Neuronal voltage-gated calcium channels: Structure, function, and dysfunction

Neuron

Volumn 82, Issue 1, 2014, Pages 24-45

  Simms, Brett A ^a   Zamponi, Gerald W ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PROTEIN CAV1.1; PROTEIN CAV1.2; PROTEIN CAV1.3; PROTEIN CAV1.4; PROTEIN CAV2.1; PROTEIN CAV2.2; PROTEIN CAV2.3; PROTEIN CAV3.1; PROTEIN CAV3.2; PROTEIN CAV3.3; PROTEIN CAVALPHA1; PROTEIN CAVALPHA2DELTA1; PROTEIN CAVALPHA2DELTA4; PROTEIN CAVBETA1; PROTEIN CAVBETA4; SNARE PROTEIN; SNX 482; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ACTION POTENTIAL; AUTISM; BRAIN DEPTH STIMULATION; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; HUMAN; HYPOKALEMIC PERIODIC PARALYSIS; MEMORY DISORDER; MENTAL DEFICIENCY; MUSCLE WEAKNESS; MUTATIONAL ANALYSIS; MYOCLONUS EPILEPSY; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVOUS SYSTEM FUNCTION; NEUROMODULATION; NEURONAL FIRING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SUBUNIT; REVIEW; SEIZURE; SPINOCEREBELLAR DEGENERATION; SYNAPTIC TRANSMISSION; TRANSCRIPTION REGULATION;

ANIMALS; BRAIN DISEASES; CALCIUM CHANNELS; HUMANS; NEURONS;

EID: 84897470727     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.03.016     Document Type: Review

References (337)

1. Adams M.E., Myers R.A., Imperial J.S., Olivera B.M. Toxityping rat brain calcium channels with omega-toxins from spider and cone snail venoms. Biochemistry 1993, 32:12566-12570.
2. Adams P.J., Garcia E., David L.S., Mulatz K.J., Spacey S.D., Snutch T.P. Ca(V)2.1 P/Q-type calcium channel alternative splicing affects the functional impact of familial hemiplegic migraine mutations: implications for calcium channelopathies. Channels (Austin) 2009, 3:110-121.
3. Altier C., Garcia-Caballero A., Simms B., You H., Chen L., Walcher J., Tedford H.W., Hermosilla T., Zamponi G.W. The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels. Nat. Neurosci. 2011, 14:173-180.
4. Alviña K., Ellis-Davies G., Khodakhah K. T-type calcium channels mediate rebound firing in intact deep cerebellar neurons. Neuroscience 2009, 158:635-641.
5. Anderson M.P., Mochizuki T., Xie J., Fischler W., Manger J.P., Talley E.M., Scammell T.E., Tonegawa S. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc. Natl. Acad. Sci. USA 2005, 102:1743-1748.
6. Anderson D., Mehaffey W.H., Iftinca M., Rehak R., Engbers J.D., Hameed S., Zamponi G.W., Turner R.W. Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes. Nat. Neurosci. 2010, 13:333-337.
7. Anderson D., Rehak R., Hameed S., Mehaffey W.H., Zamponi G.W., Turner R.W. Regulation of the KV4.2 complex by CaV3.1 calcium channels. Channels (Austin) 2010, 4:163-167.
8. Anderson D., Engbers J.D., Heath N.C., Bartoletti T.M., Mehaffey W.H., Zamponi G.W., Turner R.W. The Cav3-Kv4 complex acts as a calcium sensor to maintain inhibitory charge transfer during extracellular calcium fluctuations. J. Neurosci. 2013, 33:7811-7824.
9. Arikkath J., Campbell K.P. Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr. Opin. Neurobiol. 2003, 13:298-307.
10. Armstrong C.M., Matteson D.R. Two distinct populations of calcium channels in a clonal line of pituitary cells. Science 1985, 227:65-67.
11. Astori S., Wimmer R.D., Prosser H.M., Corti C., Corsi M., Liaudet N., Volterra A., Franken P., Adelman J.P., Lüthi A. The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus. Proc. Natl. Acad. Sci. USA 2011, 108:13823-13828.
12. Bader P.L., Faizi M., Kim L.H., Owen S.F., Tadross M.R., Alfa R.W., Bett G.C., Tsien R.W., Rasmusson R.L., Shamloo M. Mouse model of Timothy syndrome recapitulates triad of autistic traits. Proc. Natl. Acad. Sci. USA 2011, 108:15432-15437.
13. Bading H., Ginty D.D., Greenberg M.E. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 1993, 260:181-186.
14. Baig S.M., Koschak A., Lieb A., Gebhart M., Dafinger C., Nürnberg G., Ali A., Ahmad I., Sinnegger-Brauns M.J., Brandt N., et al. Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness. Nat. Neurosci. 2011, 14:77-84.
15. Ball S.L., Powers P.A., Shin H.S., Morgans C.W., Peachey N.S., Gregg R.G. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest. Ophthalmol. Vis. Sci. 2002, 43:1595-1603.
16. Barclay J., Balaguero N., Mione M., Ackerman S.L., Letts V.A., Brodbeck J., Canti C., Meir A., Page K.M., Kusumi K., et al. Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J. Neurosci. 2001, 21:6095-6104.
17. Barrett C.F., Tsien R.W. The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels. Proc. Natl. Acad. Sci. USA 2008, 105:2157-2162.
18. Bats C., Groc L., Choquet D. The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking. Neuron 2007, 53:719-734.
19. Bazzazi H., Ben Johny M., Adams P.J., Soong T.W., Yue D.T. Continuously tunable Ca(2+) regulation of RNA-edited CaV1.3 channels. Cell Rep. 2013, 5:367-377.
20. Bean B.P. Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology. J. Gen. Physiol. 1985, 86:1-30.
21. Bech-Hansen N.T., Naylor M.J., Maybaum T.A., Pearce W.G., Koop B., Fishman G.A., Mets M., Musarella M.A., Boycott K.M. Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness. Nat. Genet. 1998, 19:264-267.
22. Belardetti F., Zamponi G.W. Calcium channels as therapeutic targets. Wiley Interdiscip. Rev. Membr. Transp. Signal. 2012, 1:433-451.
23. Ben Johny M., Yang P.S., Bazzazi H., Yue D.T. Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels. Nat. Commun. 2013, 4:1717.
24. Berggren P.O., Yang S.N., Murakami M., Efanov A.M., Uhles S., Köhler M., Moede T., Fernström A., Appelskog I.B., Aspinwall C.A., et al. Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis. Cell 2004, 119:273-284.
25. Berjukow S., Marksteiner R., Gapp F., Sinnegger M.J., Hering S. Molecular mechanism of calcium channel block by isradipine. Role of a drug-induced inactivated channel conformation. J. Biol. Chem. 2000, 275:22114-22120.
26. Berkefeld H., Fakler B. Repolarizing responses of BKCa-Cav complexes are distinctly shaped by their Cav subunits. J. Neurosci. 2008, 28:8238-8245.
27. Berkefeld H., Sailer C.A., Bildl W., Rohde V., Thumfart J.O., Eble S., Klugbauer N., Reisinger E., Bischofberger J., Oliver D., et al. BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Science 2006, 314:615-620.
28. Berrou L., Bernatchez G., Parent L. Molecular determinants of inactivation within the I-II linker of alpha1E (CaV2.3) calcium channels. Biophys. J. 2001, 80:215-228.
29. Beuckmann C.T., Sinton C.M., Miyamoto N., Ino M., Yanagisawa M. N-type calcium channel alpha1B subunit (Cav2.2) knock-out mice display hyperactivity and vigilance state differences. J. Neurosci. 2003, 23:6793-6797.
30. Bezprozvanny I., Scheller R.H., Tsien R.W. Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature 1995, 378:623-626.
31. Bichet D., Cornet V., Geib S., Carlier E., Volsen S., Hoshi T., Mori Y., De Waard M. The I-II loop of the Ca2+ channel alpha1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit. Neuron 2000, 25:177-190.
32. Bourinet E., Zamponi G.W., Stea A., Soong T.W., Lewis B.A., Jones L.P., Yue D.T., Snutch T.P. The alpha 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels. J. Neurosci. 1996, 16:4983-4993.
33. Bourinet E., Soong T.W., Sutton K., Slaymaker S., Mathews E., Monteil A., Zamponi G.W., Nargeot J., Snutch T.P. Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat. Neurosci. 1999, 2:407-415.
34. Bourinet E., Stotz S.C., Spaetgens R.L., Dayanithi G., Lemos J., Nargeot J., Zamponi G.W. Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels. Biophys. J. 2001, 81:79-88.
35. Brice N.L., Dolphin A.C. Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line. J. Physiol. 1999, 515:685-694.
36. Brodbeck J., Davies A., Courtney J.M., Meir A., Balaguero N., Canti C., Moss F.J., Page K.M., Pratt W.S., Hunt S.P., et al. The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function. J. Biol. Chem. 2002, 277:7684-7693.
