메뉴 건너뛰기




Volumn 22, Issue 4, 2014, Pages 208-217

GSK3β and the control of infectious bacterial diseases

Author keywords

Cytokines; GSK3 ; Immune evasion; Inflammation; Septic shock; TLRs

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; 4 BENZYL 2 METHYL 1,2,4 THIADIAZOLIDINE 3,5 DIONE; GLYCOGEN SYNTHASE KINASE 3BETA; ISOENZYME; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84897371692     PISSN: 0966842X     EISSN: 18784380     Source Type: Journal    
DOI: 10.1016/j.tim.2014.01.009     Document Type: Review
Times cited : (85)

References (87)
  • 1
    • 78651075836 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: a point of convergence for the host inflammatory response
    • Wang H., et al. Glycogen synthase kinase 3: a point of convergence for the host inflammatory response. Cytokine 2011, 53:130-140.
    • (2011) Cytokine , vol.53 , pp. 130-140
    • Wang, H.1
  • 2
    • 0025286104 scopus 로고
    • Molecular cloning and expression of glycogen synthase kinase-3/factor A
    • Woodgett J.R. Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J. 1990, 9:2431-2438.
    • (1990) EMBO J. , vol.9 , pp. 2431-2438
    • Woodgett, J.R.1
  • 3
    • 0034612636 scopus 로고    scopus 로고
    • Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    • Hoeflich K.P., et al. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 2000, 406:86-90.
    • (2000) Nature , vol.406 , pp. 86-90
    • Hoeflich, K.P.1
  • 4
    • 84859369193 scopus 로고    scopus 로고
    • Modulation of GSK-3beta activity in Venezuelan equine encephalitis virus infection
    • Kehn-Hall K., et al. Modulation of GSK-3beta activity in Venezuelan equine encephalitis virus infection. PLoS ONE 2012, 7:e34761.
    • (2012) PLoS ONE , vol.7
    • Kehn-Hall, K.1
  • 5
    • 77952487841 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus
    • Spinnler K., et al. Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus. Med. Mycol. 2010, 48:589-597.
    • (2010) Med. Mycol. , vol.48 , pp. 589-597
    • Spinnler, K.1
  • 6
    • 79956047327 scopus 로고    scopus 로고
    • Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases
    • Osolodkin D.I., et al. Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases. Parasitology 2011, 1-11.
    • (2011) Parasitology , pp. 1-11
    • Osolodkin, D.I.1
  • 7
    • 0030951346 scopus 로고    scopus 로고
    • Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue
    • Cross D.A., et al. Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS Lett. 1997, 406:211-215.
    • (1997) FEBS Lett. , vol.406 , pp. 211-215
    • Cross, D.A.1
  • 8
    • 43249106330 scopus 로고    scopus 로고
    • Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation
    • Thornton T.M., et al. Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science 2008, 320:667-670.
    • (2008) Science , vol.320 , pp. 667-670
    • Thornton, T.M.1
  • 9
    • 84880962366 scopus 로고    scopus 로고
    • 2+ increase in mouse dendritic cells
    • 2+increase in mouse dendritic cells. Biochem. Biophys. Res. Commun. 2013, 437:336-341.
    • (2013) Biochem. Biophys. Res. Commun. , vol.437 , pp. 336-341
    • Russo, A.1
  • 10
    • 0035800662 scopus 로고    scopus 로고
    • P90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils
    • De Mesquita D.D., et al. p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils. FEBS Lett. 2001, 502:84-88.
    • (2001) FEBS Lett. , vol.502 , pp. 84-88
    • De Mesquita, D.D.1
  • 11
    • 0032821768 scopus 로고    scopus 로고
    • A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
    • Thomas G.M., et al. A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin. FEBS Lett. 1999, 458:247-251.
    • (1999) FEBS Lett. , vol.458 , pp. 247-251
    • Thomas, G.M.1
  • 12
    • 0034969088 scopus 로고    scopus 로고
    • A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation
    • Frame S., et al. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol. Cell 2001, 7:1321-1327.
    • (2001) Mol. Cell , vol.7 , pp. 1321-1327
    • Frame, S.1
  • 13
    • 0035665719 scopus 로고    scopus 로고
    • The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation
    • Bax B., et al. The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. Structure 2001, 9:1143-1152.
