Protective effects of lithium: A new look at an old drug with potential antioxidative and anti-inflammatory effects in an animal model of sepsis

International Immunopharmacology

Volumn 16, Issue 1, 2013, Pages 35-40

  Albayrak, Abdulmecit ^a   Halici, Zekai ^a   Polat, Beyzagul ^b   Karakus, Emre ^b   Cadirci, Elif ^b   Bayir, Yasin ^b   Kunak, Semih ^c   Karcioglu, Saliha Sena ^a   Yigit, Serdar ^a   Unal, Deniz ^a   Atamanalp, Sabri Selcuk ^a  

^a ATATURK UNIVERSITY   (Turkey)

^b ATATÜRK UNIVERSITY   (Turkey)

^c GIRESUN UNIVERSITY   (Turkey)

Author keywords

IL 1 ; Lithium; Lung injury; Oxidative stress; Polymicrobial sepsis; TNF

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; GLUTATHIONE; INTERLEUKIN 6; LITHIUM; LITHURIL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOPHARMACOLOGY; LUNG PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; PROTEIN BLOOD LEVEL; RAT; SEPSIS; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CYTOKINES; DINOPROST; DISEASE MODELS, ANIMAL; GLUTATHIONE; LITHIUM CARBONATE; MALE; RATS; RATS, WISTAR; SEPSIS; SUPEROXIDE DISMUTASE;

EID: 84875942000     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.03.018     Document Type: Article

References (62)

