Inhaled aerosolized insulin: A "topical" anti-inflammatory treatment for acute lung injury and respiratory distress syndrome?

Inflammation

Volumn 33, Issue 5, 2010, Pages 315-319

  Shapiro, Haim ^a   Kagan, Ilya ^a   Shalita Chesner, Michal ^a   Singer, Joelle ^a   Singer, Pierre ^a  

^a RABIN MEDICAL CENTER   (Israel)

Author keywords

acute lung injury; acute respiratory distress syndrome; insulin; nuclear factor kappa B

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SOMATOMEDIN C;

ANTIINFLAMMATORY ACTIVITY; CHEMOPROPHYLAXIS; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; LUNG INJURY; NONHUMAN; OXIDATIVE STRESS; RESPIRATORY DISTRESS SYNDROME; REVIEW; TRANSCRIPTION REGULATION; UPREGULATION;

ACUTE LUNG INJURY; ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD GLUCOSE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 77956060500     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-010-9187-2     Document Type: Review

References (39)

1. SK Leaver TW Evans 2007 Acute respiratory distress syndrome BMJ 335 7616 389 394 10.1136/bmj.39293.624699.AD 1:CAS:528:DC%2BD2sXhtFems7nL 17717368
2. GR Bernard A Artigas KL Brigham J Carlet K Falke L Hudson, et al. 1994 The American-European consensus conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination American Journal of Respiratory and Critical Care Medicine 149 818 824 1:STN:280: DyaK2c7mtlCnsA%3D%3D 7509706
3. CA Piantadosi DA Schwartz 2004 The acute respiratory distress syndrome Annals of Internal Medicine 141 6 460 470 15381520
4. AP Wheeler GR Bernard 2007 Acute lung injury and the acute respiratory distress syndrome: a clinical review Lancet 369 9572 1553 1564 10.1016/S0140-6736(07)60604-7 17482987
5. KM Dungan SS Braithwaite JC Preiser 2009 Stress hyperglycaemia Lancet 373 9677 1798 1807 10.1016/S0140-6736(09)60553-5 1:CAS:528:DC%2BD1MXmtlektrw%3D 19465235
6. BG Fahy AM Sheehy DB Coursin 2009 Glucose control in the intensive care unit Critical Care Medicine 37 5 1769 1776 10.1097/CCM.0b013e3181a19ceb 1:CAS:528:DC%2BD1MXksF2mt7o%3D 19325461
7. T Hayashi T Hirano T Yamamoto Y Ito M Adachi 2006 Intensive insulin therapy reduces small dense low-density lipoprotein particles in patients with type 2 diabetes mellitus: relationship to triglyceride-rich lipoprotein subspecies Metabolism 55 7 879 884 10.1016/j.metabol.2006.02.014 1:CAS:528:DC%2BD28XlvFKisL4%3D 16784958
8. D Mesotten JV Swinnen F Vanderhoydonc PJ Wouters G Van den Berghe 2004 Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy Journal of Clinical Endocrinology and Metabolism 89 1 219 226 10.1210/jc.2003-030760 1:CAS:528:DC%2BD2cXmvFCjsw%3D%3D 14715853
9. M Wendel R Paul AR Heller 2007 Lipoproteins in inflammation and sepsis. II. Clinical aspects Intensive Care Medicine 33 1 25 35 10.1007/s00134-006-0433- x 1:CAS:528:DC%2BD1cXhtFSgtrjK 17093984
10. R Muniyappa M Iantorno MJ Quon 2008 An integrated view of insulin resistance and endothelial dysfunction Endocrinology and Metabolism Clinics of North America 37 3 685 711 10.1016/j.ecl.2008.06.001 1:CAS:528: DC%2BD1cXht1Kqs77E 18775359
11. P Dandona P Mohanty A Chaudhuri R Garg A Aljada 2005 Insulin infusion in acute illness Journal of Clinical Investigation 115 8 2069 2072 10.1172/JCI26045 1:CAS:528:DC%2BD2MXntFCmt7Y%3D 16075050
