Targeted disruption of the voltage-dependent calcium channel α2/δ-1-subunit

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 1, 2009, Pages

  Fuller Bicer, Geraldine A ^a   Varadi, Gyula ^a   Koch, Sheryl E ^a   Ishii, Masakazu ^a   Bodi, Ilona ^a   Kadeer, Nijiat ^b   Muth, James N ^a   Mikala, Gabor ^a   Petrashevskaya, Natalia N ^a   Jordan, Michael A ^c   Zhang, Sui Po ^d   Qin, Ning ^d   Flores, Christopher M ^d   Isaacsohn, Idit ^a   Varadi, Maria ^a   Mori, Yasuo ^a   Jones, W Keith ^b   Schwartz, Arnold ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c DNA Analysis   (United States)

^d JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Cardiac calcium channel; Gabapentin binding; Murine knockout model; Myocardial contractility

Indexed keywords

CALCIUM CHANNEL L TYPE; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; EXON; FEMALE; GENE DELETION; HEART MUSCLE CONTRACTILITY; ISOLATED HEART; KNOCKOUT MOUSE; MALE; MEMBRANE DAMAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINES; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CYCLOHEXANECARBOXYLIC ACIDS; ELECTROPHYSIOLOGY; EXONS; GAMMA-AMINOBUTYRIC ACID; GENOTYPE; HEART; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 67650046364     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00122.2009     Document Type: Article

References (40)