37. Buraei Z., Yang J. The ß subunit of voltage-gated Ca2+ channels. Physiol. Rev. 2010, 90:1461-1506.
38. Burgess D.L., Jones J.M., Meisler M.H., Noebels J.L. Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell 1997, 88:385-392.
39. Burgess D.L., Biddlecome G.H., McDonough S.I., Diaz M.E., Zilinski C.A., Bean B.P., Campbell K.P., Noebels J.L. beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol. Cell. Neurosci. 1999, 13:293-311.
40. Busquet P., Nguyen N.K., Schmid E., Tanimoto N., Seeliger M.W., Ben-Yosef T., Mizuno F., Akopian A., Striessnig J., Singewald N. CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype. Int. J. Neuropsychopharmacol. 2010, 13:499-513.
41. Cain S.M., Snutch T.P. Voltage-gated calcium channels and disease. Biofactors 2011, 37:197-205.
42. Cantí C., Nieto-Rostro M., Foucault I., Heblich F., Wratten J., Richards M.W., Hendrich J., Douglas L., Page K.M., Davies A., Dolphin A.C. The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels. Proc. Natl. Acad. Sci. USA 2005, 102:11230-11235.
43. Carabelli V., Marcantoni A., Comunanza V., Carbone E. Fast exocytosis mediated by T- and L-type channels in chromaffin cells: distinct voltage-dependence but similar Ca2+ -dependence. Eur. Biophys. J. 2007, 36:753-762.
44. Carbone E., Marcantoni A., Giancippoli A., Guido D., Carabelli V. T-type channels-secretion coupling: evidence for a fast low-threshold exocytosis. Pflugers Arch. 2006, 453:373-383.
45. Catterall W.A. Ion channel voltage sensors: structure, function, and pathophysiology. Neuron 2010, 67:915-928.
46. Catterall W.A., Perez-Reyes E., Snutch T.P., Striessnig J. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol. Rev. 2005, 57:411-425.
47. Chan C.S., Guzman J.N., Ilijic E., Mercer J.N., Rick C., Tkatch T., Meredith G.E., Surmeier D.J. 'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature 2007, 447:1081-1086.
48. Chang K.T., Berg D.K. Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons. Neuron 2001, 32:855-865.
49. Chang B., Heckenlively J.R., Bayley P.R., Brecha N.C., Davisson M.T., Hawes N.L., Hirano A.A., Hurd R.E., Ikeda A., Johnson B.A., et al. The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses. Vis. Neurosci. 2006, 23:11-24.
50. Chaudhuri D., Chang S.Y., DeMaria C.D., Alvania R.S., Soong T.W., Yue D.T. Alternative splicing as a molecular switch for Ca2+/calmodulin-dependent facilitation of P/Q-type Ca2+ channels. J. Neurosci. 2004, 24:6334-6342.
51. Chaudhuri D., Issa J.B., Yue D.T. Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels. J. Gen. Physiol. 2007, 129:385-401.
52. Chen C.C., Lamping K.G., Nuno D.W., Barresi R., Prouty S.J., Lavoie J.L., Cribbs L.L., England S.K., Sigmund C.D., Weiss R.M., et al. Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science 2003, 302:1416-1418.
53. Chen Y.H., Li M.H., Zhang Y., He L.L., Yamada Y., Fitzmaurice A., Shen Y., Zhang H., Tong L., Yang J. Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Nature 2004, 429:675-680.
54. Chen R.S., Deng T.C., Garcia T., Sellers Z.M., Best P.M. Calcium channel gamma subunits: a functionally diverse protein family. Cell Biochem. Biophys. 2007, 47:178-186.
55. Choi S., Na H.S., Kim J., Lee J., Lee S., Kim D., Park J., Chen C.C., Campbell K.P., Shin H.S. Attenuated pain responses in mice lacking Ca(V)3.2 T-type channels. Genes Brain Behav. 2007, 6:425-431.
56. Chu P.J., Robertson H.M., Best P.M. Calcium channel gamma subunits provide insights into the evolution of this gene family. Gene 2001, 280:37-48.
57. Clapham D.E. Calcium signaling. Cell 2007, 131:1047-1058.
58. Coulter D.A., Huguenard J.R., Prince D.A. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann. Neurol. 1989, 25:582-593.
59. Cribbs L.L., Lee J.H., Yang J., Satin J., Zhang Y., Daud A., Barclay J., Williamson M.P., Fox M., Rees M., Perez-Reyes E. Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circ. Res. 1998, 83:103-109.
60. Cueni L., Canepari M., Luján R., Emmenegger Y., Watanabe M., Bond C.T., Franken P., Adelman J.P., Lüthi A. T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. Nat. Neurosci. 2008, 11:683-692.
61. Curtis B.M., Catterall W.A. Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules. Biochemistry 1984, 23:2113-2118.
62. Dai S., Hall D.D., Hell J.W. Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol. Rev. 2009, 89:411-452.
63. Dao D.T., Mahon P.B., Cai X., Kovacsics C.E., Blackwell R.A., Arad M., Shi J., Zandi P.P., O'Donnell P., Knowles J.A., et al. Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. Biol. Psychiatry 2010, 68:801-810. Bipolar Genome Study (BiGS) Consortium.
64. Davies A., Kadurin I., Alvarez-Laviada A., Douglas L., Nieto-Rostro M., Bauer C.S., Pratt W.S., Dolphin A.C. The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc. Natl. Acad. Sci. USA 2010, 107:1654-1659.
65. Davies J.N., Jarvis S.E., Zamponi G.W. Bipartite syntaxin 1A interactions mediate CaV2.2 calcium channel regulation. Biochem. Biophys. Res. Commun. 2011, 411:562-568.
66. Deisseroth K., Heist E.K., Tsien R.W. Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature 1998, 392:198-202.
67. DeMaria C.D., Soong T.W., Alseikhan B.A., Alvania R.S., Yue D.T. Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels. Nature 2001, 411:484-489.
68. Depil K., Beyl S., Stary-Weinzinger A., Hohaus A., Timin E., Hering S. Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein. J. Biol. Chem. 2011, 286:31557-31564.
69. Destexhe A., Neubig M., Ulrich D., Huguenard J. Dendritic low-threshold calcium currents in thalamic relay cells. J. Neurosci. 1998, 18:3574-3588.
70. Dick I.E., Tadross M.R., Liang H., Tay L.H., Yang W., Yue D.T. A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels. Nature 2008, 451:830-834.
71. Doering C.J., Zamponi G.W. Molecular pharmacology of non-L-type calcium channels. Curr. Pharm. Des. 2005, 11:1887-1898.
72. Doering C.J., Hamid J., Simms B., McRory J.E., Zamponi G.W. Cav1.4 encodes a calcium channel with low open probability and unitary conductance. Biophys. J. 2005, 89:3042-3048.
73. Dolmetsch R.E., Pajvani U., Fife K., Spotts J.M., Greenberg M.E. Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science 2001, 294:333-339.
74. Dolphin A.C. The α2δ subunits of voltage-gated calcium channels. Biochim. Biophys. Acta 2013, 1828:1541-1549.
75. Dubel S.J., Starr T.V., Hell J., Ahlijanian M.K., Enyeart J.J., Catterall W.A., Snutch T.P. Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel. Proc. Natl. Acad. Sci. USA 1992, 89:5058-5062.
76. Eckle V.S., Shcheglovitov A., Vitko I., Dey D., Yap C.C., Winckler B., Perez-Reyes E. Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility. J. Physiol. 2014, 592:795-809.
77. Egger V., Svoboda K., Mainen Z.F. Mechanisms of lateral inhibition in the olfactory bulb: efficiency and modulation of spike-evoked calcium influx into granule cells. J. Neurosci. 2003, 23:7551-7558.
78. Eickelberg O., Roth M., Mussmann R., Rüdiger J.J., Tamm M., Perruchoud A.P., Block L.H. Calcium channel blockers activate the interleukin-6 gene via the transcription factors NF-IL6 and NF-kappaB in primary human vascular smooth muscle cells. Circulation 1999, 99:2276-2282.
79. Ellinor P.T., Yang J., Sather W.A., Zhang J.F., Tsien R.W. Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions. Neuron 1995, 15:1121-1132.
80. Engbers J.D., Anderson D., Asmara H., Rehak R., Mehaffey W.H., Hameed S., McKay B.E., Kruskic M., Zamponi G.W., Turner R.W. Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. Proc. Natl. Acad. Sci. USA 2012, 109:2601-2606.
81. Erickson M.G., Alseikhan B.A., Peterson B.Z., Yue D.T. Preassociation of calmodulin with voltage-gated Ca(2+) channels revealed by FRET in single living cells. Neuron 2001, 31:973-985.
82. Erickson M.G., Liang H., Mori M.X., Yue D.T. FRET two-hybrid mapping reveals function and location of L-type Ca2+ channel CaM preassociation. Neuron 2003, 39:97-107.
