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Volumn 5, Issue 4, 2011, Pages 527-535

Lipids in cystic fibrosis

Author keywords

amitripyline; ceramide; Cftr; cystic fibrosis; Pseudomonas aeruginosa

Indexed keywords

15 KETO PROSTAGLANDIN 2; AMITRIPTYLINE; AMLODIPINE; CERAMIDE; CHLORPROTHIXENE; CYTOKINE; DESIPRAMINE; FLUOXETINE; LIPID; PROSTAGLANDIN; SERTRALINE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; TRIMIPRAMINE; UNCLASSIFIED DRUG;

EID: 80052625342     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/ers.11.36     Document Type: Review
Times cited : (13)

References (108)
  • 3
    • 0026649122 scopus 로고
    • An animal model for cystic fibrosis made by gene targeting
    • Snouwaert JN, Brigman KK, Latour AM et al. An animal model for cystic fibrosis made by gene targeting. Science 257, 1083-1088 (1992).
    • (1992) Science , vol.257 , pp. 1083-1088
    • Snouwaert, J.N.1    Brigman, K.K.2    Latour, A.M.3
  • 5
    • 0026834192 scopus 로고
    • Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells
    • Dorin JR, Dickinson P, Emslie E et al. Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells. Transgenic Res. 1, 101-105 (1992).
    • (1992) Transgenic Res. , vol.1 , pp. 101-105
    • Dorin, J.R.1    Dickinson, P.2    Emslie, E.3
  • 7
    • 0028047688 scopus 로고
    • CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse
    • Gray MA, Winpenny JP, Porteous DJ, Dorin JR, Argent BE. CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse. Am. J. Physiol. 266, C213-C221 (1994).
    • (1994) Am. J. Physiol. , vol.266
    • Gray, M.A.1    Winpenny, J.P.2    Porteous, D.J.3    Dorin, J.R.4    Argent, B.E.5
  • 8
    • 0029153220 scopus 로고
    • Generation and characterization of a delta F508 cystic fibrosis mouse model
    • Colledge WH, Abella BS, Southern KW et al. Generation and characterization of a delta F508 cystic fibrosis mouse model. Nat. Genet. 10, 445-452 (1995).
    • (1995) Nat. Genet. , vol.10 , pp. 445-452
    • Colledge, W.H.1    Abella, B.S.2    Southern, K.W.3
  • 9
    • 0028892299 scopus 로고
    • A mouse model for the delta F508 allele of cystic fibrosis
    • Zeiher BG, Eichwald E, Zabner J et al. A mouse model for the delta F508 allele of cystic fibrosis. J. Clin. Invest. 96, 2051-2064 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 2051-2064
    • Zeiher, B.G.1    Eichwald, E.2    Zabner, J.3
  • 14
    • 1642277855 scopus 로고    scopus 로고
    • Characteristic Multiorgan Pathology of Cystic Fibrosis in a Long-Living Cystic Fibrosis Transmembrane Regulator Knockout Murine Model
    • Durie PR, Kent G, Phillips MJ, Ackerley CA. Characteristic multiorgan pathology of cystic fibrosis in a long-living cystic fibrosis transmembrane regulator knockout murine model. Am. J. Pathol. 164, 1481-1493 (2004). (Pubitemid 38387813)
    • (2004) American Journal of Pathology , vol.164 , Issue.4 , pp. 1481-1493
    • Durie, P.R.1    Kent, G.2    Phillips, M.J.3    Ackerley, C.A.4
  • 15
    • 58049114862 scopus 로고    scopus 로고
    • Generation of a conditional null allele for Cftr in mice
    • Hodges CA, Cotton CU, Palmert MR, Drumm ML. Generation of a conditional null allele for Cftr in mice. Genesis 46, 546-552 (2008).
    • (2008) Genesis , vol.46 , pp. 546-552
    • Hodges, C.A.1    Cotton, C.U.2    Palmert, M.R.3    Drumm, M.L.4
  • 16
    • 77956379893 scopus 로고    scopus 로고
    • Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis
    • Sun X, Sui H, Fisher JT et al. Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. J. Clin. Invest. 120, 3149-3160 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 3149-3160
    • Sun, X.1    Sui, H.2    Fisher, J.T.3
  • 17
    • 78649915334 scopus 로고    scopus 로고
    • Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia
    • Chen J.H, Stoltz, DA, Karp PH et al. Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia. Cell 143, 911-923 (2010).
