, W.P.1
-
8
-
-
0034469910
-
Physiologic role of interleukin-1 receptor antagonist
-
Arend W.P., and Gabay C. Physiologic role of interleukin-1 receptor antagonist. Arthritis Res 2 (2000) 245-248
-
(2000)
Arthritis Res
, vol.2
, pp. 245-248
-
-
Arend, W.P.1
Gabay, C.2
-
9
-
-
5644300463
-
Ultraviolet A-induced modulation of Bcl-XL by p38 MAPK in human keratinocytes: post-transcriptional regulation through the 3′-untranslated region
-
Bachelor M.A., and Bowden G.T. Ultraviolet A-induced modulation of Bcl-XL by p38 MAPK in human keratinocytes: post-transcriptional regulation through the 3′-untranslated region. J Biol Chem 279 (2004) 42658-42668
-
(2004)
J Biol Chem
, vol.279
, pp. 42658-42668
-
-
Bachelor, M.A.1
Bowden, G.T.2
-
11
-
-
0026726492
-
Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide
-
Ballou L.R., Chao C.P., Holness M.A., Barker S.C., and Raghow R. Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J Biol Chem 267 (1992) 20044-20050
-
(1992)
J Biol Chem
, vol.267
, pp. 20044-20050
-
-
Ballou, L.R.1
Chao, C.P.2
Holness, M.A.3
Barker, S.C.4
Raghow, R.5
-
12
-
-
0035116014
-
Molecular analysis of acid ceramidase deficiency in patients with Farber disease
-
Bar J., Linke T., Ferlinz K., Neumann U., Schuchman E.H., and Sandhoff K. Molecular analysis of acid ceramidase deficiency in patients with Farber disease. Hum Mutat 17 (2001) 199-209
-
(2001)
Hum Mutat
, vol.17
, pp. 199-209
-
-
Bar, J.1
Linke, T.2
Ferlinz, K.3
Neumann, U.4
Schuchman, E.H.5
Sandhoff, K.6
-
13
-
-
0030037297
-
Stimulation of the ceramide pathway partially mimics lipopolysaccharide-induced responses in murine peritoneal macrophages
-
Barber S.A., Detore G., McNally R., and Vogel S.N. Stimulation of the ceramide pathway partially mimics lipopolysaccharide-induced responses in murine peritoneal macrophages. Infect Immun 64 (1996) 3397-3400
-
(1996)
Infect Immun
, vol.64
, pp. 3397-3400
-
-
Barber, S.A.1
Detore, G.2
McNally, R.3
Vogel, S.N.4
-
14
-
-
0024405827
-
The biology of cachectin/TNF-a primary mediator of the host response
-
Beutler B., and Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol 7 (1989) 625-655
-
(1989)
Annu Rev Immunol
, vol.7
, pp. 625-655
-
-
Beutler, B.1
Cerami, A.2
-
15
-
-
22144486976
-
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators
-
Billich A., Bornancin F., Mechtcheriakova D., Natt F., Huesken D., and Baumruker T. Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. Cell Signal 17 (2005) 1203-1217
-
(2005)
Cell Signal
, vol.17
, pp. 1203-1217
-
-
Billich, A.1
Bornancin, F.2
Mechtcheriakova, D.3
Natt, F.4
Huesken, D.5
Baumruker, T.6
-
18
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann V., Davis M.D., Heise C.E., Albert R., Cottens S., Hof R., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277 (2002) 21453-21457
-
(2002)
J Biol Chem
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
-
19
-
-
0036773971
-
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
-
Brinkmann V., and Lynch K.R. FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr Opin Immunol 14 (2002) 569-575
-
(2002)
Curr Opin Immunol
, vol.14
, pp. 569-575
-
-
Brinkmann, V.1
Lynch, K.R.2
-
20
-
-
0034142317
-
FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation
-
Brinkmann V., Pinschewer D., Chiba K., and Feng L. FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation. Trends Pharmacol Sci 21 (2000) 49-52
-
(2000)
Trends Pharmacol Sci
, vol.21
, pp. 49-52
-
-
Brinkmann, V.1
Pinschewer, D.2
Chiba, K.3
Feng, L.4
-
21
-
-
0035884709
-
FTY720: altered lymphocyte traffic results in allograft protection
-
Brinkmann V., Pinschewer D.D., Feng L., and Chen S. FTY720: altered lymphocyte traffic results in allograft protection. Transplantation 72 (2001) 764-769
-
(2001)
Transplantation
, vol.72
, pp. 764-769
-
-
Brinkmann, V.1
Pinschewer, D.D.2
Feng, L.3
Chen, S.4
-
22
-
-
4043147733
-
The discovery and development of antiinflammatory drugs
-
Brune K., and Hinz B. The discovery and development of antiinflammatory drugs. Arthritis Rheum 50 (2004) 2391-2399
-
(2004)
Arthritis Rheum
, vol.50
, pp. 2391-2399
-
-
Brune, K.1
Hinz, B.2
-
24
-
-
0035282334
-
Mammalian MAP kinase signalling cascades
-
Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 (2001) 37-40
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.1
Karin, M.2
-
25
-
-
0029558130
-
Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription
-
Chang Y., Abe A., and Shayman J.A. Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription. Proc Natl Acad Sci U S A 92 (1995) 12275-12279
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 12275-12279
-
-
Chang, Y.1
Abe, A.2
Shayman, J.A.3
-
26
-
-
0037204948
-
TNF-R1 signaling: a beautiful pathway
-
Chen G., and Goeddel D.V. TNF-R1 signaling: a beautiful pathway. Science 296 (2002) 1634-1635
-
(2002)
Science
, vol.296
, pp. 1634-1635
-
-
Chen, G.1
Goeddel, D.V.2
-
27
-
-
0034960320
-
TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu
-
Chen W., Frank M.E., Jin W., and Wahl S.M. TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 14 (2001) 715-725
-
(2001)
Immunity
, vol.14
, pp. 715-725
-
-
Chen, W.1
Frank, M.E.2
Jin, W.3
Wahl, S.M.4
-
28
-
-
3242796768
-
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
-
Cinamon G., Matloubian M., Lesneski M.J., Xu Y., Low C., Lu T., et al. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol 5 (2004) 713-720
-
(2004)
Nat Immunol
, vol.5
, pp. 713-720
-
-
Cinamon, G.1
Matloubian, M.2
Lesneski, M.J.3
Xu, Y.4
Low, C.5
Lu, T.6
-
29
-
-
12244274338
-
Sphingolipids and the immune system
-
Cinque B., Di Marzio L., Centi C., Di Rocco C., Riccardi C., and Grazia Cifone M. Sphingolipids and the immune system. Pharmacol Res 47 (2003) 421-437
-
(2003)
Pharmacol Res
, vol.47
, pp. 421-437
-
-
Cinque, B.1
Di Marzio, L.2
Centi, C.3
Di Rocco, C.4
Riccardi, C.5
Grazia Cifone, M.6
-
31
-
-
27444444769
-
What does tumour necrosis factor excess do to the immune system long term?
