-
1
-
-
38049037834
-
Basic concepts and recent developments in human steroid hormone biosynthesis
-
Ghayee HK, Auchus RJ 2007 Basic concepts and recent developments in human steroid hormone biosynthesis. Rev Endocr Metab Disord 8:289-300.
-
(2007)
Rev Endocr Metab Disord
, vol.8
, pp. 289-300
-
-
Ghayee, H.K.1
Auchus, R.J.2
-
2
-
-
18044391471
-
Adrenal corticosteroid biosynthesis, metabolism, and action
-
viii
-
Arlt W, Stewart PM 2005 Adrenal corticosteroid biosynthesis, metabolism, and action. Endocrinol Metab Clin North Am 34: 293-313, viii
-
(2005)
Endocrinol Metab Clin North Am
, vol.34
, pp. 293-313
-
-
Arlt, W.1
Stewart, P.M.2
-
3
-
-
34548412080
-
Transcriptional regulation of adrenocortical steroidogenic gene expression
-
Sewer MB, Dammer EB, Jagarlapudi S 2007 Transcriptional regulation of adrenocortical steroidogenic gene expression. Drug Metab Rev 39:371-388.
-
(2007)
Drug Metab Rev
, vol.39
, pp. 371-388
-
-
Sewer, M.B.1
Dammer, E.B.2
Jagarlapudi, S.3
-
4
-
-
0038823652
-
ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex
-
Sewer MB, Waterman MR 2003 ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex. Microsc Res Tech 61:300-307.
-
(2003)
Microsc Res Tech
, vol.61
, pp. 300-307
-
-
Sewer, M.B.1
Waterman, M.R.2
-
5
-
-
79951665862
-
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders
-
Miller WL, Auchus RJ 2011 The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev 32:81-151.
-
(2011)
Endocr Rev
, vol.32
, pp. 81-151
-
-
Miller, W.L.1
Auchus, R.J.2
-
6
-
-
27644505023
-
Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: More complicated than we thought
-
Stocco DM, Wang X, Jo Y, Manna PR 2005 Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought. Mol Endocrinol 19:2647-2659.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 2647-2659
-
-
Stocco, D.M.1
Wang, X.2
Jo, Y.3
Manna, P.R.4
-
7
-
-
0030047248
-
Regulation of the acute production of steroids in steroidogenic cells
-
Stocco DM, Clark BJ 1996 Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17:221-244.
-
(1996)
Endocr Rev
, vol.17
, pp. 221-244
-
-
Stocco, D.M.1
Clark, B.J.2
-
8
-
-
28044439874
-
SF-1 (nuclear receptor 5A1) activity is activated by cyclic via p300-mediated recruitment to active foci, acetylation, and increased DNA binding
-
Chen WY, Juan LJ, Chung BC 2005 SF-1 (nuclear receptor 5A1) activity is activated by cyclic via p300-mediated recruitment to active foci, acetylation, and increased DNA binding. Mol Cell Biol 25:10442-10453.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10442-10453
-
-
Chen, W.Y.1
Juan, L.J.2
Chung, B.C.3
-
9
-
-
0033120086
-
Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: Integration of hormone signaling in reproduction and stress
-
Hammer GD, Krylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL, Ingraham HA 1999 Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell 3:521-526.
-
(1999)
Mol Cell
, vol.3
, pp. 521-526
-
-
Hammer, G.D.1
Krylova, I.2
Zhang, Y.3
Darimont, B.D.4
Simpson, K.5
Weigel, N.L.6
Ingraham, H.A.7
-
10
-
-
0035813148
-
Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5
-
Jacob AL, Lund J, Martinez P, Hedin L 2001 Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5. J Biol Chem 276:37659-37664.
-
(2001)
J Biol Chem
, vol.276
, pp. 37659-37664
-
-
Jacob, A.L.1
Lund, J.2
Martinez, P.3
Hedin, L.4
-
11
-
-
18544386359
-
Steroidogenic factor 1: An essential mediator of endocrine development
-
Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, Bakke M, Zhao L, Frigeri C, Hanley NA, Stallings N, Schimmer BP 2002 Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog Horm Res 57:19-36.
-
(2002)
Recent Prog Horm Res
, vol.57
, pp. 19-36
-
-
Parker, K.L.1
Rice, D.A.2
Lala, D.S.3
Ikeda, Y.4
Luo, X.5
Wong, M.6
Bakke, M.7
Zhao, L.8
Frigeri, C.9
Hanley, N.A.10
Stallings, N.11
Schimmer, B.P.12
-
12
-
-
0038712560
-
Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin _ gene
-
Gummow BM, Winnay JN, Hammer GD 2003 Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin _ gene. J Biol Chem 278:26572-26579.
-
(2003)
J Biol Chem
, vol.278
, pp. 26572-26579
-
-
Gummow, B.M.1
Winnay, J.N.2
Hammer, G.D.3
-
13
-
-
0141591505
-
Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy
-
Jordan BK, Shen JH, Olaso R, Ingraham HA, Vilain E 2003 Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy. Proc Natl Acad Sci USA 100:10866-10871.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10866-10871
-
-
Jordan, B.K.1
Shen, J.H.2
Olaso, R.3
Ingraham, H.A.4
Vilain, E.5
-
14
-
-
0036153174
-
Interaction between Dax-1 and steroidogenic factor-1 in vivo: Increased adrenal responsiveness to ACTH in the absence of Dax-1
-
Babu PS, Bavers DL, Beuschlein F, Shah S, Jeffs B, Jameson JL, Hammer GD 2002 Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1. Endocrinology 143:665-673.
-
(2002)
Endocrinology
, vol.143
, pp. 665-673
-
-
Babu, P.S.1
Bavers, D.L.2
Beuschlein, F.3
Shah, S.4
Jeffs, B.5
Jameson, J.L.6
Hammer, G.D.7
-
15
-
-
0031020234
-
DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita
-
Ito M, Yu R, Jameson JL 1997 DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita. Mol Cell Biol 17:1476-1483.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1476-1483
-
-
Ito, M.1
Yu, R.2
Jameson, J.L.3
-
16
-
-
0842334477
-
RaineyWE2004 The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production
-
Bassett MH, Suzuki T, Sasano H, White PC, RaineyWE2004 The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production. Mol Endocrinol 18:279-290.