    • (2010) Cell , vol.143 , pp. 911-923
    • Chen, J.H.1    Stoltz, D.A.2    Karp, P.H.3
  • 18
    • 77749237132 scopus 로고    scopus 로고
    • Pathology of gastrointestinal organs in a porcine model of cystic fibrosis
    • Meyerholz DK, Stoltz DA, Pezzulo AA, Welsh MJ. Pathology of gastrointestinal organs in a porcine model of cystic fibrosis. Am. J. Pathol. 176, 1377-1389 (2010).
    • (2010) Am. J. Pathol. , vol.176 , pp. 1377-1389
    • Meyerholz, D.K.1    Stoltz, D.A.2    Pezzulo, A.A.3    Welsh, M.J.4
  • 19
    • 78349237748 scopus 로고    scopus 로고
    • Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children
    • Meyerholz DK, Stoltz DA, Namati E et al. Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am. J. Respir. Crit. Med. 182, 1251-1261 (2010).
    • (2010) Am. J. Respir. Crit. Med. , vol.182 , pp. 1251-1261
    • Meyerholz, D.K.1    Stoltz, D.A.2    Namati, E.3
  • 20
    • 77952974496 scopus 로고    scopus 로고
    • Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
    • 29ra31
    • Stoltz DA, Meyerhold DK, Pezzulo et al. Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci. Trans. Med. 2, 29ra31 (2010).
    • (2010) Sci. Trans. Med. , vol.2
    • Stoltz, D.A.1    Meyerhold, D.K.2    Pezzulo3
  • 21
    • 33947664101 scopus 로고    scopus 로고
    • Early inflammation in the airways of a cystic fibrosis foetus
    • DOI 10.1016/j.jcf.2006.12.001, PII S1569199306001536
    • Verhaeghe C, Delbecque K, de Leval L, Oury C, Bours V. Early inflammation in the airways of a cystic fibrosis foetus. J. Cyst. Fibros. 6, 304-308 (2007). (Pubitemid 46971896)
    • (2007) Journal of Cystic Fibrosis , vol.6 , Issue.4 , pp. 304-308
    • Verhaeghe, C.1    Delbecque, K.2    De Leval, L.3    Oury, C.4    Bours, V.5
  • 22
    • 0028914085 scopus 로고
    • Early pulmonary inflammation in infants with cystic fibrosis
    • Khan TZ, Wagener JS, Bost T et al. Early pulmonary inflammation in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 151, 1075-1082 (1995).
    • (1995) Am. J. Respir. Crit. Care Med. , vol.151 , pp. 1075-1082
    • Khan, T.Z.1    Wagener, J.S.2    Bost, T.3
  • 25
    • 0028674710 scopus 로고
    • Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium in gland ducts and in recruited neutrophils
    • Inoue H, Massion PP, Ueki IF et al. Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils. Am. J. Respir. Cell Mol. Biol. 11, 651-663 (1994).
    • (1994) Am. J. Respir. Cell Mol. Biol. , vol.11 , pp. 651-663
    • Inoue, H.1    Massion, P.P.2    Ueki, I.F.3
  • 27
    • 0029372481 scopus 로고
    • Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis
    • Bonfield TL, Konstan MW, Burfeind P et al. Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis. Am. J. Respir. Cell Mol. Biol. 13, 257-261 (1995).
    • (1995) Am. J. Respir. Cell Mol. Biol. , vol.13 , pp. 257-261
    • Bonfield, T.L.1    Konstan, M.W.2    Burfeind, P.3
  • 28
    • 0033831270 scopus 로고    scopus 로고
    • Exaggerated activation of nuclear factor-kappaB and altered IkB-b processing in cystic fibrosis bronchial epithelial cells
    • Venkatakrishnan A, Stecenko AA, King G et al. Exaggerated activation of nuclear factor-kappaB and altered IkB-b processing in cystic fibrosis bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 23, 396-403 (2000).
