GSK-3β inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat

Critical Care Medicine

Volumn 33, Issue 9, 2005, Pages 1903-1912

  Dugo, Laura ^a   Collin, Marika ^a   Allen, David A ^a   Patel, Nimesh S A ^a   Bauer, Inge ^b   Mervaala, Eero M A ^c   Louhelainen, Marjut ^c   Foster, Simon J ^d   Yaqoob, Muhammad M ^a   Thiemermann, Christoph ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b SAARLAND UNIVERSITY   (Germany)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Endotoxemia; GSK 3 ; Inflammation; Lipopolysaccharide; Peptidoglycan; TDZD 8

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MESSENGER RNA; PEPTIDOGLYCAN; SERINE; SERINE THREONINE PROTEIN KINASE GLYCOGEN SYNTHASE KINASE 3; TDZD 8; UNCLASSIFIED DRUG; 4 BENZYL 2 METHYL 1,2,4 THIADIAZOLIDINE 3,5 DIONE; 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE; AMINOPHENOL DERIVATIVE; BACTERIAL POLYSACCHARIDE; CREATINE KINASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INDOLE DERIVATIVE; LIPOPOLYSACCHARIDE; MALEIMIDE DERIVATIVE; THIADIAZOLE DERIVATIVE; TRIACYLGLYCEROL LIPASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTOXEMIA; IN VITRO STUDY; INFLAMMATION; LIVER CELL DAMAGE; MALE; NEUROMUSCULAR DISEASE; NONHUMAN; ORGAN INJURY; PANCREAS INJURY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; BLOOD; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; KIDNEY DISEASE; LIVER; METABOLISM; PATHOLOGY; PHOSPHORYLATION; RANDOMIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

ALANINE TRANSAMINASE; AMINOPHENOLS; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOTTING, WESTERN; CELLS, CULTURED; CREATINE KINASE; CREATININE; ENDOTOXEMIA; GLYCOGEN SYNTHASE KINASE 3; INDOLES; KIDNEY DISEASES; LIPASE; LIPOPOLYSACCHARIDES; LIVER; MALE; MALEIMIDES; NF-KAPPA B; PEPTIDOGLYCAN; PHOSPHORYLATION; POLYSACCHARIDES, BACTERIAL; PROSPECTIVE STUDIES; RANDOM ALLOCATION; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIADIAZOLES;

EID: 24944567775     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000178350.21839.44     Document Type: Article

References (35)