1. Barclay J, Balaguero N, Mione M, Ackerman SL, Letts VA, Brodbeck J, Canti C, Meir A, Page KM, Kusumi K, Perez-Reyes E, Lander ES, Frankel WN, Gardiner RM, Dolphin AC, Rees M. Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J Neurosci 21: 6095-6104, 2001.
2. 2+ channels. FEBS Lett 364: 129-133, 1995.
3. Brill J, Klocke R, Paul D, Boison D, Gouder N, Klugbauer N, Hofmann F, Becker CM, Becker K. entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. J Biol Chem 279: 7322-7330, 2004.
4. Canti C, Davies A, Dolphin A. Calcium channel α2δ subunits: structure, functions and target site for drugs. Curr Neuropharm 1: 209-217, 2003.
5. 2+ channels. Annu Rev Cell Dev Biol 16: 521-555, 2000.
6. 2+ channels. J Biol Chem 270: 30036-30044, 1995.
7. Chin H, Mock B, Kim HL, Kim H, Kozak CA. The gene for the dihydropyridine-sensitive calcium channel alpha 2 subunit (CCHL2A) maps to the proximal region of mouse chromosome 5. Genomics 13: 1325-1327, 1992.
8. Chouinard G. The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs. J Psychiatry Neurosci 31: 168-176, 2006.
9. De Jongh KS, Warner C, Catterall WA. Subunits of purified calcium channels. Alpha 2 and delta are encoded by the same gene. J Biol Chem 265: 14738-14741, 1990.
10. Ellis SB, Williams ME, Ways NR, Brenner R, Sharp AH, Leung AT, Campbell KP, McKenna E, Koch WJ, Hui A. Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel. Science 241: 1661-1664, 1988.
11. García K, Nabhani T, García J. The calcium channel alpha2/delta1 subunit is involved in extracellular signalling. J Physiol 586: 727-738, 2008.
12. Gee NS, Brown JP, Dissanayake VU, Offord J, Thurlow R, Woodruff GN. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem 271: 5768-5776, 1996.
13. Gong HC, Hang J, Kohler W, Li L, Su TZ. Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes. J Membr Biol 184: 35-43, 2001.
14. Groner F, Rubio M, Schulte-Euler P, Matthes J, Khan IF, Bodi I, Koch SE, Schwartz A, Herzig S. Single-channel gating and regulation of human L-type calcium channels in cardiomyocytes of transgenic mice. Biochem Biophys Res Commun 314: 878-884, 2004.
15. 2+ channel alpha2delta and alpha1 subunits. J Biol Chem 272: 18508-18512, 1997.
16. Iles DE, Lehmann-Horn F, Scherer SW, Tsui LC, Olde Weghuis D, Suijkerbuijk RF, Heytens L, Mikala G, Schwartz A, Ellis FR, Stewart AD, Deufel T, Wieringa B. Localization of the gene encoding the alpha 2/delta-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families. Hum Mol Genet 3: 969-975, 1994.
17. Ivanov SV, Ward JM, Tessarollo L, McAreavey D, Sachdev V, Fananapazir L, Banks MK, Morris N, Djurickovic D, Devor-Henneman DE, Wei MH, Alvord GW, Gao B, Richardson JA, Minna JD, Rogawski MA, Lerman MI. Cerebellar ataxia, seizures, premature death and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene. Am J Pathol 165: 1007-1018, 2004.
18. Klugbauer N, Marais E, Hofmann F. Calcium channel alpha2delta subunits: differential expression, function, and drug binding. J Bioenerg Biomembr 35: 639-647, 2003.
19. Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, Hofmann F, Klugbauer N. Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. EMBO J 22: 6027-6034, 2003.
20. Newton RA, Bingham S, Case PC, Sanger GJ, Lawson SN. Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury. Brain Res Mol Brain Res 95: 1-8, 2001.
21. 2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling. J Biol Chem 280: 2229-2237, 2005.
22. Petrashevskaya NN, Bodi I, Rubio M, Molkentin JD, Schwartz A. Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse. Cardiovasc Res 54: 117-132, 2002.
23. Powell JA, Petherbridge L, Flucher BE. Formation of triads without the dihydropyridine receptor alpha subunits in cell lines from dysgenic skeletal muscle. J Cell Biol 134: 375-387, 1996.
24. Qin N, Yagel S, Momplaisir ML, Codd EE, D'Andrea MR. Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. Mol Pharmacol 62: 485-496, 2002.
25. Schafer WR, Sanchez BM, Kenyon CJ. Genes affecting sensitivity to serotonin in Caenorhabditis elegans. Genetics 143: 1219-1230, 1996.
26. Seisenberger C, Specht V, Welling A, Platzer J, Pfeifer A, Kühbandner S, Striessnig J, Klugbauer N, Feil R, Hofmann F. Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse. J Biol Chem 275: 39193-39199, 2000.
27. i restores uncoupled beta-adrenergic signaling in isolated perfused transgenic mouse hearts. Circ Res 88: 9-11, 2001.
28. Singer D, Biel M, Lotan I, Flockerzi V, Hofmann F, Dascal N. The roles of the subunits in the function of the calcium channel. Science 253: 1553-1557, 1991.
29. 2+-channel alpha 2/delta subunit in Xenopus oocytes. Biochim Biophys Acta 1137: 39-44, 1992.
30. Striessnig J, Scheffauer F, Mitterdorfer J, Schirmer M, Glossmann H. Identification of the benzothiazepine-binding polypeptide of skeletal muscle calcium channels with (+)-cis-azidodiltiazem and anti-ligand antibodies. J Biol Chem 265: 363-370, 1990.
31. Tanabe T, Beam KG, Powell JA, Numa S. Restoration of excitation-contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA. Nature 336: 134-139, 1988.
32. Tareilus E, Roux M, Qin N, Olcese R, Zhou J, Stefani E, Birnbaumer L. A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit. Proc Natl Acad Sci USA 94: 1703-1708, 1997.
33. 2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling. Proc Natl Acad Sci USA 104: 11091-11096, 2007.
34. Varadi G, Lory P, Schultz D, Varadi M, Schwartz A. Acceleration of activation and inactivation by the beta subunit of the skeletal muscle calcium channel. Nature 352: 159-162, 1991.
35. Wycisk KA, Budde B, Feil S, Skosyrski S, Buzzi F, Neidhardt J, Glaus E, Nürnberg P, Ruether K, Berger W. Structural and functional abnormalities of retinal ribbon synapses due to Cacna2d4 mutation. Invest Ophthalmol Vis Sci 47: 3523-3530, 2006.
36. Xiao HS, Huang QH, Zhang FX, Bao L, Lu YJ, Guo C, Yang L, Huang WJ, Fu G, Xu SH, Cheng XP, Yan Q, Zhu ZD, Zhang X, Chen Z, Han ZG, Zhang X. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci USA 99: 8360-8365, 2002.
37. Yaksh TL. Calcium channels as therapeutic targets in neuropathic pain. J Pain 7: S13-S30, 2006.
38. Yamaguchi H, Okuda M, Mikala G, Fukasawa K, Varadi G. Cloning of the beta(2a) subunit of the voltage-dependent calcium channel from human heart: cooperative effect of alpha(2)/delta and beta(2a) on the membrane expression of the alpha(1C) subunit. Biochem Biophys Res Commun 267: 156-163, 2000.
39. Yasuda T, Chen L, Barr W, McRory JE, Lewis RJ, Adams DJ, Zamponi GW. Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. Eur J Neurosci 20: 1-13, 2004.
40. Zhou YY, Wang SQ, Zhu WZ, Chruscinski A, Kobilka BK. Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology. Am J Physiol Heart Circ Physiol 279: H429-H436, 2000.