    • (2000) Am. J. Respir. Cell Mol. Biol. , vol.23 , pp. 396-403
    • Venkatakrishnan, A.1    Stecenko, A.A.2    King, G.3
  • 31
    • 0022485439 scopus 로고
    • Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis
    • Goldstein W, Döring G. Lysosomal enzymes from polymorphonuclear leukocytes and protease inhibitors in patients with cystic fibrosis. Am. Rev. Respir. Dis. 134, 49-56 (1986). (Pubitemid 16057459)
    • (1986) American Review of Respiratory Disease , vol.134 , Issue.1 , pp. 49-56
    • Goldstein, W.1    Doring, G.2
  • 34
    • 0037154837 scopus 로고    scopus 로고
    • Extracellular DNA required for bacterial biofilm formation
    • DOI 10.1126/science.295.5559.1487
    • Whitchurch CB, Tolker-Nielsen T, Ragas PC, Mattick JS. Extracellular DNA required for bacterial biofilm formation. Science 295, 1487 (2002). (Pubitemid 34173996)
    • (2002) Science , vol.295 , Issue.5559 , pp. 1487
    • Whitchurch, C.B.1    Tolker-Nielsen, T.2    Ragas, P.C.3    Mattick, J.S.4
  • 35
    • 0036167851 scopus 로고    scopus 로고
    • Reduced oxygen concentrations in airway mucus contribute to the early and late pathogenesis of Pseudomonas aeruginosa CF airways infection
    • Worlitzsch D, Tarran R, Ulrich M et al. Reduced oxygen concentrations in airway mucus contribute to the early and late pathogenesis of Pseudomonas aeruginosa CF airways infection. J. Clin. Invest. 109, 317-325 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 317-325
    • Worlitzsch, D.1    Tarran, R.2    Ulrich, M.3
  • 38
    • 0035877054 scopus 로고    scopus 로고
    • Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract
    • Schroeder TH, Reiniger N, Meluleni G et al. Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract. J. Immunol. 166, 7410-7418 (2001). (Pubitemid 32525618)
    • (2001) Journal of Immunology , vol.166 , Issue.12 , pp. 7410-7418
    • Schroeder, T.H.1    Reiniger, N.2    Meluleni, G.3    Grout, M.4    Coleman, F.T.5    Pier, G.B.6
  • 39
    • 77956296581 scopus 로고    scopus 로고
    • Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation
    • Muenzner P, Bachmann V, Zimmermann W, Hentschel J, Hauck CR. Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation. Science 329, 1197-1201 (2010).
    • (2010) Science , vol.329 , pp. 1197-1201
    • Muenzner, P.1    Bachmann, V.2    Zimmermann, W.3    Hentschel, J.4    Hauck, C.R.5
  • 40
    • 0033761316 scopus 로고    scopus 로고
    • CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa
    • Grassmè H, Kirschnek S, Riethmüeller J et al. CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science 290, 527-530 (2000).
    • (2000) Science , vol.290 , pp. 527-530
    • Grassmè, H.1    Kirschnek, S.2    Riethmüeller, J.3
  • 41
    • 0037408254 scopus 로고    scopus 로고
    • Apoptotic response of Chang cells to infection with Pseudomonas aeruginosa strains PAK and PAO-I: Molecular ordering of the apoptosis signaling cascade and role of type IV pili
    • DOI 10.1128/IAI.71.5.2665-2673.2003
    • Jendrossek V, Fillon S, Belka C et al. Apoptotic response of Chang cells to infection with Pseudomonas aeruginosa strains PAK and PAO-I: molecular ordering of the apoptosis signaling cascade and role of type IV pili. Infect. Immun. 71, 2665-2673 (2003). (Pubitemid 36519882)
    • (2003) Infection and Immunity , vol.71 , Issue.5 , pp. 2665-2673
    • Jendrossek, V.1    Fillon, S.2    Belka, C.3    Muller, I.4    Puttkammer, B.5    Lang, F.6
  • 43
    • 0041701380 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator
    • DOI 10.1165/rcmb.4898
    • Cannon CL, Kowalski MP, Stopak KS, Pier GB. Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator. Am. J. Resp. Cell Mol. Biol. 29, 188-197 (2003). (Pubitemid 36936646)
    • (2003) American Journal of Respiratory Cell and Molecular Biology , vol.29 , Issue.2 , pp. 188-197
    • Cannon, C.L.1    Kowalski, M.P.2    Stopak, K.S.3    Pier, G.B.4
  • 44
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
    • Fadok VA, Bratton DL, Konowal A et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/ paracrine mechanisms involving TGF-β, PGE2, and PAF. J. Clin. Invest. 101, 890-898 (1998). (Pubitemid 28096086)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.4 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 46
    • 57249094345 scopus 로고    scopus 로고
    • Expression levels of FAS are regulated through an evolutionary conserved element in intron 2 which modulates cystic fibrosis disease severity
    • Kumar V, Becker T, Jansen S et al. Expression levels of FAS are regulated through an evolutionary conserved element in intron 2, which modulates cystic fibrosis disease severity. Genes Immun. 9, 689-696 (2008).