-
Mol Endocrinol
, vol.18
, pp. 279-290
-
-
Bassett, M.H.1
Suzuki, T.2
Sasano, H.3
White, P.C.4
-
17
-
-
0034455587
-
Nuclear receptors Nor1 and NGFI-B/Nur77play similar, albeit distinct, roles in the hypothalamo-pituitaryadrenal axis
-
Fernandez PM, Brunel F, Jimenez MA, Saez JM, Cereghini S, Zakin MM 2000 Nuclear receptors Nor1 and NGFI-B/Nur77play similar, albeit distinct, roles in the hypothalamo-pituitaryadrenal axis. Endocrinology 141:2392-2400.
-
(2000)
Endocrinology
, vol.141
, pp. 2392-2400
-
-
Fernandez, P.M.1
Brunel, F.2
Jimenez, M.A.3
Saez, J.M.4
Cereghini, S.5
Zakin, M.M.6
-
18
-
-
14744282485
-
The NGFI-B family of transcription factors regulates expression of 3 β -hydroxysteroid dehydrogenase type 2 in the human ovary
-
Havelock JC, Smith AL, Seely JB, Dooley CA, Rodgers RJ, Rainey WE, Carr BR 2005 The NGFI-B family of transcription factors regulates expression of 3 β -hydroxysteroid dehydrogenase type 2 in the human ovary. Mol Hum Reprod 11:79-85.
-
(2005)
Mol Hum Reprod
, vol.11
, pp. 79-85
-
-
Havelock, J.C.1
Smith, A.L.2
Seely, J.B.3
Dooley, C.A.4
Rodgers, R.J.5
Rainey, W.E.6
Carr, B.R.7
-
19
-
-
50649097876
-
The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I
-
Martin LJ, Boucher N, Brousseau C, Tremblay JJ 2008 The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I. Mol Endocrinol 22:2021-2037.
-
(2008)
Mol Endocrinol
, vol.22
, pp. 2021-2037
-
-
Martin, L.J.1
Boucher, N.2
Brousseau, C.3
Tremblay, J.J.4
-
20
-
-
58149279854
-
Multiple roles for sphingolipids in steroid hormone biosynthesis
-
Lucki NC, Sewer MB 2008 Multiple roles for sphingolipids in steroid hormone biosynthesis. Subcell Biochem 49:387-412.
-
(2008)
Subcell Biochem
, vol.49
, pp. 387-412
-
-
Lucki, N.C.1
Sewer, M.B.2
-
21
-
-
58149277751
-
Roles of bioactive sphingolipids in cancer biology and therapeutics
-
Saddoughi SA, Song P, Ogretmen B 2008 Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem 49:413-440.
-
(2008)
Subcell Biochem
, vol.49
, pp. 413-440
-
-
Saddoughi, S.A.1
Song, P.2
Ogretmen, B.3
-
22
-
-
38549152194
-
Principles of bioactive lipid signaling: Lessons from sphingolipids
-
Hannun YA, Obeid LM 2008 Principles of bioactive lipid signaling: lessons from sphingolipids. Nat Rev Mol Cell Biol 9:139-150.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
23
-
-
0033566338
-
KlukM1999 Sphingosine-1-phosphate: Extracellular mediator or intracellular second messenger?
-
Hla T, Lee MJ, Ancellin N, Liu CH, Thangada S, Thompson BD, KlukM1999 Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? Biochem Pharmacol 58:201-207.
-
Biochem Pharmacol
, vol.58
, pp. 201-207
-
-
Hla, T.1
Lee, M.J.2
Ancellin, N.3
Liu, C.H.4
Thangada, S.5
Thompson, B.D.6
-
25
-
-
34247520569
-
Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate
-
Kihara A, Mitsutake S, Mizutani Y, Igarashi Y 2007 Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Prog Lipid Res 46:126-144.
-
(2007)
Prog Lipid Res
, vol.46
, pp. 126-144
-
-
Kihara, A.1
Mitsutake, S.2
Mizutani, Y.3
Igarashi, Y.4
-
26
-
-
46049100072
-
Sphingolipids in macroautophagy
-
Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, Ghidoni R, Botti J, Codogno P 2008 Sphingolipids in macroautophagy. Methods Mol Biol 445:159-173.
-
(2008)
Methods Mol Biol
, vol.445
, pp. 159-173
-
-
Lavieu, G.1
Scarlatti, F.2
Sala, G.3
Carpentier, S.4
Levade, T.5
Ghidoni, R.6
Botti, J.7
Codogno, P.8
-
27
-
-
47649131293
-
Nuclear sphingolipids: Metabolism and signaling
-
Ledeen RW, Wu G 2008 Nuclear sphingolipids: metabolism and signaling. J Lipid Res 49:1176-1186.
-
(2008)
J Lipid Res
, vol.49
, pp. 1176-1186
-
-
Ledeen, R.W.1
Wu, G.2
-
28
-
-
33751250805
-
Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1
-
Urs AN, Dammer E, Sewer MB 2006 Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. Endocrinology 147:5249-5258.
-
(2006)
Endocrinology
, vol.147
, pp. 5249-5258
-
-
Urs, A.N.1
Dammer, E.2
Sewer, M.B.3
-
29
-
-
77950517958
-
The interplay between bioactive sphingolipids and steroid hormones
-
Lucki NC, Sewer MB 2010 The interplay between bioactive sphingolipids and steroid hormones. Steroids 75:390-399.
-
(2010)
Steroids
, vol.75
, pp. 390-399
-
-
Lucki, N.C.1
Sewer, M.B.2
-
30
-
-
11244309781
-
SewerMB2004 ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism
-
Ozbay T, Merrill Jr AH, SewerMB2004 ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. Endocr Res 30:787-794.
