Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation

American Journal of Pathology

Volumn 181, Issue 4, 2012, Pages 1414-1425

  Rom, Slava ^a   Fan, Shongshan ^a   Reichenbach, Nancy ^a   Dykstra, Holly ^a   Ramirez, Servio H ^a   Persidsky, Yuri ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; COFILIN; F ACTIN; GLYCOGEN SYNTHASE KINASE 3BETA; INTEGRIN; RAC1 PROTEIN; VERY LATE ACTIVATION ANTIGEN 4;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; CROSS LINKING; CYTOSKELETON; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MONOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ACTIN DEPOLYMERIZING FACTORS; AIDS DEMENTIA COMPLEX; BLOOD-BRAIN BARRIER; BRAIN; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; DOWN-REGULATION; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTEGRIN ALPHA4BETA1; MACROPHAGES; MICROFILAMENT PROTEINS; MONOCYTES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PSEUDOPODIA; RAC1 GTP-BINDING PROTEIN; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

EID: 84866511781     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.06.018     Document Type: Article

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