α2δ expression sets presynaptic calcium channel abundance and release probability

Nature

Volumn 486, Issue 7401, 2012, Pages 122-125

  Hoppa, Michael B ^a   Lana, Beatrice ^b   Margas, Wojciech ^b   Dolphin, Annette C ^b   Ryan, Timothy A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCIUM; CHAPERONE; GABAPENTIN; METAL ION DEPENDENT ADHESION SITE; PREGABALIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VON WILLEBRAND FACTOR;

ALCOHOL; CALCIUM; CELL ORGANELLE; CHELATE; GENE EXPRESSION; IDENTIFICATION METHOD; ION; MOLECULAR ANALYSIS; PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; EXOCYTOSIS; GENE MUTATION; NERVE CELL; NEUROTRANSMITTER RELEASE; NONHUMAN; PREDICTION; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; RAT;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNELS; CALCIUM SIGNALING; EXOCYTOSIS; MICE; NEUROTRANSMITTER AGENTS; PRESYNAPTIC TERMINALS; PROBABILITY; RATS;

RATTUS;

EID: 84861947988     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11033     Document Type: Article

References (34)

1. Llinás, R., Steinberg, I. Z. & Walton, K. Presynaptic calcium currents and their relation to synaptic transmission: voltage clamp study in squid giant synapse and theoretical model for the calcium gate. Proc. Natl Acad. Sci. USA 73, 2918-2922 (1976).
2. Neher, E. & Sakaba, T. Multiple roles of calcium ions in the regulation of neurotransmitter release. Neuron 59, 861-872 (2008).
3. Davies, A. et al. The a2d subunits of voltage-gated calcium channels form GPIanchored proteins, a posttranslational modification essential for function. Proc. Natl Acad. Sci. USA 107, 1654-1659 (2010).
4. Field, M. J. et al. Identification of the a2-d-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc. Natl Acad. Sci. USA 103, 17537-17542 (2006).
5. Wang, M., Offord, J., Oxender, D. L.&Su, T. Z. Structural requirement of the calciumchannel subunit a2d for gabapentin binding. Biochem. J. 342, 313-320 (1999).
6. Neely, G. G. et al. A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene. Cell 143, 628-638 (2010).
7. Gao, B. et al. Functional properties of a new voltage-dependent calcium channel a2d auxiliary subunit gene (CACNA2D2). J. Biol.Chem.275, 12237-12242(2000).
8. Arikkath, J. & Campbell, K. P. Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr. Opin. Neurobiol. 13, 298-307 (2003).
9. Catterall, W. A. Structureandregulation of voltage-gated Ca21 channels. Annu. Rev. Cell Dev. Biol. 16, 521-555 (2000).
10. Dunlap, K., Luebke, J. I. & Turner, T. J. Exocytotic Ca21 channels in mammalian central neurons. Trends Neurosci. 18, 89-98 (1995).
11. Cao, Y. Q. et al. Presynaptic Ca21 channels compete for channel type-preferring slots in altered neurotransmission arising from Ca21 channelopathy. Neuron 43, 387-400 (2004).
12. Watschinger, K. et al. Functional properties and modulation of extracellular epitope-tagged CaV2.1 voltage-gated calcium channels. Channels 2, 461-473 (2008).
13. Winterfield, J. R. & Swartz, K. J. A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels. J. Gen. Physiol. 116, 637-644 (2000).
14. Dolphin, A. C. Calcium channel diversity: multiple roles of calcium channel subunits. Curr. Opin. Neurobiol. 19, 237-244 (2009).
15. Pragnell, M. et al. Calciumchannel b-subunit binds to a conserved motif in the I-II cytoplasmic linker of the a1-subunit. Nature 368, 67-70 (1994).
16. Schneggenburger, R., Sakaba, T.& Neher, E. Vesicle pools and short-termsynaptic depression: lessons from a large synapse. Trends Neurosci. 25, 206-212 (2002).
17. Ariel, P. & Ryan, T. A. Optical mapping of release properties in synapses. Front. Neural Circuits 4, 18 (2010).
18. Catterall, W. A. & Few, A. P. Calciumchannel regulation and presynaptic plasticity. Neuron 59, 882-901 (2008).
19. Tian, L. et al.Imaging neural activity inworms, flies and mice withimprovedGCaMP calcium indicators. Nature Methods 6, 875-881 (2009).
20. Dodge, F. A. Jr & Rahamimoff, R. Co-operative action a calciumions in transmitter release at the neuromuscular junction. J. Physiol. (Lond.) 193, 419-432 (1967).
21. Parekh, A. B. Ca21 microdomains near plasmamembrane Ca21 channels: impact on cell function. J. Physiol. (Lond.) 586, 3043-3054 (2008).
22. Cant́, C. et al. Themetal-ion-dependent adhesion site in the Von Willebrand factor-A domain of a2d subunits is key to trafficking voltage-gated Ca21 channels. Proc. Natl Acad. Sci. USA 102, 11230-11235 (2005).
23. Springer, T. A. Complement and the multifaceted functions of VWA and integrin I domains. Structure 14, 1611-1616 (2006).
24. Lacy, D. B., Wigelsworth, D. J., Scobie, H. M., Young, J. A. & Collier, R. J. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proc. Natl Acad. Sci. USA 101, 6367-6372 (2004).
25. Whittaker, C. A. & Hynes, R. O. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Mol. Biol. Cell 13, 3369-3387 (2002).
26. Davies, A. et al. The calciumchannel a2d-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function. J. Neurosci. 26, 8748-8757 (2006).
27. Brown, J. T. & Randall, A. Gabapentin fails to alter P/Q-type Ca21 channelmediated synaptic transmission in the hippocampus in vitro. Synapse 55, 262-269 (2005).
28. Tran-Van-Minh, A. & Dolphin, A. C. The a2d ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit a2d-2. J. Neurosci. 30, 12856-12867 (2010).
29. Kurshan, P. T., Oztan, A.& Schwarz, T. L. Presynaptic a2d-3 is required for synaptic morphogenesis independent of its Ca21-channel functions. Nature Neurosci. 12, 1415-1423 (2009).
30. Kim, S. H. & Ryan, T. A. CDK5 serves as a major control point in neurotransmitter release. Neuron 67, 797-809 (2010).
31. Miesenböck, G., De Angelis, D. A. & Rothman, J. E. Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature 394, 192-195 (1998).
32. Voglmaier, S. M. et al. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron 51, 71-84 (2006).
33. Shaner, N. C. et al. Improving the photostability of brightmonomeric orange and red fluorescent proteins. Nature Methods 5, 545-551 (2008).
34. Viard, P. et al. PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nature Neurosci. 7, 939-946 (2004).