Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids

Journal of Biological Chemistry

Volumn 281, Issue 11, 2006, Pages 7324-7331

  Kono, Mari ^a   Dreier, Jennifer L ^a   Ellis, Jessica M ^a   Allende, Maria L ^a   Kalkofen, Danielle N ^a   Sanders, Kathleen M ^a   Bielawski, Jacek ^b   Bielawska, Alicja ^b   Hannun, Yusuf A ^b   Proia, Richard L ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; CELL MEMBRANES; ENZYME KINETICS; LIPIDS; METABOLITES; PHOSPHATES;

CERAMIDASE; CERAMIDE; KINASE; MAMMALS;

GENETIC ENGINEERING;

ACYLSPHINGOSINE DEACYLASE; SPHINGOLIPID; AMIDASE; CERAMIDE; DRUG DERIVATIVE; LYSOPHOSPHOLIPID; NEUTRAL CERAMIDASE 2, MOUSE; PHOSPHOTRANSFERASE; SPHINGOMYELIN; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE;

ARTICLE; ASAH2 GENE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME DEGRADATION; GENE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SMALL INTESTINE; ALLELE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL MEMBRANE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GENE VECTOR; GENETICS; HETEROZYGOTE; INTESTINE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; NORTHERN BLOTTING; PHOSPHORYLATION; PHYSIOLOGY; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME; TISSUE DISTRIBUTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

EUKARYOTA; MAMMALIA;

ALLELES; AMIDOHYDROLASES; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL MEMBRANE; CERAMIDES; CHROMATOGRAPHY, LIQUID; GENETIC VECTORS; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; INTESTINE, SMALL; INTESTINES; LYSOPHOSPHOLIPIDS; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MODELS, GENETIC; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPHINGOLIPIDS; SPHINGOMYELINS; SPHINGOSINE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 33646154333     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M508382200     Document Type: Article

References (43)