12. L Langouche I Vanhorebeek D Vlasselaers S Vander Perre PJ Wouters K Skogstrand TK Hansen G Van den Berghe 2005 Intensive insulin therapy protects the endothelium of critically ill patients Journal of Clinical Investigation 115 8 2277 2286 10.1172/JCI25385 1:CAS:528:DC%2BD2MXntFCmur0%3D 16075063
13. P Dandona A Aljada P Mohanty H Ghanim W Hamouda E Assian S Ahmad 2001 Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? Journal of Clinical Endocrinology and Metabolism 86 7 3257 3265 10.1210/jc.86.7.3257 1:CAS:528:DC%2BD3MXlt1GjtLk%3D 11443198
14. A Aljada H Ghanim P Mohanty N Kapur P Dandona 2002 Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations Journal of Clinical Endocrinology and Metabolism 87 1419 1422 10.1210/jc.87.3.1419 1:CAS:528:DC%2BD38XitlWnt7g%3D 11889219
15. P Dandona A Chaudhuri P Mohanty H Ghanim 2007 Anti-inflammatory effects of insulin Current Opinion in Clinical Nutrition and Metabolic Care 10 4 511 517 10.1097/MCO.0b013e3281e38774 1:CAS:528:DC%2BD2sXotl2lt78%3D 17563472
16. A Aljada H Ghanim R Saadeh P Dandona 2001 Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells Journal of Clinical Endocrinology and Metabolism 86 1 450 453 10.1210/jc.86.1.450 1:CAS:528:DC%2BD3MXhtVGntLw%3D 11232040
17. A Aljada P Mohanty H Ghanim T Abdo D Tripathy A Chaudhuri P Dandona 2004 Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect American Journal of Clinical Nutrition 79 4 682 690 1:CAS:528: DC%2BD2cXivFyktb8%3D 15051615
18. JL Evans ID Goldfine BA Maddux GM Grodsky 2003 Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 52 1 1 8 10.2337/diabetes.52.1.1 1:CAS:528:DC%2BD3sXisVWquw%3D%3D 12502486
19. L Dugo M Collin DA Allen O Murch SJ Foster MM Yaqoob C Thiemermann 2006 Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose: role of glycogen synthase kinase-3beta inhibition Critical Care Medicine 34 5 1489 1496 10.1097/01.CCM.0000215457.83953.E3 1:CAS:528: DC%2BD28XjslCqtLk%3D 16557150
20. MG Jeschke H Rensing D Klein T Schubert AE Mautes U Bolder RS Croner 2005 Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats Journal of Hepatology 42 6 870 879 10.1016/j.jhep.2004.12.036 1:CAS:528:DC%2BD2MXktVGmt7o%3D 15885358
21. LB Kidd GA Schabbauer JP Luyendyk TD Holscher RE Tilley M Tencati N Mackman 2008 Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice Journal of Pharmacology and Experimental Therapeutics 326 1 348 353 10.1124/jpet.108.138891 1:CAS:528:DC%2BD1cXotlylt7k%3D 18445780
22. S Hagiwara H Iwasaka A Hasegawa H Koga T Noguchi 2008 Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model Critical Care Medicine 36 8 2407 2413 10.1097/CCM.0b013e318180b3ba 1:CAS:528:DC%2BD1cXptFSmtrk%3D 18596634
23. VP Guntur R Dhand 2007 Inhaled insulin: extending the horizons of inhalation therapy Respiratory Care 52 7 911 922 17594734
24. J Kling 2008 Inhaled insulin's last gasp? Nature Biotechnology 26 5 479 480 10.1038/nbt0508-479 1:CAS:528:DC%2BD1cXls12jt78%3D 18464758
25. J Mitri AG Pittas 2009 Inhaled insulin-what went wrong Nat Clin Pract Endocrinol Metab 5 1 24 25 10.1038/ncpendmet1007 18981990
