Conserved Ca2+-antagonist-binding properties and putative folding structure of a recombinant high-affinity dihydropyridine-binding domain

Biochemical Journal

Volumn 347, Issue 3, 2000, Pages 829-836

  Huber, Irene ^a   Wappl, Edwin ^a   Herzog, Alexander ^b   Mitterdorfer, Jörg ^a   Glossmann, Hartmut ^a   Langer, Thierry ^b   Striessnig, Jörg ^a  

^a A 6020   (Austria)

^b lnst fur Pharmazeutische Chemie   (Austria)

Author keywords

Ca2+ channel blocker; Drug receptor; Mutagenesis

Indexed keywords

CALCIUM ANTAGONIST; CALCIUM CHANNEL; DIHYDROPYRIDINE; DILTIAZEM; ISRADIPINE; MIBEFRADIL; MUTANT PROTEIN; NIFEDIPINE; NIMODIPINE; NITRENDIPINE; POTASSIUM CHANNEL; RECEPTOR SUBUNIT; TETRANDRINE; TRITIUM; 1,4 DIHYDROPYRIDINE; 1,4-DIHYDROPYRIDINE; BACTERIAL PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; DIHYDROPYRIDINE DERIVATIVE; HYBRID PROTEIN; PROKARYOTIC POTASSIUM CHANNEL;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MODEL; PRIORITY JOURNAL; PROTEIN FOLDING; STEREOCHEMISTRY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RABBIT; SEQUENCE ALIGNMENT; STEREOISOMERISM; THERMODYNAMICS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CELL LINE; CELL MEMBRANE; DIHYDROPYRIDINES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RABBITS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 0034192309     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3470829     Document Type: Article

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