Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors

Mechanisms of Ageing and Development

Volumn 132, Issue 6-7, 2011, Pages 274-286

  Fallah, Mosoka P ^a   Chelvarajan, R Lakshman ^a   Garvy, Beth A ^a   Bondada, Subbarao ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Aging; Macrophages; Phosphatidyl inosital 3 kinase (PI3K); Streptococcus pneumoniae; Toll Like receptors

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P100; PROTEIN P100 DELTA; PROTEIN P85; PROTEIN P85 BETA; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL KILLING; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION REGULATION; LIGAND BINDING; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPLEEN CELL; STREPTOCOCCUS PNEUMONIAE; UPREGULATION;

AGING; ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOKINES; FEMALE; LYMPHOCYTE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED BALB C; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPLEEN; STREPTOCOCCUS PNEUMONIAE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

MUS; POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 79961209264     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2011.05.003     Document Type: Article

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