    • (2001) Structure , vol.9 , pp. 1143-1152
    • Bax, B.1
  • 14
    • 73149097234 scopus 로고    scopus 로고
    • Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)
    • Beurel E., et al. Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). Trends Immunol. 2010, 31:24-31.
    • (2010) Trends Immunol. , vol.31 , pp. 24-31
    • Beurel, E.1
  • 15
    • 84867427919 scopus 로고    scopus 로고
    • Sensing of microbial molecular patterns by Toll-like receptors
    • Song D.H., Lee J.O. Sensing of microbial molecular patterns by Toll-like receptors. Immunol. Rev. 2012, 250:216-229.
    • (2012) Immunol. Rev. , vol.250 , pp. 216-229
    • Song, D.H.1    Lee, J.O.2
  • 16
    • 84870310393 scopus 로고    scopus 로고
    • Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice
    • Adamowicz K., et al. Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice. Mol. Med. 2012, 28:1190-1196.
    • (2012) Mol. Med. , vol.28 , pp. 1190-1196
    • Adamowicz, K.1
  • 17
    • 23944486750 scopus 로고    scopus 로고
    • Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
    • Martin M., et al. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat. Immunol. 2005, 6:777-784.
    • (2005) Nat. Immunol. , vol.6 , pp. 777-784
    • Martin, M.1
  • 18
    • 4944243782 scopus 로고    scopus 로고
    • GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity
    • Viatour P., et al. GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. Mol. Cell 2004, 16:35-45.
    • (2004) Mol. Cell , vol.16 , pp. 35-45
    • Viatour, P.1
  • 19
    • 0036081578 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes
    • Schwabe R.F., Brenner D.A. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 283:G204-G211.
    • (2002) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.283
    • Schwabe, R.F.1    Brenner, D.A.2
  • 20
    • 0141928780 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability
    • Demarchi F., et al. Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability. J. Biol. Chem. 2003, 278:39583-39590.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39583-39590
    • Demarchi, F.1
  • 21
    • 0037207474 scopus 로고    scopus 로고
    • BetaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932
    • Lang V., et al. betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol. Cell. Biol. 2003, 23:402-413.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 402-413
    • Lang, V.1
  • 22
    • 58149198796 scopus 로고    scopus 로고
    • IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta
    • Wang H., et al. IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta. J. Immunol. 2008, 181:6797-6802.
    • (2008) J. Immunol. , vol.181 , pp. 6797-6802
    • Wang, H.1
  • 23
    • 59849109973 scopus 로고    scopus 로고
    • Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2
    • Rehani K., et al. Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2. J. Immunol. 2009, 182:547-553.
    • (2009) J. Immunol. , vol.182 , pp. 547-553
    • Rehani, K.1
  • 24
    • 11244334132 scopus 로고    scopus 로고
    • A novel signaling pathway mediates the inhibition of CCL3/4 expression by prostaglandin E2
    • Jing H., et al. A novel signaling pathway mediates the inhibition of CCL3/4 expression by prostaglandin E2. J. Biol. Chem. 2004, 279:55176-55186.
    • (2004) J. Biol. Chem. , vol.279 , pp. 55176-55186
    • Jing, H.1
  • 25
    • 33745807628 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase gene in glial cells
    • Saha R.N., Pahan K. Regulation of inducible nitric oxide synthase gene in glial cells. Antioxid. Redox Signal. 2006, 8:929-947.
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 929-947
    • Saha, R.N.1    Pahan, K.2
  • 26
    • 33646595287 scopus 로고    scopus 로고
    • IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins
    • Hu X., et al. IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity 2006, 24:563-574.
    • (2006) Immunity , vol.24 , pp. 563-574
    • Hu, X.1
  • 27
    • 39149125131 scopus 로고    scopus 로고
    • Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells
    • Rehani K., et al. Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells. Biochim. Biophys. Acta 2008, 1783:375-382.
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 375-382
    • Rehani, K.1
  • 28
    • 64149112132 scopus 로고    scopus 로고
    • STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria
    • Samavati L., et al. STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria. Mol. Immunol. 2009, 46:1867-1877.
    • (2009) Mol. Immunol. , vol.46 , pp. 1867-1877
    • Samavati, L.1
  • 29
    • 52049094596 scopus 로고    scopus 로고
    • Differential regulation of STAT family members by glycogen synthase kinase-3
    • Beurel E., Jope R.S. Differential regulation of STAT family members by glycogen synthase kinase-3. J. Biol. Chem. 2008, 283:21934-21944.