83. Eroglu C., Allen N.J., Susman M.W., O'Rourke N.A., Park C.Y., Ozkan E., Chakraborty C., Mulinyawe S.B., Annis D.S., Huberman A.D., et al. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell 2009, 139:380-392.
84. Escayg A., De Waard M., Lee D.D., Bichet D., Wolf P., Mayer T., Johnston J., Baloh R., Sander T., Meisler M.H. Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. Am. J. Hum. Genet. 2000, 66:1531-1539.
85. Fallon J.L., Halling D.B., Hamilton S.L., Quiocho F.A. Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel. Structure 2005, 13:1881-1886.
86. * calmodulins. Proc. Natl. Acad. Sci. USA 2009, 106:5135-5140.
87. Fang K., Colecraft H.M. Mechanism of auxiliary β-subunit-mediated membrane targeting of L-type (Ca(V)1.2) channels. J. Physiol. 2011, 589:4437-4455.
88. Findeisen F., Rumpf C.H., Minor D.L. Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain. J. Mol. Biol. 2013, 425:3217-3234.
89. Fouad G., Dalakas M., Servidei S., Mendell J.R., Van den Bergh P., Angelini C., Alderson K., Griggs R.C., Tawil R., Gregg R., et al. Genotype-phenotype correlations of DHP receptor alpha 1-subunit gene mutations causing hypokalemic periodic paralysis. Neuromuscul. Disord. 1997, 7:33-38.
90. Fox A.P., Nowycky M.C., Tsien R.W. Single-channel recordings of three types of calcium channels in chick sensory neurones. J. Physiol. 1987, 394:173-200.
91. 2+ channels and vesicles to add release sites and promote refilling. Neuron 2010, 68:724-738.
92. Fuller M.D., Emrick M.A., Sadilek M., Scheuer T., Catterall W.A. Molecular mechanism of calcium channel regulation in the fight-or-flight response. Sci. Signal. 2010, 3:ra70.
93. Fuller-Bicer G.A., Varadi G., Koch S.E., Ishii M., Bodi I., Kadeer N., Muth J.N., Mikala G., Petrashevskaya N.N., Jordan M.A., et al. Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit. Am. J. Physiol. Heart Circ. Physiol. 2009, 297:H117-H124.
94. Giordano T.P., Tropea T.F., Satpute S.S., Sinnegger-Brauns M.J., Striessnig J., Kosofsky B.E., Rajadhyaksha A.M. Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity. J. Neurosci. 2010, 30:17051-17062.
95. Giusti-Rodríguez P., Sullivan P.F. The genomics of schizophrenia: update and implications. J. Clin. Invest. 2013, 123:4557-4563.
96. Gomez-Ospina N., Tsuruta F., Barreto-Chang O., Hu L., Dolmetsch R. The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor. Cell 2006, 127:591-606.
97. Gomez-Ospina N., Panagiotakos G., Portmann T., Pasca S.P., Rabah D., Budzillo A., Kinet J.P., Dolmetsch R.E. A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT. PLoS ONE 2013, 8:e60526.
98. Gomora J.C., Daud A.N., Weiergräber M., Perez-Reyes E. Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol. Pharmacol. 2001, 60:1121-1132.
99. Graef I.A., Mermelstein P.G., Stankunas K., Neilson J.R., Deisseroth K., Tsien R.W., Crabtree G.R. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature 1999, 401:703-708.
100. Graf E.R., Valakh V., Wright C.M., Wu C., Liu Z., Zhang Y.Q., DiAntonio A. RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction. J. Neurosci. 2012, 32:16586-16596.
101. Green E.K., Grozeva D., Jones I., Jones L., Kirov G., Caesar S., Gordon-Smith K., Fraser C., Forty L., Russell E., et al. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol. Psychiatry 2010, 15:1016-1022. Wellcome Trust Case Control Consortium.
102. Gregg R.G., Messing A., Strube C., Beurg M., Moss R., Behan M., Sukhareva M., Haynes S., Powell J.A., Coronado R., Powers P.A. Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. Proc. Natl. Acad. Sci. USA 1996, 93:13961-13966.
103. Griessmeier K., Cuny H., Rötzer K., Griesbeck O., Harz H., Biel M., Wahl-Schott C. Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels. J. Biol. Chem. 2009, 284:29809-29816.
104. Haeseleer F., Imanishi Y., Maeda T., Possin D.E., Maeda A., Lee A., Rieke F., Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat. Neurosci. 2004, 7:1079-1087.
105. Hagalili Y., Bachnoff N., Atlas D. The voltage-gated Ca(2+) channel is the Ca(2+) sensor protein of secretion. Biochemistry 2008, 47:13822-13830.
106. Hagiwara S., Nakajima S. Effects of the intracellular Ca ion concentration upon the excitability of the muscle fiber membrane of a barnacle. J. Gen. Physiol. 1966, 49:807-818.
107. 2+ channel Ca(V)1.2. Neuron 2013, 78:483-497.
108. Hamid J., Peloquin J.B., Monteil A., Zamponi G.W. Determinants of the differential gating properties of Cav3.1 and Cav3.3 T-type channels: a role of domain IV?. Neuroscience 2006, 143:717-728.
109. Hatakeyama S., Wakamori M., Ino M., Miyamoto N., Takahashi E., Yoshinaga T., Sawada K., Imoto K., Tanaka I., Yoshizawa T., et al. Differential nociceptive responses in mice lacking the alpha(1B) subunit of N-type Ca(2+) channels. Neuroreport 2001, 12:2423-2427.
110. He K., An Z., Wang Q., Li T., Li Z., Chen J., Li W., Wang T., Ji J., Feng G., et al. CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population. Br. J. Psychiatry 2014, 204:36-39.
111. Hemara-Wahanui A., Berjukow S., Hope C.I., Dearden P.K., Wu S.B., Wilson-Wheeler J., Sharp D.M., Lundon-Treweek P., Clover G.M., Hoda J.C., et al. A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of Cav1.4 channel activation. Proc. Natl. Acad. Sci. USA 2005, 102:7553-7558.
112. Herlitze S., Hockerman G.H., Scheuer T., Catterall W.A. Molecular determinants of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel alpha1A subunit. Proc. Natl. Acad. Sci. USA 1997, 94:1512-1516.
113. Hernández-Ochoa E.O., Contreras M., Cseresnyés Z., Schneider M.F. Ca2+ signal summation and NFATc1 nuclear translocation in sympathetic ganglion neurons during repetitive action potentials. Cell Calcium 2007, 41:559-571.
114. Heron S.E., Phillips H.A., Mulley J.C., Mazarib A., Neufeld M.Y., Berkovic S.F., Scheffer I.E. Genetic variation of CACNA1H in idiopathic generalized epilepsy. Ann. Neurol. 2004, 55:595-596.
115. Heron S.E., Khosravani H., Varela D., Bladen C., Williams T.C., Newman M.R., Scheffer I.E., Berkovic S.F., Mulley J.C., Zamponi G.W. Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants. Ann. Neurol. 2007, 62:560-568.
116. Hibino H., Pironkova R., Onwumere O., Rousset M., Charnet P., Hudspeth A.J., Lesage F. Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit. Proc. Natl. Acad. Sci. USA 2003, 100:307-312.
117. Hirano M., Kokunai Y., Nagai A., Nakamura Y., Saigoh K., Kusunoki S., Takahashi M.P. A novel mutation in the calcium channel gene in a family with hypokalemic periodic paralysis. J. Neurol. Sci. 2011, 309:9-11.
118. Hirtz J.J., Boesen M., Braun N., Deitmer J.W., Kramer F., Lohr C., Müller B., Nothwang H.G., Striessnig J., Löhrke S., Friauf E. Cav1.3 calcium channels are required for normal development of the auditory brainstem. J. Neurosci. 2011, 31:8280-8294.
119. Hoppa M.B., Lana B., Margas W., Dolphin A.C., Ryan T.A. α2δ expression sets presynaptic calcium channel abundance and release probability. Nature 2012, 486:122-125.
120. Hoshi T., Zagotta W.N., Aldrich R.W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 1990, 250:533-538.
121. Hu D., Barajas-Martinez H., Nesterenko V.V., Pfeiffer R., Guerchicoff A., Cordeiro J.M., Curtis A.B., Pollevick G.D., Wu Y., Burashnikov E., Antzelevitch C. Dual variation in SCN5A and CACNB2b underlies the development of cardiac conduction disease without Brugada syndrome. Pacing Clin. Electrophysiol. 2010, 33:274-285.
122. 2+-dependent inactivation. Neuron 2012, 73:304-316.
123. Huber I., Wappl E., Herzog A., Mitterdorfer J., Glossmann H., Langer T., Striessnig J. Conserved Ca2+-antagonist-binding properties and putative folding structure of a recombinant high-affinity dihydropyridine-binding domain. Biochem. J. 2000, 347:829-836.
124. Hudmon A., Schulman H., Kim J., Maltez J.M., Tsien R.W., Pitt G.S. CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J. Cell Biol. 2005, 171:537-547.
