Chronic colitis is associated with a reduction of mucosal alkaline sphingomyelinase activity

Inflammatory Bowel Diseases

Volumn 8, Issue 4, 2002, Pages 258-263

  Sjöqvist, Urban ^a,d   Hertervig, Erik ^b   Nilsson, Åke ^b   Duan, Rui Dong ^b   Öst, Åke ^c   Tribukait, Bernhard ^c   Löfberg, Robert ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d STOCKHOLM SÖDER HOSPITAL   (Sweden)

Author keywords

Alkaline sphingomyelinase; Crohn's disease; DNA flow cytometry; Inflammatory bowel disease; Ulcerative colitis

Indexed keywords

SPHINGOMYELIN PHOSPHODIESTERASE;

ADULT; AGE; ANEUPLOIDY; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; COLITIS; COLON ADENOMA; COLON BIOPSY; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE MARKER; DYSPLASIA; EARLY DIAGNOSIS; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; SENESCENCE;

EID: 0036066564     PISSN: 10780998     EISSN: None     Source Type: Journal    
DOI: 10.1097/00054725-200207000-00004     Document Type: Article

References (31)

1. Neutral sphingomyelinase
2. Sphingomyelinases
3. The presence of sphingomyelin- and ceramide-cleaving enzymes in the small intestinal tract
4. Alkaline sphingomyelinase activity in rat gastrointestinal tract: Distribution and characterization
5. Distribution of alkaline sphingomyelinase activity in human beings and animals
6. Localization and capacity of sphingolyelin digestion in the rat intestinal tract
7. Programmed cell death induced by ceramide
8. Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice
9. Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: Implications for dietary carcinogenesis
10. Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma
11. Familial adenomatous polyposis is associated with a marked decrease in alkaline sphingomyelinase activity; a key factor to the unrestrained cell proliferation
12. Colorectal cancer in ulcerative colitis: A cohort study of primary referrals from three centres
13. Ulcerative colitis and colorectal cancer. A population-based study
14. Screening and surveillance colonoscopy in chronic Crohn's colitis
15. Chemical synthesis of choline-labeled lecithins and sphingomyelins
16. Identification of an alkaline sphingomyelinase activity in human bile
17. Magnesium-dependent sphingomyelinase
18. Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications
19. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis
20. Preparation of cell nuclei from fresh tissues for high-quality DNA flow cytometry
21. Colonoscopic surveillance in long-standing total ulcerative colitis - A 15-year follow-up study
22. Dysplasia and deoxyribonucleic acid aneuploidy in the assessment of precancerous changes in chronic ulcerative colitis. Observer variation and correlations
23. Early detection of malignancy in ulcerative colitis. A flow-cytometric DNA study
24. Colorectal cancer surveillance in patients with ulcerative colitis
25. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid
26. Ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in the rat colon
27. Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis
28. Increased expression of proliferative Ki-67 nuclear antigen is correlated with dysplastic colorectal epithelium in ulcerative colitis
29. Telomere reduction in human colorectal carcinoma and with ageing
30. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
31. Telomeres, cancer, and immortality