-
Clark J., Vagenas P., Panesar M., and Cope A.P. What does tumour necrosis factor excess do to the immune system long term?. Ann Rheum Dis 64 Suppl. 4 (2005) iv70-iv76
-
(2005)
Ann Rheum Dis
, vol.64
, Issue.SUPPL. 4
-
-
Clark, J.1
Vagenas, P.2
Panesar, M.3
Cope, A.P.4
-
32
-
-
0037180768
-
The immunopathogenesis of sepsis
-
Cohen J. The immunopathogenesis of sepsis. Nature 420 (2002) 885-891
-
(2002)
Nature
, vol.420
, pp. 885-891
-
-
Cohen, J.1
-
33
-
-
0028848344
-
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation
-
Coroneos E., Martinez M., McKenna S., and Kester M. Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation. J Biol Chem 270 (1995) 23305-23309
-
(1995)
J Biol Chem
, vol.270
, pp. 23305-23309
-
-
Coroneos, E.1
Martinez, M.2
McKenna, S.3
Kester, M.4
-
34
-
-
0027204621
-
Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production
-
Del Prete G., De Carli M., Almerigogna F., Giudizi M.G., Biagiotti R., and Romagnani S. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 150 (1993) 353-360
-
(1993)
J Immunol
, vol.150
, pp. 353-360
-
-
Del Prete, G.1
De Carli, M.2
Almerigogna, F.3
Giudizi, M.G.4
Biagiotti, R.5
Romagnani, S.6
-
36
-
-
0030610362
-
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
-
DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E., and Karin M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388 (1997) 548-554
-
(1997)
Nature
, vol.388
, pp. 548-554
-
-
DiDonato, J.A.1
Hayakawa, M.2
Rothwarf, D.M.3
Zandi, E.4
Karin, M.5
-
37
-
-
0031452476
-
Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock
-
Dinarello C.A. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest 112 (1997) 321S-329S
-
(1997)
Chest
, vol.112
-
-
Dinarello, C.A.1
-
38
-
-
0033600850
-
Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain
-
El Bawab S., Bielawska A., and Hannun Y.A. Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain. J Biol Chem 274 (1999) 27948-27955
-
(1999)
J Biol Chem
, vol.274
, pp. 27948-27955
-
-
El Bawab, S.1
Bielawska, A.2
Hannun, Y.A.3
-
39
-
-
0034647935
-
Molecular cloning and characterization of a human mitochondrial ceramidase
-
El Bawab S., Roddy P., Qian T., Bielawska A., Lemasters J.J., and Hannun Y.A. Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem 275 (2000) 21508-21513
-
(2000)
J Biol Chem
, vol.275
, pp. 21508-21513
-
-
El Bawab, S.1
Roddy, P.2
Qian, T.3
Bielawska, A.4
Lemasters, J.J.5
Hannun, Y.A.6
-
40
-
-
0035929560
-
Human acid ceramidase: processing, glycosylation, and lysosomal targeting
-
Ferlinz K., Kopal G., Bernardo K., Linke T., Bar J., Breiden B., et al. Human acid ceramidase: processing, glycosylation, and lysosomal targeting. J Biol Chem 276 (2001) 35352-35360
-
(2001)
J Biol Chem
, vol.276
, pp. 35352-35360
-
-
Ferlinz, K.1
Kopal, G.2
Bernardo, K.3
Linke, T.4
Bar, J.5
Breiden, B.6
-
41
-
-
0025005862
-
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes
-
Fu J.Y., Masferrer J.L., Seibert K., Raz A., and Needleman P. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem 265 (1990) 16737-16740
-
(1990)
J Biol Chem
, vol.265
, pp. 16737-16740
-
-
Fu, J.Y.1
Masferrer, J.L.2
Seibert, K.3
Raz, A.4
Needleman, P.5
-
42
-
-
0036164426
-
p38 MAPK inhibition reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of PMN accumulation
-
Gao F., Yue T.L., Shi D.W., Christopher T.A., Lopez B.L., Ohlstein E.H., et al. p38 MAPK inhibition reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of PMN accumulation. Cardiovasc Res 53 (2002) 414-422
-
(2002)
Cardiovasc Res
, vol.53
, pp. 414-422
-
-
Gao, F.1
Yue, T.L.2
Shi, D.W.3
Christopher, T.A.4
Lopez, B.L.5
Ohlstein, E.H.6
-
43
-
-
0031897632
-
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
-
Ghosh S., May M.J., and Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16 (1998) 225-260
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 225-260
-
-
Ghosh, S.1
May, M.J.2
Kopp, E.B.3
-
45
-
-
0037468614
-
Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages
-
Gomez-Munoz A., Kong J., Salh B., and Steinbrecher U.P. Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. FEBS Lett 539 (2003) 56-60
-
(2003)
FEBS Lett
, vol.539
, pp. 56-60
-
-
Gomez-Munoz, A.1
Kong, J.2
Salh, B.3
Steinbrecher, U.P.4
-
46
-
-
21244479753
-
Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway
-
Gomez-Munoz A., Kong J.Y., Parhar K., Wang S.W., Gangoiti P., Gonzalez M., et al. Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway. FEBS Lett 579 (2005) 3744-3750
-
(2005)
FEBS Lett
, vol.579
, pp. 3744-3750
-
-
Gomez-Munoz, A.1
Kong, J.Y.2
Parhar, K.3
Wang, S.W.4
Gangoiti, P.5
Gonzalez, M.6
-
47
-
-
0036905055
-
Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells
-
Graeler M., and Goetzl E.J. Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J 16 (2002) 1874-1878
-
(2002)
FASEB J
, vol.16
, pp. 1874-1878
-
-
Graeler, M.1
Goetzl, E.J.2
-
48
-
-
0030784482
-
Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation
-
Haimovitz-Friedman A., Cordon-Cardo C., Bayoumy S., Garzotto M., McLoughlin M., Gallily R., et al. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J Exp Med 186 (1997) 1831-1841
-
(1997)
J Exp Med
, vol.186
, pp. 1831-1841
-
-
Haimovitz-Friedman, A.1
Cordon-Cardo, C.2
Bayoumy, S.3
Garzotto, M.4
McLoughlin, M.5
Gallily, R.6
-
49
-
-
23844519961
-
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor
-
Hait N.C., Sarkar S., Le Stunff H., Mikami A., Maceyka M., Milstien S., et al. Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J Biol Chem 280 (2005) 29462-29469
-
(2005)
J Biol Chem
, vol.280
, pp. 29462-29469
-
-
Hait, N.C.1
Sarkar, S.2
Le Stunff, H.3
Mikami, A.4
Maceyka, M.5
Milstien, S.6
-
50
-
-
0347611095
-
Molecular machinery for non-vesicular trafficking of ceramide
-
Hanada K., Kumagai K., Yasuda S., Miura Y., Kawano M., Fukasawa M., et al. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426 (2003) 803-809
-
(2003)
Nature
, vol.426
, pp. 803-809
-
-
Hanada, K.1
Kumagai, K.2
Yasuda, S.3
Miura, Y.4
Kawano, M.5
Fukasawa, M.6
-
51
-
-
0037135626
-
The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind
-
Hannun Y.A., and Obeid L.M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 277 (2002) 25847-25850
-
(2002)
J Biol Chem
, vol.277
, pp. 25847-25850
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
54
-
-
0033973670
-
Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes
-
Hernandez O.M., Discher D.J., Bishopric N.H., and Webster K.A. Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes. Circ Res 86 (2000) 198-204
-
(2000)
Circ Res
, vol.86
, pp. 198-204