    • (2008) J. Biol. Chem. , vol.283 , pp. 21934-21944
    • Beurel, E.1    Jope, R.S.2
  • 30
    • 0346103717 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages
    • Williams L., et al. Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J. Immunol. 2004, 172:567-576.
    • (2004) J. Immunol. , vol.172 , pp. 567-576
    • Williams, L.1
  • 31
    • 84872770975 scopus 로고    scopus 로고
    • Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function
    • Kawashima K., et al. Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function. Life Sci. 2012, 91:1027-1032.
    • (2012) Life Sci. , vol.91 , pp. 1027-1032
    • Kawashima, K.1
  • 32
    • 66449111088 scopus 로고    scopus 로고
    • Reflex control of immunity
    • Tracey K.J. Reflex control of immunity. Nat. Rev. Immunol. 2009, 9:418-428.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 418-428
    • Tracey, K.J.1
  • 33
    • 84869863148 scopus 로고    scopus 로고
    • Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells
    • Bagaitkar J., et al. Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells. Tob. Induc. Dis. 2012, 10:18.
    • (2012) Tob. Induc. Dis. , vol.10 , pp. 18
    • Bagaitkar, J.1
  • 34
    • 70350321911 scopus 로고    scopus 로고
    • Tobacco use increases susceptibility to bacterial infection
    • Bagaitkar J., et al. Tobacco use increases susceptibility to bacterial infection. Tob. Induc. Dis. 2008, 4:12.
    • (2008) Tob. Induc. Dis. , vol.4 , pp. 12
    • Bagaitkar, J.1
  • 35
    • 23844454674 scopus 로고    scopus 로고
    • Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    • de Jonge W.J., et al. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat. Immunol. 2005, 6:844-851.
    • (2005) Nat. Immunol. , vol.6 , pp. 844-851
    • de Jonge, W.J.1
  • 36
    • 84880664704 scopus 로고    scopus 로고
    • The role of JAK-3 in regulating TLR-mediated inflammatory cytokine production in innate immune cells
    • Wang H., et al. The role of JAK-3 in regulating TLR-mediated inflammatory cytokine production in innate immune cells. J. Immunol. 2013, 191:1164-1174.
    • (2013) J. Immunol. , vol.191 , pp. 1164-1174
    • Wang, H.1
  • 37
    • 0032614379 scopus 로고    scopus 로고
    • Cellular mechanisms of wingless/Wnt signal transduction
    • Dierick H., Bejsovec A. Cellular mechanisms of wingless/Wnt signal transduction. Curr. Top. Dev. Biol. 1999, 43:153-190.
    • (1999) Curr. Top. Dev. Biol. , vol.43 , pp. 153-190
    • Dierick, H.1    Bejsovec, A.2
  • 38
    • 34249034925 scopus 로고    scopus 로고
    • β-Catenin activity negatively regulates bacteria-induced inflammation
    • Duan Y., et al. β-Catenin activity negatively regulates bacteria-induced inflammation. Lab. Invest. 2007, 87:613-624.
    • (2007) Lab. Invest. , vol.87 , pp. 613-624
    • Duan, Y.1
  • 39
    • 79955479506 scopus 로고    scopus 로고
    • Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses
    • Schaale K., et al. Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses. Eur. J. Cell Biol. 2011, 90:553-559.
    • (2011) Eur. J. Cell Biol. , vol.90 , pp. 553-559
    • Schaale, K.1
  • 40
    • 79952979166 scopus 로고    scopus 로고
    • Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblasts
    • Sakurai R., et al. Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblasts. Exp. Lung Res. 2011, 37:144-154.
    • (2011) Exp. Lung Res. , vol.37 , pp. 144-154
    • Sakurai, R.1
  • 41
    • 84867518351 scopus 로고    scopus 로고
    • Curcumin protects against regional myocardial ischemia/reperfusion injury through activation of RISK/GSK-3beta and inhibition of p38 MAPK and JNK
    • Jeong C.W., et al. Curcumin protects against regional myocardial ischemia/reperfusion injury through activation of RISK/GSK-3beta and inhibition of p38 MAPK and JNK. J. Cardiovasc. Pharmacol. Ther. 2012, 17:387-394.
    • (2012) J. Cardiovasc. Pharmacol. Ther. , vol.17 , pp. 387-394
    • Jeong, C.W.1
  • 42
    • 84884903877 scopus 로고    scopus 로고
    • Activator or inhibitor? GSK-3 as a new drug target
    • Takahashi-Yanaga F. Activator or inhibitor? GSK-3 as a new drug target. Biochem. Pharmacol. 2013, 86:191-199.