1. Futerman, A. H., and Hannun, Y. A. (2004) EMBO Rep. 5, 777-782
2. Smith, W. L., and Merrill, A. H., Jr. (2002) J. Biol. Chem. 277, 25841-25842
3. Koch, J., Gartner, S., Li, C. M., Quintern, L. E., Bernardo, K., Levran, O., Schnabel, D., Desnick, R. J., Schuchman, E. H., and Sandhoff, K. (1996) J. Biol. Chem. 271, 33110-33115
4. Li, C. M., Park, J. H., He, X., Levy, B., Chen, F., Arai, K., Adler, D. A., Disteche, C. M., Koch, J., Sandhoff, K., and Schuchman, E. H. (1999) Genomics 62, 223-231
5. Li, C. M., Hong, S. B., Kopal, G., He, X., Linke, T., Hou, W. S., Koch, J., Gatt, S., Sandhoff, K., and Schuchman, E. H. (1998) Genomics 50, 267-274
6. Moser, H. W., Linke, T., Fensom, A. H., Levade, T., and Sandhoff, K. (2001) The Metabolic & Molecular Bases of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D., eds) Vol. 3, 8th Ed., pp. 3573-3588, McGraw-Hill Medical, New York
7. Mao, C., Xu, R., Szulc, Z. M., Bielawski, J., Becker, K. P., Bielawska, A., Galadari, S. H., Hu, W., and Obeid, L. M. (2003) J. Biol. Chem. 278, 31184-31191
8. Mao, C., Xu, R., Szulc, Z. M., Bielawska, A., Galadari, S. H., and Obeid, L. M. (2001) J. Biol. Chem. 276, 26577-26588
9. Tani, M., Okino, N., Mori, K., Tanigawa, T., Izu, H., and Ito, M. (2000) J. Biol. Chem. 275, 11229-11234
10. Okino, N., Mori, K., and Ito, M. (2002) Biochem. Biophys. Res. Commun. 299, 160-166
11. Choi, M. S., Anderson, M. A., Zhang, Z., Zimonjic, D. B., Popescu, N., and Mukherjee, A. B. (2003) Gene (Amst.) 315, 113-122
12. El Bawab, S., Roddy, P., Qian, T., Bielawska, A., Lemasters, J. J., and Hannun, Y. A. (2000) J. Biol. Chem. 275, 21508-21513
13. Mitsutake, S., Tani, M., Okino, N., Mori, K., Ichinose, S., Omori, A., Iida, H., Nakamura, T., and Ito, M. (2001) J. Biol. Chem. 276, 26249-26259
14. Yoshimura, Y., Tani, M., Okino, N., Iida, H., and Ito, M. (2004) J. Biol. Chem. 279, 44012-44022
15. Yoshimura, Y., Okino, N., Tani, M., and Ito, M. (2002) J. Biochem. (Tokyo) 132, 229-236
16. Okino, N., Ichinose, S., Omori, A., Imayama, S., Nakamura, T., and Ito, M. (1999) J. Biol. Chem. 274, 36616-36622
17. Tani, M., Iida, H., and Ito, M. (2003) J. Biol. Chem. 278, 10523-10530
18. Lundgren, P., Nilsson, A., and Duan, R. D. (2001) Dig. Dis. Sci. 46, 765-772
19. Schmelz, E. M. (2004) Front. Biosci. 9, 2632-2639
20. Dillehay, D. L., Webb, S. K., Schmelz, E. M., and Merrill, A. H., Jr. (1994) J. Nutr. 124, 615-620
21. Schmelz, E. M., Dillehay, D. L., Webb, S. K., Reiter, A., Adams, J., and Merrill, A. H., Jr. (1996) Cancer Res. 56, 4936-4941
22. Schmelz, E. M., Sullards, M. C., Dillehay, D. L., and Merrill, A. H., Jr. (2000) J. Nutr. 130, 522-527
23. Schmelz, E. M., Roberts, P. C., Kustin, E. M., Lemonnier, L. A., Sullards, M. C., Dillehay, D. L., and Merrill, A. H., Jr. (2001) Cancer Res. 61, 6723-6729
24. Symolon, H., Schmelz, E. M., Dillehay, D. L., and Merrill, A. H., Jr. (2004) J. Nutr. 134, 1157-1161
25. Nehls, M., Kyewski, B., Messerle, M., Waldschutz, R., Schuddekopf, K., Smith, A. J., and Boehm, T. (1996) Science 272, 886-889
26. Liu, Y., Wada, R., Kawai, H., Sango, K., Deng, C., Tai, T., McDonald, M. P., Araujo, K., Crawley, J. N., Bierfreund, U., Sandhoff, K., Suzuki, K., and Proia, R. L. (1999) J. Clin. Investig. 103, 497-505
27. Sweetser, D. A., Birkenmeier, E. H., Hoppe, P. C., McKeel, D. W., and Gordon, J. I. (1988) Genes Dev. 2, 1318-1332
28. Wada, R., Tifft, C. J., and Proia, R. L. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10954-10959
29. Tani, M., Okino, N., Mitsutake, S., Tanigawa, T., Izu, H., and Ito, M. (2000) J. Biol. Chem. 275, 3462-3468
30. Bielawski, J., Szulc, Z. M., Hannun, Y. A., and Bielawska, A. (2006) Methods, in press
31. Sullards, M. C., and Merrill, A. H., Jr. (2001) Sci. STKE 2001, 67/PL1
32. Duan, R. D., Bergman, T., Xu, N., Wu, J., Cheng, Y., Duan, J., Nelander, S., Palmberg, C., and Nilsson, A. (2003) J. Biol. Chem. 278, 38528-38536
33. Li, C. M., Park, J. H., Simonaro, C. M., He, X., Gordon, R. E., Friedman, A. H., Ehleiter, D., Paris, F., Manova, K., Hepbildikler, S., Fuks, Z., Sandhoff, K., Kolesnick, R., and Schuchman, E. H. (2002) Genomics 79, 218-224
34. Duan, R. D., Nyberg, L., and Nilsson, A. (1995) Biochim. Biophys. Acta 1259, 49-55
35. Duan, R. D., Hertervig, E., Nyberg, L., Hauge, T., Sternby, B., Lillienau, J., Farooqi, A., and Nilsson, A. (1996) Dig. Dis. Sci. 41, 1801-1806
36. Nilsson, A., and Duan, R. D. (1999) Chem. Phys. Lipids 102, 97-105
37. Kirby, R. J., Zheng, S., Tso, P., Howles, P. N., and Hui, D. Y. (2002) J. Biol. Chem. 277, 4104-4109
38. Vesper, H., Schmelz, E. M., Nikolova-Karakashian, M. N., Dillehay, D. L., Lynch, D. V., and Merrill, A. H., Jr. (1999) J. Nutr. 129, 1239-1250
39. Nilsson, A. (1968) Biochim. Biophys. Acta 164, 575-584
40. Nilsson, A. (1969) Biochim. Biophys. Acta 187, 113-121
41. Schmelz, E. M., Crall, K. J., Larocque, R., Dillehay, D. L., and Merrill, A. H., Jr. (1994) J. Nutr. 124, 702-712
42. Olivera, A., and Spiegel, S. (2001) Prostaglandins 64, 123-134
43. Liu, H., Chakravarty, D., Maceyka, M., Milstien, S., and Spiegel, S. (2002) Prog. Nucleic Acids Res. Mol. Biol. 71, 493-511