-
-
Hernandez, O.M.1
Discher, D.J.2
Bishopric, N.H.3
Webster, K.A.4
-
56
-
-
0035793866
-
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
-
Hobson J.P., Rosenfeldt H.M., Barak L.S., Olivera A., Poulton S., Caron M.G., et al. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science 291 (2001) 1800-1803
-
(2001)
Science
, vol.291
, pp. 1800-1803
-
-
Hobson, J.P.1
Rosenfeldt, H.M.2
Barak, L.S.3
Olivera, A.4
Poulton, S.5
Caron, M.G.6
-
57
-
-
0035957326
-
Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis
-
Hong K.H., Bonventre J.C., O'Leary E., Bonventre J.V., and Lander E.S. Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc Natl Acad Sci U S A 98 (2001) 3935-3939
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 3935-3939
-
-
Hong, K.H.1
Bonventre, J.C.2
O'Leary, E.3
Bonventre, J.V.4
Lander, E.S.5
-
58
-
-
0035340952
-
Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors
-
Hsu Y.W., Chi K.H., Huang W.C., and Lin W.W. Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors. J Immunol 166 (2001) 5388-5397
-
(2001)
J Immunol
, vol.166
, pp. 5388-5397
-
-
Hsu, Y.W.1
Chi, K.H.2
Huang, W.C.3
Lin, W.W.4
-
60
-
-
7244250149
-
Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase
-
Ibrahim F.B., Pang S.J., and Melendez A.J. Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase. J Biol Chem 279 (2004) 44802-44811
-
(2004)
J Biol Chem
, vol.279
, pp. 44802-44811
-
-
Ibrahim, F.B.1
Pang, S.J.2
Melendez, A.J.3
-
61
-
-
0036186843
-
Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor
-
Itakura A., Tanaka A., Aioi A., Tonogaito H., and Matsuda H. Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor. Exp Hematol 30 (2002) 272-278
-
(2002)
Exp Hematol
, vol.30
, pp. 272-278
-
-
Itakura, A.1
Tanaka, A.2
Aioi, A.3
Tonogaito, H.4
Matsuda, H.5
-
62
-
-
0028246298
-
Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells
-
Joseph C.K., Wright S.D., Bornmann W.G., Randolph J.T., Kumar E.R., Bittman R., et al. Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells. J Biol Chem 269 (1994) 17606-17610
-
(1994)
J Biol Chem
, vol.269
, pp. 17606-17610
-
-
Joseph, C.K.1
Wright, S.D.2
Bornmann, W.G.3
Randolph, J.T.4
Kumar, E.R.5
Bittman, R.6
-
63
-
-
1242293632
-
2 plays a key role in the pathogenesis of multiple sclerosis-like disease
-
2 plays a key role in the pathogenesis of multiple sclerosis-like disease. Neuron 41 (2004) 323-335
-
(2004)
Neuron
, vol.41
, pp. 323-335
-
-
Kalyvas, A.1
David, S.2
-
64
-
-
0031590746
-
Inhibition of chemotactic motility and trans-endothelial migration of human neutrophils by sphingosine 1-phosphate
-
Kawa S., Kimura S., Hakomori S., and Igarashi Y. Inhibition of chemotactic motility and trans-endothelial migration of human neutrophils by sphingosine 1-phosphate. FEBS Lett 420 (1997) 196-200
-
(1997)
FEBS Lett
, vol.420
, pp. 196-200
-
-
Kawa, S.1
Kimura, S.2
Hakomori, S.3
Igarashi, Y.4
-
65
-
-
4043111231
-
Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activation
-
Khan M.A., Kang J., and Steiner T.S. Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activation. Immunology 112 (2004) 651-660
-
(2004)
Immunology
, vol.112
, pp. 651-660
-
-
Khan, M.A.1
Kang, J.2
Steiner, T.S.3
-
66
-
-
0026007737
-
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation
-
Kim M.Y., Linardic C., Obeid L., and Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J Biol Chem 266 (1991) 484-489
-
(1991)
J Biol Chem
, vol.266
, pp. 484-489
-
-
Kim, M.Y.1
Linardic, C.2
Obeid, L.3
Hannun, Y.4
-
67
-
-
0042357147
-
Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells
-
Kim J.I., Jo E.J., Lee H.Y., Cha M.S., Min J.K., Choi C.H., et al. Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. J Biol Chem 278 (2003) 31731-31736
-
(2003)
J Biol Chem
, vol.278
, pp. 31731-31736
-
-
Kim, J.I.1
Jo, E.J.2
Lee, H.Y.3
Cha, M.S.4
Min, J.K.5
Choi, C.H.6
-
68
-
-
0035890151
-
Ceramide accelerates dephosphorylation of extracellular signal-regulated kinase 1/2 to decrease prostaglandin D(2) production in RBL-2H3 cells
-
Kitatani K., Akiba S., Hayama M., and Sato T. Ceramide accelerates dephosphorylation of extracellular signal-regulated kinase 1/2 to decrease prostaglandin D(2) production in RBL-2H3 cells. Arch Biochem Biophys 395 (2001) 208-214
-
(2001)
Arch Biochem Biophys
, vol.395
, pp. 208-214
-
-
Kitatani, K.1
Akiba, S.2
Hayama, M.3
Sato, T.4
-
69
-
-
2442539389
-
2 expression via generation of reactive oxygen species in tumor necrosis factor-alpha-stimulated mesangial cells
-
2 expression via generation of reactive oxygen species in tumor necrosis factor-alpha-stimulated mesangial cells. Cell Signal 16 (2004) 967-974
-
(2004)
Cell Signal
, vol.16
, pp. 967-974
-
-
Kitatani, K.1
Akiba, S.2
Sato, T.3
-
70
-
-
0032508706
-
Molecular cloning and functional characterization of murine sphingosine kinase
-
Kohama T., Olivera A., Edsall L., Nagiec M.M., Dickson R., and Spiegel S. Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem 273 (1998) 23722-23728
-
(1998)
J Biol Chem
, vol.273
, pp. 23722-23728
-
-
Kohama, T.1
Olivera, A.2
Edsall, L.3
Nagiec, M.M.4
Dickson, R.5
Spiegel, S.6
-
71
-
-
4143153013
-
Drosophila glucosylceramide synthase: a negative regulator of cell death mediated by proapoptotic factors
-
Kohyama-Koganeya A., Sasamura T., Oshima E., Suzuki E., Nishihara S., Ueda R., et al. Drosophila glucosylceramide synthase: a negative regulator of cell death mediated by proapoptotic factors. J Biol Chem 279 (2004) 35995-36002
-
(2004)
J Biol Chem
, vol.279
, pp. 35995-36002
-
-
Kohyama-Koganeya, A.1
Sasamura, T.2
Oshima, E.3
Suzuki, E.4
Nishihara, S.5
Ueda, R.6
-
72
-
-
0028297068
-
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
-
Kolesnick R., and Golde D.W. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77 (1994) 325-328
-
(1994)
Cell
, vol.77
, pp. 325-328
-
-
Kolesnick, R.1
Golde, D.W.2
-
73
-
-
0031919157
-
Regulation of ceramide production and apoptosis
-
Kolesnick R.N., and Kronke M. Regulation of ceramide production and apoptosis. Annu Rev Physiol 60 (1998) 643-665
-
(1998)
Annu Rev Physiol
, vol.60
, pp. 643-665
-
-
Kolesnick, R.N.1
Kronke, M.2
-
74
-
-
0033884050
-
Compartmentalization of ceramide signaling: physical foundations and biological effects
-
Kolesnick R.N., Goni F.M., and Alonso A. Compartmentalization of ceramide signaling: physical foundations and biological effects. J Cell Physiol 184 (2000) 285-300
-
(2000)
J Cell Physiol
, vol.184
, pp. 285-300
-
-
Kolesnick, R.N.1
Goni, F.M.2
Alonso, A.3
-
76
-
-
0028948622
-
Sphingomyelin synthesis in endosomal compartments?