125. Huguenard J.R. Anatomical and physiological considerations in thalamic rhythm generation. J. Sleep Res. 1998, 7(Suppl 1):24-29.
126. Hulme J.T., Yarov-Yarovoy V., Lin T.W., Scheuer T., Catterall W.A. Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. J. Physiol. 2006, 576:87-102.
127. Hurley M.J., Brandon B., Gentleman S.M., Dexter D.T. Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins. Brain 2013, 136:2077-2097.
128. Impey S., Mark M., Villacres E.C., Poser S., Chavkin C., Storm D.R. Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus. Neuron 1996, 16:973-982.
129. Imredy J.P., Yue D.T. Mechanism of Ca(2+)-sensitive inactivation of L-type Ca2+ channels. Neuron 1994, 12:1301-1318.
130. 2+ channel due to a familial hemiplegic migraine mutation. Neuron 2014, 81:91-102.
131. Jacus M.O., Uebele V.N., Renger J.J., Todorovic S.M. Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons. J. Neurosci. 2012, 32:9374-9382.
132. Jagodic M.M., Pathirathna S., Nelson M.T., Mancuso S., Joksovic P.M., Rosenberg E.R., Bayliss D.A., Jevtovic-Todorovic V., Todorovic S.M. Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J. Neurosci. 2007, 27:3305-3316.
133. Jagodic M.M., Pathirathna S., Joksovic P.M., Lee W., Nelson M.T., Naik A.K., Su P., Jevtovic-Todorovic V., Todorovic S.M. Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J. Neurophysiol. 2008, 99:3151-3156.
134. Jalkanen R., Mäntyjärvi M., Tobias R., Isosomppi J., Sankila E.M., Alitalo T., Bech-Hansen N.T. X linked cone-rod dystrophy, CORDX3, is caused by a mutation in the CACNA1F gene. J. Med. Genet. 2006, 43:699-704.
135. Jarvis S.E., Zamponi G.W. Distinct molecular determinants govern syntaxin 1A-mediated inactivation and G-protein inhibition of N-type calcium channels. J. Neurosci. 2001, 21:2939-2948.
136. Jeng C.J., Chen Y.T., Chen Y.W., Tang C.Y. Dominant-negative effects of human P/Q-type Ca2+ channel mutations associated with episodic ataxia type 2. Am. J. Physiol. Cell Physiol. 2006, 290:C1209-C1220.
137. Jeon D., Kim S., Chetana M., Jo D., Ruley H.E., Lin S.Y., Rabah D., Kinet J.P., Shin H.S. Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nat. Neurosci. 2010, 13:482-488.
138. Jing Z., Rutherford M.A., Takago H., Frank T., Fejtova A., Khimich D., Moser T., Strenzke N. Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse. J. Neurosci. 2013, 33:4456-4467.
139. Jodice C., Mantuano E., Veneziano L., Trettel F., Sabbadini G., Calandriello L., Francia A., Spadaro M., Pierelli F., Salvi F., et al. Episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6) due to CAG repeat expansion in the CACNA1A gene on chromosome 19p. Hum. Mol. Genet. 1997, 6:1973-1978.
140. Jouvenceau A., Eunson L.H., Spauschus A., Ramesh V., Zuberi S.M., Kullmann D.M., Hanna M.G. Human epilepsy associated with dysfunction of the brain P/Q-type calcium channel. Lancet 2001, 358:801-807.
141. Jun K., Piedras-Rentería E.S., Smith S.M., Wheeler D.B., Lee S.B., Lee T.G., Chin H., Adams M.E., Scheller R.H., Tsien R.W., Shin H.S. Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc. Natl. Acad. Sci. USA 1999, 96:15245-15250.
142. Kadurin I., Alvarez-Laviada A., Ng S.F., Walker-Gray R., D'Arco M., Fadel M.G., Pratt W.S., Dolphin A.C. Calcium currents are enhanced by α2δ-1 lacking its membrane anchor. J. Biol. Chem. 2012, 287:33554-33566.
143. Kaeser P.S., Deng L., Wang Y., Dulubova I., Liu X., Rizo J., Südhof T.C. RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell 2011, 144:282-295.
144. Kaneko S., Cooper C.B., Nishioka N., Yamasaki H., Suzuki A., Jarvis S.E., Akaike A., Satoh M., Zamponi G.W. Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site. J. Neurosci. 2002, 22:82-92.
145. Kang S., Cooper G., Dunne S.F., Dusel B., Luan C.H., Surmeier D.J., Silverman R.B. CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease. Nat. Commun. 2012, 3:1146.
146. Katz B., Miledi R. The timing of calcium action during neuromuscular transmission. J. Physiol. 1967, 189:535-544.
147. Khosravani H., Altier C., Simms B., Hamming K.S., Snutch T.P., Mezeyova J., McRory J.E., Zamponi G.W. Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy. J. Biol. Chem. 2004, 279:9681-9684.
148. Khosravani H., Bladen C., Parker D.B., Snutch T.P., McRory J.E., Zamponi G.W. Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy. Ann. Neurol. 2005, 57:745-749.
149. Kim C., Jun K., Lee T., Kim S.S., McEnery M.W., Chin H., Kim H.L., Park J.M., Kim D.K., Jung S.J., et al. Altered nociceptive response in mice deficient in the alpha(1B) subunit of the voltage-dependent calcium channel. Mol. Cell. Neurosci. 2001, 18:235-245.
150. Kim D., Song I., Keum S., Lee T., Jeong M.J., Kim S.S., McEnery M.W., Shin H.S. Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels. Neuron 2001, 31:35-45.
151. Kim E.Y., Rumpf C.H., Fujiwara Y., Cooley E.S., Van Petegem F., Minor D.L. Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation. Structure 2008, 16:1455-1467.
152. Kim E.Y., Rumpf C.H., Van Petegem F., Arant R.J., Findeisen F., Cooley E.S., Isacoff E.Y., Minor D.L. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J. 2010, 29:3924-3938.
153. Kipfer S., Jung S., Lemke J.R., Kipfer-Kauer A., Howell J.P., Kaelin-Lang A., Nyffeler T., Gutbrod K., Abicht A., Müri R.M. Novel CACNA1A mutation(s) associated with slow saccade velocities. J. Neurol. 2013, 260:3010-3014.
154. Kiyonaka S., Wakamori M., Miki T., Uriu Y., Nonaka M., Bito H., Beedle A.M., Mori E., Hara Y., De Waard M., et al. RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat. Neurosci. 2007, 10:691-701.
155. Klassen T., Davis C., Goldman A., Burgess D., Chen T., Wheeler D., McPherson J., Bourquin T., Lewis L., Villasana D., et al. Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy. Cell 2011, 145:1036-1048.
156. Knoflach D., Kerov V., Sartori S.B., Obermair G.J., Schmuckermair C., Liu X., Sothilingam V., Garrido M.G., Baker S.A., Glösmann M., et al. Cav1.4 IT mouse as model for vision impairment in human congenital stationary night blindness type 2. Channels (Austin) 2013, 7:7.
157. Kraus R.L., Sinnegger M.J., Glossmann H., Hering S., Striessnig J. Familial hemiplegic migraine mutations change alpha1A Ca2+ channel kinetics. J. Biol. Chem. 1998, 273:5586-5590.
158. Krey J.F., Paşca S.P., Shcheglovitov A., Yazawa M., Schwemberger R., Rasmusson R., Dolmetsch R.E. Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons. Nat. Neurosci. 2013, 16:201-209.
159. Langwieser N., Christel C.J., Kleppisch T., Hofmann F., Wotjak C.T., Moosmang S. Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels. J. Neurosci. 2010, 30:8367-8375.
160. Lansman J.B., Hess P., Tsien R.W. Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore. J. Gen. Physiol. 1986, 88:321-347.
161. Lee A., Wong S.T., Gallagher D., Li B., Storm D.R., Scheuer T., Catterall W.A. Ca2+/calmodulin binds to and modulates P/Q-type calcium channels. Nature 1999, 399:155-159.
162. Lee J.H., Daud A.N., Cribbs L.L., Lacerda A.E., Pereverzev A., Klöckner U., Schneider T., Perez-Reyes E. Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J. Neurosci. 1999, 19:1912-1921.
163. Lee A., Zhou H., Scheuer T., Catterall W.A. Molecular determinants of Ca(2+)/calmodulin-dependent regulation of Ca(v)2.1 channels. Proc. Natl. Acad. Sci. USA 2003, 100:16059-16064.
164. Lee M.T., Chen C.H., Lee C.S., Chen C.C., Chong M.Y., Ouyang W.C., Chiu N.Y., Chuo L.J., Chen C.Y., Tan H.K., et al. Genome-wide association study of bipolar I disorder in the Han Chinese population. Mol. Psychiatry 2011, 16:548-556.
165. Lee A.S., Gonzales K.L., Lee A., Moosmang S., Hofmann F., Pieper A.A., Rajadhyaksha A.M. Selective genetic deletion of cacna1c in the mouse prefrontal cortex. Mol. Psychiatry 2012, 17:1051.
