A destructive interaction mechanism accounts for dominant-negative effects of misfolded mutants of voltage-gated calcium channels

Journal of Neuroscience

Volumn 28, Issue 17, 2008, Pages 4501-4511

  Mezghrani, Alexandre ^a   Monteil, Arnaud ^a   Watschinger, Katrin ^b   Sinnegger Brauns, Martina J ^b   Barrère, Christian ^a   Bourinet, Emmanuel ^a   Nargeot, Joël ^a   Striessnig, Jörg ^b   Lory, Philippe ^a  

^a UNIV MONTPELLIER   (France)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Dominant negative activity; Endoplasmic reticulum; Episodic ataxia type 2; Misfolding; P Q type; Proteasome; T type; Voltage gated calcium channel

Indexed keywords

CALCIUM CHANNEL T TYPE; PROTEASOME; PROTEIN SUBUNIT; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; VOLTAGE DEPENDENT CALCIUM CHANNEL (P Q TYPE); VOLTAGE-DEPENDENT CALCIUM CHANNEL (P-Q TYPE);

ARTICLE; BINDING COMPETITION; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MUTANT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; WILD TYPE; AMINO ACID SUBSTITUTION; CELL LINE; CEREBELLAR ATAXIA; CHEMISTRY; COMPARATIVE STUDY; GENE DELETION; GENETICS; METABOLISM; PROTEIN FOLDING; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, N-TYPE; CELL LINE; CELL LINE, TUMOR; CEREBELLAR ATAXIA; HUMANS; PROTEIN FOLDING; SEQUENCE DELETION;

EID: 43749103339     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2844-07.2008     Document Type: Article

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