-
(author reply 149)
-
Koval M., Futerman A.H., and Pagano R.E. Sphingomyelin synthesis in endosomal compartments?. Trends Cell Biol 5 (1995) 148-149 (author reply 149)
-
(1995)
Trends Cell Biol
, vol.5
, pp. 148-149
-
-
Koval, M.1
Futerman, A.H.2
Pagano, R.E.3
-
77
-
-
0038352072
-
BcR-induced apoptosis involves differential regulation of C16- and C24-ceramide formation and sphingolipid-dependent activation of the proteasome
-
Kroesen B.J., Jacobs S., Pettus B.J., Sietsma H., Kok J.W., Hannun Y.A., et al. BcR-induced apoptosis involves differential regulation of C16- and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem 278 (2003) 14723-14731
-
(2003)
J Biol Chem
, vol.278
, pp. 14723-14731
-
-
Kroesen, B.J.1
Jacobs, S.2
Pettus, B.J.3
Sietsma, H.4
Kok, J.W.5
Hannun, Y.A.6
-
78
-
-
14844332032
-
CERT mediates intermembrane transfer of various molecular species of ceramides
-
Kumagai K., Yasuda S., Okemoto K., Nishijima M., Kobayashi S., and Hanada K. CERT mediates intermembrane transfer of various molecular species of ceramides. J Biol Chem 280 (2005) 6488-6495
-
(2005)
J Biol Chem
, vol.280
, pp. 6488-6495
-
-
Kumagai, K.1
Yasuda, S.2
Okemoto, K.3
Nishijima, M.4
Kobayashi, S.5
Hanada, K.6
-
79
-
-
0036311889
-
Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases
-
Kveberg L., Bryceson Y., Inngjerdingen M., Rolstad B., and Maghazachi A.A. Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases. Eur J Immunol 32 (2002) 1856-1864
-
(2002)
Eur J Immunol
, vol.32
, pp. 1856-1864
-
-
Kveberg, L.1
Bryceson, Y.2
Inngjerdingen, M.3
Rolstad, B.4
Maghazachi, A.A.5
-
80
-
-
0029151453
-
Ceramide induces interleukin 6 gene expression in human fibroblasts
-
Laulederkind S.J., Bielawska A., Raghow R., Hannun Y.A., and Ballou L.R. Ceramide induces interleukin 6 gene expression in human fibroblasts. J Exp Med 182 (1995) 599-604
-
(1995)
J Exp Med
, vol.182
, pp. 599-604
-
-
Laulederkind, S.J.1
Bielawska, A.2
Raghow, R.3
Hannun, Y.A.4
Ballou, L.R.5
-
81
-
-
0027076645
-
Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide
-
Lee S.H., Soyoola E., Chanmugam P., Hart S., Sun W., Zhong H., et al. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267 (1992) 25934-25938
-
(1992)
J Biol Chem
, vol.267
, pp. 25934-25938
-
-
Lee, S.H.1
Soyoola, E.2
Chanmugam, P.3
Hart, S.4
Sun, W.5
Zhong, H.6
-
82
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee J.C., Laydon J.T., McDonnell P.C., Gallagher T.F., Kumar S., Green D., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372 (1994) 739-746
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
-
83
-
-
0008206988
-
TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival
-
Lee S.Y., Reichlin A., Santana A., Sokol K.A., Nussenzweig M.C., and Choi Y. TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival. Immunity 7 (1997) 703-713
-
(1997)
Immunity
, vol.7
, pp. 703-713
-
-
Lee, S.Y.1
Reichlin, A.2
Santana, A.3
Sokol, K.A.4
Nussenzweig, M.C.5
Choi, Y.6
-
84
-
-
0142195819
-
Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine-palmitoyl transferase
-
Lightle S., Tosheva R., Lee A., Queen-Baker J., Boyanovsky B., Shedlofsky S., et al. Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine-palmitoyl transferase. Arch Biochem Biophys 419 (2003) 120-128
-
(2003)
Arch Biochem Biophys
, vol.419
, pp. 120-128
-
-
Lightle, S.1
Tosheva, R.2
Lee, A.3
Queen-Baker, J.4
Boyanovsky, B.5
Shedlofsky, S.6
-
85
-
-
0030298294
-
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
-
Liu Z.G., Hsu H., Goeddel D.V., and Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87 (1996) 565-576
-
(1996)
Cell
, vol.87
, pp. 565-576
-
-
Liu, Z.G.1
Hsu, H.2
Goeddel, D.V.3
Karin, M.4
-
86
-
-
0034733556
-
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
-
Liu H., Sugiura M., Nava V.E., Edsall L.C., Kono K., Poulton S., et al. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem 275 (2000) 19513-19520
-
(2000)
J Biol Chem
, vol.275
, pp. 19513-19520
-
-
Liu, H.1
Sugiura, M.2
Nava, V.E.3
Edsall, L.C.4
Kono, K.5
Poulton, S.6
-
87
-
-
26844442547
-
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools
-
Long J., Darroch P., Wan K.F., Kong K.C., Ktistakis N., Pyne N.J., et al. Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. Biochem J 391 (2005) 25-32
-
(2005)
Biochem J
, vol.391
, pp. 25-32
-
-
Long, J.1
Darroch, P.2
Wan, K.F.3
Kong, K.C.4
Ktistakis, N.5
Pyne, N.J.6
-
88
-
-
0033037483
-
Sphingolipid metabolism in the regulation of bioactive molecules
-
Luberto C., and Hannun Y.A. Sphingolipid metabolism in the regulation of bioactive molecules. Lipids 34 Suppl. (1999) S5-S11
-
(1999)
Lipids
, vol.34 SUPPL
-
-
Luberto, C.1
Hannun, Y.A.2
-
89
-
-
0041856515
-
Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme
-
Luberto C., Stonehouse M.J., Collins E.A., Marchesini N., El-Bawab S., Vasil A.I., et al. Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme. J Biol Chem 278 (2003) 32733-32743
-
(2003)
J Biol Chem
, vol.278
, pp. 32733-32743
-
-
Luberto, C.1
Stonehouse, M.J.2
Collins, E.A.3
Marchesini, N.4
El-Bawab, S.5
Vasil, A.I.6
-
90
-
-
0033528695
-
Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion
-
Ma X.L., Kumar S., Gao F., Louden C.S., Lopez B.L., Christopher T.A., et al. Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation 99 (1999) 1685-1691
-
(1999)
Circulation
, vol.99
, pp. 1685-1691
-
-
Ma, X.L.1
Kumar, S.2
Gao, F.3
Louden, C.S.4
Lopez, B.L.5
Christopher, T.A.6
-
91
-
-
22544461952
-
Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism
-
Ma Y., Pitson S., Hercus T., Murphy J., Lopez A., and Woodcock J. Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. J Biol Chem 280 (2005) 26011-26017
-
(2005)
J Biol Chem
, vol.280
, pp. 26011-26017
-
-
Ma, Y.1
Pitson, S.2
Hercus, T.3
Murphy, J.4
Lopez, A.5
Woodcock, J.6
-
92
-
-
27744547965
-
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
-
Maceyka M., Sankala H., Hait N.C., Le Stunff H., Liu H., Toman R., et al. SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem 280 (2005) 37118-37129
-
(2005)
J Biol Chem
, vol.280
, pp. 37118-37129
-
-
Maceyka, M.1
Sankala, H.2
Hait, N.C.3
Le Stunff, H.4
Liu, H.5
Toman, R.6
-
93
-
-
0033555928
-
Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog
-
MacKichan M.L., and DeFranco A.L. Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog. J Biol Chem 274 (1999) 1767-1775