-
Endocr Res
, vol.30
, pp. 787-794
-
-
Ozbay, T.1
Merrill, A.H.2
-
31
-
-
32644440485
-
Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulating element binding protein 1
-
Ozbay T, Rowan A, Leon A, Patel P, Sewer MB 2006 Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulating element binding protein 1. Endocrinology 147:1427-1437.
-
(2006)
Endocrinology
, vol.147
, pp. 1427-1437
-
-
Ozbay, T.1
Rowan, A.2
Leon, A.3
Patel, P.4
Sewer, M.B.5
-
32
-
-
67650234014
-
The c-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells
-
Lucki N, Sewer MB 2009 The c-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells. Biochim Biophys Acta 1791:706-713.
-
(2009)
Biochim Biophys Acta
, vol.1791
, pp. 706-713
-
-
Lucki, N.1
Sewer, M.B.2
-
33
-
-
50049090026
-
Ceramidases: Regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
-
Mao C, Obeid LM 2008 Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta 1781:424-434.
-
(2008)
Biochim Biophys Acta
, vol.1781
, pp. 424-434
-
-
Mao, C.1
Obeid, L.M.2
-
34
-
-
45549093120
-
Autoproteolytic cleavage and activation of human acid ceramidase
-
Shtraizent N, Eliyahu E, Park JH, He X, Shalgi R, Schuchman EH 2008 Autoproteolytic cleavage and activation of human acid ceramidase. J Biol Chem 283:11253-11259.
-
(2008)
J Biol Chem
, vol.283
, pp. 11253-11259
-
-
Shtraizent, N.1
Eliyahu, E.2
Park, J.H.3
He, X.4
Shalgi, R.5
Schuchman, E.H.6
-
35
-
-
0029070822
-
Purification, characterization, and biosynthesis of human acid ceramidase
-
Bernardo K, Hurwitz R, Zenk T, Desnick RJ, Ferlinz K, Schuchman EH, Sandhoff K 1995 Purification, characterization, and biosynthesis of human acid ceramidase. J Biol Chem 270:11098-11102.
-
(1995)
J Biol Chem
, vol.270
, pp. 11098-11102
-
-
Bernardo, K.1
Hurwitz, R.2
Zenk, T.3
Desnick, R.J.4
Ferlinz, K.5
Schuchman, E.H.6
Sandhoff, K.7
-
36
-
-
0026317132
-
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme
-
Wang E, Norred WP, Bacon CW, Riley RT, Merrill Jr AH 1991 Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266:14486-14490.
-
(1991)
J Biol Chem
, vol.266
, pp. 14486-14490
-
-
Wang, E.1
Norred, W.P.2
Bacon, C.W.3
Riley, R.T.4
Merrill, A.H.5
-
37
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
-
Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, Spiegel S 1996 Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381:800-803.
-
(1996)
Nature
, vol.381
, pp. 800-803
-
-
Cuvillier, O.1
Pirianov, G.2
Kleuser, B.3
Vanek, P.G.4
Coso, O.A.5
Gutkind, S.6
Spiegel, S.7
-
38
-
-
0036303786
-
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
-
Kolesnick R 2002 The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110:3-8.
-
(2002)
J Clin Invest
, vol.110
, pp. 3-8
-
-
Kolesnick, R.1
-
39
-
-
0037203305
-
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
-
Maceyka M, Payne SG, Milstien S, Spiegel S 2002 Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta 1585:193-201.
-
(2002)
Biochim Biophys Acta
, vol.1585
, pp. 193-201
-
-
Maceyka, M.1
Payne, S.G.2
Milstien, S.3
Spiegel, S.4
-
40
-
-
34247554203
-
SchuchmanEH2007 Acid ceramidase is a novel factor required for early embryo survival
-
Eliyahu E, Park JH, Shtraizent N, He X, SchuchmanEH2007 Acid ceramidase is a novel factor required for early embryo survival. FASEB J 21:1403-1409.
-
FASEB J
, vol.21
, pp. 1403-1409
-
-
Eliyahu, E.1
Park, J.H.2
Shtraizent, N.3
He, X.4
-
41
-
-
42549100356
-
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy
-
Saad AF, Meacham WD, Bai A, Anelli V, Elojeimy S, Mahdy AE, Turner LS, Cheng J, Bielawska A, Bielawski J, Keane TE, Obeid LM, Hannun YA, Norris JS, Liu X 2007 The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther 6:1455-1460.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 1455-1460
-
-
Saad, A.F.1
Meacham, W.D.2
Bai, A.3
Anelli, V.4
Elojeimy, S.5
Mahdy, A.E.6
Turner, L.S.7
Cheng, J.8
Bielawska, A.9
Bielawski, J.10
Keane, T.E.11
Obeid, L.M.12
Hannun, Y.A.13
Norris, J.S.14
Liu, X.15
-
42
-
-
61649091570
-
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer
-
Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, Keane TE, Taha MI, Hammouda HM, Norris JS, Liu X 2009 Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther 17:430-438.
-
(2009)
Mol Ther
, vol.17
, pp. 430-438
-
-
Mahdy, A.E.1
Cheng, J.C.2
Li, J.3
Elojeimy, S.4
Meacham, W.D.5
Turner, L.S.6
Bai, A.7
Gault, C.R.8
McPherson, A.S.9
Garcia, N.10
Beckham, T.H.11
Saad, A.12
Bielawska, A.13
Bielawski, J.14
Hannun, Y.A.15
Keane, T.E.16
Taha, M.I.17
Hammouda, H.M.18
Norris, J.S.19
Liu, X.20
more..
-
43
-
-
34250732783
-
Role of acid ceramidase in resistance to FasL: Therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy
-
Elojeimy S, Liu X, McKillop JC, El-Zawahry AM, Holman DH, Cheng JY, Meacham WD, Mahdy AE, Saad AF, Turner LS, Cheng J, A Day T, Dong JY, Bielawska A, Hannun YA, Norris JS 2007 Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther 15:1259-1263.