26. K Rave T Heise A Pfützner AH Boss 2008 Coverage of postprandial blood glucose excursions with inhaled technosphere insulin in comparison to subcutaneously injected regular human insulin in subjects with type 2 diabetes Diabetes Care 30 9 2307 2308 10.2337/dc07-0478
27. J Rosenstock R Bergenstal RA Defronzo IB Hirsch D Klonoff AH Boss D Kramer R Petrucci W Yu B Levy 0008 Study Group 2008 Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents Diabetes Care 31 11 2177 2182 10.2337/dc08-0315 1:CAS:528:DC%2BD1cXhsVeqsL3O 18678610
28. Bergenstal et al. Comparative Efficacy and Safety of AFRESA™ and a Rapid-Acting Analog Both Given with Glargine in Subjects with T1DM in a 52-Week Study. Abstract # 479-P, ADA conference 2009. http://ww2.aievolution.com/ ada0901/index.cfm?do = abs.viewAbs&abs = 6624 accessed October 2009.
29. ADA 2009: New Inhaled Insulin Has Rapid Onset of Action With No Adverse Effect on Lung Function. Medscape Medical News. http://www.medscape.com/ viewarticle/704092. accessed October 2009.
30. HOW DOES THE TECHNOSPHERE® INSULIN SYSTEM WORK? http://www. mannkindcorp.com/technosphere-insulin.aspx. accessed July 13 2009.
31. PK Gonzalez J Zhuang SR Doctrow B Malfroy PF Benson MJ Menconi MP Fink 1996 Role of oxidant stress in the adult respiratory distress syndrome: evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury Shock 6 Suppl 1 S23 S26 8828094
32. JO Martins FL Zanoni DO Martins R Coimbra JE Krieger S Jancar P Sannomiya 2009 Insulin regulates cytokines and intercellular adhesion molecule-1 gene expression through nuclear factor-kappaB activation in LPS-induced acute lung injury in rats Shock 31 4 404 409 10.1097/SHK.0b013e318186275e 1:CAS:528:DC%2BD1MXjtF2ltro%3D 18791499
33. MJ de Oliveira AR Meyer-Pflug TC Alba-Loureiro H Melbostad JW Costa da Cruz R Coimbra R Curi P Sannomiya 2006 Modulation of lipopolysaccharide-induced acute lung inflammation: role of insulin Shock 25 3 260 266 10.1097/01.shk. 0000194042.18699.b4
34. HI Chen DY Yeh HL Liou SJ Kao 2006 Insulin attenuates endotoxin-induced acute lung injury in conscious rats Critical Care Medicine 34 3 758 764 10.1097/01.CCM.0000201902.37115.22 1:CAS:528:DC%2BD28Xhs12gu7w%3D 16505662
35. TC Alba-Loureiro EF Martins RG Landgraf S Jancar R Curi P Sannomiya 2006 Role of insulin on PGE2 generation during LPS-induced lung inflammation in rats Life Sciences 78 6 578 585 10.1016/j.lfs.2005.05.057 1:CAS:528: DC%2BD2MXhtlWqu7bM 16143347
36. M Donnelly C Condron P Murray D Bouchier-Hayes 2007 Modulation of the glycemic response using insulin attenuates the pulmonary response in an animal trauma model Journal of Trauma 63 2 351 357 10.1097/01.ta.0000251599.80602.d1 1:CAS:528:DC%2BD2sXhtVeiu7nL 17693835
37. JO Martins M Ferracini N Ravanelli RG Landgraf S Jancar 2008 Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-kappaB activation in alveolar macrophages Cellular Physiology and Biochemistry 22 1-4 279 286 10.1159/000149806 1:CAS:528:DC%2BD1cXhtVKlsL7F 18769055
38. Honiden, S., and M. N. Gong. 2009. Diabetes, insulin, and development of acute lung injury. Critical Care Medicine, Jun 15. [Epub ahead of print.
39. PM Krein PJ Sabatini W Tinmouth FH Green BW Winston 2003 American Journal of Respiratory and Critical Care Medicine 167 1 83 90 10.1164/rccm.2201012 12502480