-
(1999)
J Biol Chem
, vol.274
, pp. 1767-1775
-
-
MacKichan, M.L.1
DeFranco, A.L.2
-
94
-
-
0036883903
-
Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents
-
MacKinnon A.C., Buckley A., Chilvers E.R., Rossi A.G., Haslett C., and Sethi T. Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. J Immunol 169 (2002) 6394-6400
-
(2002)
J Immunol
, vol.169
, pp. 6394-6400
-
-
MacKinnon, A.C.1
Buckley, A.2
Chilvers, E.R.3
Rossi, A.G.4
Haslett, C.5
Sethi, T.6
-
95
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
Mandala S., Hajdu R., Bergstrom J., Quackenbush E., Xie J., Milligan J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 (2002) 346-349
-
(2002)
Science
, vol.296
, pp. 346-349
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
Quackenbush, E.4
Xie, J.5
Milligan, J.6
-
96
-
-
0034629140
-
Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity
-
Mao C., Xu R., Bielawska A., and Obeid L.M. Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. J Biol Chem 275 (2000) 6876-6884
-
(2000)
J Biol Chem
, vol.275
, pp. 6876-6884
-
-
Mao, C.1
Xu, R.2
Bielawska, A.3
Obeid, L.M.4
-
97
-
-
0034613279
-
Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide
-
Mao C., Xu R., Bielawska A., Szulc Z.M., and Obeid L.M. Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. J Biol Chem 275 (2000) 31369-31378
-
(2000)
J Biol Chem
, vol.275
, pp. 31369-31378
-
-
Mao, C.1
Xu, R.2
Bielawska, A.3
Szulc, Z.M.4
Obeid, L.M.5
-
98
-
-
0035854766
-
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide
-
Mao C., Xu R., Szulc Z.M., Bielawska A., Galadari S.H., and Obeid L.M. Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J Biol Chem 276 (2001) 26577-26588
-
(2001)
J Biol Chem
, vol.276
, pp. 26577-26588
-
-
Mao, C.1
Xu, R.2
Szulc, Z.M.3
Bielawska, A.4
Galadari, S.H.5
Obeid, L.M.6
-
99
-
-
0043234296
-
Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides
-
Mao C., Xu R., Szulc Z.M., Bielawski J., Becker K.P., Bielawska A., et al. Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. J Biol Chem 278 (2003) 31184-31191
-
(2003)
J Biol Chem
, vol.278
, pp. 31184-31191
-
-
Mao, C.1
Xu, R.2
Szulc, Z.M.3
Bielawski, J.4
Becker, K.P.5
Bielawska, A.6
-
100
-
-
2342570273
-
Acid and neutral sphingomyelinases: roles and mechanisms of regulation
-
Marchesini N., and Hannun Y.A. Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol 82 (2004) 27-44
-
(2004)
Biochem Cell Biol
, vol.82
, pp. 27-44
-
-
Marchesini, N.1
Hannun, Y.A.2
-
101
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
Matloubian M., Lo C.G., Cinamon G., Lesneski M.J., Xu Y., Brinkmann V., et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427 (2004) 355-360
-
(2004)
Nature
, vol.427
, pp. 355-360
-
-
Matloubian, M.1
Lo, C.G.2
Cinamon, G.3
Lesneski, M.J.4
Xu, Y.5
Brinkmann, V.6
-
102
-
-
0033515668
-
Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release
-
Medvedev A.E., Blanco J.C., Qureshi N., and Vogel S.N. Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release. J Biol Chem 274 (1999) 9342-9350
-
(1999)
J Biol Chem
, vol.274
, pp. 9342-9350
-
-
Medvedev, A.E.1
Blanco, J.C.2
Qureshi, N.3
Vogel, S.N.4
-
103
-
-
3242791547
-
2+ signals, enzyme release, cytokine production, and chemotaxis
-
2+ signals, enzyme release, cytokine production, and chemotaxis. J Immunol 173 (2004) 1596-1603
-
(2004)
J Immunol
, vol.173
, pp. 1596-1603
-
-
Melendez, A.J.1
Ibrahim, F.B.2
-
104
-
-
0031868263
-
Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin
-
Memon R.A., Holleran W.M., Moser A.H., Seki T., Uchida Y., Fuller J., et al. Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin. Arterioscler Thromb Vasc Biol 18 (1998) 1257-1265
-
(1998)
Arterioscler Thromb Vasc Biol
, vol.18
, pp. 1257-1265
-
-
Memon, R.A.1
Holleran, W.M.2
Moser, A.H.3
Seki, T.4
Uchida, Y.5
Fuller, J.6
-
105
-
-
0033538445
-
Regulation of glycosphingolipid metabolism in liver during the acute phase response
-
Memon R.A., Holleran W.M., Uchida Y., Moser A.H., Ichikawa S., Hirabayashi Y., et al. Regulation of glycosphingolipid metabolism in liver during the acute phase response. J Biol Chem 274 (1999) 19707-19713
-
(1999)
J Biol Chem
, vol.274
, pp. 19707-19713
-
-
Memon, R.A.1
Holleran, W.M.2
Uchida, Y.3
Moser, A.H.4
Ichikawa, S.5
Hirabayashi, Y.6
-
106
-
-
0030685825
-
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
-
Mercurio F., Zhu H., Murray B.W., Shevchenko A., Bennett B.L., Li J., et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278 (1997) 860-866
-
(1997)
Science
, vol.278
, pp. 860-866
-
-
Mercurio, F.1
Zhu, H.2
Murray, B.W.3
Shevchenko, A.4
Bennett, B.L.5
Li, J.6
-
107
-
-
0021814377
-
Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues
-
Merrill Jr. A.H., Nixon D.W., and Williams R.D. Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues. J Lipid Res 26 (1985) 617-622
-
(1985)
J Lipid Res
, vol.26
, pp. 617-622
-
-
Merrill Jr., A.H.1
Nixon, D.W.2
Williams, R.D.3
-
108
-
-
0024496181
-
Modulation of protein kinase C and diverse cell functions by sphingosine-a pharmacologically interesting compound linking sphingolipids and signal transduction
-
Merrill Jr. A.H., and Stevens V.L. Modulation of protein kinase C and diverse cell functions by sphingosine-a pharmacologically interesting compound linking sphingolipids and signal transduction. Biochim Biophys Acta 1010 (1989) 131-139
-
(1989)
Biochim Biophys Acta
, vol.1010
, pp. 131-139
-
-
Merrill Jr., A.H.1
Stevens, V.L.2
-
109
-
-
0023036582
-
Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s)
-
Merrill Jr. A.H., and Wang E. Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). J Biol Chem 261 (1986) 3764-3769
-
(1986)
J Biol Chem
, vol.261
, pp. 3764-3769
-
-
Merrill Jr., A.H.1
Wang, E.2
-
110
-
-
0030963660
-
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
-
Michel C., van Echten-Deckert G., Rother J., Sandhoff K., Wang E., and Merrill Jr. A.H. Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. J Biol Chem 272 (1997) 22432-22437
-
(1997)
J Biol Chem
, vol.272
, pp. 22432-22437
-
-
Michel, C.1
van Echten-Deckert, G.2
Rother, J.3
Sandhoff, K.4
Wang, E.5
Merrill Jr., A.H.6
-
111
-
-
0035854705
-
Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney
-
Mitsutake S., Tani M., Okino N., Mori K., Ichinose S., Omori A., et al. Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney. J Biol Chem 276 (2001) 26249-26259
