Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells

Journal of Neuroscience

Volumn 21, Issue 16, 2001, Pages 6095-6104

  Barclay, Jane ^a,f   Balaguero, Nuria ^b   Mione, Marina ^b   Ackerman, Susan L ^c   Letts, Verity A ^c   Brodbeck, Jens ^b   Canti, Carles ^b   Meir, Alon ^b   Page, Karen M ^b   Kusumi, Kenro ^d   Perez Reyes, Edward ^e   Lander, Eric S ^d   Frankel, Wayne N ^c   Gardiner, R Mark ^a   Dolphin, Annette C ^b   Rees, Michele ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c JACKSON LABORATORY   (United States)

^d WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^e UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^f Novartis Inst for Medical Sciences   (United Kingdom)

Author keywords

Ataxia; Calcium channel; Cerebellum; Epilepsy; Mouse mutant; Purkinje cell; Subunit

Indexed keywords

CALCIUM CHANNEL; GENE PRODUCT; PROTEIN CACNA2D2; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CEREBELLUM; CHROMOSOME 9; CONTROLLED STUDY; EPILEPSY; GENE MAPPING; GENE MUTATION; GRANULE CELL; MOUSE MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PHENOTYPE; PRIORITY JOURNAL; PURKINJE CELL; XENOPUS;

EID: 0035882271     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-16-06095.2001     Document Type: Article

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