    • (2013) Biochem. Pharmacol. , vol.86 , pp. 191-199
    • Takahashi-Yanaga, F.1
  • 43
    • 24944567775 scopus 로고    scopus 로고
    • GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat
    • Dugo L., et al. GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat. Crit. Care Med. 2005, 33:1903-1912.
    • (2005) Crit. Care Med. , vol.33 , pp. 1903-1912
    • Dugo, L.1
  • 44
    • 84859946299 scopus 로고    scopus 로고
    • Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia
    • Noh K.T., et al. Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia. J. Biol. Chem. 2012, 287:14226-14233.
    • (2012) J. Biol. Chem. , vol.287 , pp. 14226-14233
    • Noh, K.T.1
  • 45
    • 33749336485 scopus 로고    scopus 로고
    • Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice
    • Ha T., et al. Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice. Am. J. Physiol. Heart Circ. Physiol. 2006, 291:H1910-H1918.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291
    • Ha, T.1
  • 46
    • 46449107402 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta suppresses tumor necrosis factor-alpha expression in cardiomyocytes during lipopolysaccharide stimulation
    • Shen E., et al. Glycogen synthase kinase-3beta suppresses tumor necrosis factor-alpha expression in cardiomyocytes during lipopolysaccharide stimulation. J. Cell. Biochem. 2008, 104:329-338.
    • (2008) J. Cell. Biochem. , vol.104 , pp. 329-338
    • Shen, E.1
  • 47
    • 78951480982 scopus 로고    scopus 로고
    • LPS impairs phospholipid synthesis by triggering beta-transducin repeat-containing protein (beta-TrCP)-mediated polyubiquitination and degradation of the surfactant enzyme acyl-CoA:lysophosphatidylcholine acyltransferase I (LPCAT1)
    • Zou C., et al. LPS impairs phospholipid synthesis by triggering beta-transducin repeat-containing protein (beta-TrCP)-mediated polyubiquitination and degradation of the surfactant enzyme acyl-CoA:lysophosphatidylcholine acyltransferase I (LPCAT1). J. Biol. Chem. 2011, 286:2719-2727.
    • (2011) J. Biol. Chem. , vol.286 , pp. 2719-2727
    • Zou, C.1
  • 48
    • 77956060500 scopus 로고    scopus 로고
    • Inhaled aerosolized insulin: a 'topical' anti-inflammatory treatment for acute lung injury and respiratory distress syndrome?
    • Shapiro H., et al. Inhaled aerosolized insulin: a 'topical' anti-inflammatory treatment for acute lung injury and respiratory distress syndrome?. Inflammation 2010, 33:315-319.
    • (2010) Inflammation , vol.33 , pp. 315-319
    • Shapiro, H.1
  • 49
    • 84875942000 scopus 로고    scopus 로고
    • Protective effects of lithium: a new look at an old drug with potential antioxidative and anti-inflammatory effects in an animal model of sepsis
    • Albayrak A., et al. Protective effects of lithium: a new look at an old drug with potential antioxidative and anti-inflammatory effects in an animal model of sepsis. Int. Immunopharmacol. 2013, 16:35-40.
    • (2013) Int. Immunopharmacol. , vol.16 , pp. 35-40
    • Albayrak, A.1
  • 50
    • 79952153637 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3β activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnover
    • Bertsch S., et al. Inhibition of glycogen synthase kinase 3β activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnover. Shock 2011, 35:266-274.
    • (2011) Shock , vol.35 , pp. 266-274
    • Bertsch, S.1
  • 51
    • 84860822029 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B activation in mouse osteoblasts
    • Die L., et al. Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B activation in mouse osteoblasts. Mol. Immunol. 2012, 52:38-49.
    • (2012) Mol. Immunol. , vol.52 , pp. 38-49
    • Die, L.1
  • 52
    • 84882777501 scopus 로고    scopus 로고
    • Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3beta signaling pathway
    • Ishikawa M., et al. Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3beta signaling pathway. Biochim. Biophys. Acta 2013, 1832:2035-2043.