1. R.C. Bone, R.A. Balk, F.B. Cerra, R.P. Dellinger, A.M. Fein, and W.A. Knaus Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Chest 101 1992 1644 1655
2. R.C. Bone The pathogenesis of sepsis Ann Intern Med 115 1991 457 469
3. C.R. Raetz, R.J. Ulevitch, S.D. Wright, C.H. Sibley, A. Ding, and C.F. Nathan Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction FASEB J 5 1991 2652 2660
4. D.C. Morrison, and J.L. Ryan Bacterial endotoxins and host immune responses Adv Immunol 28 1979 293 450
5. L.S. Young, R.A. Proctor, B. Beutler, W.R. McCabe, and J.N. Sheagren University of California/Davis Interdepartmental Conference on gram-negative septicemia Rev Infect Dis 13 1991 666 687
6. Z.X. Liang, J.P. Sun, P. Wang, Q. Tian, Z. Yang, and L.A. Chen Bone marrow-derived mesenchymal stem cells protect rats from endotoxin-induced acute lung injury Chin Med J 124 2011 2715 2722
7. J.M. Alonso de Vega, J. Diaz, E. Serrano, and L.F. Carbonell Oxidative stress in critically ill patients with systemic inflammatory response syndrome Crit Care Med 30 2002 1782 1786
8. P.S. Martins, E.G. Kallas, M.C. Neto, M.A. Dalboni, S. Blecher, and R. Salomao Upregulation of reactive oxygen species generation and phagocytosis, and increased apoptosis in human neutrophils during severe sepsis and septic shock Shock 20 2003 208 212
9. E. Crimi, V. Sica, A.S. Slutsky, H. Zhang, S. Williams-Ignarro, and L.J. Ignarro Role of oxidative stress in experimental sepsis and multisystem organ dysfunction Free Radic Res 40 2006 665 672
10. E. Cadirci, B.Z. Altunkaynak, Z. Halici, F. Odabasoglu, M.H. Uyanik, and C. Gundogdu Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats Shock 33 2010 479 484
11. A. Uyanik, D. Unal, M.H. Uyanik, Z. Halici, F. Odabasoglu, and Z.B. Altunkaynak The effects of polymicrobial sepsis with diabetes mellitus on kidney tissues in ovariectomized rats Ren Fail 32 2010 592 602
12. A. Albayrak, M.H. Uyanik, F. Odabasoglu, Z. Halici, A. Uyanik, and Y. Bayir The effects of diabetes and/or polymicrobial sepsis on the status of antioxidant enzymes and pro-inflammatory cytokines on heart, liver, and lung of ovariectomized rats J Surg Res 169 2011 67 75
13. H.R. Pilcher Drug research: the ups and downs of lithium Nature 425 2003 118 120
14. A. Yildiz, E. Vieta, S. Leucht, and R.J. Baldessarini Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials Neuropsychopharmacology 36 2011 375 389
15. A.L. Price, and G.R. Marzani-Nissen Bipolar disorders: a review Am Fam Physician 85 2012 483 493
16. P.A. Baeuerle, and D. Baltimore NF-kappa B: ten years after Cell 87 1996 13 20
17. F. Bosetti, J. Rintala, R. Seemann, T.A. Rosenberger, M.A. Contreras, and S.I. Rapoport Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain Mol Psychiatry 7 2002 845 850
18. R. Yassa Leukocytosis during long-term lithium treatment N Y State J Med 81 1981 1479 1480
19. M.H. Rapaport, and H.K. Manji The effects of lithium on ex vivo cytokine production Biol Psychiatry 50 2001 217 224
20. H. Li, Q. Li, X. Du, Y. Sun, X. Wang, and G. Kroemer Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells J Cereb Blood Flow Metab 31 2011 2106 2115
21. S. Nahman, R.H. Belmaker, and A.N. Azab Effects of lithium on lipopolysaccharide-induced inflammation in rat primary glia cells Innate Immun 18 2012 447 458
22. M.E. Altunkaynak, E. Ozbek, B.Z. Altunkaynak, I. Can, D. Unal, and B. Unal The effects of high-fat diet on the renal structure and morphometric parametric of kidneys in rats J Anat 212 2008 845 852
23. D.K. Biswas, Q. Shi, S. Baily, I. Strickland, S. Ghosh, and A.B. Pardee NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis Proc Natl Acad Sci U S A 101 2004 10137 10142
24. A.J. Gelenberg, J.M. Kane, M.B. Keller, P. Lavori, J.F. Rosenbaum, and K. Cole Comparison of standard and low serum levels of lithium for maintenance treatment of bipolar disorder N Engl J Med 321 1989 1489 1493
25. F. Nejadkey, A. Nahavandi, A.R. Dehpour, and A.R. Mani Role of nitric oxide in the gastro-protective effect of lithium Pathophysiology 13 2006 85 89
26. C. Baethge, P. Gruschka, A. Berghofer, M. Bauer, B. Muller-Oerlinghausen, and T. Bschor Prophylaxis of schizoaffective disorder with lithium or carbamazepine: outcome after long-term follow-up J Affect Disord 79 2004 43 50
27. T. Engel, P. Goni-Oliver, E. Gomez de Barreda, J.J. Lucas, F. Hernandez, and J. Avila Lithium, a potential protective drug in Alzheimer's disease Neurodegener Dis 5 2008 247 249
28. F. Fornai, P. Longone, L. Cafaro, O. Kastsiuchenka, M. Ferrucci, and M.L. Manca Lithium delays progression of amyotrophic lateral sclerosis Proc Natl Acad Sci U S A 105 2008 2052 2057
29. S. Bertsch, C.H. Lang, and T.C. Vary Inhibition of glycogen synthase kinase 3[beta] activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnover Shock 35 2011 266 274
30. M. Gitlin Treatment-resistant bipolar disorder Mol Psychiatry 11 2006 227 240
31. K. Vijaimohan, J. Mallika, and D.C. Shyamala Chemoprotective effect of sobatum against lithium-induced oxidative damage in rats J Young Pharm 2 2010 68 73