-
(2007)
Mol Ther
, vol.15
, pp. 1259-1263
-
-
Elojeimy, S.1
Liu, X.2
McKillop, J.C.3
El-Zawahry, A.M.4
Holman, D.H.5
Cheng, J.Y.6
Meacham, W.D.7
Mahdy, A.E.8
Saad, A.F.9
Turner, L.S.10
Cheng, J.11
A Day, T.12
Dong, J.Y.13
Bielawska, A.14
Hannun, Y.A.15
Norris, J.S.16
-
44
-
-
0033839592
-
Human acid ceramidase is overexpressed but not mutated in prostate cancer
-
Seelan RS, Qian C, Yokomizo A, Bostwick DG, Smith DI, Liu W 2000 Human acid ceramidase is overexpressed but not mutated in prostate cancer. Gene Chromosome Canc 29:137-146.
-
(2000)
Gene Chromosome Canc
, vol.29
, pp. 137-146
-
-
Seelan, R.S.1
Qian, C.2
Yokomizo, A.3
Bostwick, D.G.4
Smith, D.I.5
Liu, W.6
-
46
-
-
59649118043
-
SR-BI-mediated HDL cholesteryl ester delivery in the adrenal gland
-
Connelly MA 2009 SR-BI-mediated HDL cholesteryl ester delivery in the adrenal gland. Mol Cell Endocrinol 300:83-88.
-
(2009)
Mol Cell Endocrinol
, vol.300
, pp. 83-88
-
-
Connelly, M.A.1
-
47
-
-
77953561361
-
Mammalian ceramide synthases
-
Levy M, Futerman AH 2010 Mammalian ceramide synthases. IUBMB Life 62:347-356.
-
(2010)
IUBMB Life
, vol.62
, pp. 347-356
-
-
Levy, M.1
Futerman, A.H.2
-
48
-
-
0034193457
-
Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids
-
Tvrdik P, Westerberg R, Silve S, Asadi A, Jakobsson A, Cannon B, Loison G, Jacobsson A 2000 Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. J Cell Biol 149:707-718.
-
(2000)
J Cell Biol
, vol.149
, pp. 707-718
-
-
Tvrdik, P.1
Westerberg, R.2
Silve, S.3
Asadi, A.4
Jakobsson, A.5
Cannon, B.6
Loison, G.7
Jacobsson, A.8
-
49
-
-
70350244514
-
Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism
-
Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H 2009 Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism. Cancer Res 69:8133-8140.
-
(2009)
Cancer Res
, vol.69
, pp. 8133-8140
-
-
Tamura, K.1
Makino, A.2
Hullin-Matsuda, F.3
Kobayashi, T.4
Furihata, M.5
Chung, S.6
Ashida, S.7
Miki, T.8
Fujioka, T.9
Shuin, T.10
Nakamura, Y.11
Nakagawa, H.12
-
50
-
-
0027446362
-
The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase
-
Wilson TE, Mouw AR, Weaver CA, Milbrandt J, Parker KL 1993 The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol Cell Biol 13:861-868.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 861-868
-
-
Wilson, T.E.1
Mouw, A.R.2
Weaver, C.A.3
Milbrandt, J.4
Parker, K.L.5
-
51
-
-
67449158981
-
Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis
-
Nogueira EF, Xing Y, Morris CA, Rainey WE 2009 Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis. J Mol Endocrinol 42: 319-330.
-
(2009)
J Mol Endocrinol
, vol.42
, pp. 319-330
-
-
Nogueira, E.F.1
Xing, Y.2
Morris, C.A.3
Rainey, W.E.4
-
52
-
-
21244452625
-
Molecular biology of the 3 β-hydroxysteroid dehydrogenase/ δ5-δ4 isomerase gene family
-
Simard J, Ricketts ML, Gingras S, Soucy P, Feltus FA, Melner MH 2005 Molecular biology of the 3 β-hydroxysteroid dehydrogenase/ δ5-δ4 isomerase gene family. Endocr Rev 26:525-582.
-
(2005)
Endocr Rev
, vol.26
, pp. 525-582
-
-
Simard, J.1
Ricketts, M.L.2
Gingras, S.3
Soucy, P.4
Feltus, F.A.5
Melner, M.H.6
-
53
-
-
0036212259
-
Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription
-
Sewer MB, Nguyen VQ, Huang CJ, Tucker PW, Kagawa N, Waterman MR 2002 Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription. Endocrinology 143:1280-1290.
-
(2002)
Endocrinology
, vol.143
, pp. 1280-1290
-
-
Sewer, M.B.1
Nguyen, V.Q.2
Huang, C.J.3
Tucker, P.W.4
Kagawa, N.5
Waterman, M.R.6
-
54
-
-
3142695794
-
Cholesterol uptake in adrenal and gonadal tissues: The SR-BI and 'selective' pathway connection
-
Azhar S, Leers-Sucheta S, Reaven E 2003 Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and 'selective' pathway connection. Front Biosci 8:s998-s1029
-
(2003)
Front Biosci
, vol.8
-
-
Azhar, S.1
Leers-Sucheta, S.2
Reaven, E.3
-
55
-
-
0042889456
-
PAP7, a PBR/PKA-RIα-associated protein: A new element in the relay of the hormonal induction of steroidogenesis
-
Liu J, Li H, Papadopoulos V 2003 PAP7, a PBR/PKA-RIα-associated protein: a new element in the relay of the hormonal induction of steroidogenesis. J Steroid Biochem Mol Biol 85:576-586
-
(2003)
J Steroid Biochem Mol Biol
, vol.85
, pp. 576-586
-
-
Liu, J.1
Li, H.2
Papadopoulos, V.3
-
56
-
-
0042737939
-
Peripheral-type benzodiazepine receptor: Structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis
-
Lacapère JJ, Papadopoulos V 2003 Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids 68:569-585.
-
(2003)
Steroids
, vol.68
, pp. 569-585
-
-
Lacapère, J.J.1
Papadopoulos, V.2
-
57
-
-
0035047848
-
StAR protein and the regulation of steroid hormone biosynthesis
-
Stocco DM 2001 StAR protein and the regulation of steroid hormone biosynthesis. Annu Rev Physiol 63:193-213.