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 2035-2043
    • Ishikawa, M.1
  • 53
    • 84875432622 scopus 로고    scopus 로고
    • Regulatory role of GSK-3 beta on NF-kappa B, nitric oxide, and TNF-alpha in group A streptococcal infection
    • Chang Y.T., et al. Regulatory role of GSK-3 beta on NF-kappa B, nitric oxide, and TNF-alpha in group A streptococcal infection. Mediators Inflamm. 2013, 2013:720689.
    • (2013) Mediators Inflamm. , vol.2013 , pp. 720689
    • Chang, Y.T.1
  • 54
    • 84866734236 scopus 로고    scopus 로고
    • Neuroprotective effects of pretreatment with propofol in LPS-induced BV-2 microglia cells: role of TLR4 and GSK-3beta
    • Gui B., et al. Neuroprotective effects of pretreatment with propofol in LPS-induced BV-2 microglia cells: role of TLR4 and GSK-3beta. Inflammation 2012, 35:1632-1640.
    • (2012) Inflammation , vol.35 , pp. 1632-1640
    • Gui, B.1
  • 55
    • 58249117791 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice
    • Zhang P., et al. Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice. Mol. Immunol. 2009, 46:677-687.
    • (2009) Mol. Immunol. , vol.46 , pp. 677-687
    • Zhang, P.1
  • 56
    • 84866494960 scopus 로고    scopus 로고
    • GSK-3 mediates the release of IL-1beta, TNF-alpha and IL-10 from cortical glia
    • Green H.F., Nolan Y.M. GSK-3 mediates the release of IL-1beta, TNF-alpha and IL-10 from cortical glia. Neurochem. Int. 2012, 61:666-671.
    • (2012) Neurochem. Int. , vol.61 , pp. 666-671
    • Green, H.F.1    Nolan, Y.M.2
  • 57
    • 68249159584 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells
    • Huang W.C., et al. Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells. Immunology 2009, 128:e275-e286.
    • (2009) Immunology , vol.128
    • Huang, W.C.1
  • 58
    • 84866511781 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation
    • Rom S., et al. Glycogen synthase kinase 3beta inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation. Am. J. Pathol. 2012, 181:1414-1425.
    • (2012) Am. J. Pathol. , vol.181 , pp. 1414-1425
    • Rom, S.1
  • 59
    • 69049102099 scopus 로고    scopus 로고
    • Staphylococcus aureus induces microglial inflammation via a glycogen synthase kinase 3beta-regulated pathway
    • Cheng Y.L., et al. Staphylococcus aureus induces microglial inflammation via a glycogen synthase kinase 3beta-regulated pathway. Infect. Immun. 2009, 77:4002-4008.
    • (2009) Infect. Immun. , vol.77 , pp. 4002-4008
    • Cheng, Y.L.1
  • 60
    • 79961209264 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors
    • Fallah M.P., et al. Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors. Mech. Ageing Dev. 2011, 132:274-286.
    • (2011) Mech. Ageing Dev. , vol.132 , pp. 274-286
    • Fallah, M.P.1
  • 61
    • 84856785397 scopus 로고    scopus 로고
    • Manipulation of kinase signaling by bacterial pathogens
    • Krachler A.M., et al. Manipulation of kinase signaling by bacterial pathogens. J. Cell Biol. 2011, 195:1083-1092.
    • (2011) J. Cell Biol. , vol.195 , pp. 1083-1092
    • Krachler, A.M.1
  • 62
    • 33744457909 scopus 로고    scopus 로고
    • Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation
    • Mukherjee S., et al. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science 2006, 312:1211-1214.
    • (2006) Science , vol.312 , pp. 1211-1214
    • Mukherjee, S.1
  • 63
    • 42949162611 scopus 로고    scopus 로고
    • RNAi screen reveals an Abl kinase-dependent host cell pathway involved in Pseudomonas aeruginosa internalization
    • Pielage J.F., et al. RNAi screen reveals an Abl kinase-dependent host cell pathway involved in Pseudomonas aeruginosa internalization. PLoS Pathog. 2008, 4:e1000031.
    • (2008) PLoS Pathog. , vol.4
    • Pielage, J.F.1
  • 64
    • 84877832916 scopus 로고    scopus 로고
    • Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence
    • Choi C.H., et al. Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence. Cell. Microbiol. 2013, 15:961-976.
    • (2013) Cell. Microbiol. , vol.15 , pp. 961-976
    • Choi, C.H.1
  • 65
    • 84876829405 scopus 로고    scopus 로고
    • The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-kappaB RelA/p65
    • Takeuchi H., et al. The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-kappaB RelA/p65. PLoS Pathog. 2013, 9:e1003326.