    • (2008) Genes Immun. , vol.9 , pp. 689-696
    • Kumar, V.1    Becker, T.2    Jansen, S.3
  • 48
    • 0025784535 scopus 로고
    • Defective acidification of intracellular organelles in cystic fibrosis
    • Barasch J, Kiss B, Prince A et al. Defective acidification of intracellular organelles in cystic fibrosis. Nature 352, 70-73 (1991). (Pubitemid 21896700)
    • (1991) Nature , vol.352 , Issue.6330 , pp. 70-73
    • Barasch, J.1    Kiss, B.2    Prince, A.3    Saiman, L.4    Gruenert, D.5    Al-Awqati, Q.6
  • 49
    • 35748973573 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages
    • DOI 10.1074/jbc.M705296200
    • Haggie PM, Verkman AS. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. J. Biol. Chem. 282, 31422-31428 (2007). (Pubitemid 350044877)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.43 , pp. 31422-31428
    • Haggie, P.M.1    Verkman, A.S.2
  • 51
    • 0033884050 scopus 로고    scopus 로고
    • Compartmentalization of Ceramide Signaling: Physical Foundations and Biological Effects
    • DOI 10.1002/1097-4652(200009)184:3<285::AID-JCP2>3.0.CO;2-3
    • Kolesnick RN, Goni FM, Alonso A. Compartmentalization of ceramide signaling: physical foundations and biological effects. J. Cell Physiol. 184, 285-300 (2000). (Pubitemid 30625491)
    • (2000) Journal of Cellular Physiology , vol.184 , Issue.3 , pp. 285-300
    • Kolesnick, R.N.1    Goni, F.M.2    Alonso, A.3
  • 52
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • DOI 10.1038/42408
    • Simons K, Ikonen E. Functional rafts in cell membranes. Nature 387, 569-572 (1997). (Pubitemid 27248754)
    • (1997) Nature , vol.387 , Issue.6633 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 53
    • 61349094652 scopus 로고    scopus 로고
    • Direct observation of the nanoscale dynamics of membrane lipids in a living cell
    • Eggeling C, Ringemann C, Medda R et al. Direct observation of the nanoscale dynamics of membrane lipids in a living cell. Nature 457, 1159-1162 (2009).
    • (2009) Nature , vol.457 , pp. 1159-1162
    • Eggeling, C.1    Ringemann, C.2    Medda, R.3
  • 54
    • 0035827632 scopus 로고    scopus 로고
    • CD95 signaling via ceramide-rich membrane rafts
    • Grassmè H, Jekle A, Riehle A et al. CD95 signaling via ceramide-rich membrane rafts. J. Biol. Chem. 276, 20589-20596 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 20589-20596
    • Grassmè, H.1    Jekle, A.2    Riehle, A.3
  • 55
    • 0242574357 scopus 로고    scopus 로고
    • Raft ceramide in molecular medicine
    • DOI 10.1038/sj.onc.1207146
    • Gulbins E, Kolesnick R. Raft ceramide in molecular medicine. Oncogene 22, 7070-7077 (2003). (Pubitemid 37386676)
    • (2003) Oncogene , vol.22 , Issue.45 REV. ISS. 5 , pp. 7070-7077
    • Gulbins, E.1    Kolesnick, R.2
  • 57
    • 0034604554 scopus 로고    scopus 로고
    • Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae
    • DOI 10.1016/S0014-5793(00)01851-2, PII S0014579300018512
    • Hauck CR, Grassmè H, Bock J et al. Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae. FEBS Lett. 478, 260-266 (2000). (Pubitemid 30621628)
    • (2000) FEBS Letters , vol.478 , Issue.3 , pp. 260-266
    • Hauck, C.R.1    Grassme, H.2    Bock, J.3    Jendrossek, V.4    Ferlinz, K.5    Meyer, T.F.6    Gulbins, E.7
  • 61
    • 33748664357 scopus 로고    scopus 로고
    • TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis
    • DOI 10.1038/sj.onc.1209568, PII 1209568
    • Dumitru CA, Gulbins E. TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis. Oncogene 25, 5612-5625 (2006). (Pubitemid 44387617)
    • (2006) Oncogene , vol.25 , Issue.41 , pp. 5612-5625
    • Dumitru, C.A.1    Gulbins, E.2
  • 62
    • 4344697840 scopus 로고    scopus 로고
    • Cell surface ceramide generation precedes and controls FcγRII clustering and phosphorylation in rafts