-
(2001)
Annu Rev Physiol
, vol.63
, pp. 193-213
-
-
Stocco, D.M.1
-
58
-
-
33845504474
-
Nonclassic congenital lipoid adrenal hyperplasia: A new disorder of the steroidogenic acute regulatory protein with very late presentation and normal male genitalia
-
Baker BY, Lin L, Kim CJ, Raza J, Smith CP, Miller WL, Achermann JC 2006 Nonclassic congenital lipoid adrenal hyperplasia: a new disorder of the steroidogenic acute regulatory protein with very late presentation and normal male genitalia. J Clin Endocrinol Metab 91:4781-4785.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 4781-4785
-
-
Baker, B.Y.1
Lin, L.2
Kim, C.J.3
Raza, J.4
Smith, C.P.5
Miller, W.L.6
Achermann, J.C.7
-
60
-
-
0242636865
-
Intratesticular delivery of tumor necrosis factor-α and ceramide directly abrogates steroidogenic acute regulatory protein expression and Leydig cell steroidogenesis in aadult rats
-
Morales V, Santana P, Díaz R, Tabraue C, Gallardo G, Ló pez Blanco F, Hernández I, Fanjul LF, Ruiz de Galarreta CM 2003 Intratesticular delivery of tumor necrosis factor-α and ceramide directly abrogates steroidogenic acute regulatory protein expression and Leydig cell steroidogenesis in aadult rats. Endocrinology 144:4763-4772.
-
(2003)
Endocrinology
, vol.144
, pp. 4763-4772
-
-
Morales, V.1
Santana, P.2
Díaz, R.3
Tabraue, C.4
Gallardo, G.5
López Blanco, F.6
Hernández, I.7
Fanjul, L.F.8
Ruiz de Galarreta, C.M.9
-
61
-
-
0028930638
-
Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells
-
Santana P, Llanes L, Hernandez I, Gallardo G, Quintana J, Gonzalez J, Estevez F, Ruiz de Galarreta C, Fanjul LF 1995 Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells. Endocrinology 136:2345-2348.
-
(1995)
Endocrinology
, vol.136
, pp. 2345-2348
-
-
Santana, P.1
Llanes, L.2
Hernandez, I.3
Gallardo, G.4
Quintana, J.5
Gonzalez, J.6
Estevez, F.7
Ruiz de Galarreta, C.8
Fanjul, L.F.9
-
62
-
-
0025757185
-
Increased steroid hormone secretion in mouse Leydig tumor cells after induction of cholesterol translocation by sphingomyelin degradation
-
Pörn MI, Tenhunen J, Slotte JP 1991 Increased steroid hormone secretion in mouse Leydig tumor cells after induction of cholesterol translocation by sphingomyelin degradation. Biochim Biophys Acta 1093:7-12.
-
(1991)
Biochim Biophys Acta
, vol.1093
, pp. 7-12
-
-
Pörn, M.I.1
Tenhunen, J.2
Slotte, J.P.3
-
63
-
-
0037472648
-
Sphingosine-1-phosphate stimulates cortisol secretion
-
Rábano M Rábano M, Peña A, Brizuela L, Marino A, Macarulla JM, Trueba M, Gómez-Muñoz A 2003 Sphingosine-1-phosphate stimulates cortisol secretion. FEBS Lett 535:101-105.
-
(2003)
FEBS Lett
, vol.535
, pp. 101-105
-
-
Rábano, M.1
Rábano, M.2
Peña, A.3
Brizuela, L.4
Marino, A.5
Macarulla, J.M.6
Trueba, M.7
Gómez-Muñoz, A.8
-
64
-
-
1842661007
-
Inhibition of steroidogenesis and induction of apoptosis in rat luteal cells by cell-permeable ceramide in vitro
-
Li QL, Ni J, Bian SL, Yao LC, Zhu H, Zhang W 2001 Inhibition of steroidogenesis and induction of apoptosis in rat luteal cells by cell-permeable ceramide in vitro. Sheng Li Xue Bao 53:142-146.
-
(2001)
Sheng Li Xue Bao
, vol.53
, pp. 142-146
-
-
Li, Q.L.1
Ni, J.2
Bian, S.L.3
Yao, L.C.4
Zhu, H.5
Zhang, W.6
-
66
-
-
0029960157
-
Sphingomyelinase inhibits in vitro Leydig cell function
-
Degnan BM, Bourdelat-Parks B, Daniel A, Salata K, Francis GL 1996 Sphingomyelinase inhibits in vitro Leydig cell function. Ann Clin Lab Sci 26:234-242.
-
(1996)
Ann Clin Lab Sci
, vol.26
, pp. 234-242
-
-
Degnan, B.M.1
Bourdelat-Parks, B.2
Daniel, A.3
Salata, K.4
Francis, G.L.5
-
67
-
-
9344265205
-
Interleukin-1β stimulates sphingomyelin hydrolysis in cultured granulosa cells: Evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis
-
Santana P, Llanes L, Hernandez I, Gonzalez-Robayna I, Tabraue C, Gonzalez-Reyes J, Quintana J, Estevez F, Ruiz de Galarreta CM, Fanjul LF 1996 Interleukin-1β stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis. Endocrinology 137:2480-2489.
-
(1996)
Endocrinology
, vol.137
, pp. 2480-2489
-
-
Santana, P.1
Llanes, L.2
Hernandez, I.3
Gonzalez-Robayna, I.4
Tabraue, C.5
Gonzalez-Reyes, J.6
Quintana, J.7
Estevez, F.8
Ruiz de Galarreta, C.M.9
Fanjul, L.F.10
-
68
-
-
34948819302
-
Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways
-
Brizuela L, Rábano M, Gangoiti P, Narbona N, Macarulla JM, Trueba M, Gómez-Muñoz A 2007 Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways. J Lipid Res 48:2264-2274.