-
(2001)
J Biol Chem
, vol.276
, pp. 26249-26259
-
-
Mitsutake, S.1
Tani, M.2
Okino, N.3
Mori, K.4
Ichinose, S.5
Omori, A.6
-
112
-
-
2342418547
-
Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells
-
Mitsutake S., Kim T.J., Inagaki Y., Kato M., Yamashita T., and Igarashi Y. Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells. J Biol Chem 279 (2004) 17570-17577
-
(2004)
J Biol Chem
, vol.279
, pp. 17570-17577
-
-
Mitsutake, S.1
Kim, T.J.2
Inagaki, Y.3
Kato, M.4
Yamashita, T.5
Igarashi, Y.6
-
115
-
-
0036113192
-
A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis
-
Nagase T., Uozumi N., Ishii S., Kita Y., Yamamoto H., Ohga E., et al. A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nat Med 8 (2002) 480-484
-
(2002)
Nat Med
, vol.8
, pp. 480-484
-
-
Nagase, T.1
Uozumi, N.2
Ishii, S.3
Kita, Y.4
Yamamoto, H.5
Ohga, E.6
-
117
-
-
0033559424
-
Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
-
Nick J.A., Avdi N.J., Young S.K., Lehman L.A., McDonald P.P., Frasch S.C., et al. Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils. J Clin Invest 103 (1999) 851-858
-
(1999)
J Clin Invest
, vol.103
, pp. 851-858
-
-
Nick, J.A.1
Avdi, N.J.2
Young, S.K.3
Lehman, L.A.4
McDonald, P.P.5
Frasch, S.C.6
-
118
-
-
0034651730
-
Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation
-
Nick J.A., Young S.K., Brown K.K., Avdi N.J., Arndt P.G., Suratt B.T., et al. Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation. J Immunol 164 (2000) 2151-2159
-
(2000)
J Immunol
, vol.164
, pp. 2151-2159
-
-
Nick, J.A.1
Young, S.K.2
Brown, K.K.3
Avdi, N.J.4
Arndt, P.G.5
Suratt, B.T.6
-
119
-
-
0031026140
-
Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils
-
Niiro H., Otsuka T., Izuhara K., Yamaoka K., Ohshima K., Tanabe T., et al. Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils. Blood 89 (1997) 1621-1628
-
(1997)
Blood
, vol.89
, pp. 1621-1628
-
-
Niiro, H.1
Otsuka, T.2
Izuhara, K.3
Yamaoka, K.4
Ohshima, K.5
Tanabe, T.6
-
120
-
-
0033544651
-
Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production
-
Niwa M., Kozawa O., Matsuno H., Kanamori Y., Hara A., and Uematsu T. Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production. Life Sci 66 (2000) 245-256
-
(2000)
Life Sci
, vol.66
, pp. 245-256
-
-
Niwa, M.1
Kozawa, O.2
Matsuno, H.3
Kanamori, Y.4
Hara, A.5
Uematsu, T.6
-
122
-
-
0344875587
-
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors
-
Olivera A., Rosenfeldt H.M., Bektas M., Wang F., Ishii I., Chun J., et al. Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem 278 (2003) 46452-46460
-
(2003)
J Biol Chem
, vol.278
, pp. 46452-46460
-
-
Olivera, A.1
Rosenfeldt, H.M.2
Bektas, M.3
Wang, F.4
Ishii, I.5
Chun, J.6
-
123
-
-
0030033449
-
IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts
-
Onoe Y., Miyaura C., Kaminakayashiki T., Nagai Y., Noguchi K., Chen Q.R., et al. IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts. J Immunol 156 (1996) 758-764
-
(1996)
J Immunol
, vol.156
, pp. 758-764
-
-
Onoe, Y.1
Miyaura, C.2
Kaminakayashiki, T.3
Nagai, Y.4
Noguchi, K.5
Chen, Q.R.6
-
124
-
-
0035408611
-
Cytokines: past, present, and future
-
Oppenheim J.J. Cytokines: past, present, and future. Int J Hematol 74 (2001) 3-8
-
(2001)
Int J Hematol
, vol.74
, pp. 3-8
-
-
Oppenheim, J.J.1
-
125
-
-
0034283837
-
The Rel/NF-kappa B family: friend and foe
-
Perkins N.D. The Rel/NF-kappa B family: friend and foe. Trends Biochem Sci 25 (2000) 434-440
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 434-440
-
-
Perkins, N.D.1
-
126
-
-
20444402239
-
Molecular mechanisms and regulation of ceramide transport
-
Perry R.J., and Ridgway N.D. Molecular mechanisms and regulation of ceramide transport. Biochim Biophys Acta 1734 (2005) 220-234
-
(2005)
Biochim Biophys Acta
, vol.1734
, pp. 220-234
-
-
Perry, R.J.1
Ridgway, N.D.2
-
127
-
-
0034708594
-
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
-
Perry D.K., Carton J., Shah A.K., Meredith F., Uhlinger D.J., and Hannun Y.A. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem 275 (2000) 9078-9084
-
(2000)
J Biol Chem
, vol.275
, pp. 9078-9084
-
-
Perry, D.K.1
Carton, J.2
Shah, A.K.3
Meredith, F.4
Uhlinger, D.J.5
Hannun, Y.A.6
-
128
-
-
0037203342
-
Ceramide in apoptosis: an overview and current perspectives
-
Pettus B.J., Chalfant C.E., and Hannun Y.A. Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta 1585 (2002) 114-125
-
(2002)
Biochim Biophys Acta
, vol.1585
, pp. 114-125
-
-
Pettus, B.J.1
Chalfant, C.E.2
Hannun, Y.A.3
-
129
-
-
0141755365
-
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release
-
Pettus B.J., Bielawska A., Spiegel S., Roddy P., Hannun Y.A., and Chalfant C.E. Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem 278 (2003) 38206-38213
-
(2003)
J Biol Chem
, vol.278
, pp. 38206-38213
-
-
Pettus, B.J.1
Bielawska, A.2
Spiegel, S.3
Roddy, P.4
Hannun, Y.A.5
Chalfant, C.E.6
-
130
-
-
0041703016
-
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha
-
Pettus B.J., Bielawski J., Porcelli A.M., Reames D.L., Johnson K.R., Morrow J., et al. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J 17 (2003) 1411-1421
-
(2003)
FASEB J
, vol.17
, pp. 1411-1421
-
-
Pettus, B.J.1
Bielawski, J.2
Porcelli, A.M.3
Reames, D.L.4
Johnson, K.R.5
Morrow, J.6
-
132
-
-
1542319001
-
Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry
-
Pettus B.J., Kroesen B.J., Szulc Z.M., Bielawska A., Bielawski J., Hannun Y.A., et al. Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry. Rapid Commun Mass Spectrom 18 (2004) 577-583
-
(2004)
Rapid Commun Mass Spectrom
, vol.18
, pp. 577-583
-
-
Pettus, B.J.1
Kroesen, B.J.2
Szulc, Z.M.3
Bielawska, A.4
Bielawski, J.5
Hannun, Y.A.6
-
134
-
-
0034120178
-
FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory
-
Pinschewer D.D., Ochsenbein A.F., Odermatt B., Brinkmann V., Hengartner H., and Zinkernagel R.M. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J Immunol 164 (2000) 5761-5770
-
(2000)
J Immunol
, vol.164
, pp. 5761-5770
-
-
Pinschewer, D.D.1
Ochsenbein, A.F.2
Odermatt, B.3
Brinkmann, V.4
Hengartner, H.5
Zinkernagel, R.M.6
-
135
-
-
0033526803
-
The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering
-
Prieschl E.E., Csonga R., Novotny V., Kikuchi G.E., and Baumruker T. The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering. J Exp Med 190 (1999) 1-8