    • (2013) PLoS Pathog. , vol.9
    • Takeuchi, H.1
  • 66
    • 84857216736 scopus 로고    scopus 로고
    • HijAkt: the PI3K/Akt pathway in virus replication and pathogenesis
    • Dunn E.F., Connor J.H. HijAkt: the PI3K/Akt pathway in virus replication and pathogenesis. Prog. Mol. Biol. Transl. Sci. 2012, 106:223-250.
    • (2012) Prog. Mol. Biol. Transl. Sci. , vol.106 , pp. 223-250
    • Dunn, E.F.1    Connor, J.H.2
  • 67
    • 68049090013 scopus 로고    scopus 로고
    • Addressing the effects of Salmonella internalization in host cell signaling on a reverse-phase protein array
    • Molero C., et al. Addressing the effects of Salmonella internalization in host cell signaling on a reverse-phase protein array. Proteomics 2009, 9:3652-3665.
    • (2009) Proteomics , vol.9 , pp. 3652-3665
    • Molero, C.1
  • 68
    • 34247119640 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane
    • Kierbel A., et al. Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane. J. Cell Biol. 2007, 177:21-27.
    • (2007) J. Cell Biol. , vol.177 , pp. 21-27
    • Kierbel, A.1
  • 69
    • 0141780931 scopus 로고    scopus 로고
    • M1 protein triggers a phosphoinositide cascade for group A Streptococcus invasion of epithelial cells
    • Purushothaman S.S., et al. M1 protein triggers a phosphoinositide cascade for group A Streptococcus invasion of epithelial cells. Infect. Immun. 2003, 71:5823-5830.
    • (2003) Infect. Immun. , vol.71 , pp. 5823-5830
    • Purushothaman, S.S.1
  • 70
    • 0036130660 scopus 로고    scopus 로고
    • Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism
    • Kwok T., et al. Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism. Infect. Immun. 2002, 70:2108-2120.
    • (2002) Infect. Immun. , vol.70 , pp. 2108-2120
    • Kwok, T.1
  • 71
    • 0036326980 scopus 로고    scopus 로고
    • Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells
    • Coombes B.K., Mahony J.B. Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells. Cell. Microbiol. 2002, 4:447-460.
    • (2002) Cell. Microbiol. , vol.4 , pp. 447-460
    • Coombes, B.K.1    Mahony, J.B.2
  • 72
    • 0033546175 scopus 로고    scopus 로고
    • The Listeria monocytogenes protein InlB is an agonist of mammalian phosphoinositide 3-kinase
    • Ireton K., et al. The Listeria monocytogenes protein InlB is an agonist of mammalian phosphoinositide 3-kinase. J. Biol. Chem. 1999, 274:17025-17032.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17025-17032
    • Ireton, K.1
  • 73
    • 67650742320 scopus 로고    scopus 로고
    • Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells
    • Popova T., et al. Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells. FEMS Immunol. Med. Microbiol. 2009, 56:129-142.
    • (2009) FEMS Immunol. Med. Microbiol. , vol.56 , pp. 129-142
    • Popova, T.1
  • 74
    • 80855140116 scopus 로고    scopus 로고
    • The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells
    • Oviedo-Boyso J., et al. The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. Infect. Immun. 2011, 79:4569-4577.
    • (2011) Infect. Immun. , vol.79 , pp. 4569-4577
    • Oviedo-Boyso, J.1
  • 75
    • 0036366158 scopus 로고    scopus 로고
    • YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathway
    • Sauvonnet N., et al. YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathway. Mol. Microbiol. 2002, 45:805-815.
    • (2002) Mol. Microbiol. , vol.45 , pp. 805-815
    • Sauvonnet, N.1
  • 76
    • 15744385951 scopus 로고    scopus 로고
    • The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt
    • Knodler L.A., et al. The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt. J. Biol. Chem. 2005, 280:9058-9064.
    • (2005) J. Biol. Chem. , vol.280 , pp. 9058-9064
    • Knodler, L.A.1
  • 77
    • 37449032424 scopus 로고    scopus 로고
    • Invasion of HeLa cells by group B Streptococcus requires the phosphoinositide-3-kinase signalling pathway and modulates phosphorylation of host-cell Akt and glycogen synthase kinase-3
    • Burnham C.A., et al. Invasion of HeLa cells by group B Streptococcus requires the phosphoinositide-3-kinase signalling pathway and modulates phosphorylation of host-cell Akt and glycogen synthase kinase-3. Microbiology 2007, 153:4240-4252.
