Role of Glycogen Synthase Kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus

Medical Mycology

Volumn 48, Issue 4, 2010, Pages 589-597

  Spinnler, Katrin ^a   Mezger, Markus ^a   Steffens, Michael ^b   Sennefelder, Helga ^a   Kurzai, Oliver ^a   Einsele, Hermann ^a   Loeffler, Juergen ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Aspergillus fumigatus; Glycogen synthase kinase 3; Human dendritic cells; LiCl; SB415286; Small interfering RNA

Indexed keywords

2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; GLYCOGEN SYNTHASE KINASE 3; INTERLEUKIN 10; LITHIUM CHLORIDE;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC TRANSFECTION; IN VITRO STUDY; INNATE IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; RNA INTERFERENCE;

AMINOPHENOLS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-10; LITHIUM CHLORIDE; MALEIMIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

ASPERGILLUS FUMIGATUS;

EID: 77952487841     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693780903420625     Document Type: Article

References (20)

1. Singh N, Paterson DL. Aspergillus infections in transplant recipients. Clin Microbiol Rev 2005;18:44-69.
2. Latge JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 1999;12:310-350.
3. Burns S, Thrasher AJ. Dendritic cells: the bare bones of immunity. Curr Biol 2004;14:965-967.
4. Levitz SM. Interactions of Toll-like receptors with fungi. Microbes Infect 2004;6:1351-1355.
5. Hebart H, Bollinger C, Fisch P, et al. Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies. Blood 2002;100:4521-4528.
6. Mezger M, Kneitz S, Wozniok I, et al. Proinflammatory response of immature human dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes. J Infect Dis 2008;197:924-931.
7. Martin M, Rehani K, Jope RS, Michalek SM. Toll-like receptormediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 2005;6:777-784.
8. Becker Y. Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy - a review. Virus Genes 2006;33:235-252.
9. Grigoleit U, Riegler S, Einsele H, et al. Human cytomegalovirus induces a direct inhibitory effect on antigen presentation by monocytederived immature dendritic cells. Br J Haematol 2002;119:189-198.
10. Loeffler J, Swatoch P, Akhawi-Araghi D, Hebart H, Einsele H. Automated RNA extraction by MagNA Pure followed by rapid quantification of cytokine and chemokine gene expression with use of fluorescence resonance energy transfer. Clin Chem 2003;49:955-958.
11. Mezger M, Steffens M, Beyer M, et al. Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells. Blood 2008;111:534-536.
12. Woodgett JR, Ohashi PS. GSK3: an in-Toll-erant protein kinase? Nat Immunol 2005;6:751-752.
13. Ono T, Yanagawa Y, Iwabuchi K, Nonomura K, Onoe K. Glycogen synthase kinase 3 activity during development of bone marrow-derived dendritic cells (DCs) essential for the DC function to induce T helper 2 polarization. Immunology 2007;122:189-198.
14. Rodionova E, Conzelmann M, Maraskovsky E, et al. GSK-3 mediates differentiation and activation of proinflammatory dendritic cells. Blood 2007;109:1584-1592.
15. Ryves WJ, Harwood AJ. Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem Biophys Res Commun 2001;280:720-725.
16. Chalecka-Franaszek E, Chuang DM. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc Natl Acad Sci USA 1999;96:8745-8750.
17. Coghlan MP, Culbert AA, Cross DA, et al. Selective small molecules inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 2000;7:793-803.
18. Gantner BN, Simmons RM, Underhill DM. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. Embo J 2005;24:1277-1286.
19. Cenci E, Mencacci A, Del Sero G, et al. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J Infect Dis 1999;180:1957-1968.
20. Kwok JB, Hallupp M, Loy CT, et al. GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. Ann Neurol 2005;58:829-839.