Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Kuo, Selena Z ^a   Blair, Katherine J ^a   Rahimy, Elham ^a   Kiang, Alan ^a   Abhold, Eric ^a   Fan, Jian Bing ^b   Wang Rodriguez, Jessica ^c   Altuna, Xabier ^d   Ongkeko, Weg M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b ILLUMINA INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HOSPITAL DONOSTIA   (Spain)

Author keywords

Akt; Cancer stem cells; EMT; Head and neck squamous cell carcinoma; MicroRNA; Salinomycin

Indexed keywords

BMI1 PROTEIN; CISPLATIN; GLYCOGEN SYNTHASE KINASE 3BETA; HERMES ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SALINOMYCIN; TRANSCRIPTION FACTOR ZEB1; UVOMORULIN; VIMENTIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NICK END LABELING; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTIGENS, CD44; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, SQUAMOUS CELL; CELL DEATH; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CISPLATIN; DRUG INTERACTIONS; ENZYME ACTIVATION; EPITHELIAL-MESENCHYMAL TRANSITION; HEAD AND NECK NEOPLASMS; HUMANS; MICRORNAS; MITOGEN-ACTIVATED PROTEIN KINASE 7; NEOPLASTIC STEM CELLS; PACLITAXEL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRANS; RNA, MESSENGER;

EID: 84869888380     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-556     Document Type: Article

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