-
(1999)
J Exp Med
, vol.190
, pp. 1-8
-
-
Prieschl, E.E.1
Csonga, R.2
Novotny, V.3
Kikuchi, G.E.4
Baumruker, T.5
-
136
-
-
0031048067
-
Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2
-
Reinhard C., Shamoon B., Shyamala V., and Williams L.T. Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J 16 (1997) 1080-1092
-
(1997)
EMBO J
, vol.16
, pp. 1080-1092
-
-
Reinhard, C.1
Shamoon, B.2
Shyamala, V.3
Williams, L.T.4
-
137
-
-
0031468671
-
The role of sphingolipids in the process of signal transduction
-
Riboni L., Viani P., Bassi R., Prinetti A., and Tettamanti G. The role of sphingolipids in the process of signal transduction. Prog Lipid Res 36 (1997) 153-195
-
(1997)
Prog Lipid Res
, vol.36
, pp. 153-195
-
-
Riboni, L.1
Viani, P.2
Bassi, R.3
Prinetti, A.4
Tettamanti, G.5
-
138
-
-
0034618754
-
Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells
-
Romiti E., Meacci E., Tani M., Nuti F., Farnararo M., Ito M., et al. Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells. Biochem Biophys Res Commun 275 (2000) 746-751
-
(2000)
Biochem Biophys Res Commun
, vol.275
, pp. 746-751
-
-
Romiti, E.1
Meacci, E.2
Tani, M.3
Nuti, F.4
Farnararo, M.5
Ito, M.6
-
139
-
-
0042346123
-
Inhibition of a p38/stress-activated protein kinase-2-dependent phosphatase restores function of IL-1 receptor-associate kinase-1 and reverses Toll-like receptor 2- and 4-dependent tolerance of macrophages
-
Ropert C., Closel M., Chaves A.C., and Gazzinelli R.T. Inhibition of a p38/stress-activated protein kinase-2-dependent phosphatase restores function of IL-1 receptor-associate kinase-1 and reverses Toll-like receptor 2- and 4-dependent tolerance of macrophages. J Immunol 171 (2003) 1456-1465
-
(2003)
J Immunol
, vol.171
, pp. 1456-1465
-
-
Ropert, C.1
Closel, M.2
Chaves, A.C.3
Gazzinelli, R.T.4
-
140
-
-
21844457949
-
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
-
Rosen H., and Goetzl E.J. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol 5 (2005) 560-570
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 560-570
-
-
Rosen, H.1
Goetzl, E.J.2
-
141
-
-
0035206388
-
The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility
-
Rosenfeldt H.M., Hobson J.P., Milstien S., and Spiegel S. The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility. Biochem Soc Trans 29 (2001) 836-839
-
(2001)
Biochem Soc Trans
, vol.29
, pp. 836-839
-
-
Rosenfeldt, H.M.1
Hobson, J.P.2
Milstien, S.3
Spiegel, S.4
-
144
-
-
33748037246
-
Colocalization of oxidized low-density lipoprotein, caspase-3, cyclooxygenase-2, and macrophage migration inhibitory factor in arteriosclerotic human carotid arteries
-
Schlittenhardt D., Schmiedt W., Bonaterra G.A., Metz J., and Kinscherf R. Colocalization of oxidized low-density lipoprotein, caspase-3, cyclooxygenase-2, and macrophage migration inhibitory factor in arteriosclerotic human carotid arteries. Cell Tissue (2005) 1-11
-
(2005)
Cell Tissue
, pp. 1-11
-
-
Schlittenhardt, D.1
Schmiedt, W.2
Bonaterra, G.A.3
Metz, J.4
Kinscherf, R.5
-
145
-
-
0035819885
-
Targeting ceramide metabolism-a strategy for overcoming drug resistance
-
Senchenkov A., Litvak D.A., and Cabot M.C. Targeting ceramide metabolism-a strategy for overcoming drug resistance. J Natl Cancer Inst 93 (2001) 347-357
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 347-357
-
-
Senchenkov, A.1
Litvak, D.A.2
Cabot, M.C.3
-
146
-
-
0025358788
-
Arachidonic acid cascade and signal transduction
-
Shimizu T., and Wolfe L.S. Arachidonic acid cascade and signal transduction. J Neurochem 55 (1990) 1-15
-
(1990)
J Neurochem
, vol.55
, pp. 1-15
-
-
Shimizu, T.1
Wolfe, L.S.2
-
147
-
-
28244456527
-
Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes
-
Singer I.I., Tian M., Wickham L.A., Lin J., Matheravidathu S.S., Forrest M.J., et al. Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes. J Immunol 175 (2005) 7151-7161
-
(2005)
J Immunol
, vol.175
, pp. 7151-7161
-
-
Singer, I.I.1
Tian, M.2
Wickham, L.A.3
Lin, J.4
Matheravidathu, S.S.5
Forrest, M.J.6
-
148
-
-
12644272789
-
Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
-
Song H.Y., Regnier C.H., Kirschning C.J., Goeddel D.V., and Rothe M. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci U S A 94 (1997) 9792-9796
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 9792-9796
-
-
Song, H.Y.1
Regnier, C.H.2
Kirschning, C.J.3
Goeddel, D.V.4
Rothe, M.5
-
149
-
-
0038218405
-
Sphingosine-1-phosphate: an enigmatic signalling lipid
-
Spiegel S., and Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 4 (2003) 397-407
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 397-407
-
-
Spiegel, S.1
Milstien, S.2
-
150
-
-
0037189475
-
Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization
-
Sugiura M., Kono K., Liu H., Shimizugawa T., Minekura H., Spiegel S., et al. Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem 277 (2002) 23294-23300
-
(2002)
J Biol Chem
, vol.277
, pp. 23294-23300
-
-
Sugiura, M.1
Kono, K.2
Liu, H.3
Shimizugawa, T.4
Minekura, H.5
Spiegel, S.6
-
151
-
-
0034602149
-
Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene
-
Takaku K., Sonoshita M., Sasaki N., Uozumi N., Doi Y., Shimizu T., et al. Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene. J Biol Chem 275 (2000) 34013-34016
-
(2000)
J Biol Chem
, vol.275
, pp. 34013-34016
-
-
Takaku, K.1
Sonoshita, M.2
Sasaki, N.3
Uozumi, N.4
Doi, Y.5
Shimizu, T.6
-
152
-
-
0034602962
-
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized
-
Tani M., Okino N., Mitsutake S., Tanigawa T., Izu H., and Ito M. Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. J Biol Chem 275 (2000) 3462-3468
-
(2000)
J Biol Chem
, vol.275
, pp. 3462-3468
-
-
Tani, M.1
Okino, N.2
Mitsutake, S.3
Tanigawa, T.4
Izu, H.5
Ito, M.6
-
153
-
-
0034646698
-
Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases
-
Tani M., Okino N., Mori K., Tanigawa T., Izu H., and Ito M. Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem 275 (2000) 11229-11234
-
(2000)
J Biol Chem
, vol.275
, pp. 11229-11234
-
-
Tani, M.1
Okino, N.2
Mori, K.3
Tanigawa, T.4
Izu, H.5
Ito, M.6
-
154
-
-
27744558995
-
Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu
-
Tani M., Igarashi Y., and Ito M. Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. J Biol Chem 280 (2005) 36592-36600
-
(2005)
J Biol Chem
, vol.280