166. Letts V.A., Felix R., Biddlecome G.H., Arikkath J., Mahaffey C.L., Valenzuela A., Bartlett F.S., Mori Y., Campbell K.P., Frankel W.N. The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit. Nat. Genet. 1998, 19:340-347.
167. Li H., Pink M.D., Murphy J.G., Stein A., Dell'Acqua M.L., Hogan P.G. Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling. Nat. Struct. Mol. Biol. 2012, 19:337-345.
168. Liang H., DeMaria C.D., Erickson M.G., Mori M.X., Alseikhan B.A., Yue D.T. Unified mechanisms of Ca2+ regulation across the Ca2+ channel family. Neuron 2003, 39:951-960.
169. Liao P., Yong T.F., Liang M.C., Yue D.T., Soong T.W. Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles. Cardiovasc. Res. 2005, 68:197-203.
170. Lin Y., Lai X., Chen B., Xu Y., Huang B., Chen Z., Zhu S., Yao J., Jiang Q., Huang H., et al. Genetic variations in CYP17A1, CACNB2 and PLEKHA7 are associated with blood pressure and/or hypertension in She ethnic minority of China. Atherosclerosis 2011, 219:709-714.
171. Lipkind G.M., Fozzard H.A. Molecular modeling of interactions of dihydropyridines and phenylalkylamines with the inner pore of the L-type Ca2+ channel. Mol. Pharmacol. 2003, 63:499-511.
172. Lipscombe D. Neuronal proteins custom designed by alternative splicing. Curr. Opin. Neurobiol. 2005, 15:358-363.
173. Lipscombe D., Andrade A., Allen S.E. Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences. Biochim. Biophys. Acta 2013, 1828:1522-1529.
174. Liu Z., Vogel H.J. Structural basis for the regulation of L-type voltage-gated calcium channels: interactions between the N-terminal cytoplasmic domain and Ca(2+)-calmodulin. Front. Mol. Neurosci. 2012, 5:38.
175. Liu X., Yang P.S., Yang W., Yue D.T. Enzyme-inhibitor-like tuning of Ca(2+) channel connectivity with calmodulin. Nature 2010, 463:968-972.
176. Liu K.S., Siebert M., Mertel S., Knoche E., Wegener S., Wichmann C., Matkovic T., Muhammad K., Depner H., Mettke C., et al. RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Science 2011, 334:1565-1569.
177. Liu X., Kerov V., Haeseleer F., Majumder A., Artemyev N., Baker S.A., Lee A. Dysregulation of Cav 1.4 channels disrupts the maturation of photoreceptor synaptic ribbons in congenital stationary night blindness type 2. Channels (Austin) 2013, 7:7.
178. Lodha N., Bonfield S., Orton N.C., Doering C.J., McRory J.E., Mema S.C., Rehak R., Sauvé Y., Tobias R., Stell W.K., Bech-Hansen N.T. Congenital stationary night blindness in mice - a tale of two Cacna1f mutants. Adv. Exp. Med. Biol. 2010, 664:549-558.
179. Lodha N., Loucks C.M., Beaulieu C., Parboosingh J.S., Bech-Hansen N.T. Congenital stationary night blindness: mutation update and clinical variability. Adv. Exp. Med. Biol. 2012, 723:371-379.
180. Lu A.T., Dai X., Martinez-Agosto J.A., Cantor R.M. Support for calcium channel gene defects in autism spectrum disorders. Mol. Autism 2012, 3:18.
181. Mangoni M.E., Traboulsie A., Leoni A.L., Couette B., Marger L., Le Quang K., Kupfer E., Cohen-Solal A., Vilar J., Shin H.S., et al. Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels. Circ. Res. 2006, 98:1422-1430.
182. Marger F., Gelot A., Alloui A., Matricon J., Ferrer J.F., Barrère C., Pizzoccaro A., Muller E., Nargeot J., Snutch T.P., et al. T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. Proc. Natl. Acad. Sci. USA 2011, 108:11268-11273.
183. Mark M.D., Maejima T., Kuckelsberg D., Yoo J.W., Hyde R.A., Shah V., Gutierrez D., Moreno R.L., Kruse W., Noebels J.L., Herlitze S. Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations. J. Neurosci. 2011, 31:4311-4326.
184. Marom M., Hagalili Y., Sebag A., Tzvier L., Atlas D. Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx. J. Biol. Chem. 2010, 285:6996-7005.
185. Marshall J., Dolan B.M., Garcia E.P., Sathe S., Tang X., Mao Z., Blair L.A. Calcium channel and NMDA receptor activities differentially regulate nuclear C/EBPbeta levels to control neuronal survival. Neuron 2003, 39:625-639.
186. Matsuda S., Kakegawa W., Budisantoso T., Nomura T., Kohda K., Yuzaki M. Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression. Nat. Commun. 2013, 4:2759.
187. Maximov A., Bezprozvanny I. Synaptic targeting of N-type calcium channels in hippocampal neurons. J. Neurosci. 2002, 22:6939-6952.
188. McCleskey E.W., Fox A.P., Feldman D.H., Cruz L.J., Olivera B.M., Tsien R.W., Yoshikami D. Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proc. Natl. Acad. Sci. USA 1987, 84:4327-4331.
189. McRory J.E., Hamid J., Doering C.J., Garcia E., Parker R., Hamming K., Chen L., Hildebrand M., Beedle A.M., Feldcamp L., et al. The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution. J. Neurosci. 2004, 24:1707-1718.
190. Meissner M., Weissgerber P., Londoño J.E., Prenen J., Link S., Ruppenthal S., Molkentin J.D., Lipp P., Nilius B., Freichel M., Flockerzi V. Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene. J. Biol. Chem. 2011, 286:15875-15882.
191. Mezghrani A., Monteil A., Watschinger K., Sinnegger-Brauns M.J., Barrère C., Bourinet E., Nargeot J., Striessnig J., Lory P. A destructive interaction mechanism accounts for dominant-negative effects of misfolded mutants of voltage-gated calcium channels. J. Neurosci. 2008, 28:4501-4511.
192. Mich P.M., Horne W.A. Alternative splicing of the Ca2+ channel beta4 subunit confers specificity for gabapentin inhibition of Cav2.1 trafficking. Mol. Pharmacol. 2008, 74:904-912.
193. Mikami A., Imoto K., Tanabe T., Niidome T., Mori Y., Takeshima H., Narumiya S., Numa S. Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 1989, 340:230-233.
194. Minor D.L., Findeisen F. Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation. Channels (Austin) 2010, 4:459-474.
195. Molineux M.L., McRory J.E., McKay B.E., Hamid J., Mehaffey W.H., Rehak R., Snutch T.P., Zamponi G.W., Turner R.W. Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons. Proc. Natl. Acad. Sci. USA 2006, 103:5555-5560.
196. Moosmang S., Haider N., Klugbauer N., Adelsberger H., Langwieser N., Müller J., Stiess M., Marais E., Schulla V., Lacinova L., et al. Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J. Neurosci. 2005, 25:9883-9892.
197. Morgans C.W. Neurotransmitter release at ribbon synapses in the retina. Immunol. Cell Biol. 2000, 78:442-446.
198. Mori Y., Nishida M., Shimizu S., Ishii M., Yoshinaga T., Ino M., Sawada K., Niidome T. Ca(2+) channel alpha(1B) subunit (Ca(V) 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system. Trends Cardiovasc. Med. 2002, 12:270-275.
199. Mori M.X., Vander Kooi C.W., Leahy D.J., Yue D.T. Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+. Structure 2008, 16:607-620.
200. Morrill J.A., Cannon S.C. Effects of mutations causing hypokalaemic periodic paralysis on the skeletal muscle L-type Ca2+ channel expressed in Xenopus laevis oocytes. J. Physiol. 1999, 520:321-336.
201. Morrill J.A., Brown R.H., Cannon S.C. Gating of the L-type Ca channel in human skeletal myotubes: an activation defect caused by the hypokalemic periodic paralysis mutation R528H. J. Neurosci. 1998, 18:10320-10334.
202. Müller C.S., Haupt A., Bildl W., Schindler J., Knaus H.G., Meissner M., Rammner B., Striessnig J., Flockerzi V., Fakler B., Schulte U. Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Proc. Natl. Acad. Sci. USA 2010, 107:14950-14957.
203. Murphy T.H., Worley P.F., Baraban J.M. L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron 1991, 7:625-635.
204. Namkung Y., Smith S.M., Lee S.B., Skrypnyk N.V., Kim H.L., Chin H., Scheller R.H., Tsien R.W., Shin H.S. Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons. Proc. Natl. Acad. Sci. USA 1998, 95:12010-12015.
205. Newcomb R., Szoke B., Palma A., Wang G., Chen Xh., Hopkins W., Cong R., Miller J., Urge L., Tarczy-Hornoch K., et al. Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry 1998, 37:15353-15362.