    • DOI 10.1074/jbc.M402170200
    • Abdel Shakor AB, Kwiatkowska K, Sobota A. Cell surface ceramide generation precedes and controls FcgRII clustering and phosphorylation in rafts. J. Biol. Chem. 279, 36778-36787 (2004). (Pubitemid 39129026)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.35 , pp. 36778-36787
    • Shakor, A.B.A.1    Kwiatkowska, K.2    Sobota, A.3
  • 64
    • 22544476850 scopus 로고    scopus 로고
    • Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms
    • DOI 10.1074/jbc.M500835200
    • Grassmè H, Riehle A, Wilker B, Gulbins E. Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms. J. Biol. Chem. 280, 26256-26262 (2005). (Pubitemid 41022223)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.28 , pp. 26256-26262
    • Grassme, H.1    Riehle, A.2    Wilker, B.3    Gulbins, E.4
  • 70
    • 0027428283 scopus 로고
    • Ceramide-activated protein phosphatase: Partial purification and relationship to protein phosphatase 2A
    • Dobrowsky RT, Hannun YA. Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv. Lipid Res. 25, 91-104 (1993).
    • (1993) Adv. Lipid Res. , vol.25 , pp. 91-104
    • Dobrowsky, R.T.1    Hannun, Y.A.2
  • 71
    • 0029003788 scopus 로고
    • PKC zeta is a molecular switch in signal transduction of TNF-α bifunctionally regulated by ceramide and arachidonic acid
    • Muller G, Ayoub M, Storz P et al. PKC zeta is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J. 14, 1961-1969 (1995).
    • (1995) EMBO J. , vol.14 , pp. 1961-1969
    • Muller, G.1    Ayoub, M.2    Storz, P.3
  • 72
    • 0032514649 scopus 로고    scopus 로고
    • Selective ceramide binding to protein kinase C-α and -δ isoenzymes in renal mesangial cells
    • DOI 10.1021/bi981401i
    • Huwiler A, Fabbro D, Pfeilschifter J. Selective ceramide binding to protein kinase C-alpha; and -d isoenzymes in renal mesangial cells. Biochemistry 37, 14556-14562 (1998). (Pubitemid 28489064)
    • (1998) Biochemistry , vol.37 , Issue.41 , pp. 14556-14562
    • Huwiler, A.1    Fabbro, D.2    Pfeilschifter, J.3
  • 75
    • 0033598821 scopus 로고    scopus 로고
    • Stimulation of CD95 Fas blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids
    • USA
    • Lepple-Wienhues A, Belka C, Laun T et al. Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids. Proc. Natl Acad. Sci. USA 96, 13795-13800 (1999).
    • (1999) Proc. Natl Acad. Sci. , vol.96 , pp. 13795-13800
    • Lepple-Wienhues, A.1    Belka, C.2    Laun, T.3
  • 77
    • 79952206109 scopus 로고    scopus 로고
    • Ceramide generation is essential for enhancement of viral uptake in dendretic cells
    • Avota E, Gulbins E, Schneider-Schaulies S. Ceramide generation is essential for enhancement of viral uptake in dendretic cells. PLoS Pathog. 7(2), e1001290 (2011).
    • (2011) PLoS Pathog. , vol.7 , Issue.2
    • Avota, E.1    Gulbins, E.2    Schneider-Schaulies, S.3
  • 78
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • DOI 10.1038/nrm2329, PII NRM2329
    • Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9, 139-150 (2008). (Pubitemid 351158911)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.2 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 81
    • 56149096194 scopus 로고    scopus 로고
    • Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis
    • Zhang Y, Li X, Carpinteiro A, Gulbins E. Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis. J. Immunol. 181, 4247-4254 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 4247-4254
    • Zhang, Y.1    Li, X.2    Carpinteiro, A.3    Gulbins, E.4
  • 82
    • 79952454531 scopus 로고    scopus 로고
    • Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections
    • Zhang Y, Li X, Carpinteiro A et al. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat. Med. 17(3), 341-346 (2011).
