Reduced cardiac L-type Ca2+ current in Cavβ2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation

Circulation Research

Volumn 99, Issue 7, 2006, Pages 749-757

  Weissgerber, Petra ^a   Held, Brigitte ^a   Bloch, Wilhelm ^b   Kaestner, Lars ^a   Chien, Kenneth R ^c   Fleischmann, Bernd K ^d   Lipp, Peter ^a   Flockerzi, Veit ^a   Freichel, Marc ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

Ca v 2 subunit; Cardiac development; Embryonic death; Heart failure; L type Ca 2+ Channel

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM BETA2 SUBUNIT; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; GENE DISRUPTION; HEART BLOOD VESSEL; HEART CONTRACTION; HEART DEVELOPMENT; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART MUSCLE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE REGENERATION; VASCULAR DISEASE;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; BLOOD VESSELS; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNELS, L-TYPE; CARDIAC OUTPUT, LOW; ELECTRIC CONDUCTIVITY; EMBRYO; EMBRYONIC DEVELOPMENT; FETAL DEATH; GENE EXPRESSION; HEART; HEART RATE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; PROTEIN ISOFORMS;

EID: 33749347260     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000243978.15182.c1     Document Type: Article

References (30)

1. Reuter H. Calcium channel modulation by neurotransmitters, enzymes and drugs. Nature. 1983;301:569-574.
2. Bers DM. Cardiac excitation-contraction coupling. Nature. 2002;415:198-205.
3. Fabiato A, Fabiato F. Calcium and cardiac excitation-contraction coupling. Annu Rev Physiol. 1979;41:473-484.
4. Catterall WA. Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol. 2000;16:521-555.
5. Mikami A, Imoto K, Tanabe T, Niidome T, Mori Y, Takeshima H, Narumiya S, Numa S. Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature. 1989;340:230-233.
6. Seisenberger C, Specht V, Welling A, Platzer J, Pfeifer A, Kuhbandner S, Striessnig J, Klugbauer N, Feil R, Hofmann F. Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse. J Biol Chem. 2000;275:39193-39199.
7. Xu M, Welling A, Paparisto S, Hofmann F, Klugbauer N. Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice. J Biol Chem. 2003;278:40837-40841.
8. Chaudhari N. A single nucleotide deletion in the skeletal muscle-specific calcium channel transcript of muscular dysgenesis (mdg) mice. J Biol Chem. 1992;267:25636-25639.
9. Mangoni ME, Couette B, Bourinet E, Platzer J, Reimer D, Striessnig J, Nargeot J. Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity. Proc Natl Acad Sci U S A. 2003;100:5543-5548.
10. Zhang Z, Xu Y, Song H, Rodriguez J, Tuteja D, Namkung Y, Shin HS, Chiamvimonvat N. Functional Roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circ Res. 2002;90:981-987.
11. Ludwig A, Flockerzi V, Hofmann F. Regional expression and cellular localization of the alpha1 and beta subunit of high voltage-activated calcium channels in rat brain. J Neurosci. 1997;17:1339-1349.
12. Murakami M, Fleischmann B, De Felipe C, Freichel M, Trost C, Ludwig A, Wissenbach U, Schwegler H, Hofmann F, Hescheler J, Flockerzi V, Cavalie A. Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. J Biol Chem. 2002;277:40342-40351.
13. Berggren PO, Yang SN, Murakami M, Efanov AM, Uhles S, Kohler M, Moede T, Fernstrom A, Appelskog IB, Aspinwall CA, Zaitsev SV, Larsson O, de Vargas LM, Fecher-Trost C, Weissgerber P, Ludwig A, Leibiger B, Juntti-Berggren L, Barker CJ, Gromada J, Freichel M, Leibiger IB, Flockerzi V. Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis. Cell. 2004;119:273-284.
14. Richards MW, Butcher AJ, Dolphin AC. Ca2+ channel beta-subunits: structural insights AID our understanding. Trends Pharmacol Sci. 2004;25:626-632.
15. Gregg RG, Messing A, Strube C, Beurg M, Moss R, Behan M, Sukhareva M, Haynes S, Powell JA, Coronado R, Powers PA. Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. Proc Natl Acad Sci U S A. 1996;93:13961-13966.
16. Namkung Y, Smith SM, Lee SB, Skrypnyk NV, Kim HL, Chin H, Scheller RH, Tsien RW, Shin HS. Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons. Proc Natl Acad Sci U S A. 1998;95:12010-12015.
17. Burgess DL, Jones JM, Meisler MH, Noebels JL. Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell. 1997;88:385-392.
18. Fleischmann M, Bloch W, Kolossov E, Andressen C, Muller M, Brem G, Hescheler J, Addicks K, Fleischmann BK. Cardiac specific expression of the green fluorescent protein during early murine embryonic development. FEBS Lett. 1998;440:370-376.
19. Wettschureck N, Rutten H, Zywietz A, Gehring D, Wilkie TM, Chen J, Chien KR, Offermanns S. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med. 2001;7:1236-1240.
20. Novak A, Guo C, Yang W, Nagy A, Lobe CG. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis. 2000;28:147-155.
21. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 1981;391:85-100.
22. Acosta L, Haase H, Morano I, Moorman AF, Franco D. Regional expression of L-type calcium channel subunits during cardiac development. Dev Dyn. 2004;230:131-136.
23. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6:389-395.
24. Pearson HA, Dolphin AC. Inhibition of omega-conotoxin-sensitive Ca2+ channel currents by internal Mg2+ in cultured rat cerebellar granule neurones. Pflugers Arch. 1993;425:518-527.
25. Jinnah HA, Yitta S, Drew T, Kim BS, Visser JE, Rothstein JD. Calcium channel activation and self-biting in mice. Proc Natl Acad Sci U S A. 1999;96:15228-15232.
26. An RH, Davies MP, Doevendans PA, Kubalak SW, Bangalore R, Chien KR, Kass RS. Developmental changes in beta-adrenergic modulation of L-type Ca2+ channels in embryonic mouse heart. Circ Res. 1996;78:371-378.
27. Davies MP, An RH, Doevendans P, Kubalak S, Chien KR, Kass RS. Developmental changes in ionic channel activity in the embryonic murine heart. Circ Res. 1996;78:15-25.
28. Ball SL, Powers PA, Shin HS, Morgans CW, Peachey NS, Gregg RG. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci. 2002;43:1595-1603.
29. Li J, Puceat M, Perez-Terzic C, Mery A, Nakamura K, Michalak M, Krause KH, Jaconi ME. Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis. J Cell Biol. 2002;158:103-113.
30. Koushik SV, Wang J, Rogers R, Moskophidis D, Lambert NA, Creazzo TL, Conway SJ. Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J. 2001;15:1209-1211.