Identification and characterization of novel human Cav2.2 (α1B calcium channel variants lacking the synaptic protein interaction site

Journal of Neuroscience

Volumn 22, Issue 1, 2002, Pages 82-92

  Kaneko, Shuji ^a   Cooper, Conan B ^b   Nishioka, Naoto ^a   Yamasaki, Hironobu ^a   Suzuki, Atsushi ^a   Jarvis, Scott E ^b   Akaike, Akinori ^a   Satoh, Masamichi ^a   Zamponi, Gerald W ^b  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Alternative splicing; Class B calcium channel; G ; Human brain; Synprint site; Syntaxin; conotoxins

Indexed keywords

CALCIUM CHANNEL N TYPE; COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; OMEGA CONOTOXIN GVIA; OMEGA CONOTOXIN MVIIA; SYNTAXIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA LIBRARY; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROTRANSMISSION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; SYNAPSE;

EID: 0036139986     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-01-00082.2002     Document Type: Article

References (53)

1. 1A calcium channels by different G protein β subunit isoforms
2. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage-dependence
3. Functional impact of syntaxin on gating of N-type and Q-type calcium channels
4. 2+ channel gating
5. 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization
6. Calcium channel gating and modulation by transmitters depend on cellular compartmentalization
7. Direct binding of G-protein βγ complex to voltage-dependent calcium channels
8. Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin
9. 1B subunit controls reversibility of ω-conotoxin GVIA and MVIIA block
10. Interactions between a pore-blocking peptide and the voltage-sensor of a sodium channel: An electrostatic approach to channel geometry
11. 2+ channels expressed in Xenopus oocytes
12. 1B subunit of the N-type calcium channel
13. Identification of an integration center for crosstalk between protein kinase C and G protein modulation of N-type calcium channels
14. 1 subunit which have different COOH termini
15. 2+ channels by G-protein βγ subunits
16. Voltage-dependent modulation of N-type calcium channels by G-protein βγ subunits
17. Interactions between presynaptic calcium channels, cytoplasmic messengers, and proteins of the synaptic vesicle release complex
18. Distinct molecular determinants govern syntaxin 1A-mediated inactivation and G-protein inhibition of N-type calcium channels
19. G protein modulation of N-type calcium channels is facilitated by physical interactions between syntaxin 1A and Gβγ
20. 2+ channels via heterotrimeric G-proteins in neurons
21. 2+ channels characterized by recordings from isolated hippocampal dendritic segments
22. Cellular expression of the carboxyl terminus of a G protein coupled receptor kinase attenuates G beta gamma-mediated signaling
23. 1A subunit of the P/Q-type calcium channel
24. 2+ channel in rat sympathetic ganglia and brain
25. 1B generates functionally distinct N-type calcium channels in central and peripheral neurons
26. 2+ channel variants
27. 1B calcium channels by Gβγ in chick sensory neurons
28. Cysteine string protein regulates G protein modulation of N-type calcium channels
29. Inhibition of calcium channels in rat central and peripheral neurons by ω-conotoxin MVIIC
30. Differential expression and association of calcium channels subunits in development and disease
31. 1E Ca channels
32. 2+ channels
33. Primary structure and functional expression from complementary DNA of a brain calcium channel
34. A catalogue of splice junction sequences
35. Calcium channel diversity and neurotransmitter release: The omega-conotoxins and omega-agatoxins
36. The intracellular loop between domains I and II of the B-type calcium channel confers aspects of G-protein sensitivity to the E-type calcium channel
37. 1B subunit: Functional differences are β subunit-specific
38. 1 subunit is responsible for channel inhibition by G protein-coupled receptors
39. 2+ channel/syntaxin interaction
40. Identification of a syntaxin-binding site on N-type calcium channels
41. Determinants of PKC-dependent modulation of a family of neuronal calcium channels
42. Alpha 1B N-type calcium channel isoforms with distinct biophysical properties
43. Fast inactivation of voltage-dependent calcium channels: A hinged lid mechanism?
44. 2+ channels by protein kinase C in rat central and peripheral neurons: Disruption of G protein-mediated inhibition
45. 1 subunit
46. 2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals
47. 2+ channels in supporting hippocampal synaptic transmission
48. Structure and functional expression of an ω-conotoxin-sensitive human N-type calcium channel
49. Phosphorylation of the synaptic protein interaction site on N-type calcium channels inhibits interactions with SNARE proteins
50. Modulation of voltage-dependent calcium channels by G proteins
51. Decay of prepulse facilitation of N type calcium channels during G protein inhibition is consistent with binding of a single Gβγ subunits
52. 1 subunit
53. 2+ channel