206. Newton P.M., Orr C.J., Wallace M.J., Kim C., Shin H.S., Messing R.O. Deletion of N-type calcium channels alters ethanol reward and reduces ethanol consumption in mice. J. Neurosci. 2004, 24:9862-9869.
207. Nowycky M.C., Fox A.P., Tsien R.W. Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 1985, 316:440-443.
208. Obeid T., Awada A., al Rajeh S., Chaballout A. Thyroxine exacerbates absence seizures in juvenile myoclonic epilepsy. Neurology 1996, 47:605-606.
209. Ohkubo T., Inoue Y., Kawarabayashi T., Kitamura K. Identification and electrophysiological characteristics of isoforms of T-type calcium channel Ca(v)3.2 expressed in pregnant human uterus. Cell. Physiol. Biochem. 2005, 16:245-254.
210. Ohta T., Ohba T., Suzuki T., Watanabe H., Sasano H., Murakami M. Decreased calcium channel currents and facilitated epinephrine release in the Ca2+ channel beta3 subunit-null mice. Biochem. Biophys. Res. Commun. 2010, 394:464-469.
211. Olivera B.M., Cruz L.J., de Santos V., LeCheminant G.W., Griffin D., Zeikus R., McIntosh J.M., Galyean R., Varga J., Gray W.R., et al. Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom. Biochemistry 1987, 26:2086-2090.
212. Oliveria S.F., Dell'Acqua M.L., Sather W.A. AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Neuron 2007, 55:261-275.
213. Opatowsky Y., Chen C.C., Campbell K.P., Hirsch J.A. Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain. Neuron 2004, 42:387-399.
214. Orestes P., Osuru H.P., McIntire W.E., Jacus M.O., Salajegheh R., Jagodic M.M., Choe W., Lee J., Lee S.S., Rose K.E., et al. Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes 2013, 62:3828-3838.
215. Oz S., Benmocha A., Sasson Y., Sachyani D., Almagor L., Lee A., Hirsch J.A., Dascal N. Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1. J. Biol. Chem. 2013, 288:12680-12691.
216. Page K.M., Heblich F., Margas W., Pratt W.S., Nieto-Rostro M., Chaggar K., Sandhu K., Davies A., Dolphin A.C. N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2. J. Biol. Chem. 2010, 285:835-844.
217. Pan Z.H., Hu H.J., Perring P., Andrade R. T-type Ca(2+) channels mediate neurotransmitter release in retinal bipolar cells. Neuron 2001, 32:89-98.
218. Paşca S.P., Portmann T., Voineagu I., Yazawa M., Shcheglovitov A., Paşca A.M., Cord B., Palmer T.D., Chikahisa S., Nishino S., et al. Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat. Med. 2011, 17:1657-1662.
219. Payne H.L., Donoghue P.S., Connelly W.M., Hinterreiter S., Tiwari P., Ives J.H., Hann V., Sieghart W., Lees G., Thompson C.L. Aberrant GABA(A) receptor expression in the dentate gyrus of the epileptic mutant mouse stargazer. J. Neurosci. 2006, 26:8600-8608.
220. Perez-Reyes E. Molecular physiology of low-voltage-activated t-type calcium channels. Physiol. Rev. 2003, 83:117-161.
221. Perez-Reyes E., Cribbs L.L., Daud A., Lacerda A.E., Barclay J., Williamson M.P., Fox M., Rees M., Lee J.H. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 1998, 391:896-900.
222. Peterson B.Z., DeMaria C.D., Adelman J.P., Yue D.T. Calmodulin is the Ca2+ sensor for Ca2+ -dependent inactivation of L-type calcium channels. Neuron 1999, 22:549-558.
223. Peterson B.Z., Lee J.S., Mulle J.G., Wang Y., de Leon M., Yue D.T. Critical determinants of Ca(2+)-dependent inactivation within an EF-hand motif of L-type Ca(2+) channels. Biophys. J. 2000, 78:1906-1920.
224. Pietrobon D. Calcium channels and channelopathies of the central nervous system. Mol. Neurobiol. 2002, 25:31-50.
225. Pietrobon D. CaV2.1 channelopathies. Pflugers Arch. 2010, 460:375-393.
226. Pietrobon D., Moskowitz M.A. Pathophysiology of migraine. Annu. Rev. Physiol. 2013, 75:365-391.
227. Platzer J., Engel J., Schrott-Fischer A., Stephan K., Bova S., Chen H., Zheng H., Striessnig J. Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels. Cell 2000, 102:89-97.
228. Powell K.L., Cain S.M., Ng C., Sirdesai S., David L.S., Kyi M., Garcia E., Tyson J.R., Reid C.A., Bahlo M., et al. A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy. J. Neurosci. 2009, 29:371-380.
229. Pragnell M., De Waard M., Mori Y., Tanabe T., Snutch T.P., Campbell K.P. Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit. Nature 1994, 368:67-70.
230. Ptácek L.J., Tawil R., Griggs R.C., Engel A.G., Layzer R.B., Kwieciński H., McManis P.G., Santiago L., Moore M., Fouad G., et al. Dihydropyridine receptor mutations cause hypokalemic periodic paralysis. Cell 1994, 77:863-868.
231. Rajadhyaksha A., Barczak A., Macías W., Leveque J.C., Lewis S.E., Konradi C. L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. J. Neurosci. 1999, 19:6348-6359.
232. Rajapaksha W.R., Wang D., Davies J.N., Chen L., Zamponi G.W., Fisher T.E. Novel splice variants of rat CaV2.1 that lack much of the synaptic protein interaction site are expressed in neuroendocrine cells. J. Biol. Chem. 2008, 283:15997-16003.
233. Randall A., Tsien R.W. Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. J. Neurosci. 1995, 15:2995-3012.
234. Rehak R., Bartoletti T.M., Engbers J.D., Berecki G., Turner R.W., Zamponi G.W. Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes. PLoS ONE 2013, 8:e61844.
235. Rettig J., Sheng Z.H., Kim D.K., Hodson C.D., Snutch T.P., Catterall W.A. Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25. Proc. Natl. Acad. Sci. USA 1996, 93:7363-7368.
236. Reuter H. The dependence of slow inward current in Purkinje fibres on the extracellular calcium-concentration. J. Physiol. 1967, 192:479-492.
237. Richards K.S., Swensen A.M., Lipscombe D., Bommert K. Novel CaV2.1 clone replicates many properties of Purkinje cell CaV2.1 current. Eur. J. Neurosci. 2007, 26:2950-2961.
238. Rousset M., Cens T., Restituito S., Barrere C., Black J.L., McEnery M.W., Charnet P. Functional roles of gamma2, gamma3 and gamma4, three new Ca2+ channel subunits, in P/Q-type Ca2+ channel expressed in Xenopus oocytes. J. Physiol. 2001, 532:583-593.
239. Rozanski G.M., Nath A.R., Adams M.E., Stanley E.F. Low voltage-activated calcium channels gate transmitter release at the dorsal root ganglion sandwich synapse. J. Physiol. 2013, 591:5575-5583.
240. Ryu M.J., Lee C., Kim J., Shin H.S., Yu M.H. Proteomic analysis of stargazer mutant mouse neuronal proteins involved in absence seizure. J. Neurochem. 2008, 104:1260-1270.
241. Saegusa H., Kurihara T., Zong S., Kazuno A., Matsuda Y., Nonaka T., Han W., Toriyama H., Tanabe T. Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J. 2001, 20:2349-2356.
242. Saegusa H., Matsuda Y., Tanabe T. Effects of ablation of N- and R-type Ca(2+) channels on pain transmission. Neurosci. Res. 2002, 43:1-7.
243. Saegusa H., Wakamori M., Matsuda Y., Wang J., Mori Y., Zong S., Tanabe T. Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells. Mol. Cell. Neurosci. 2007, 34:261-270.
244. 2+ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. J. Neurosci. 2011, 31:13562-13575.
245. Schierberl K., Giordano T., Satpute S., Hao J., Kaur G., Hofmann F., Moosmang S., Striessnig J., Rajadhyaksha A. Cav 1.3 L-type Ca (2+) channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure. Channels (Austin) 2012, 6:11-17.
246. Seisenberger C., Specht V., Welling A., Platzer J., Pfeifer A., Kühbandner S., Striessnig J., Klugbauer N., Feil R., Hofmann F. Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse. J. Biol. Chem. 2000, 275:39193-39199.
247. Serysheva I.I., Ludtke S.J., Baker M.R., Chiu W., Hamilton S.L. Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy. Proc. Natl. Acad. Sci. USA 2002, 99:10370-10375.
248. Sharp A.H., Campbell K.P. Characterization of the 1,4-dihydropyridine receptor using subunit-specific polyclonal antibodies. Evidence for a 32,000-Da subunit. J. Biol. Chem. 1989, 264:2816-2825.
249. Sheng Z.H., Rettig J., Takahashi M., Catterall W.A. Identification of a syntaxin-binding site on N-type calcium channels. Neuron 1994, 13:1303-1313.
