Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/α1G T-type calcium channels

Circulation Research

Volumn 98, Issue 11, 2006, Pages 1422-1430

  Mangoni, Matteo E ^a   Traboulsie, Achraf ^a   Leoni, Anne Laure ^b   Couette, Brigitte ^a   Marger, Laurine ^a   Le Quang, Khai ^b   Kupfer, Elodie ^a   Cohen Solal, Anne ^a   Vilar, José ^c   Shin, Hee Sup ^d   Escande, Denis ^b   Charpentier, Flavien ^b   Nargeot, Joël ^a   Lory, Philippe ^a  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b L INSTITUT DU THORAX   (France)

^c INSERM   (France)

^d Korea Institute of Science and Technology   (South Korea)

Author keywords

Conduction; Knockout mice; Pacemaker activity; Sinoatrial node; T type calcium channel

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; ION CHANNEL; CA(V)3.1 PROTEIN, MOUSE; HYPNOTIC SEDATIVE AGENT; ISOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; CACNA1G GENE; CALCIUM CURRENT; CELL ISOLATION; CONTROLLED STUDY; DIASTOLE; ELECTROCARDIOGRAM; GENE; GENE DISRUPTION; GENE INACTIVATION; HEART ATRIOVENTRICULAR NODE; HEART BEAT; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE EXCITABILITY; HEART RIGHT ATRIUM; MAMMAL; MOUSE; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; SINUS NODE; TELEMETRY; WILD TYPE; ANIMAL; ELECTRIC CONDUCTIVITY; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; HEART RATE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; ATRIOVENTRICULAR NODE; BRADYCARDIA; CALCIUM CHANNELS, T-TYPE; ELECTRIC CONDUCTIVITY; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; HEART RATE; HYPNOTICS AND SEDATIVES; MICE; MICE, KNOCKOUT; PROTEIN ISOFORMS; SINOATRIAL NODE;

EID: 33745403607     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000225862.14314.49     Document Type: Article

References (34)

1. Irisawa H, Brown HF, Giles W. Cardiac pacemaking in the sinoatrial node. Physiol Rev. 1993;73:197-227.
2. Boyett MR, Honjo H, Kodama I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res. 2000;47:658-687.
3. Difrancesco D. Serious workings of the funny current. Prog Biophys Mol Biol. 2006;90:13-25.
4. Lakatta EG, Maltsev VA, Bogdanov KY, Stern MD, Vinogradova TM. Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance. Circ Res. 2003;92:e45-e50.
5. 2+ release is not a dominating factor in sinoatrial node pacemaker activity. Circ Res. 2003;92:e41-e44.
6. Baruscotti M, Bucchi A, Difrancesco D. Physiology and pharmacology of the cardiac pacemaker ("funny") current. Pharmacol Ther. 2005;107:59-79.
7. Stieber J, Herrmann S, Feil S, Loster J, Feil R, Biel M, Hofmann F, Ludwig A. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A. 2003;100:15235-15240.
8. 2+ current to electrical activity in sinoatrial nodal myocytes of rabbits. Am J Physiol. 1999;276:H1064-H1077.
9. 1D, calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circ Res. 2002;90:981-987.
10. 2+ channels in cardiac pacemaker activity. Proc Natl Acad Sci U S A. 2003;100:5543-5548.
11. 2+ release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells. Circ Res. 2002;90:73-79.
12. Lei M, Jones SA, Liu J, Lancaster MK, Fung SS, Dobrzynski H, Camelliti P, Maier SK, Noble D, Boyett MR. Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking. J Physiol. 2004;559:835-848.
13. Baruscotti M, DiFrancesco D, Robinson RB. A TTX-sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino-atrial node cells. J Physiol. 1996;492:21-30.
14. Maier SK, Westenbroek RE, Yamanushi TT, Dobrzynski H, Boyett MR, Catterall WA, Scheuer T. An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node. Proc Natl Acad Sci U S A. 2003;100:3507-3512.
15. Lei M, Goddard C, Liu J, Leoni AL, Royer A, Fung SS, Xiao G, Ma A, Zhang H, Charpentier F, Vandenberg JI, Colledge WH, Grace AA, Huang CL. Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a. J Physiol. 2005;567:387-400.
16. Munk AA, Adjemian RA, Zhao J, Ogbaghebriel A, Shrier A. Electrophysiological properties of morphologically distinct cells isolated from the rabbit atrioventricular node. J Physiol. 1996;493:801-818.
17. Yuill KH, Hancox JC. Characteristics of single cells isolated from the atrioventricular node of the adult guinea-pig heart. Pflugers Arch. 2002; 445:311-320.
18. Efimov IR, Nikolski VP, Rothenberg F, Greener ID, Li J, Dobrzynski H, Boyett M. Structure-function relationship in the AV junction. Anat Rec A Discov Mol Cell Evol Biol. 2004;280:952-965.
19. Papadatos GA, Wallerstein PM, Head CE, Ratcliff R, Brady PA, Benndorf K, Saumarez RC, Trezise AE, Huang CL, Vandenberg JI, Colledge WH, Grace AA. Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A. 2002;99:6210-6215.
20. Hagiwara N, Irisawa H, Kameyama M. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol. 1988;395:233-253.
21. 2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol. 2000;524:415-422.
22. f) in isolated mouse sino-atrial cells. Cardiovasc Res. 2001;52: 51-64.
23. 2+ currents in canine cardiac Purkinje cells. Am J Physiol. 1989;256: H1478-H1492.
24. 2+ currents in single canine Purkinje cells. Circ Res. 1989;65:1735-1750.
25. Perez-Reyes E. Molecular physiology of low-voltage-activated T-type calcium channels. Physiol Rev. 2003;83:117-161.
26. 2+ channels. Neuron. 2001;31:35-45.
27. Lee JH, Gomora JC, Cribbs LL, Perez-Reyes E. Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H. Biophys J. 1999;77:3034-3042.
28. Lande G, Demolombe S, Bammert A, Moorman A, Charpentier F, Escande D. Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part II: pharmacological profile. Cardiovasc Res. 2001; 50:328-334.
29. 2+ channels. Science. 2003;302:1416-1418.
30. Royer A, van Veen TA, Le Bouter S, Marionneau C, Griol-Charhbili V, Leoni AL, Steenman M, van Rijen HV, Demolombe S, Goddard CA, Richer C, Escoubet B, Jarry-Guichard T, Colledge WH, Gros D, de Bakker JM, Grace AA, Escande D, Charpentier F. Mouse model of SCN5A-linked hereditary Lenegre's disease: age-related conduction slowing and myocardial fibrosis. Circulation. 2005;111:1738-1746.
31. 2+ channel gene family. Circ Res. 1998;83:103-109.
32. 1G subunit that forms T-type calcium channels. J Biol Chem. 2000;275:6090-6100.
33. Hu K, Qu Y, Yue Y, Boutjdir M. Functional basis of sinus bradycardia in congenital heart block. Circ Res. 2004;94:e32-e38.
34. Birch PJ, Dekker LV, James IF, Southan A, Cronk D. Strategies to identify ion channel modulators: current and novel approaches to target neuropathic pain. Drug Discov Today. 2004;9:410-418.