-
J Lipid Res
, vol.48
, pp. 2264-2274
-
-
Brizuela, L.1
Rábano, M.2
Gangoiti, P.3
Narbona, N.4
Macarulla, J.M.5
Trueba, M.6
Gómez-Muñoz, A.7
-
69
-
-
33744830854
-
Sphingosine-1-phosphate: A novel stimulator of aldosterone secretion
-
Brizuela L, Rábano M, Peñ a A, Gangoiti P, Macarulla JM, Trueba M, Gómez-Muñoz A 2006 Sphingosine-1-phosphate: a novel stimulator of aldosterone secretion. J Lipid Res 47:1238-1249.
-
(2006)
J Lipid Res
, vol.47
, pp. 1238-1249
-
-
Brizuela, L.1
Rábano, M.2
Peña, A.3
Gangoiti, P.4
Macarulla, J.M.5
Trueba, M.6
Gómez-Muñoz, A.7
-
70
-
-
0033602656
-
Inhibitory effects of TNF on mouse tumor Leydig cells: possible role of ceramide in the mechanism of action
-
Budnik LT, Jähner D Mukhopadhyay AK 1999 Inhibitory effects of TNF on mouse tumor Leydig cells: possible role of ceramide in the mechanism of action. Mol Cell Endocrinol 150:39-46.
-
(1999)
Mol Cell Endocrinol
, vol.150
, pp. 39-46
-
-
Budnik, L.T.1
Jähner, D.2
Mukhopadhyay, A.K.3
-
71
-
-
1542327552
-
Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis
-
Kraemer FB, Shen WJ, Harada K, Patel S, Osuga J, Ishibashi S, Azhar S 2004 Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis. Mol Endocrinol 18:549-557.
-
(2004)
Mol Endocrinol
, vol.18
, pp. 549-557
-
-
Kraemer, F.B.1
Shen, W.J.2
Harada, K.3
Patel, S.4
Osuga, J.5
Ishibashi, S.6
Azhar, S.7
-
72
-
-
0036936614
-
PBR, StAR, and PKA: Partners in cholesterol transport in steroidogenic cells
-
Hauet T, Liu J, Li H, Gazouli M, Culty M, Papadopoulos V 2002 PBR, StAR, and PKA: partners in cholesterol transport in steroidogenic cells. Endocr Res 28:395-401.
-
(2002)
Endocr Res
, vol.28
, pp. 395-401
-
-
Hauet, T.1
Liu, J.2
Li, H.3
Gazouli, M.4
Culty, M.5
Papadopoulos, V.6
-
73
-
-
0242290164
-
Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: Facilitation of cholesterol transfer in adrenal
-
Shen WJ, Patel S, Natu V, Hong R, Wang J, Azhar S, Kraemer FB 2003 Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal. J Biol Chem 278:43870-43876.
-
(2003)
J Biol Chem
, vol.278
, pp. 43870-43876
-
-
Shen, W.J.1
Patel, S.2
Natu, V.3
Hong, R.4
Wang, J.5
Azhar, S.6
Kraemer, F.B.7
-
74
-
-
33847041060
-
Mechanism of StAR's regulation of mitochondrial cholesterol import
-
Miller WL 2007 Mechanism of StAR's regulation of mitochondrial cholesterol import. Mol Cell Endocrinol 265-266:46-50.
-
(2007)
Mol Cell Endocrinol
, pp. 265-266
-
-
Miller, W.L.1
-
75
-
-
26244433172
-
DAX1 origin, function, and novel role
-
Niakan KK, McCabe ER 2005 DAX1 origin, function, and novel role. Mol Genet Metab 86:70-83.
-
(2005)
Mol Genet Metab
, vol.86
, pp. 70-83
-
-
Niakan, K.K.1
McCabe, E.R.2
-
76
-
-
0032076964
-
Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression
-
Nachtigal MW, Hirokawa Y, Enyeart-VanHouten DL, Flanagan JN, Hammer GD, Ingraham HA 1998 Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Cell 93:445-454.
-
(1998)
Cell
, vol.93
, pp. 445-454
-
-
Nachtigal, M.W.1
Hirokawa, Y.2
Enyeart-Vanhouten, D.L.3
Flanagan, J.N.4
Hammer, G.D.5
Ingraham, H.A.6
-
77
-
-
64649091704
-
E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis
-
Ehrlund A, Anthonisen EH, Gustafsson N, Venteclef N, Robertson Remen K, Damdimopoulos AE, Galeeva A, Pelto-Huikko M, Lalli E, Steffensen KR, Gustafsson JA, Treuter E 2009 E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis. Mol Cell Biol 29:2230-2242.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2230-2242
-
-
Ehrlund, A.1
Anthonisen, E.H.2
Gustafsson, N.3
Venteclef, N.4
Robertson Remen, K.5
Damdimopoulos, A.E.6
Galeeva, A.7
Pelto-Huikko, M.8
Lalli, E.9
Steffensen, K.R.10
Gustafsson, J.A.11
Treuter, E.12
-
78
-
-
67650252269
-
Histone H3 acetylation of StAR and decrease in DAX-1 is involved in the luteinization of bovine granulosa cells during in vitro culture
-
Shimizu T, Sudo N, Yamashita H, Murayama C, Miyazaki H, Miyamoto A 2009 Histone H3 acetylation of StAR and decrease in DAX-1 is involved in the luteinization of bovine granulosa cells during in vitro culture. Mol Cell Biochem 328:41-47.
-
(2009)
Mol Cell Biochem
, vol.328
, pp. 41-47
-
-
Shimizu, T.1
Sudo, N.2
Yamashita, H.3
Murayama, C.4
Miyazaki, H.5
Miyamoto, A.6
-
80
-
-
0032842536
-
Ceramide increases steroid hormone production in MA-10 Leydig cells
-
Kwun C, Patel A, Pletcher S, Lyons B, Abdelrahim M, Nicholson D, Morris E, Salata K, Francis GL 1999 Ceramide increases steroid hormone production in MA-10 Leydig cells. Steroids 64:499-509.