250. Sheng Z.H., Rettig J., Cook T., Catterall W.A. Calcium-dependent interaction of N-type calcium channels with the synaptic core complex. Nature 1996, 379:451-454.
251. Simms B.A., Zamponi G.W. Trafficking and stability of voltage-gated calcium channels. Cell. Mol. Life Sci. 2012, 69:843-856.
252. Simms B.A., Souza I.A., Zamponi G.W. A novel calmodulin site in the Cav1.2 N-terminus regulates calcium-dependent inactivation. Pflugers Arch. 2013, Published online December 19, 2013. 10.1007/s00424-013-1423-9.
253. Singh A., Hamedinger D., Hoda J.C., Gebhart M., Koschak A., Romanin C., Striessnig J. C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels. Nat. Neurosci. 2006, 9:1108-1116.
254. Singh B., Monteil A., Bidaud I., Sugimoto Y., Suzuki T., Hamano S., Oguni H., Osawa M., Alonso M.E., Delgado-Escueta A.V., et al. Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in brief #962. Online. Hum. Mutat. 2007, 28:524-525.
255. Sokolov S., Scheuer T., Catterall W.A. Gating pore current in an inherited ion channelopathy. Nature 2007, 446:76-78.
256. Song I., Kim D., Choi S., Sun M., Kim Y., Shin H.S. Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice. J. Neurosci. 2004, 24:5249-5257.
257. Soong T.W., Stea A., Hodson C.D., Dubel S.J., Vincent S.R., Snutch T.P. Structure and functional expression of a member of the low voltage-activated calcium channel family. Science 1993, 260:1133-1136.
258. Spaetgens R.L., Zamponi G.W. Multiple structural domains contribute to voltage-dependent inactivation of rat brain alpha(1E) calcium channels. J. Biol. Chem. 1999, 274:22428-22436.
259. Spafford J.D., Munno D.W., Van Nierop P., Feng Z.P., Jarvis S.E., Gallin W.J., Smit A.B., Zamponi G.W., Syed N.I. Calcium channel structural determinants of synaptic transmission between identified invertebrate neurons. J. Biol. Chem. 2003, 278:4258-4267.
260. Splawski I., Timothy K.W., Sharpe L.M., Decher N., Kumar P., Bloise R., Napolitano C., Schwartz P.J., Joseph R.M., Condouris K., et al. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 2004, 119:19-31.
261. Splawski I., Timothy K.W., Decher N., Kumar P., Sachse F.B., Beggs A.H., Sanguinetti M.C., Keating M.T. Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proc. Natl. Acad. Sci. USA 2005, 102:8089-8096. discussion 8086-8088.
262. Splawski I., Yoo D.S., Stotz S.C., Cherry A., Clapham D.E., Keating M.T. CACNA1H mutations in autism spectrum disorders. J. Biol. Chem. 2006, 281:22085-22091.
263. Staes M., Talavera K., Klugbauer N., Prenen J., Lacinova L., Droogmans G., Hofmann F., Nilius B. The amino side of the C-terminus determines fast inactivation of the T-type calcium channel alpha1G. J. Physiol. 2001, 530:35-45.
264. Stanika R.I., Villanueva I., Kazanina G., Andrews S.B., Pivovarova N.B. Comparative impact of voltage-gated calcium channels and NMDA receptors on mitochondria-mediated neuronal injury. J. Neurosci. 2012, 32:6642-6650.
265. Stotz S.C., Zamponi G.W. Identification of inactivation determinants in the domain IIS6 region of high voltage-activated calcium channels. J. Biol. Chem. 2001, 276:33001-33010.
266. Stotz S.C., Zamponi G.W. Structural determinants of fast inactivation of high voltage-activated Ca(2+) channels. Trends Neurosci. 2001, 24:176-181.
267. Stotz S.C., Hamid J., Spaetgens R.L., Jarvis S.E., Zamponi G.W. Fast inactivation of voltage-dependent calcium channels. A hinged-lid mechanism?. J. Biol. Chem. 2000, 275:24575-24582.
268. Stotz S.C., Jarvis S.E., Zamponi G.W. Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage-dependent inactivation of HVA calcium channels. J. Physiol. 2004, 554:263-273.
269. Striessnig J. Lonely but diverse: Cav1.3 L-type Ca(2+) channels in cochlear inner hair cells. Channels (Austin) 2013, 7:133-134.
270. Strohmaier J., Amelang M., Hothorn L.A., Witt S.H., Nieratschker V., Gerhard D., Meier S., Wüst S., Frank J., Loerbroks A., et al. The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population. Mol. Psychiatry 2013, 18:607-613.
271. Strube C., Beurg M., Powers P.A., Gregg R.G., Coronado R. Reduced Ca2+ current, charge movement, and absence of Ca2+ transients in skeletal muscle deficient in dihydropyridine receptor beta 1 subunit. Biophys. J. 1996, 71:2531-2543.
272. Subramanyam P., Obermair G.J., Baumgartner S., Gebhart M., Striessnig J., Kaufmann W.A., Geley S., Flucher B.E. Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells. Channels (Austin) 2009, 3:343-355.
273. Sutton K.G., McRory J.E., Guthrie H., Murphy T.H., Snutch T.P. P/Q-type calcium channels mediate the activity-dependent feedback of syntaxin-1A. Nature 1999, 401:800-804.
274. Tadmouri A., Kiyonaka S., Barbado M., Rousset M., Fablet K., Sawamura S., Bahembera E., Pernet-Gallay K., Arnoult C., Miki T., et al. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. EMBO J. 2012, 31:3730-3744.
275. Tadross M.R., Dick I.E., Yue D.T. Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel. Cell 2008, 133:1228-1240.
276. Tadross M.R., Ben Johny M., Yue D.T. Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels. J. Gen. Physiol. 2010, 135:197-215.
277. Tan B.Z., Jiang F., Tan M.Y., Yu D., Huang H., Shen Y., Soong T.W. Functional characterization of alternative splicing in the C terminus of L-type CaV1.3 channels. J. Biol. Chem. 2011, 286:42725-42735.
278. Tan G.M., Yu D., Wang J., Soong T.W. Alternative splicing at C terminus of Ca(V)1.4 calcium channel modulates calcium-dependent inactivation, activation potential, and current density. J. Biol. Chem. 2012, 287:832-847.
279. Tanabe T., Takeshima H., Mikami A., Flockerzi V., Takahashi H., Kangawa K., Kojima M., Matsuo H., Hirose T., Numa S. Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature 1987, 328:313-318.
280. Tanabe T., Beam K.G., Powell J.A., Numa S. Restoration of excitation-contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA. Nature 1988, 336:134-139.
281. Tandan S., Wang Y., Wang T.T., Jiang N., Hall D.D., Hell J.W., Luo X., Rothermel B.A., Hill J.A. Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel. Circ. Res. 2009, 105:51-60.
282. 2+ release from stores. J. Neurosci. 2011, 31:13546-13561.
283. Tang L., Gamal El-Din T.M., Payandeh J., Martinez G.Q., Heard T.M., Scheuer T., Zheng N., Catterall W.A. Structural basis for Ca2+ selectivity of a voltage-gated calcium channel. Nature 2014, 505:56-61.
284. Tedford H.W., Zamponi G.W. Direct G protein modulation of Cav2 calcium channels. Pharmacol. Rev. 2006, 58:837-862.
285. Tesli M., Skatun K.C., Ousdal O.T., Brown A.A., Thoresen C., Agartz I., Melle I., Djurovic S., Jensen J., Andreassen O.A. CACNA1C risk variant and amygdala activity in bipolar disorder, schizophrenia and healthy controls. PLoS ONE 2013, 8:e56970.
286. Thompson M.A., Ginty D.D., Bonni A., Greenberg M.E. L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels. J. Biol. Chem. 1995, 270:4224-4235.
287. Tippens A.L., Pare J.F., Langwieser N., Moosmang S., Milner T.A., Smith Y., Lee A. Ultrastructural evidence for pre- and postsynaptic localization of Cav1.2 L-type Ca2+ channels in the rat hippocampus. J. Comp. Neurol. 2008, 506:569-583.
288. Tomita S., Adesnik H., Sekiguchi M., Zhang W., Wada K., Howe J.R., Nicoll R.A., Bredt D.S. Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 2005, 435:1052-1058.
289. Tottene A., Conti R., Fabbro A., Vecchia D., Shapovalova M., Santello M., van den Maagdenberg A.M., Ferrari M.D., Pietrobon D. Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron 2009, 61:762-773.
290. Ulrich D., Huguenard J.R. GABA(A)-receptor-mediated rebound burst firing and burst shunting in thalamus. J. Neurophysiol. 1997, 78:1748-1751.
291. Urbano F.J., Piedras-Rentería E.S., Jun K., Shin H.S., Uchitel O.D., Tsien R.W. Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels. Proc. Natl. Acad. Sci. USA 2003, 100:3491-3496.