1. Frame S, Cohen P: GSK3 takes centre stage more than 20 years after its discovery. Biochem J 2001; 359:1-16
2. Van Wauwe J, Haefner B: Glycogen synthase kinase-3 as drug target: From wallflower to center of attention. Drug News Perspect 2003; 16:557-565
3. Cohen J, Abraham E: Microbiologic findings and correlations with serum tumor necrosis factor-alpha in patients with severe sepsis and septic shock. J Infect Dis 1999; 180:116-121
4. Embi N, Rylatt DB, Cohen P: Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem 1980; 107:519-527
5. Woodgett JR: Judging a protein by more than its name: GSK-3. Sci STKE 2001; 2001:RE12
6. Cross DA, Alessi DR, Cohen P, et al: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378:785-789
7. Hoeflich KP, Luo J, Rubie EA, et al: Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 2000; 406:86-90
8. Beg AA, Sha WC, Bronson RT, et al: Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 1995; 376:167-170
9. Li Q, Van Antwerp D, Mercurio F, et al: Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 1999; 284:321-325
10. Dugo L, Collin M, Cuzzocrea S, et al: 15d-prostaglandin J(2) reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. Eur J Pharmacol 2004; 498:295-301
11. Thiemermann C, Ruetten H, Wu CC, et al: The multiple organ dysfunction syndrome caused by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol 1995; 116:2845-2851
12. Baue AE: The multiple organ or system failure syndrome. In: Pathophysiology of Shock, Sepsis, and Organ Failure. Schlag G, Rede H (Eds). Berlin, Springer-Verlag, 1993, pp 1004-1018
13. Hewett JA, Jean PA, Kunkel SL, et al: Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury. Am J Physiol 1993; 265: G1011-G1015
14. Ruetten H, Thiemermann C: Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: A possible role for protein tyrosine kinase. Br J Pharmacol 1997; 122:59-70
15. McDonald MC, Filipe HM, Thiemermann C: Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock. Br J Pharmacol 1999; 128:1339-1345
16. Martinez A, Alonso M, Castro A, et al: First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem 2002; 45:1292-1299
17. Coghlan MP, Culbert AA, Cross DA, et al: Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 2000; 7:793-803
18. Gross ER, Hsu AK, Gross GJ: Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res 2004; 94:960-966
19. Dignam JD, Lebovitz RM, Roeder RG: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983; 11:1475-1489
20. Rensing H, Jaeschke H, Bauer I, et al: Differential activation pattern of redox-sensitive transcription factors and stress-inducible dilator systems heme oxygenase-1 and inducible nitric oxide synthase in hemorrhagic and endotoxic shock. Crit Care Med 2001; 29:1962-1971
21. Essani NA, McGuire GM, Manning AM, et al: Endotoxin-induced activation of the nuclear transcription factor kappa B and expression of E-selectin messenger RNA in hepatocytes, Kupffer cells, and endothelial cells in vivo. J Immunol 1996; 156:2956-2963
22. Heyen JR, Blasi ER, Nikula K, et al: Structural, functional, and molecular characterization of the SHHF model of heart failure. Am J Physiol Heart Circ Physiol 2002; 283: H1775-H1784
23. Farjah M, Roxas BP, Geenen DL, et al: Dietary salt regulates renal SGK1 abundance: Relevance to salt sensitivity in the Dahl rat. Hypertension 2003; 41:874-878
24. Foster PL, Marinus MG: Levels of epsilon, an essential replication subunit of Escherichia coli DNA polymerase III, are controlled by heat shock proteins. J Bacteriol 1992; 174:7509-7516
25. Kirschning CJ, Wesche H, Merrill AT, et al: Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med 1998; 188:2091-2097
26. Zingarelli B: Peptidoglycan is an important pathogenic factor of the inflammatory response in sepsis. Crit Care Med 2004; 32:613-614
27. Wray GM, Foster SJ, Hinds CJ, et al: A cell wall component from pathogenic and non-pathogenic Gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the rat. Shock 2001; 15:135-142
28. Demarchi F, Bertoli C, Sandy P, et al: Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability. J Biol Chem 2003; 278:39583-39590
29. Schwabe RF, Brenner DA: Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol 2002; 283:G204-G211
30. Takada Y, Fang X, Jamaluddin MS, et al: Genetic deletion of glycogen synthase kinase-3beta abrogates activation of I Ba kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by TNF. J Biol Chem 2004; 279:39541-39554
31. Buss H, Dorrie A, Schmitz ML, et al: Constitutive and IL-1-inducible phosphorylation of p65 NF-kB at serine 536 is mediated by multiple protein kinases including IKKalpha, IKKbbeta, IKKepsilon, TBK1 and an unknown kinase and couples p65 to TAFII31-mediated IL-8 transcription. J Biol Chem 2004; 31:55633-55643
32. Buss H, Dorrie A, Schmitz ML, et al: Phosphorylation of serine 468 by GSK-3b negatively regulates basal p65 NF-kB activity. J Biol Chem 2004; 279:49571-49574
33. Wang JE, Dahle MK, Yndestad A, et al: Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat. Crit Care Med 2004; 32:546-552
34. Zingarelli B, Sheehan M, Wong HR: Nuclear factor-kappaB as a therapeutic target in critical care medicine. Crit Care Med 2003; 31: S105-S111
35. Eldar-Finkelman H: Glycogen synthase kinase 3: An emerging therapeutic target. Trends Mol Med 2002; 8:126-132