    • (2011) Nat. Med. , vol.17 , Issue.3 , pp. 341-346
    • Zhang, Y.1    Li, X.2    Carpinteiro, A.3
  • 83
    • 67249133362 scopus 로고    scopus 로고
    • Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis
    • Yu H, Zeidan YH, Wu BX et al. Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. Am. J. Respir. Cell Mol. Biol. 41, 367-375 (2009).
    • (2009) Am. J. Respir. Cell Mol. Biol. , vol.41 , pp. 367-375
    • Yu, H.1    Zeidan, Y.H.2    Wu, B.X.3
  • 84
    • 78650052094 scopus 로고    scopus 로고
    • Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function
    • Perrotta C, Bizzozero L, Cazzato D et al. Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function. J. Biol. Chem. 285, 40240-40251 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 40240-40251
    • Perrotta, C.1    Bizzozero, L.2    Cazzato, D.3
  • 85
    • 78751622827 scopus 로고    scopus 로고
    • Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes
    • Edelmann B, Bertsch U, Tchikov V et al. Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes. EMBO J. 30, 379-394 (2011).
    • (2011) EMBO J. , vol.30 , pp. 379-394
    • Edelmann, B.1    Bertsch, U.2    Tchikov, V.3
  • 87
    • 34250315352 scopus 로고    scopus 로고
    • Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells
    • Zhang AY, Yi F, Jin S et al. Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells. Antioxid. Redox Signal. 9, 817-828 (2007).
    • (2007) Antioxid. Redox Signal. , vol.9 , pp. 817-828
    • Zhang, A.Y.1    Yi, F.2    Jin, S.3
  • 89
    • 0346103721 scopus 로고    scopus 로고
    • Localization of Cystic Fibrosis Transmembrane Conductance Regulator to Lipid Rafts of Epithelial Cells Is Required for Pseudomonas aeruginosa-Induced Cellular Activation
    • Kowalski MP, Pier GB. Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation. J. Immunol. 172, 418-425 (2004). (Pubitemid 38020496)
    • (2004) Journal of Immunology , vol.172 , Issue.1 , pp. 418-425
    • Kowalski, M.P.1    Pier, G.B.2
  • 91
    • 14244264008 scopus 로고    scopus 로고
    • Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2
    • DOI 10.1074/jbc.M411702200
    • Zaas DW, Duncan MJ, Li G, Wright JR, Abraham SN. Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. J. Biol. Chem. 280, 4864-4872 (2005). (Pubitemid 40288660)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.6 , pp. 4864-4872
    • Zaas, D.W.1    Duncan, M.J.2    Li, G.3    Wright, J.R.4    Abraham, S.N.5
  • 92
    • 68849110377 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa
    • Bajmoczi M, Gadjeva M, Alper SL, Pier GB, Golan DE. Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa. Am. J. Physiol. Cell Physiol. 297, C263-C277 (2009).
    • (2009) Am. J. Physiol. Cell Physiol. , vol.297
    • Bajmoczi, M.1    Gadjeva, M.2    Alper, S.L.3    Pier, G.B.4    Golan, D.E.5
  • 93
    • 77951668726 scopus 로고    scopus 로고
    • Caveolae caveolins and cavins: Complex control of cellular signalling and inflammation
    • Chidlow JH Jr, Sessa WC. Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation. Cardiovasc. Res. 86, 219-225 (2010).
    • (2010) Cardiovasc. Res. , vol.86 , pp. 219-225
    • Chidlow, Jr.J.H.1    Sessa, W.C.2
  • 94
    • 77953251984 scopus 로고    scopus 로고
    • Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis
    • Becker KA, Riethmuller J, Luth A et al. Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis. Am. J. Respir. Cell Mol. Biol. 42, 716-724 (2010).
    • (2010) Am. J. Respir. Cell Mol. Biol. , vol.42 , pp. 716-724
    • Becker, K.A.1    Riethmuller, J.2    Luth, A.3
  • 95
    • 78650177234 scopus 로고    scopus 로고
    • Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death
    • Becker KA, Tummler B, Gulbins E, Grassmè H. Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death. Biochem. Biophys. Res. Commun. 403, 368-374 (2010).