292. van den Maagdenberg A.M., Pietrobon D., Pizzorusso T., Kaja S., Broos L.A., Cesetti T., van de Ven R.C., Tottene A., van der Kaa J., Plomp J.J., et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 2004, 41:701-710.
293. van den Maagdenberg A.M., Pizzorusso T., Kaja S., Terpolilli N., Shapovalova M., Hoebeek F.E., Barrett C.F., Gherardini L., van de Ven R.C., Todorov B., et al. High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice. Ann. Neurol. 2010, 67:85-98.
294. Van Petegem F., Clark K.A., Chatelain F.C., Minor D.L. Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature 2004, 429:671-675.
295. Van Petegem F., Chatelain F.C., Minor D.L. Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nat. Struct. Mol. Biol. 2005, 12:1108-1115.
296. Vandael D.H., Zuccotti A., Striessnig J., Carbone E. Ca(V)1.3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells. J. Neurosci. 2012, 32:16345-16359.
297. Vandael D.H., Mahapatra S., Calorio C., Marcantoni A., Carbone E. Cav1.3 and Cav1.2 channels of adrenal chromaffin cells: emerging views on cAMP/cGMP-mediated phosphorylation and role in pacemaking. Biochim. Biophys. Acta 2013, 1828:1608-1618.
298. Vitko I., Chen Y., Arias J.M., Shen Y., Wu X.R., Perez-Reyes E. Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J. Neurosci. 2005, 25:4844-4855.
299. Wadel K., Neher E., Sakaba T. The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release. Neuron 2007, 53:563-575.
300. Wahl-Schott C., Baumann L., Cuny H., Eckert C., Griessmeier K., Biel M. Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain. Proc. Natl. Acad. Sci. USA 2006, 103:15657-15662.
301. Waithe D., Ferron L., Page K.M., Chaggar K., Dolphin A.C. Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation. J. Biol. Chem. 2011, 286:9598-9611.
302. Walsh C.P., Davies A., Butcher A.J., Dolphin A.C., Kitmitto A. Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture. J. Biol. Chem. 2009, 284:22310-22321.
303. Walsh C.P., Davies A., Nieto-Rostro M., Dolphin A.C., Kitmitto A. Labelling of the 3D structure of the cardiac L-type voltage-gated calcium channel. Channels (Austin) 2009, 3:387-392.
304. Watase K., Barrett C.F., Miyazaki T., Ishiguro T., Ishikawa K., Hu Y., Unno T., Sun Y., Kasai S., Watanabe M., et al. Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels. Proc. Natl. Acad. Sci. USA 2008, 105:11987-11992.
305. Weber A.M., Wong F.K., Tufford A.R., Schlichter L.C., Matveev V., Stanley E.F. N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release. Nat. Neurosci. 2010, 13:1348-1350.
306. Weiergräber M., Henry M., Radhakrishnan K., Hescheler J., Schneider T. Hippocampal seizure resistance and reduced neuronal excitotoxicity in mice lacking the Cav2.3 E/R-type voltage-gated calcium channel. J. Neurophysiol. 2007, 97:3660-3669.
307. Weiss N., Zamponi G.W. Regulation of voltage-gated calcium channels by synaptic proteins. Adv. Exp. Med. Biol. 2012, 740:759-775.
308. Weiss N., Hameed S., Fernández-Fernández J.M., Fablet K., Karmazinova M., Poillot C., Proft J., Chen L., Bidaud I., Monteil A., et al. A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis. J. Biol. Chem. 2012, 287:2810-2818.
309. Weissgerber P., Held B., Bloch W., Kaestner L., Chien K.R., Fleischmann B.K., Lipp P., Flockerzi V., Freichel M. Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ. Res. 2006, 99:749-757.
310. West J.W., Patton D.E., Scheuer T., Wang Y., Goldin A.L., Catterall W.A. A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation. Proc. Natl. Acad. Sci. USA 1992, 89:10910-10914.
311. Wheeler D.B., Randall A., Tsien R.W. Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science 1994, 264:107-111.
312. Wheeler D.G., Barrett C.F., Tsien R.W. L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors. Neuropharmacology 2006, 51:27-36.
313. Wheeler D.G., Barrett C.F., Groth R.D., Safa P., Tsien R.W. CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling. J. Cell Biol. 2008, 183:849-863.
314. Wheeler D.G., Groth R.D., Ma H., Barrett C.F., Owen S.F., Safa P., Tsien R.W. Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression. Cell 2012, 149:1112-1124.
315. White J.A., McKinney B.C., John M.C., Powers P.A., Kamp T.J., Murphy G.G. Conditional forebrain deletion of the L-type calcium channel Ca V 1.2 disrupts remote spatial memories in mice. Learn. Mem. 2008, 15:1-5.
316. Williams M.E., Brust P.F., Feldman D.H., Patthi S., Simerson S., Maroufi A., McCue A.F., Veliçelebi G., Ellis S.B., Harpold M.M. Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel. Science 1992, 257:389-395.
317. Williams M.E., Feldman D.H., McCue A.F., Brenner R., Velicelebi G., Ellis S.B., Harpold M.M. Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. Neuron 1992, 8:71-84.
318. Wolf M., Eberhart A., Glossmann H., Striessnig J., Grigorieff N. Visualization of the domain structure of an L-type Ca2+ channel using electron cryo-microscopy. J. Mol. Biol. 2003, 332:171-182.
319. Wong F.K., Stanley E.F. Rab3a interacting molecule (RIM) and the tethering of pre-synaptic transmitter release site-associated CaV2.2 calcium channels. J. Neurochem. 2010, 112:463-473.
320. Wu G.Y., Deisseroth K., Tsien R.W. Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. USA 2001, 98:2808-2813.
321. Wu F., Mi W., Hernández-Ochoa E.O., Burns D.K., Fu Y., Gray H.F., Struyk A.F., Schneider M.F., Cannon S.C. A calcium channel mutant mouse model of hypokalemic periodic paralysis. J. Clin. Invest. 2012, 122:4580-4591.
322. Wycisk K.A., Zeitz C., Feil S., Wittmer M., Forster U., Neidhardt J., Wissinger B., Zrenner E., Wilke R., Kohl S., Berger W. Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy. Am. J. Hum. Genet. 2006, 79:973-977.
323. Xu W., Lipscombe D. Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J. Neurosci. 2001, 21:5944-5951.
324. Xu X., Lee Y.J., Holm J.B., Terry M.D., Oswald R.E., Horne W.A. The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 via a PXVXL binding motif. J. Biol. Chem. 2011, 286:9677-9687.
325. Yang J., Ellinor P.T., Sather W.A., Zhang J.F., Tsien R.W. Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature 1993, 366:158-161.
326. Yang P.S., Alseikhan B.A., Hiel H., Grant L., Mori M.X., Yang W., Fuchs P.A., Yue D.T. Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells. J. Neurosci. 2006, 26:10677-10689.
327. Yang P.S., Johny M.B., Yue D.T. Allostery in Ca(2+) channel modulation by calcium-binding proteins. Nat. Chem. Biol. 2014, 10:231-238.
328. Yasuda T., Chen L., Barr W., McRory J.E., Lewis R.J., Adams D.J., Zamponi G.W. Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. Eur. J. Neurosci. 2004, 20:1-13.
329. Zamponi G.W. Calmodulin lobotomized: novel insights into calcium regulation of voltage-gated calcium channels. Neuron 2003, 39:879-881.
330. Zamponi G.W. Regulation of presynaptic calcium channels by synaptic proteins. J. Pharmacol. Sci. 2003, 92:79-83.
331. Zamponi G.W., Bourinet E., Nelson D., Nargeot J., Snutch T.P. Crosstalk between G proteins and protein kinase C mediated by the calcium channel alpha1 subunit. Nature 1997, 385:442-446.
332. Zamponi G.W., Stotz S.C., Staples R.J., Andro T.M., Nelson J.K., Hulubei V., Blumenfeld A., Natale N.R. Unique structure-activity relationship for 4-isoxazolyl-1,4-dihydropyridines. J. Med. Chem. 2003, 46:87-96.
333. Zhang Y., Mori M., Burgess D.L., Noebels J.L. Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J. Neurosci. 2002, 22:6362-6371.
334. Zhang H., Maximov A., Fu Y., Xu F., Tang T.S., Tkatch T., Surmeier D.J., Bezprozvanny I. Association of CaV1.3 L-type calcium channels with Shank. J. Neurosci. 2005, 25:1037-1049.
335. Zhang H., Fu Y., Altier C., Platzer J., Surmeier D.J., Bezprozvanny I. Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB. Eur. J. Neurosci. 2006, 23:2297-2310.
336. Zhang Y., Yamada Y., Fan M., Bangaru S.D., Lin B., Yang J. The beta subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6. J. Biol. Chem. 2010, 285:2527-2536.
337. Zühlke R.D., Pitt G.S., Deisseroth K., Tsien R.W., Reuter H. Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature 1999, 399:159-162.