    • (2007) Microbiology , vol.153 , pp. 4240-4252
    • Burnham, C.A.1
  • 78
    • 0038730882 scopus 로고    scopus 로고
    • Exploitation of host epithelial signaling networks by respiratory bacterial pathogens
    • Li J.D. Exploitation of host epithelial signaling networks by respiratory bacterial pathogens. J. Pharmacol. Sci. 2003, 91:1-7.
    • (2003) J. Pharmacol. Sci. , vol.91 , pp. 1-7
    • Li, J.D.1
  • 79
    • 59449108480 scopus 로고    scopus 로고
    • Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway
    • Nakayama M., et al. Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. J. Biol. Chem. 2009, 284:1612-1619.
    • (2009) J. Biol. Chem. , vol.284 , pp. 1612-1619
    • Nakayama, M.1
  • 80
    • 74949095434 scopus 로고    scopus 로고
    • Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA
    • Isomoto H., et al. Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA. Tohoku J. Exp. Med. 2010, 220:3-14.
    • (2010) Tohoku J. Exp. Med. , vol.220 , pp. 3-14
    • Isomoto, H.1
  • 81
    • 67650447457 scopus 로고    scopus 로고
    • Host Wnt/beta-catenin pathway triggered by Helicobacter pylori correlates with regression of gastric intestinal metaplasia after H. pylori eradication
    • Hung K.H., et al. Host Wnt/beta-catenin pathway triggered by Helicobacter pylori correlates with regression of gastric intestinal metaplasia after H. pylori eradication. J. Med. Microbiol. 2009, 58:567-576.
    • (2009) J. Med. Microbiol. , vol.58 , pp. 567-576
    • Hung, K.H.1
  • 82
    • 84876971455 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitory peptide attenuates Helicobacter pylori-mediated hyper-proliferation in AGS enteric epithelial cells
    • Himaya S.W., et al. EGFR tyrosine kinase inhibitory peptide attenuates Helicobacter pylori-mediated hyper-proliferation in AGS enteric epithelial cells. Toxicol. Appl. Pharmacol. 2013, 269:205-214.
    • (2013) Toxicol. Appl. Pharmacol. , vol.269 , pp. 205-214
    • Himaya, S.W.1
  • 83
    • 79960736360 scopus 로고    scopus 로고
    • Kinase activity profiling of Gram-negative pneumonia
    • Hoogendijk A.J., et al. Kinase activity profiling of Gram-negative pneumonia. Mol. Med. 2011, 17:741-747.
    • (2011) Mol. Med. , vol.17 , pp. 741-747
    • Hoogendijk, A.J.1
  • 84
    • 84869888380 scopus 로고    scopus 로고
    • Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt
    • Kuo S.Z., et al. Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt. BMC Cancer 2012, 12:556.
    • (2012) BMC Cancer , vol.12 , pp. 556
    • Kuo, S.Z.1
  • 85
    • 84867633099 scopus 로고    scopus 로고
    • S632A3, a new glutarimide antibiotic, suppresses lipopolysaccharide-induced pro-inflammatory responses via inhibiting the activation of glycogen synthase kinase 3beta
    • Deng H., et al. S632A3, a new glutarimide antibiotic, suppresses lipopolysaccharide-induced pro-inflammatory responses via inhibiting the activation of glycogen synthase kinase 3beta. Exp. Cell Res. 2012, 318:2592-2603.
    • (2012) Exp. Cell Res. , vol.318 , pp. 2592-2603
    • Deng, H.1
  • 86
    • 79953230902 scopus 로고    scopus 로고
    • + T cells
    • +T cells. J. Biol. Chem. 2011, 286:11275-11282.
    • (2011) J. Biol. Chem. , vol.286 , pp. 11275-11282
    • Szeto, G.L.1
  • 87
    • 34948896426 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta inhibition attenuates the development of bleomycin-induced lung injury
    • Cuzzocrea S., et al. Glycogen synthase kinase-3beta inhibition attenuates the development of bleomycin-induced lung injury. Int. J. Immunopathol. Pharmacol. 2007, 20:619-630.
    • (2007) Int. J. Immunopathol. Pharmacol. , vol.20 , pp. 619-630
    • Cuzzocrea, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.