    • (2010) Biochem. Biophys. Res. Commun. , vol.403 , pp. 368-374
    • Becker, K.A.1    Tummler, B.2    Gulbins, E.3    Grassmè, H.4
  • 96
  • 97
    • 77954504913 scopus 로고    scopus 로고
    • Alterations in ceramide concentration and pH determine the release of reactive oxygen species by Cftr-deficient macrophages on infection
    • Zhang Y, Li X, Grassmè H, Doring G, Gulbins E. Alterations in ceramide concentration and pH determine the release of reactive oxygen species by Cftr-deficient macrophages on infection. J. Immunol. 184, 5104-5111 (2009).
    • (2009) J. Immunol. , vol.184 , pp. 5104-5111
    • Zhang, Y.1    Li, X.2    Grassmè, H.3    Doring, G.4    Gulbins, E.5
  • 98
    • 77956641729 scopus 로고    scopus 로고
    • Ceramide is increased in the lower airway epithelium of people with advanced cystic fibrosis lung disease
    • Brodlie M, McKean MC, Johnson GE et al. Ceramide is increased in the lower airway epithelium of people with advanced cystic fibrosis lung disease. Am. J. Respir. Crit. Care Med. 182, 369-375 (2010).
    • (2010) Am. J. Respir. Crit. Care Med. , vol.182 , pp. 369-375
    • Brodlie, M.1    McKean, M.C.2    Johnson, G.E.3
  • 99
    • 79251588056 scopus 로고    scopus 로고
    • Critical modifier role of membrane-cystic fibrosis transmembrane conductance regulator-dependent ceramide signaling in lung injury and emphysema
    • Bodas M, Min T, Mazur S, Vij N. Critical modifier role of membrane-cystic fibrosis transmembrane conductance regulator-dependent ceramide signaling in lung injury and emphysema. J. Immunol. 186, 602-613 (2010).
    • (2010) J. Immunol. , vol.186 , pp. 602-613
    • Bodas, M.1    Min, T.2    Mazur, S.3    Vij, N.4
  • 103
    • 77749246086 scopus 로고    scopus 로고
    • Pharmacological correction of a defect in ppar-gamma signaling ameliorates disease severity in Cftr-deficient mice
    • Harmon GS, Dumlao DS, Ng DT et al. Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nat. Med. 16, 313-318 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 313-318
    • Harmon, G.S.1    Dumlao, D.S.2    Ng, D.T.3
  • 105
    • 38349158920 scopus 로고    scopus 로고
    • Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model
    • Kornhuber J, Tripal P, Reichel M et al. Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. J. Med. Chem. 51, 219-237 (2008).
    • (2008) J. Med. Chem. , vol.51 , pp. 219-237
    • Kornhuber, J.1    Tripal, P.2    Reichel, M.3
  • 106
    • 0028468309 scopus 로고
    • The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts
    • Hurwitz R, Ferlinz K, Sandhoff K. The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts. Biol. Chem. Hoppe Seyler 375, 447-450 (1994). (Pubitemid 2120332)
    • (1994) Biological Chemistry Hoppe-Seyler , vol.375 , Issue.7 , pp. 447-450
    • Hurwitz, R.1    Ferlinz, K.2    Sandhoff, K.3
  • 107
    • 70349995082 scopus 로고    scopus 로고
    • Potent and selective inhibition of acid sphingomyelinase by bisphosphonates
    • Roth AG, Drescher D, Yang Y et al. Potent and selective inhibition of acid sphingomyelinase by bisphosphonates. Angew Chem. Int. Ed. Engl. 48, 7560-7563 (2009).
    • (2009) Angew Chem. Int. Ed. Engl. , vol.48 , pp. 7560-7563
    • Roth, A.G.1    Drescher, D.2    Yang, Y.3
  • 108
    • 67650429993 scopus 로고    scopus 로고
    • Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis
    • Riethmuller J, Anthonysamy J, Serra E et al. Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis. Cell Physiol. Biochem. 24, 65-72 (2009).
    • (2009) CellPhysiol. Biochem. , vol.24 , pp. 65-72
    • Riethmuller, J.1    Anthonysamy, J.2    Serra, E.3


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