-
(1999)
Steroids
, vol.64
, pp. 499-509
-
-
Kwun, C.1
Patel, A.2
Pletcher, S.3
Lyons, B.4
Abdelrahim, M.5
Nicholson, D.6
Morris, E.7
Salata, K.8
Francis, G.L.9
-
81
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides T 2007 Chromatin modifications and their function. Cell 128:693-705.
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
82
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
-
Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S 2009 Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325:1254-1257.
-
(2009)
Science
, vol.325
, pp. 1254-1257
-
-
Hait, N.C.1
Allegood, J.2
Maceyka, M.3
Strub, G.M.4
Harikumar, K.B.5
Singh, S.K.6
Luo, C.7
Marmorstein, R.8
Kordula, T.9
Milstien, S.10
Spiegel, S.11
-
83
-
-
17544366509
-
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase
-
Bielawska A, Greenberg MS, Perry D, Jayadev S, Shayman JA, McKay C, Hannun YA 1996 (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem 271:12646-12654.
-
(1996)
J Biol Chem
, vol.271
, pp. 12646-12654
-
-
Bielawska, A.1
Greenberg, M.S.2
Perry, D.3
Jayadev, S.4
Shayman, J.A.5
McKay, C.6
Hannun, Y.A.7
-
84
-
-
0035854766
-
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide
-
Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM 2001 Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J Biol Chem 276:26577-26588.
-
(2001)
J Biol Chem
, vol.276
, pp. 26577-26588
-
-
Mao, C.1
Xu, R.2
Szulc, Z.M.3
Bielawska, A.4
Galadari, S.H.5
Obeid, L.M.6
-
85
-
-
33748665711
-
Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P
-
Xu R, Jin J, Hu W, Sun W, Bielawski J, Szulc Z, Taha T, Obeid LM, Mao C 2006 Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J 20:1813-1825.
-
(2006)
FASEB J
, vol.20
, pp. 1813-1825
-
-
Xu, R.1
Jin, J.2
Hu, W.3
Sun, W.4
Bielawski, J.5
Szulc, Z.6
Taha, T.7
Obeid, L.M.8
Mao, C.9
-
86
-
-
38149088114
-
Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calciuminduced differentiation of epidermal keratinocytes
-
Sun W, Xu R, Hu W, Jin J, Crellin HA, Bielawski J, Szulc ZM, Thiers BH, Obeid LM, Mao C 2008 Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calciuminduced differentiation of epidermal keratinocytes. J Invest Dermatol 128:389-397.
-
(2008)
J Invest Dermatol
, vol.128
, pp. 389-397
-
-
Sun, W.1
Xu, R.2
Hu, W.3
Jin, J.4
Crellin, H.A.5
Bielawski, J.6
Szulc, Z.M.7
Thiers, B.H.8
Obeid, L.M.9
Mao, C.10
-
87
-
-
17444368619
-
ItoM2005 Subcellular localization of human neutral ceramidase expressed in HEK293 cells
-
Hwang YH, Tani M, Nakagawa T, Okino N, ItoM2005 Subcellular localization of human neutral ceramidase expressed in HEK293 cells. Biochem Biophys Res Commun 331:37-42.
-
Biochem Biophys Res Commun
, vol.331
, pp. 37-42
-
-
Hwang, Y.H.1
Tani, M.2
Nakagawa, T.3
Okino, N.4
-
88
-
-
0034618754
-
Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells
-
Romiti E, Meacci E, Tani M, Nuti F, Farnararo M, Ito M, Bruni P 2000 Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells. Biochem Biophys Res Commun 275:746-751.
-
(2000)
Biochem Biophys Res Commun
, vol.275
, pp. 746-751
-
-
Romiti, E.1
Meacci, E.2
Tani, M.3
Nuti, F.4
Farnararo, M.5
Ito, M.6
Bruni, P.7
-
89
-
-
0035929560
-
Human acid ceramidase: Processing, glycosylation, and lysosomal targeting
-
Ferlinz K, Kopal G, Bernardo K, Linke T, Bar J, Breiden B, Neumann U, Lang F, Schuchman EH, Sandhoff K 2001 Human acid ceramidase: processing, glycosylation, and lysosomal targeting. J Biol Chem 276:35352-35360.
-
(2001)
J Biol Chem
, vol.276
, pp. 35352-35360
-
-
Ferlinz, K.1
Kopal, G.2
Bernardo, K.3
Linke, T.4
Bar, J.5
Breiden, B.6
Neumann, U.7
Lang, F.8
Schuchman, E.H.9
Sandhoff, K.10
-
90
-
-
77950890820
-
Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis
-
Hu W, Xu R, Sun W, Szulc ZM, Bielawski J, Obeid LM, Mao C 2010 Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. J Biol Chem 285:7964-7976.
-
(2010)
J Biol Chem
, vol.285
, pp. 7964-7976
-
-
Hu, W.1
Xu, R.2
Sun, W.3
Szulc, Z.M.4
Bielawski, J.5
Obeid, L.M.6
Mao, C.7
-
91
-
-
0034647935
-
Molecular cloning and characterization of a human mitochondrial ceramidase
-
El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA 2000 Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem 275:21508-21513.
-
(2000)
J Biol Chem
, vol.275
, pp. 21508-21513
-
-
El Bawab, S.1
Roddy, P.2
Qian, T.3
Bielawska, A.4
Lemasters, J.J.5
Hannun, Y.A.6
-
92
-
-
77950578526
-
Substrate specificity, membrane topology, and activityregulation of human alkaline ceramidase 2 (ACER2)
-
Sun W, Jin J, Xu R, Hu W, Szulc ZM, Bielawski J, Obeid LM, Mao C 2010 Substrate specificity, membrane topology, and activityregulation of human alkaline ceramidase 2 (ACER2). J Biol Chem 285:8995-9007.
-
(2010)
J Biol Chem
, vol.285
, pp. 8995-9007
-
-
Sun, W.1
Jin, J.2
Xu, R.3
Hu, W.4
Szulc, Z.M.5
Bielawski, J.6
Obeid, L.M.7
Mao, C.8
-
93
-
-
0020378285
-
Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls
-
Momoi T, Ben-Yoseph Y, Nadler HL 1982 Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls. Biochem J 205:419-425.