, pp. 36592-36600
-
-
Tani, M.1
Igarashi, Y.2
Ito, M.3
-
155
-
-
27444446836
-
Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets
-
Tani M., Sano T., Ito M., and Igarashi Y. Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. J Lipid Res 46 (2005) 2458-2467
-
(2005)
J Lipid Res
, vol.46
, pp. 2458-2467
-
-
Tani, M.1
Sano, T.2
Ito, M.3
Igarashi, Y.4
-
157
-
-
0034886756
-
Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart
-
Tekin D., Xi L., Zhao T., Tejero-Taldo M.I., Atluri S., and Kukreja R.C. Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart. Am J Physiol Heart Circ Physiol 281 (2001) H523-H532
-
(2001)
Am J Physiol Heart Circ Physiol
, vol.281
-
-
Tekin, D.1
Xi, L.2
Zhao, T.3
Tejero-Taldo, M.I.4
Atluri, S.5
Kukreja, R.C.6
-
158
-
-
18544406054
-
SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
-
Underwood D.C., Osborn R.R., Kotzer C.J., Adams J.L., Lee J.C., Webb E.F., et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J Pharmacol Exp Ther 293 (2000) 281-288
-
(2000)
J Pharmacol Exp Ther
, vol.293
, pp. 281-288
-
-
Underwood, D.C.1
Osborn, R.R.2
Kotzer, C.J.3
Adams, J.L.4
Lee, J.C.5
Webb, E.F.6
-
159
-
-
0036240838
-
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors
-
Vincenti M.P., and Brinckerhoff C.E. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res 4 (2002) 157-164
-
(2002)
Arthritis Res
, vol.4
, pp. 157-164
-
-
Vincenti, M.P.1
Brinckerhoff, C.E.2
-
160
-
-
15944387363
-
Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases
-
Wahl S.M., and Chen W. Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases. Arthritis Res Ther 7 (2005) 62-68
-
(2005)
Arthritis Res Ther
, vol.7
, pp. 62-68
-
-
Wahl, S.M.1
Chen, W.2
-
162
-
-
0032969285
-
Tumor necrosis factor receptor and Fas signaling mechanisms
-
Wallach D., Varfolomeev E.E., Malinin N.L., Goltsev Y.V., Kovalenko A.V., and Boldin M.P. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol 17 (1999) 331-367
-
(1999)
Annu Rev Immunol
, vol.17
, pp. 331-367
-
-
Wallach, D.1
Varfolomeev, E.E.2
Malinin, N.L.3
Goltsev, Y.V.4
Kovalenko, A.V.5
Boldin, M.P.6
-
163
-
-
0942287672
-
The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase
-
Won J.S., Im Y.B., Khan M., Singh A.K., and Singh I. The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase. J Neurochem 88 (2004) 583-593
-
(2004)
J Neurochem
, vol.88
, pp. 583-593
-
-
Won, J.S.1
Im, Y.B.2
Khan, M.3
Singh, A.K.4
Singh, I.5
-
164
-
-
0029023368
-
Does endotoxin stimulate cells by mimicking ceramide?
-
Wright S.D., and Kolesnick R.N. Does endotoxin stimulate cells by mimicking ceramide?. Immunol Today 16 (1995) 297-302
-
(1995)
Immunol Today
, vol.16
, pp. 297-302
-
-
Wright, S.D.1
Kolesnick, R.N.2
-
165
-
-
0029965928
-
Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24)
-
Wright S.C., Zheng H., and Zhong J. Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24). FASEB J 10 (1996) 325-332
-
(1996)
FASEB J
, vol.10
, pp. 325-332
-
-
Wright, S.C.1
Zheng, H.2
Zhong, J.3
-
166
-
-
4344632961
-
Sphingosine kinase protects lipopolysaccharide-activated macrophages from apoptosis
-
Wu W., Mosteller R.D., and Broek D. Sphingosine kinase protects lipopolysaccharide-activated macrophages from apoptosis. Mol Cell Biol 24 (2004) 7359-7369
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7359-7369
-
-
Wu, W.1
Mosteller, R.D.2
Broek, D.3
-
167
-
-
13144254221
-
Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway
-
Xia P., Gamble J.R., Rye K.A., Wang L., Hii C.S., Cockerill P., et al. Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. Proc Natl Acad Sci U S A 95 (1998) 14196-14201
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 14196-14201
-
-
Xia, P.1
Gamble, J.R.2
Rye, K.A.3
Wang, L.4
Hii, C.S.5
Cockerill, P.6
-
168
-
-
0025754779
-
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
-
Xie W.L., Chipman J.G., Robertson D.L., Erikson R.L., and Simmons D.L. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci U S A 88 (1991) 2692-2696
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 2692-2696
-
-
Xie, W.L.1
Chipman, J.G.2
Robertson, D.L.3
Erikson, R.L.4
Simmons, D.L.5
-
169
-
-
0034739454
-
Inhibition of phospholipase A(2) as a therapeutic target
-
Yedgar S., Lichtenberg D., and Schnitzer E. Inhibition of phospholipase A(2) as a therapeutic target. Biochim Biophys Acta 1488 (2000) 182-187
-
(2000)
Biochim Biophys Acta
, vol.1488
, pp. 182-187
-
-
Yedgar, S.1
Lichtenberg, D.2
Schnitzer, E.3
-
170
-
-
0031463025
-
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
-
Yeh W.C., Shahinian A., Speiser D., Kraunus J., Billia F., Wakeham A., et al. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 7 (1997) 715-725
-
(1997)
Immunity
, vol.7
, pp. 715-725
-
-
Yeh, W.C.1
Shahinian, A.2
Speiser, D.3
Kraunus, J.4
Billia, F.5
Wakeham, A.6
-
171
-
-
0036684043
-
Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster
-
Yoshimura Y., Okino N., Tani M., and Ito M. Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster. J Biochem (Tokyo) 132 (2002) 229-236
-
(2002)
J Biochem (Tokyo)
, vol.132
, pp. 229-236
-
-
Yoshimura, Y.1
Okino, N.2
Tani, M.3
Ito, M.4
-
172
-
-
6344244510
-
Molecular cloning and functional analysis of zebrafish neutral ceramidase
-
Yoshimura Y., Tani M., Okino N., Iida H., and Ito M. Molecular cloning and functional analysis of zebrafish neutral ceramidase. J Biol Chem 279 (2004) 44012-44022
-
(2004)
J Biol Chem
, vol.279
, pp. 44012-44022
-
-
Yoshimura, Y.1
Tani, M.2
Okino, N.3
Iida, H.4
Ito, M.5
-
173
-
-
0032575591
-
Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38
-
Yuasa T., Ohno S., Kehrl J.H., and Kyriakis J.M. Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J Biol Chem 273 (1998) 22681-22692
-
(1998)
J Biol Chem
, vol.273
, pp. 22681-22692
-
-
Yuasa, T.1
Ohno, S.2
Kehrl, J.H.3
Kyriakis, J.M.4
-
174
-
-
32644444604
-
Sphingosine kinase type 2 is essential for lymphodepletion induced by the immunomodulatory drug FTY720
-
Zemann B., Kinzel B., Muller M., Reuschel R., Mechtcheriakova D., Urtz N., et al. Sphingosine kinase type 2 is essential for lymphodepletion induced by the immunomodulatory drug FTY720. Blood 107 4 (2005) 1454-1458
-
(2005)
Blood
, vol.107
, Issue.4
, pp. 1454-1458
-
-
Zemann, B.1
Kinzel, B.2
Muller, M.3
Reuschel, R.4
Mechtcheriakova, D.5
Urtz, N.6
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