Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 24754-24764

  Rahmaniyan, Mehrdad ^a   Curley Jr , Robert W ^b   Obeid, Lina M ^a,c   Hannun, Yusuf A ^a   Kraveka, Jacqueline M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPARENT K; CERAMIDES; COFACTORS; DESATURATION; DIHYDROCERAMIDE DESATURASE; DOSE-DEPENDENT MANNER; IN-VITRO; INCUBATION TIME; INHIBITORY EFFECT; MINIMAL EFFECTS; NEUROBLASTOMA CELLS; RAT LIVER MICROSOMES; SPHINGOLIPIDS; SUBSTRATE CONCENTRATIONS; THERAPEUTIC INTERVENTION; TRITIATED WATER;

ENZYMES; METABOLISM; METABOLITES;

AMIDES;

4 OXO N (4 HYDROXYPHENYL)RETINAMIDE; 4 OXO N (4 METHOXYPHENYL)RETINAMIDE; C8 CYCLOPROPENYLCERAMIDE; CERAMIDE; CERAMIDE DERIVATIVE; DIHYDROCERAMIDE DESATURASE; DRUG METABOLITE; ENZYME; FENRETINIDE; N (4 METHOXYPHENYL)RETINAMIDE; N C8:0 DEXTRO ERYTHRO DIHYDROCERAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRITIUM OXIDE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; FATTY ACID DESATURATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INCUBATION TIME; LIVER MICROSOME; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; FENRETINIDE; MICROSOMES, LIVER; OXIDOREDUCTASES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

RATTUS;

EID: 79960127276     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.250779     Document Type: Article

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