-
(1982)
Biochem J
, vol.205
, pp. 419-425
-
-
Momoi, T.1
Ben-Yoseph, Y.2
Nadler, H.L.3
-
94
-
-
78650894782
-
Selective knockdown of ceramide synthases reveals complex inter-regulation of sphingolipid metabolism
-
Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA, Obeid LM 2011 Selective knockdown of ceramide synthases reveals complex inter-regulation of sphingolipid metabolism. J Lipid Res 52:68-77.
-
(2011)
J Lipid Res
, vol.52
, pp. 68-77
-
-
Mullen, T.D.1
Spassieva, S.2
Jenkins, R.W.3
Kitatani, K.4
Bielawski, J.5
Hannun, Y.A.6
Obeid, L.M.7
-
95
-
-
77950612993
-
Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies
-
Park H, Haynes CA, Nairn AV, Kulik M, Dalton S, Moremen K, Merrill Jr AH 2010. Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. J Lipid Res 51:480-489.
-
(2010)
J Lipid Res
, vol.51
, pp. 480-489
-
-
Park, H.1
Haynes, C.A.2
Nairn, A.V.3
Kulik, M.4
Dalton, S.5
Moremen, K.6
Merrill, A.H.7
-
96
-
-
77953728877
-
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells
-
Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R 2010 Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal 22:1300-1307.
-
(2010)
Cell Signal
, vol.22
, pp. 1300-1307
-
-
Mesicek, J.1
Lee, H.2
Feldman, T.3
Jiang, X.4
Skobeleva, A.5
Berdyshev, E.V.6
Haimovitz-Friedman, A.7
Fuks, Z.8
Kolesnick, R.9
-
97
-
-
78649790713
-
The role of the ceramide acyl chain length in neurodegeneration: Involvement of ceramide synthases
-
Ben-David O, Futerman AH 2010 The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases. Neuromolecular Med 12:341-350.
-
(2010)
Neuromolecular Med
, vol.12
, pp. 341-350
-
-
Ben-David, O.1
Futerman, A.H.2
-
98
-
-
67650239637
-
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation
-
Wu BX, Zeidan YH, Hannun YA 2009 Downregulation of neutral ceramidase by gemcitabine: implications for cell cycle regulation. Biochim Biophys Acta 1791:730-739.
-
(2009)
Biochim Biophys Acta
, pp. 730-739
-
-
Wu, B.X.1
Zeidan, Y.H.2
Hannun, Y.A.3
-
99
-
-
79957620026
-
Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression
-
Lucki NC, Sewer MB 2011 Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression. J Biol Chem 286:19399-19409.
-
(2011)
J Biol Chem
, vol.286
, pp. 19399-19409
-
-
Lucki, N.C.1
Sewer, M.B.2
-
100
-
-
0026327199
-
Lactosylceramide stimulates aortic smooth muscle cell proliferation
-
Chatterjee S 1991 Lactosylceramide stimulates aortic smooth muscle cell proliferation. Biochem Biophys Res Commun 181: 554-561.
-
(1991)
Biochem Biophys Res Commun
, vol.181
, pp. 554-561
-
-
Chatterjee, S.1
-
101
-
-
67650093494
-
Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells
-
Mu H, Wang X, Wang H, Lin P, Yao Q, Chen C 2009 Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells. Am J Physiol Heart Circ Physiol 297:H400-H408.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.297
-
-
Mu, H.1
Wang, X.2
Wang, H.3
Lin, P.4
Yao, Q.5
Chen, C.6
-
102
-
-
17544384366
-
Lactosylceramide stimulates Ras-GTP loading, kinases (MEK, Raf), p44 mitogen-activated protein kinase, and c-fos expression in human aortic smooth muscle cells
-
Bhunia AK, Han H, Snowden A, Chatterjee S 1996 Lactosylceramide stimulates Ras-GTP loading, kinases (MEK, Raf), p44 mitogen-activated protein kinase, and c-fos expression in human aortic smooth muscle cells. J Biol Chem 271:10660-10666.
-
(1996)
J Biol Chem
, vol.271
, pp. 10660-10666
-
-
Bhunia, A.K.1
Han, H.2
Snowden, A.3
Chatterjee, S.4
-
104
-
-
0027450247
-
Regulation of steroidogenesis in NCI-H295 cells: A cellular model of the human fetal adrenal
-
Staels B, Hum DW, Miller WL 1993 Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal. Mol Endocrinol 7:423-433.
-
(1993)
Mol Endocrinol
, vol.7
, pp. 423-433
-
-
Staels, B.1
Hum, D.W.2
Miller, W.L.3
-
106
-
-
0033784938
-
Analysis of sphingomyelin, glucosylceramide, ceramide, sphingosine, and sphingosine 1-phosphate by tandem mass spectrometry
-
Sullards MC 2000 Analysis of sphingomyelin, glucosylceramide, ceramide, sphingosine, and sphingosine 1-phosphate by tandem mass spectrometry. Methods Enzymol 312:32-45.
-
(2000)
Methods Enzymol
, vol.312
, pp. 32-45
-
-
Sullards, M.C.1
-
107
-
-
33846707882
-
Coregulator exchange and sphingosine-sensitive cooperativity of steroidogenic factor-1, general control nonderepressed 5, p54, and p160 coactivators regulate cyclic adenosine 3',5'-monophosphate-dependent cytochrome P450c17 transcription rate
-
Dammer EB, Leon A, Sewer MB 2007 Coregulator exchange and sphingosine-sensitive cooperativity of steroidogenic factor-1, general control nonderepressed 5, p54, and p160 coactivators regulate cyclic adenosine 3',5'-monophosphate-dependent cytochrome P450c17 transcription rate. Mol Endocrinol 21:415-438.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 415-438
-
-
Dammer, E.B.1
Leon, A.2
Sewer, M.B.3
|