32. S.C. Thakur, S.S. Thakur, S.K. Chaube, and S.P. Singh Subchronic supplementation of lithium carbonate induces reproductive system toxicity in male rat Reprod Toxicol 17 2003 683 690
33. G. Hernandez, D. Bernstein, G. Schoenbaum, and J.F. Cheer Contrasting effects of lithium chloride and CB1 receptor blockade on enduring changes in the valuation of reward Front Behav Neurosci 5 2011 53
34. T. van der Poll, and S.J. van Deventer Cytokines and anticytokines in the pathogenesis of sepsis Infect Dis Clin North Am 13 1999 413 426 [ix]
35. E. Cadirci, Z. Halici, F. Odabasoglu, A. Albayrak, E. Karakus, and D. Unal Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study Clin Exp Immunol 166 2011 374 384
36. A.K. Coskun, M. Yigiter, A. Oral, F. Odabasoglu, Z. Halici, and O. Mentes The effects of montelukast on antioxidant enzymes and proinflammatory cytokines on the heart, liver, lungs, and kidneys in a rat model of cecal ligation and puncture-induced sepsis ScientificWorldJournal 11 2011 1341 1356
37. P. Damas, D. Ledoux, M. Nys, Y. Vrindts, D. De Groote, and P. Franchimont Cytokine serum level during severe sepsis in human IL-6 as a marker of severity Ann Surg 215 1992 356 362
38. A. Ayala, J.L. Lomas, P.S. Grutkoski, and C.S. Chung Pathological aspects of apoptosis in severe sepsis and shock? Int J Biochem Cell Biol 35 2003 7 15
39. E. Beurel, and R.S. Jope Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain J Neuroinflammation 6 2009
40. C.J. Yuskaitis, and R.S. Jope Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity Cell Signal 21 2009 264 273
41. N. Abramson, and B. Melton Leukocytosis: basics of clinical assessment Am Fam Physician 62 2000 2053 2060
42. R.S. Stein, C.A. Howard, M. Brennan, and M. Czorniak Lithium carbonate and granulocyte production: dose optimization Cancer 48 1981 2697 2701
43. R. Yassa, J. Ananth, and T. Mendis Lithium salts in leukopenic disorders N Y State J Med 80 1980 1076 1079
44. R.S. Jope Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes Trends Pharmacol Sci 24 2003 441 443
45. V. Stambolic, L. Ruel, and J.R. Woodgett Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells Curr Biol 6 1996 1664 1668
46. K.P. Hoeflich, J. Luo, E.A. Rubie, M.S. Tsao, O. Jin, and J.R. Woodgett Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation Nature 406 2000 86 90
47. M. Martin, K. Rehani, R.S. Jope, and S.M. Michalek Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3 Nat Immunol 6 2005 777 784
48. D. Salvemini, Z.Q. Wang, D.M. Bourdon, M.K. Stern, M.G. Currie, and P.T. Manning Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema Eur J Pharmacol 303 1996 217 220
49. D. Salvemini, Z.Q. Wang, P.S. Wyatt, D.M. Bourdon, M.H. Marino, and P.T. Manning Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation Br J Pharmacol 118 1996 829 838
50. Z. Halici, M. Karaca, O.N. Keles, B. Borekci, F. Odabasoglu, and H. Suleyman Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation Fertil Steril 90 2008 2408 2415
51. D.S. Abdalla, and E.J. Bechara The effect of chlorpromazine and Li2CO3 on the superoxide dismutase and glutathione peroxidase activities of rat brain, liver and erythrocytes Biochem Mol Biol Int 34 1994 1085 1090
52. V. Erakovic, G. Zupan, J. Varljen, J. Laginja, and A. Simonic Lithium plus pilocarpine induced status epilepticus-biochemical changes Neurosci Res 36 2000 157 166
53. M.C. Carrillo, C. Minami, K. Kitani, W. Maruyama, K. Ohashi, and T. Yamamoto Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat Life Sci 67 2000 577 585
54. R. Machado-Vieira, A.C. Andreazza, C.I. Viale, V. Zanatto, V. Cereser Jr., and R. da Silva Vargas Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects Neurosci Lett 421 2007 33 36
55. A.C. Andreazza, C. Cassini, A.R. Rosa, M.C. Leite, L.M. de Almeida, and P. Nardin Serum S100B and antioxidant enzymes in bipolar patients J Psychiatr Res 41 2007 523 529
56. B.N. Frey, S.S. Valvassori, G.Z. Reus, M.R. Martins, F.C. Petronilho, and K. Bardini Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania J Psychiatry Neurosci 31 2006 326 332
57. R. Kannan, J.F. Kuhlenkamp, E. Jeandidier, H. Trinh, M. Ookhtens, and N. Kaplowitz Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat J Clin Invest 85 1990 2009 2013
58. O. Ortolani, A. Conti, A.R. De Gaudio, E. Moraldi, Q. Cantini, and G. Novelli The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock Am J Respir Crit Care Med 161 2000 1907 1911
59. J.A. Lawson, J. Rokach, and G.A. FitzGerald Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo J Biol Chem 274 1999 24441 24444
60. M. Sakamoto, E. Takaki, K. Yamashita, K. Watanabe, S. Tabuchi, and T. Watanabe Nonenzymatic derived lipid peroxide, 8-iso-PGF2 alpha, participates in the pathogenesis of delayed cerebral vasospasm in a canine SAH model Neurol Res 24 2002 301 306
61. S. Basu, A. Hellberg, A.T. Ulus, J. Westman, and S. Karacagil Biomarkers of free radical injury during spinal cord ischemia FEBS Lett 508 2001 36 38
62. H.S. Chung, Y.C. Lee, Y. Kyung Rhee, and S.Y. Lee Consumer acceptance of ginseng food products J Food Sci 76 2011 S516 S522